Article
Clinical Neurology
Yoon-Sang Oh, Joong-Seok Kim, Chul Hyoung Lyoo, Hosung Kim
Summary: This study found that Parkinson's disease patients with obstructive sleep apnea had significantly lower dopamine availability in the caudate nucleus compared to those without obstructive sleep apnea. This association was more pronounced in female patients. However, there was no difference in dopamine availability in other structures (putamen, globus pallidus, thalamus) between the two groups.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Lukas Mayer-Suess, Abubaker Ibrahim, Kurt Moelgg, Matteo Cesari, Michael Knoflach, Birgit Hoegl, Ambra Stefani, Stefan Kiechl, Anna Heidbreder
Summary: This review examines the relationship between sleep disorders and stroke, finding that sleep disorders are not only risk factors for stroke but also have an impact on stroke outcomes.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Neurosciences
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Summary: The use of animal models is crucial for understanding the mechanisms of Parkinson's disease. This review examines the extent to which different mouse models accurately reflect the sleep and circadian abnormalities observed in Parkinson's disease.
MOLECULAR NEURODEGENERATION
(2022)
Review
Clinical Neurology
Zheyu Xu, Kirstie N. Anderson, Nicola Pavese
Summary: Sleep disorders, such as excessive daytime sleepiness, insomnia, and rapid eye movement sleep behavior disorder (RBD), are common non-motor symptoms in Parkinson's disease (PD) which can increase over time. Further research is needed to determine if treating these sleep disorders can affect the progression of PD.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Neurosciences
Reyisha Taximaimaiti, Xingguang Luo, Xiao-Ping Wang
Summary: Sleep disorders are common in Parkinson's disease, affecting quality of life. Treatments for common sleep disorders in PD include pharmacological and non-pharmacological options aimed at improving sleep quality and minimizing side effects.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Physiology
Dieter Kunz, Henrik Oster, Oliver Rawashdeh, Wolf-Julian Neumann, Thomas Muente, Daniela Berg
Summary: The prevalence of neurodegenerative diseases, particularly Parkinson's disease, in the global north is increasing at an alarming rate, with some even calling it a pandemic. While lifestyle factors are known to contribute, the role of circadian rhythms in these diseases has not been extensively explored. Sleep and circadian rhythm disruption have been found to play a key role in neurodegeneration, particularly during the early stages of the disease. This review summarizes the current knowledge on sleep and circadian rhythm disruptions in neurodegenerative diseases, with a focus on molecular aspects and therapeutic potentials, providing valuable insights into the pathogenesis and potential treatment interventions.
Article
Neurosciences
Daniel de Castro Medeiros, Carina Plewnia, Renan Viana Mendes, Clarissa Anna Pisano, Laura Boi, Marcio Flavio Dutra Moraes, Cleiton Lopes Aguiar, Gilberto Fisone
Summary: Excessive daytime sleepiness (EDS) and sleep fragmentation are common in Parkinson's disease (PD) patients, but their mechanisms are not well understood. This study used a mouse model of PD to investigate these sleep disorders and tested the effects of dopamine replacement therapy. The results showed that a dopamine receptor agonist could alleviate EDS in PD mice, suggesting the involvement of impaired dopamine D2/D3 receptor transmission in EDS.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Charley Ximing Jin, Kate Sutherland, Thorarinn Gislason, Elin Helga Thorarinsdottir, Lia Bittencourt, Sergio Tufik, Bhajan Singh, Nigel McArdle, Peter Cistulli, Yu Sun Bin
Summary: Social jetlag is associated with daytime sleepiness in patients with obstructive sleep apnea (OSA). The study found that social jetlag of over 2 hours was significantly associated with higher levels of daytime sleepiness. Improving sleep timing could be a simple therapeutic target for reducing the impact of OSA.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Carolin F. Reichert, Simon Veitz, Miriam Buhler, Georg Gruber, Gunnar Deuring, Sophia S. Rehm, Katharina Rentsch, Corrado Garbazza, Martin Meyer, Helen Slawik, Yu-Shiuan Lin, Janine Weibel
Summary: The study found that caffeine can reduce subjective sleepiness but has individual variability in its effects on sleep. Particularly, teenagers with a higher need for deep sleep may experience a loss of slow-wave sleep at night.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Review
Neurosciences
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Subramanian Mariappan, Subramanian Rashmi, Thiwanya Choeisoongnern, Phakkharawat Sittiprapaporn, Chaiyavat Chaiyasut
Summary: Parkinson's disease is a common neurological disorder characterized by motor and non-motor features, which is more prevalent in the elderly. Sleep disorders and cognitive disturbances are common characteristics of Parkinson's disease and have important prognostic value in predicting neurodegeneration and dementia. Understanding the relationship between sleep disorders, cognitive impairment, and Parkinson's disease can aid in the development of effective treatments.
Article
Clinical Neurology
Zheyu Xu, Kirstie N. Anderson, Seyed Ehsan Saffari, Rachael A. Lawson, K. Ray Chaudhuri, David Brooks, Nicola Pavese
Summary: The study found that sleep disturbances in early Parkinson's disease patients increase over time, with insomnia being the most common issue, while a minority of patients receive treatment for their sleep disturbances.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Francesco Fanfulla, Gian Domenico Pinna, Oreste Marrone, Nadia D'Artavilla Lupo, Simona Arcovio, Maria R. Bonsignore, Elisa Morrone
Summary: The study aimed to investigate the prevalence and determinants of sleepiness at the wheel (SW) in untreated OSA patients. Determinants of SW included Epworth sleepiness scale score, depressive symptoms, and level of risk exposure. Near-miss car accidents were more commonly reported by SW+ patients compared to SW- patients, and were associated with ESS, BDI, habitual sleep duration, and ODI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Qian Xu, Chengfeng Jiang, Jingjie Ge, Jiaying Lu, Ling Li, Huan Yu, Jianjun Wu, Jian Wang, Ping Wu, Chuantao Zuo
Summary: This study aimed to compare differences between PD patients with and without probable RBD and the influence of timing of RBD onset. The results showed that PD patients with probable RBD have worse dopaminergic dysfunction and higher metabolic activity in specific brain regions. Furthermore, RBD preceding PD onset may indicate a steeper disease decline.
PARKINSONISM & RELATED DISORDERS
(2022)
Letter
Biochemistry & Molecular Biology
Horacio O. de la Iglesia, Claudia Moreno, Arne Lowden, Fernando Louzada, Elaine Marqueze, Rosa Levandovski, Luisa K. Pilz, Claudia Valeggia, Eduardo Fernandez-Duque, Diego A. Golombek, Charles A. Czeisler, Debra J. Skene, Jeanne F. Duffy, Till Roenneberg
Article
Neurosciences
Jose M. Duhart, Lucila Brocardo, Malena L. Mul Fedele, Angelo Guglielmotti, Diego A. Golombek
Review
Pharmacology & Pharmacy
Daniel P. Cardinali, Diego A. Golombek, Ruth E. Rosenstein, Luis I. Brusco, Daniel E. Vigo
PHARMACOLOGICAL RESEARCH
(2016)
Article
Multidisciplinary Sciences
Maria Eugenia Goyaa, Andres Romanowski, Carlos S. Caldart, Claire Y. Benard, Diego A. Golombek
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Psychology, Biological
Andrea P. Goldin, Mariano Sigman, Gisela Braier, Diego A. Golombek, Maria J. Leone
NATURE HUMAN BEHAVIOUR
(2020)
Article
Endocrinology & Metabolism
Leandro P. Casiraghi, Santiago A. Plano, Eduardo Fernandez-Duque, Claudia Valeggia, Diego A. Golombek, Horacio O. de la Iglesia
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
I Aiello, M. L. Mul Fedele, F. Roman, L. Marpegan, C. Caldart, J. J. Chiesa, D. A. Golombek, C. Finkielstein, N. Paladino
Article
Biochemistry & Molecular Biology
Santiago Andres Plano, Fernando Martin Baidanoff, Laura Lucia Trebucq, Sebastian Angel Suarez, Fabio Doctorovich, Diego Andres Golombek, Juan Jose Chiesa
Summary: The study reveals that light signaling at the end of subjective night can advance the phase of locomotor rhythms in hamsters through the action of free radical nitric oxide. The phase-delays at CT14 seem to be influenced by a reductive SCN environment, while an oxidative environment favors photic advances. This suggests that circadian phase-locking mechanisms should take into account the redox SCN environment and the generation of relatives of NO center dot.
Article
Biology
Ignacio Aiello, Malena Lis Mul Fedele, Fernanda Ruth Roman, Diego Andres Golombek, Natalia Paladino
Summary: The circadian system induces oscillations in physiological variables close to a 24-hour period. Dysfunctions in clock-controlled body functions may be related to poor prognosis or worse response to treatment in cancer patients. Studies on a murine melanoma model suggest that tumors could affect circadian rhythms, leading to decreased locomotor activity rhythms, nighttime activity, and dysregulated clock gene expression.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Laura Lucia Trebucq, Georgina Alexandra Cardama, Pablo Lorenzano Menna, Diego Andres Golombek, Juan Jose Chiesa, Luciano Marpegan
Summary: The study revealed circadian modulation in the efficacy of 1A-116, likely through RAC1 pathway rhythmicity, suggesting that a chronopharmacological approach is a feasible strategy to improve glioblastoma treatment.
Article
Biology
Diego Golombek, Seithikurippu Pandi-Perumal, Ruth E. Rosenstein, Per Olof Lundmark, David Warren Spence, Daniel P. Cardinali, Russel J. Reiter, Gregory M. Brown
Summary: Exposure to adequate light-dark cycle is crucial for the recovery of patients. Light exposure provides various health benefits and can improve alertness and performance among hospital staff. This commentary discusses the negative effects of nighttime light, noise, and physical procedures, and suggests important steps to create a more normal environment for intensive care unit patients, especially for those with COVID-19.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Fernando Martin Baidanoff, Laura Lucia Trebucq, Santiago Andres Plano, Phillip Eaton, Diego Andres Golombek, Juan Jose Chiesa
Summary: This study investigated the oxidation of cysteine thiols in the circadian protein period 2 (PER2) in HEK-293T cells. The results showed that cysteine oxidation can alter the stability and form of PER2. These findings reveal the importance of cysteine oxidation in the redox regulation of the molecular circadian clock.
Review
Biology
Maria Laura Migliori, Maria Eugenia Goya, Melisa Luciana Lamberti, Francisco Silva, Rosana Rota, Claire Benard, Diego Andres Golombek
Summary: Circadian rhythms are an adaptive feature found in a wide range of organisms and regulated by endogenous clocks entrained by environmental cycles. Drosophila melanogaster has been a model organism for studying circadian clocks, but Caenorhabditis elegans is emerging as a novel model for chronobiological studies due to its genetic and experimental advantages. Understanding the molecular basis and neural circuitry of C. elegans' circadian system will contribute to the study of circadian-related diseases.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Clinical Neurology
P. V. Agostino, E. M. Gatto, M. Cesarini, J. L. Etcheverry, A. Sanguinetti, D. A. Golombek
ACTA NEUROLOGICA SCANDINAVICA
(2017)
Article
Psychology, Experimental
Maria Juliana Leone, Diego Fernandez Slezak, Diego Golombek, Mariano Sigman
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)