Review
Neurosciences
Stephanie Pain, Sebastien Brot, Afsaneh Gaillard
Summary: Neuropeptide Y (NPY) plays an important role in neurodegenerative diseases and its changes may reflect the attempt to counteract the degenerative process. NPY has anti-apoptotic, anti-inflammatory, and pro-phagocytic effects, which can effectively slow down the progression of the disease.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marina Mirchandani-Duque, Miguel A. Barbancho, Alexander Lopez-Salas, Jose Erik Alvarez-Contino, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study evaluated the role of neuropeptide Y and galanin in hippocampal neurogenesis and found that they improve spatial memory by promoting cell proliferation and inducing neuroprotective factors. This finding provides a potential novel therapy for neurodegenerative cognitive-affecting diseases.
Review
Cell Biology
Linda Ines Zoungrana, Meredith Krause-Hauch, Hao Wang, Mohammad Kasim Fatmi, Lauryn Bates, Zehui Li, Parth Kulkarni, Di Ren, Ji Li
Summary: This article reviews the roles of mTOR and Nrf2 complexes and their implications in neurogenesis and neurodegenerative diseases.
Review
Nutrition & Dietetics
Gabriella Mendes Duarte, Francisco Emanoel Alves de Araujo, Joao Matheus Cae da Rocha, Francisca Idalina Neta, Amalia Cinthia Meneses do Rego, Irami Araujo Filho, Francisco Irochima Pinheiro, Eduardo Pereira de Azevedo, Ricardo Ney Cobucci, Fausto Pierdona Guzen
Summary: This review examines the efficacy and safety of seed extracts in experimental models of neurodegeneration. The results suggest that seed extracts have neuroprotective effects through their antioxidant, anti-inflammatory, and anti-apoptotic properties. However, more clinical trials are needed to validate these results and determine the optimal dose for patients with neurodegenerative diseases.
Review
Nutrition & Dietetics
Shakta Mani Satyam, Laxminarayana Kurady Bairy
Summary: Neuronutraceuticals play an important role in neuropathologies and have the potential to improve neuroinflammaging and cognitive performance. Further research is needed to understand the mechanisms and comprehensive impact of neuronutraceuticals, including randomized controlled trials and exploration of key issues.
Review
Pharmacology & Pharmacy
Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li, Ranji Cui
Summary: Berberine, a natural alkaloid compound, has been studied for its effects on neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Current evidence shows that it can inhibit neuroinflammation, oxidative stress, and endoplasmic reticulum stress, reducing neuron damage and apoptosis. Further research is needed to fully understand the specific mechanisms involved.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Gabriel Henrique Schirmbeck, Stephane Sizonenko, Eduardo Farias Sanches
Summary: Early adverse fetal environments can disrupt CNS development and breastfeeding, especially with the presence of lactoferrin, plays a crucial role in supporting brain development and preventing neuropsychiatric diseases later in life.
Review
Biochemistry & Molecular Biology
Melania Ruggiero, Rosa Calvello, Chiara Porro, Giovanni Messina, Antonia Cianciulli, Maria Antonietta Panaro
Summary: Coffee consumption with its bioactive compounds has shown to benefit human health and reduce the risk of neurodegenerative diseases. Neuroinflammation plays a critical role in the development of these diseases. Controlled caffeine delivery systems can help maintain high plasma caffeine levels for extended periods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Lina Sun, Tianbiao Liu, Jingqi Liu, Chong Gao, Xiaohui Zhang
Summary: Psychiatric and neurodegenerative diseases are a burden to society, and deficits of adult hippocampal neurogenesis are considered the main feature of these diseases. Exploring targets for improving hippocampal neural plasticity could lead to new treatments. Emerging evidence shows the broad functions of mitochondria in regulating cellular behaviors, offering multiple neural plasticities. Normalizing mitochondrial functions could enhance neural plasticity. Exercise has been indicated as an effective pathway to improve both mitochondrial functions and adult hippocampal neurogenesis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Genetics & Heredity
Ruike Wang, Yingying Wu, Rundong Liu, Mengchen Liu, Qiong Li, Yue Ba, Hui Huang
Summary: This paper provides an up-to-date evaluation of the neuroprotective mechanisms of SIRT1 in modulating neurodegeneration, highlighting the importance of protein homeostasis, aging-related signaling pathways, neurogenesis, and synaptic plasticity. The potential of targeting SIRT1 to block the occurrence and progression of neurodegenerative diseases is also discussed.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Pharmacology & Pharmacy
Irene Soles-Tarres, Nuria Cabezas-Llobet, Benjamin Lefranc, Jerome Leprince, Jordi Alberch, David Vaudry, Xavier Xifro
Summary: This study found that PACAP can exert antiapoptotic and neurotrophic effects on neuronal cells in Huntington's disease (HD) through the PAC1R receptor. In a mouse model, intranasal administration of PACAP restored motor function and increased levels of PAC1R, CBP, and BDNF in the striatum.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanfang Liao, Xue Wang, Liting Huang, Hu Qian, Wei Liu
Summary: Neurodegenerative diseases (NDs) are characterized by neuron degeneration and loss of function. Pyroptosis, a type of inflammatory process caused by Gasdermins (GSDMs) proteins, has been found to be enhanced in NDs, along with the aggregation of pathological proteins. This review aims to provide an overview of the molecular mechanisms driving pyroptosis, the links between pyroptosis and NDs, and emerging therapeutic strategies in Traditional Chinese Medicine (TCM) for inhibiting pyroptosis in the treatment of NDs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sandra Barreiro, Barbara Silva, Solida Long, Madalena Pinto, Fernando Remiao, Emilia Sousa, Renata Silva
Summary: This study suggests that fiscalins have neuroprotective effects against neurodegenerative diseases and potential as new drugs for treatment and prevention.
Article
Neurosciences
Guy Shapira, Ifat Israel-Elgali, Meitar Grad, Eden Avnat, Lital Rachmany, Yosef Sarne, Noam Shomron
Summary: A microdose of THC can improve cognitive function and cause changes in brain morphology and biochemistry in old mice, possibly by affecting gene expression related to neurogenesis and brain development.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Courtney M. Clark, Rosemary M. Clark, Joshua A. Hoyle, Tracey C. Dickson
Summary: NPY has gained interest as a potential neuroprotective agent for neurodegenerative diseases, with evidence suggesting a possible role in ALS pathogenesis. While increased NPY levels correlate with disease progression in ALS, the functional consequences are not fully understood.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Valentina Castiglioni, Andrea Faedo, Marco Onorati, Vittoria Dickinson Bocchi, Zhen Li, Raffaele Iennaco, Romina Vuono, Gaetano P. Bulfamante, Luca Muzio, Gianvito Martino, Nenad Sestan, Roger A. Barker, Elena Cattaneo
Article
Clinical Neurology
Thais Minett, Li Su, Elijah Mak, Guy Williams, Michael Firbank, Rachael A. Lawson, Alison J. Yarnall, Gordon W. Duncan, Adrian M. Owen, Tien K. Khoo, David J. Brooks, James B. Rowe, Roger A. Barker, David Burn, John T. O'Brien
JOURNAL OF NEUROLOGY
(2018)
Article
Clinical Neurology
Naveed Malek, Rimona S. Weil, Catherine Bresner, Michael A. Lawton, Katherine A. Grosset, Manuela Tan, Nin Bajaj, Roger A. Barker, David J. Burn, Thomas Foltynie, John Hardy, Nicholas W. Wood, Yoav Ben-Shlomo, Nigel W. Williams, Donald G. Grosset, Huw R. Morris
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)
Correction
Multidisciplinary Sciences
Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, M. Diana Neely, Romina Vuono, Salvatore Castaldo, Anna F. Digilio, Francesco Scalabri, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D'Esposito, Aaron B. Bowman, Roger A. Barker, Vittorio Maglione
SCIENTIFIC REPORTS
(2018)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Jan H. L. Ypinga, Allison Willis, Colleen G. Canning, Roger A. Barker, Marten Munneke, Nienke M. De Vries
JOURNAL OF PARKINSONS DISEASE
(2018)
Article
Neurosciences
Benjamin J. Clegg, Gordon W. Duncan, Tien K. Khoo, Roger A. Barker, David J. Burn, Alison J. Yarnall, Rachael A. Lawson
JOURNAL OF PARKINSONS DISEASE
(2018)
Article
Neurosciences
Julia C. Greenland, Caroline H. Williams-Gray, Roger A. Barker
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Clinical Neurology
Mayke Oosterloo, Emilia Bijlsma, Sander van Kuijk, Floor Minkes, Raymund Roos, C. E. M. de Die-Smulders
PARKINSONISM & RELATED DISORDERS
(2019)
Editorial Material
Clinical Neurology
Roger Barker, Sarah L. Mason
Article
Neurosciences
Jerome Lamontagne-Proulx, Isabelle St-Amour, Richard Labib, Jeremie Pilon, Helena L. Denis, Nathalie Cloutier, Florence Roux-Dalvai, Antony T. Vincent, Sarah L. Mason, Caroline Williams-Gray, Anne-Claire Duchez, Arnaud Droit, Steve Lacroix, Nicolas Dupre, Melanie Langlois, Sylvain Chouinard, Michel Panisset, Roger A. Barker, Eric Boilard, Francesca Cicchetti
NEUROBIOLOGY OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Roger A. Barker, Krista Farrell, Natalie Valle Guzman, Xiaoling He, Stanley E. Lazic, Sarah Moore, Robert Morris, Pamela Tyers, Ruwani Wijeyekoon, Danielle Daft, Sam Hewitt, Viswas Dayal, Thomas Foltynie, Zinovia Kefalopoulou, Philipp Mahlknecht, Nick P. Lao-Kaim, Paola Piccini, Hjalmar Bjartmarz, Anders Bjorklund, Olle Lindvall, Jenny Nelander-Wahlestedt, Malin Parmar, Gesine Paul, Hakan Widner, Alistair Church, Stephen Dunnett, Kathryn Peall, Anne Rosser, Jean Marc Gurruchaga, Stephane Palfi, Tobias Piroth, Christian Winkler
Editorial Material
Clinical Neurology
Alain Buisson, Michael Decressac
MOVEMENT DISORDERS
(2019)
Article
Clinical Neurology
Robin Reynaud-Dulaurier, Giorgia Benegiamo, Elena Marrocco, Racha Al-Tannir, Enrico Maria Surace, Johan Auwerx, Michael Decressac
Article
Biotechnology & Applied Microbiology
Robin Reynaud-Dulaurier, Michael Decressac
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Valentina Gallo, Paolo Vineis, Mariagrazia Cancellieri, Paolo Chiodini, Roger A. Barker, Carol Brayne, Neil Pearce, Roel Vermeulen, Salvatore Panico, Bas Bueno-de-Mesquita, Nicola Vanacore, Lars Forsgren, Silvia Ramat, Eva Ardanaz, Larraitz Arriola, Jesper Peterson, Oskar Hansson, Diana Gavrila, Carlotta Sacerdote, Sabina Sieri, Tilman Kuehn, Verena A. Katzke, Yvonne T. van der Schouw, Andreas Kyrozis, Giovanna Masala, Amalia Mattiello, Robert Perneczky, Lefkos Middleton, Rodolfo Saracci, Elio Riboli
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
