Article
Biology
John C. O'Donnell, Erin M. Purvis, Kaila V. T. Helm, Dayo O. Adewole, Qunzhou Zhang, Anh D. Le, D. Kacy Cullen
Summary: The Tissue-Engineered Rostral Migratory Stream (TE-RMS) developed by O'Donnell et al. uses astrocyte-like cells derived from adult gingival stem cells to facilitate directed migration of immature neurons and redirect neuroblast migration in athymic rat brains, offering a promising new approach to neuroregenerative medicine.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Jing Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li, Chunfang Wang, Kah-Leong Lim, Chengwu Zhang, Wulin Yang, Li Lu
Summary: It has been found that lipodystrophy-associated metabolic disorders caused by Seipin deficiency not only result in severe lipodystrophy but also neurological disorders. This study elucidates the underlying mechanism of Seipin deficiency-induced neuropathy and explores possible restorative strategies.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Pharmacology & Pharmacy
Andi Chen, Xiaohui Chen, Jianhui Deng, Jianjie Wei, Haitao Qian, Yongxin Huang, Shuyan Wu, Fei Gao, Cansheng Gong, Yanling Liao, Xiaochun Zheng
Summary: Hypoxic-ischemic brain damage (HIBD) is the main cause of neurological dysfunction in neonates. Olfactory cognitive dysfunction is important for feeding, the ability to detect hazardous situations, and social relationships. Dexmedetomidine (DEX) treatment could significantly improve olfactory cognitive dysfunction in neonatal rats with HIBD by promoting neurogenesis in the subventricular zone (SVZ) and enhancing the expression of brain-derived neurotrophic factor (BDNF) in microglia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yali Chen, Peng Ren, Xiongjie He, Fang Yan, Rou Gu, Jie Bai, Xianwen Zhang
Summary: Olfaction is a crucial sense that relies on the olfactory bulb (OB) as the relay station. The contribution of subventricular zone (SVZ) adult neurogenesis to OB neurogenesis is still not fully understood. Recent studies have focused on understanding the molecular and signaling pathways associated with OB neurogenesis dependent on SVZ function. This understanding is important for improving olfactory dysfunction and developing new therapies based on adult neural stem cells (aNSCs).
Article
Biochemistry & Molecular Biology
Sherleen Xue-Fu Adamson, Wei Zheng, Zeynep Sena Agim, Sarah Du, Sheila Fleming, Jonathan Shannahan, Jason Cannon
Summary: Disrupted systemic copper homeostasis can lead to olfactory dysfunction, altered adult neurogenesis, and neurochemical imbalances. Both copper deficiency and copper overload prolong the latency to uncover food, with different effects on neural proliferation and neurotransmitter levels. These findings suggest a potential link between copper dyshomeostasis and olfactory dysfunction.
Article
Cell Biology
Chrysoula Dioli, Patricia Patricio, Lucilia-Goreti Pinto, Clemence Marie, Monica Morais, Sheela Vyas, Joao M. Bessa, Luisa Pinto, Ioannis Sotiropoulos
Summary: The study demonstrates the significant role of Tau in neurogenesis under chronic stress conditions, with Tau-KO mice showing higher levels of neuronal migration. These findings highlight the importance of Tau protein in neurogenesis suppression under stress, emphasizing its role in stress-related plasticity deficits.
CELL PROLIFERATION
(2021)
Article
Environmental Sciences
Pieter Vancamp, Lucile Butruille, Anni Herranen, Anita Boelen, Jean -Baptiste Fini, Barbara A. Demeneix, Sylvie Remaud
Summary: Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia throughout adulthood. We previously demonstrated that a postnatal thyroid hormone (TH) peak orchestrates this remodelling, rendering this process vulnerable to endocrine disruption. In this study, we exposed mice to low doses of BPF, a suspected TH-disruptor, and found that it disrupted SVZ remodelling and decreased adult neuron and oligodendroglia output. These findings highlight the potential harm of alternative bisphenol compounds for human fetal brain development.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Toxicology
Bunichiro Ogawa, Yutaka Nakanishi, Masaki Wakamatsu, Yasunori Takahashi, Makoto Shibutani
Summary: Acrylamide (AA) is a neurotoxicant that inhibits synaptic function and neural cell differentiation in the hippocampus and olfactory bulb-subventricular zone (OB-SVZ) region. AA exposure decreased neuroblasts in the OB by suppressing neuronal migration and downregulating genes related to neuronal differentiation and migration. These findings indicate that AA has a similar detrimental effect on neurogenesis in the OB-SVZ as it does in the hippocampus.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jana Osacka, Alexander Kiss, Zuzana Bacova, Andrej Tillinger
Summary: Aberrant neurogenesis in the subventricular zone and hippocampus contributes to schizophrenia pathogenesis. The commonly prescribed antipsychotics haloperidol and olanzapine affect neurogenesis. This study investigates the effects of these drugs on cell proliferation and gene expression in vitro and in an animal schizophrenia model. The results suggest that chronic treatment with haloperidol and olanzapine can inhibit gene expression, but olanzapine can reverse the inhibitory effect of another drug in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Masato Sawada, Ayato Hamaguchi, Naomichi Mano, Yutaka Yoshida, Akiyoshi Uemura, Kazunobu Sawamoto
Summary: Newborn neurons exhibit an immature bipolar morphology and migrate towards their destinations. After migration, these neurons undergo controlled dendrite formation and acquire complex morphologies. The mechanisms underlying dendritic development in newborn neurons are not fully understood. This study reveals that the Sema3E-PlexinD1 signaling pathway regulates dendritic development in a domain-specific manner in the postnatal olfactory bulb (OB). The RhoJ protein, which directly interacts with PlexinD1, is also involved in the suppression of dendritic branching in the proximal domain of OB newborn granule cells.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Cell Biology
Milena Tucic, Vera Stamenkovic, Pavle Andjus
Summary: TnC plays a crucial role in regulating cell proliferation and migration during adult neurogenesis, with implications for regenerative therapies. Understanding ECM signaling in the CNS niche is essential for potential therapeutic applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Catarina Serra-Almeida, Claudia Saraiva, Marta Esteves, Raquel Ferreira, Tiago Santos, Ana Clara Cristovao, Liliana Bernardino
Summary: CtBPs are expressed in various cell types within the SVZ and play a role in regulating the growth of different types of neural cells. Modulating CtBPs can impact the proliferation and maturation of neurons and glial cells, offering potential applications in brain regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nery Jara, Manuel Cifuentes, Fernando Martinez, Ivan Gonzalez-Chavarria, Katterine Salazar, Lucas Ferrada, Francisco Nualart
Summary: Although scurvy has been almost eradicated, subclinical vitamin C deficiency is more prevalent than previously estimated and its impact on human health is not fully understood. Vitamin C plays critical roles in the central nervous system, including modulation of neurogenesis, but its effects on the adult brain's neurogenic niche are unknown.
Article
Clinical Neurology
Pu-Tien Chiang, Hsin-Hsi Tsai, Ruoh-Fang Yen, Yi-Chieh Tsai, Chi-Han Wu, Ching-Hung Chiu, Li-Kai Tsai
Summary: In this study, we assessed the use of F-18-fluorothymidine (FLT) PET to detect cerebral cell proliferation and found that it is associated with stroke severity and outcomes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Sarah J. Meller, Lexie Hernandez, Eduardo Martin-Lopez, Zachary A. Kloos, Teresa Liberia, Charles A. Greer
Summary: Microglia invade the early postnatal neuroblast migratory corridor and play an important role in maintaining homeostatic conditions necessary for normal neurodevelopment. They provide trophic support and clear excessive neurogenesis, thus promoting effective neuroblast migration. This research highlights the significance of microglia in regulating the neuroblast population and creating a permissive environment for neuroblast migration in the early postnatal period.
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)