期刊
EXPERIMENTAL NEUROLOGY
卷 222, 期 2, 页码 211-218出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2009.12.029
关键词
Cell birth; Exercise; Neural activity; Spinal cord injury; Regeneration; Rehabilitation; Stem cell
资金
- Barnes-Jewish Hospital and Barnes-Jewish Hospital Auxiliary Foundations (St Louis MO)
- Washington University School of Medicine (St Louis, MO)
- Sam Schmidt Foundation (Las Vegas, NV)
- Jack Orchard and ALS Hope Foundations (St. Louis, MO)
- NIH NINDS NS [45023, 40520, 39577]
- State of Maryland Department of Health and Mental Hygiene Spinal Cord Injury [FHA077-002]
- Johnson & Johnson Focused Giving Program
Functional electrical stimulation (FES) can restore control and offset atrophy to muscles after neurological injury However. FES has not been considered as a method for enhancing CNS regeneration. This paper demonstrates that FES dramatically enhanced progenitor cell birth in the spinal cord of rats with a chronic spinal cord Injury (SCI) A complete SCI at thoracic level 8/9 was performed oil 12 rats Three weeks later, a FES device to stimulate hindlirrib movement was implanted into these rats Twelve identically-injured rats received inactive FES implants An additional control group of uninjured rats were also examined Ten days after FES implantation, dividing cells were mat ked with biomodeoxyuridine (BrdU). The cell birth subgroup (half the animals in each group) was sacrificed immediately after completion of BrdU administration, and the cell survival Subgroup was sacrificed 7 days later In the injured cell birth Subgroup, FES induced an 82-86% increase in cell birth in the lumbar spinal cord In the injured cell survival sub.-roup, the increased lumbar newborn cell Counts persisted FES doubled the proportion of the newly-born cells which expressed nestin and other markers suggestive of tripotential progenitors In uninjured rats, FES had no effect on cell birth/survival This report suggests that controlled electrical activation of the CNS may enhance spontaneous regeneration after neurological injuries (C) 2010 Elsevier Inc All rights reserved.
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