Article
Psychology, Multidisciplinary
Julia Mehlhorn, Nelson Niski, Ke Liu, Svenja Caspers, Katrin Amunts, Christina Herold
Summary: This study provides a comprehensive and in-depth qualitative and quantitative analysis of different stages of adult neurogenesis in the brain of adult homing pigeons, revealing an uneven distribution of adult newborn neurons and glia, with the highest numbers found in the intercalated hyperpallium and the hippocampal formation.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Nutrition & Dietetics
Gemma Huguet, Irene Puig-Parnau, Jose C. E. Serrano, Meritxell Martin-Gari, Maria Rodriguez-Palmero, Jose Antonio Moreno-Munoz, Joan Tibau, Elisabet Kadar
Summary: Childhood obesity, caused by a diet rich in sugars and fatty acids, can lead to cognitive impairment and reduced neuroplasticity. A study on young female pigs found that a diet enriched with Bifidobacterium breve and omega-3 fatty acids can enhance neuroplasticity in prepubertal female pigs on a high-fat diet.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Neurosciences
Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo
Summary: This study provides a comprehensive understanding of how conditional deletion of Pten regulates the genesis of adult neural stem/progenitor cells in the dentate gyrus and subventricular zone. The results demonstrate that Pten deletion leads to successive increases in cell proliferation and immaturity, with the increase spreading to non-neurogenic areas as mice age. The study also reveals region-specific increases in apoptotic cells that parallel the increases in proliferating cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Bartkowska, Krzysztof Turlejski, Beata Tepper, Leszek Rychlik, Peter Vogel, Ruzanna Djavadian
Summary: The study found that different species of shrews have similar density of newly generated cells in the brain, but the rate of adult neurogenesis in different structures varies, suggesting that brain size does not affect the number of newly generated neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marco Ghibaudi, Alessia Amenta, Miriam Agosti, Marco Riva, Jean-Marie Graic, Francesco Bifari, Luca Bonfanti
Summary: Recently, a population of immature neurons generated prenatally, retaining immaturity for long periods and finally integrating in adult circuits has been described in the cerebral cortex. Comparative studies revealed differences in occurrence/rate of different forms of neurogenic plasticity across mammals, with gyrencephalic species having more immature neurons. To extend experimentation to large-brained mammals, including humans, it is important to detect cell markers of neurogenic plasticity in brain tissues obtained through different procedures. However, the variability in fixation methods and antibody specificity makes comparison difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Anna S. Berezovskaya, Sergey A. Tyganov, Svetlana D. Nikolaeva, Alexandra A. Naumova, Boris S. Shenkman, Margarita V. Glazova
Summary: Research shows that simulated microgravity environment leads to a decrease in hippocampal neurogenesis, while dynamic foot stimulation can restore the number of neural progenitor cells. In addition, the microgravity environment inhibits signaling pathways related to neurogenesis, while dynamic foot stimulation can prevent this inhibition.
Article
Oncology
Georgios Alkis Zisiadis, Androniki Alevyzaki, Elene Nicola, Carlos F. D. Rodrigues, Klas Blomgren, Ahmed M. Osman
Summary: Cranial irradiation negatively affects hippocampal neurogenesis and cognition, and memantine has been proposed as an intervention to improve cognitive impairments after radiotherapy. However, the mechanisms by which memantine improves neurogenesis and cognition after irradiation remain unclear. This study found that memantine can enhance neuronal proliferation and dendritic development, but does not affect neurogenesis after irradiation. The enhanced dendritic complexity of young neurons may contribute to the observed improvement in cognition.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Dumontoy, Bahrie Ramadan, Pierre-Yves Risold, Solene Pedron, Christophe Houdayer, Adeline Etievant, Lidia Cabeza, Emmanuel Haffen, Yvan Peterschmitt, Vincent Van Waes
Summary: Repeated anodal transcranial direct current stimulation (RA-tDCS) is a neuromodulatory technique that can improve memory and have antidepressant-like effects. This study aimed to evaluate the impact of RA-tDCS on hippocampal neurogenesis levels in mice. The results showed that RA-tDCS increased cell proliferation in young adult female mice, but had no effect on cell survival. No modulation of cell proliferation or survival was observed in middle-aged animals or male mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Malcolm Maden, Nicole Serrano, Monica Bermudez, Aaron G. W. Sandoval
Summary: The spiny mouse's brain has been found to have more neural stem cells with a higher proliferative rate, indicating a greater regenerative capacity. The spiny mouse also shows a higher number of neuroblasts in the dentate gyrus. Furthermore, differential expression of certain stem cell niche genes in the spiny mouse suggests potential mechanisms underlying its enhanced regenerative properties.
JOURNAL OF ANATOMY
(2021)
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Clinical Neurology
Hui Wang, Liang Liang, Can Yang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhixian Zhu
Summary: This study found that low-density lipoprotein receptor-related protein 1 (LRP1) in the hippocampus of rats is positively correlated with depressive-like behaviors. Administration of LRP1 improved depressive-like behaviors, while LRP1 knockdown alleviated the inhibition of synaptic plasticity induced by chronic unpredicted mild stress (CUMS). Furthermore, LRP1 knockdown increased synaptic plasticity through microtubule dynamics and activation of the Akt/GSK-3 beta signaling pathway. These findings suggest that LRP1 may serve as a potential therapeutic target for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Michael J. Chrusch, Selena Fu, Simon C. Spanswick, Haley A. Vecchiarelli, Payal P. Patel, Matthew N. Hill, Richard H. Dyck
Summary: Zinc plays a role in modulating synaptic plasticity, particularly in the hippocampal dentate gyrus. This study aimed to determine if vesicular zinc is important for modulating adult hippocampal neurogenesis and behavior in an experience-dependent manner. The results show that vesicular zinc is essential for enhancing adult hippocampal neurogenesis and behavior following enrichment, supporting the role of zincergic neurons in experience-dependent plasticity in the hippocampus.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sandra Ledesma-Corvi, M. Julia Garcia-Fuster
Summary: The study investigated the effects of electroconvulsive therapy (ECT) on neuroplasticity markers in the hippocampus of rats. It found sex- and age-differences in the response to ECT, and identified persistent molecular changes induced by ECT in the hippocampus of both males and females, especially in adolescence. These findings suggest the need for further exploration of the underlying reasons for the disparities and the development of personalized treatments for each sex.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Marco Ghibaudi, Luca Bonfanti
Summary: Undifferentiated neurons may exist in the neural networks of the adult mammalian brain, not only in small stem cell niches from embryonic germinal layers but also in various parenchymal brain regions. However, our understanding of these young neurons is not yet clear, and further mapping and research are needed.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Macarena S. Arrazola, Trinovita Andraini, Marion Szelechowski, Lionel Mouledous, Laetitia Arnaune-Pelloquin, Noelie Davezac, Pascale Belenguer, Claire Rampon, Marie-Christine Miquel
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Robin F. Dard, Lionel Dahan, Claire Rampon
Article
Neurosciences
Basile Coutens, Lionel Mouledous, Manta Stella, Claire Rampon, Maryse Lapeyre-Mestre, Anne Roussin, Bruno P. Guiard, Emilie Jouanjus
PSYCHOPHARMACOLOGY
(2019)
Article
Clinical Neurology
Hyun-Sook Lee, Risa Yamazaki, Dianru Wang, Sebastien Arthaud, Patrice Fort, Laura A. DeNardo, Pierre-Herve Luppi
JOURNAL OF SLEEP RESEARCH
(2020)
Editorial Material
Neurosciences
Christelle Peyron, Claire Rampon
Review
Clinical Neurology
Lionel Dahan, Claire Rampon, Cedrick Florian
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2020)
Article
Cell & Tissue Engineering
Yuriy Pomeshchik, Oxana Klementieva, Jeovanis Gil, Isak Martinsson, Marita Gronning Hansen, Tessa de Vries, Anna Sancho-Balsells, Kaspar Russ, Ekaterina Savchenko, Anna Collin, Ana Rita Vaz, Silvia Bagnoli, Benedetta Nacmias, Claire Rampon, Sandro Sorbi, Dora Brites, Gyorrgy Marko-Varga, Zaal Kokaia, Melinda Rezeli, Gunnar K. Gouras, Laurent Roybon
Article
Pharmacology & Pharmacy
Renato Maciel, Risa Yamazaki, Dianru Wang, Anna De Laet, Sebastien Cabrera, Claudio Agnorelli, Sebastien Arthaud, Paul-Antoine Libourel, Patrice Fort, Hyunsook Lee, Claudio Queiroz, Pierre-Herve Luppi
Summary: Using TRAP2 transgenic mice, different neurons were found to be activated during PS and W in the anterior cingulate and rostral and caudal retrosplenial cortices as well as the claustrum. Additionally, during PS, the distribution of neurons in the rRSP and cRSP was limited to superficial layers, in contrast to the widespread activation across all layers during W. These results clearly demonstrate at the cellular level that PS and W are two completely different states in terms of neocortical activation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Risa Yamazaki, Dianru Wang, Anna De Laet, Renato Maciel, Claudio Agnorelli, Sebastien Cabrera, Sebastien Arthaud, Paul-Antoine Libourel, Patrice Fort, Hyunsook Lee, Pierre-Herve Luppi
Summary: The study aimed to investigate the reactivation of neurons in the hippocampus and supramammillary nucleus during wakefulness and paradoxical sleep. The results showed different activated neurons in these regions during wakefulness and paradoxical sleep, and the activation of granule cells in the infrapyramidal blade of the DG during paradoxical sleep. Further research is needed to determine the role of these granule cells in memory reactivation during paradoxical sleep.
Article
Biochemistry & Molecular Biology
Bolanle Fatimat Olabiyi, Catherine Fleitas, Bahira Zammou, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espinet
Summary: Recent research has shown that adult neurogenesis is crucial for cognitive functions, particularly in memory enhancement. However, disruptions in adult neurogenesis, as seen in Alzheimer's disease, can impair spatial memory. By targeting pro-NGF signaling, memory deficits in an AD mouse model were restored, indicating a potential therapeutic target for AD involving adult neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Basile Coutens, Camille Lejards, Guillaume Bouisset, Laure Verret, Claire Rampon, Bruno P. Guiard
Summary: Mood disorders are associated with overactivity of the hypothalamic-pituitary-adrenal axis due to decreased inhibitory feedback from the hippocampus. Antidepressants can regulate the excitatory/inhibitory balance of the hippocampus to restore effective inhibition of this stress axis. Non-pharmacological strategies, such as environmental enrichment, can improve therapeutic outcome in depressed patients, but it is unknown if they can reduce the delay of action of antidepressants.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Fares Sayegh, Laurie Herraiz, Morgane Colom, Sebastien Lopez, Claire Rampon, Lionel Dahan
Summary: Dopamine plays a role in encoding memories and can encode the rewarding/aversive value of stimuli or trigger contextual learning as a novelty signal. In this study, the dopamine D1/5R antagonist SCH23390 was shown to impair contextual fear conditioning and tone-shock association following intraperitoneal injection, while intrahippocampal injection only affected contextual fear conditioning. Using the context pre-exposure facilitation effect test, it was found that SCH23390 blocked the encoding of the context during the pre-exposure phase. This provides additional evidence for the involvement of dopamine in encoding conjunctive representations of new contexts.
Article
Geriatrics & Gerontology
Y. Santin, S. Lopez, I Ader, S. Andrieu, N. Blanchard, A. Carriere, L. Casteilla, B. Cousin, N. Davezac, P. De Souto Barreto, C. Dray, N. Fazilleau, D. Gonzalez-Dunia, P. Gourdy, S. Guyonnet, N. Jabrane-Ferrat, O. Kunduzova, F. Lezoualc'h, R. Liblau, L. O. Martinez, C. Moro, P. Payoux, L. Penicaud, V Planat-Benard, C. Rampon, Y. Rolland, J-P Schanstra, F. Sierra, P. Valet, A. Varin, N. Vergnolle, B. Vellas, J. Vina, B. P. Guiard, A. Parini
Summary: Aging is a major risk factor for chronic diseases, and efforts are now focused on promoting healthy aging by identifying early biological markers associated with functional status. The INSPIRE program aims to discover mechanisms of accelerated aging and predict frailty and pathological aging using a cohort of SWISS mice. This comprehensive study will provide valuable insights into the role of dietary and exercise interventions in influencing the rate of biological aging and identifying targets for healthy aging promotion.
JOURNAL OF FRAILTY & AGING
(2021)
Article
Geriatrics & Gerontology
P. De Souto Barreto, S. Guyonnet, I Ader, S. Andrieu, L. Casteilla, N. Davezac, C. Dray, N. Fazilleau, P. Gourdy, R. Liblau, A. Parini, P. Payoux, L. Penicaud, C. Rampon, Y. Rolland, P. Valets, N. Vergnolle, B. Vellas
Summary: Aging is a key risk factor for chronic diseases and functional decline, and understanding the interplay between biological aging, disease biology, and a function-centered care approach is crucial for preventive strategies. The INSPIRE research program aims to explore how manipulation of biological aging and implementation of function-centered care pathways can contribute to healthy aging trajectories.
JOURNAL OF FRAILTY & AGING
(2021)
Review
Physiology
Christelle Peyron, Sebastien Arthaud, Manon Villalba, Patrice Fort
CURRENT OPINION IN PHYSIOLOGY
(2020)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)