Review
Cell Biology
Shashank Chetty, Reza Yarani, Ganesh Swaminathan, Rosita Primavera, Shobha Regmi, Sravanthi Rai, Jim Zhong, Abantika Ganguly, Avnesh S. Thakor
Summary: This review provides an overview of the sources, regenerative and immunomodulatory properties, clinical applications, therapeutic potential, biodistribution, and obstacles to translation of umbilical cord-mesenchymal stromal cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Xiaoyun Wu, Zhijie Ma, Yuxiao Yang, Yongxu Mu, Daocheng Wu
Summary: In this study, the safety and biodistribution of intraperitoneally transplanted umbilical cord-derived MSCs (UCMSCs) were investigated. It was found that UCMSCs cultured in a serum-free, xeno-free, and chemically defined media (UCMSCs&SXFM-CD) exhibited improved safety profiles compared to UCMSCs cultured in serum-containing media (UCMSCsSCM), with no significant toxicity or tumorigenicity observed.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Sara Bucar, Andre Dargen de Matos Branco, Marcia F. Mata, Joao Coutinho Milhano, Iris Caramalho, Joaquim M. S. Cabral, Ana Fernandes-Platzgummer, Claudia L. da Silva
Summary: The study compared the capacity of MSC from different sources to expand UCB CD34(+) cells ex vivo, with AT-derived MSC showing superior expansion potential and maintenance of primitive cells. UCM-derived MSC demonstrated inferior hematopoietic supportive capacity compared to MSC from adult tissues. Further research is needed to determine the impact of HPL on the hematopoietic supportive capacity of MSC.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Yufeng Shang, Haotong Guan, Fuling Zhou
Summary: Umbilical cord mesenchymal stem cells (UC-MSCs) have the characteristics of inhibiting tumor cell proliferation and migration, supporting hematopoietic microenvironment, and suppressing the immune system, showing great potential in the treatment of hematologic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Cong-wen Yang, Ru-dong Chen, Qing-run Zhu, Shi-jie Han, Ming-jie Kuang
Summary: This study aimed to evaluate the effectiveness of umbilical cord mesenchymal stromal cells (UC-MSCs) in patients with COVID-19. The meta-analysis results showed that UC-MSCs can reduce mortality in COVID-19 patients and there is no significant correlation between adverse events and UC-MSC treatment. Additionally, treatment with UC-MSCs was found to suppress inflammation and improve pulmonary symptoms. Therefore, UC-MSCs hold promise as a safe and effective treatment for COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Zan Tang, Junxiao Gao, Jie Wu, Guifang Zeng, Yan Liao, Zhenkun Song, Xiao Liang, Junyuan Hu, Yong Hu, Muyun Liu, Nan Li
Summary: HucMSC transplantation alleviates lung collagen accumulation and mortality in bleomycin-induced PF mice, promotes AT2 cell proliferation, inhibits lung fibroblast proliferation, and induces interferon-sensitive macrophages (IFNSMs) to secrete CXCL9 and CXCL10, recruiting more Treg cells to the injured lung.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ximena Bonilla, Ana Milena Lara, Manuela Llano-Leon, David A. Lopez-Gonzalez, David G. Hernandez-Mejia, Rosa Helena Bustos, Bernardo Camacho-Rodriguez, Ana-Maria Perdomo-Arciniegas
Summary: Umbilical cord blood is an important source of hematopoietic stem and progenitor cells, and recent research has focused on developing ex vivo expansion strategies for these cells. Co-culturing the cells with specific mesenchymal stromal cells has been found to significantly increase their cellular dose and regulate their proliferation capacity. Additionally, the secretory profile of umbilical cord blood-derived cells closely resembles that of bone marrow-derived cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jia Chen, Yuhan Chen, Xue Du, Guojun Liu, Xiaowei Fei, Jian Ru Peng, Xing Zhang, Fengjun Xiao, Xue Wang, Xiao Yang, Zhichun Feng
Summary: CB-MNCs and UC-MSCs show efficacy in alleviating BPD, with CB-MNCs having more pronounced effects in restoring lung function. Through analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks, it was found that therapeutic effects are related to regulation of GTPase activity, ERK signaling cascade, chromosome regulation, and cell cycle control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Yuanyuan Xie, Shuo Liu, Liudi Wang, Hui Yang, Chenxu Tai, Li Ling, Libo Chen, Shanshan Liu, Bin Wang
Summary: The study examined the therapeutic variations of HUCMSCs derived from different donors in a mouse liver fibrosis model, revealing consistent expressions of surface markers and viability, but distinct differences in differentiation potentials and immune regulations. The individual heterogeneity of HUCMSCs could potentially lead to diverse therapeutic outcomes in specific diseases, suggesting the importance of donor variation in stromal cell therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Se-Hwa Jung, Ji-Eun You, Soon-Won Choi, Kyung-Sun Kang, Je-Yeol Cho, Jungmook Lyu, Pyung-Hwan Kim
Summary: The study investigated the biological function of the PKD1 gene in umbilical cord blood-derived mesenchymal stem cells (UCB-MSC), finding that it can enhance differentiation ability and maintain long-term stemness, providing new possibilities for stem cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Alvin Wen Choong Chua, Dianyang Guo, Jia Chi Tan, Frances Ting Wei Lim, Chee Tian Ong, Jeyakumar Masilamani, Tony Kiat Hon Lim, William Ying Khee Hwang, Ivor Jiun Lim, Jinmiao Chen, Toan Thang Phan, Xiubo Fan
Summary: This study investigated the therapeutic efficacy and working mechanisms of human umbilical cord lining mesenchymal stromal cells (CL-MSCs) in lupus-prone mice. The results showed that CL-MSCs improved the survival and kidney function of mice by reducing lupus nephritis activity and chronicity, and lymphocyte infiltration. Additionally, CL-MSCs reduced urinary albumin-to-creatinine ratio and the production of anti-dsDNA and isotype antibodies. Mechanistically, CL-MSCs suppressed splenic neutrophils and monocytes/macrophages, reduced proinflammatory cytokines, and modulated immunomodulatory pathways. These findings highlight the potential of CL-MSCs as a novel therapy for systemic lupus erythematosus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Haiping He, Atsuko Takahashi, Takeo Mukai, Akiko Hori, Miwako Narita, Arinobu Tojo, Tonghua Yang, Tokiko Nagamura-Inoue
Summary: Mesenchymal stromal cells (MSCs) were primed with Triptolide (TPL) to enhance their immunosuppressive abilities. TPL-primed UC-MSCs showed stronger anti-proliferative effects on activated T cells, potentially offering a novel immunosuppressive cell therapy. The upregulation of IDO-1 and induction of PD-L1 in TPL-primed UC-MSCs enhanced their immunosuppressive potency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siyu Cai, Chuiqin Fan, Lichun Xie, Huifeng Zhong, Aijia Li, Siyu Lv, Maochuan Liao, Xixi Yang, Xing Su, Yue Wang, Hongwu Wang, Manna Wang, Peng Huang, Yulin Liu, Yu Wang, Yufeng Liu, Tianyou Wang, Yong Zhong, Lian Ma
Summary: This study found that foreskin mesenchymal stromal cells (FSMSCs) have better immunomodulatory capacity than human umbilical cord mesenchymal stromal cells (HuMSCs) in vitro. Moreover, immune MSCs may play a vital role in the heterogeneity of immunoregulatory properties.
CELL AND BIOSCIENCE
(2022)
Review
Cell & Tissue Engineering
Miryam Mebarki, Camille Abadie, Jerome Larghero, Audrey Cras
Summary: UC-MSCs are considered as a promising perspective for treating immune and inflammatory diseases due to their immunomodulatory and anti-inflammatory properties. The classification of UC-MSC-based products as advanced therapy medicinal products in Europe poses challenges for stakeholders in terms of adaptation from cell banks to manufacturing medicines. Despite the potential, the development of UC-MSC-based ATMPs remains a real challenge for both academic institutions and pharmaceutical companies.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Surgery
S. Shabir, J. Girdlestone, D. Briggs, B. Kaul, H. Smith, S. Daga, S. Chand, S. Jham, C. Navarrete, L. Harper, S. Ball, R. Borrows
AMERICAN JOURNAL OF TRANSPLANTATION
(2015)
Article
Pharmacology & Pharmacy
Abdullah Al-Ashwal, Fahad Alnouri, Hani Sabbour, Abdulraof Al-Mahfouz, Nasreen Al-Sayed, Maryam Razzaghy-Azar, Faisal Al-Allaf, Khalid Al-Waili, Yajnavalka Banerjee, Jacques Genest, Raul D. Santos, Khalid Al-Rasadi
CURRENT VASCULAR PHARMACOLOGY
(2015)
Article
Cell & Tissue Engineering
John Girdlestone, Jeffrey Pido-Lopez, Saket Srivastava, Jianguo Chai, Neil Leaver, Antonio Galleu, Giovanna Lombardi, Cristina V. Navarrete
Article
Endocrinology & Metabolism
Neda M. Bogari, Husni H. Rayes, Fakri Mostafa, Azza M. Abdel-Latif, Abeer Ramadan, Faisal A. Al-Allaf, Mohiuddin M. Taher, Ahmed Fawzy
DIABETES RESEARCH AND CLINICAL PRACTICE
(2015)
Article
Genetics & Heredity
Faisal A. Al-Allaf, Mohammad Athar, Zainularifeen Abduljaleel, Mohiuddin M. Taher, Wajahatullah Khan, Faisal A. Ba-hammam, Hala Abalkhail, Abdullah Alashwal
Article
Virology
Alexander Otahal, Renate Fuchs, Faisal A. Al-Allaf, Dieter Blaas
JOURNAL OF VIROLOGY
(2015)
Article
Genetics & Heredity
Burhan M. Edrees, Mohammad Athar, Faisal A. Al-Allaf, Mohiuddin M. Taher, Wajahatullah Khan, Abdellatif Bouazzaoui, Naffaa Al-Harbi, Ramzia Safar, Howaida Al-Edressi, Khawala Alansary, Abulkareem Anazi, Naji Altayeb, Muawia A. Ahmed, Zainularifeen Abduljaleel
Review
Immunology
John Girdlestone
Article
Oncology
Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung, Chae-Ok Yun
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2016)
Correction
Oncology
Adel Galal El-Shemi, Ahmad Mohammed Ashshi, Youjin Na, Yan Li, Mohammed Basalamah, Faisal Ahmad Al-Allaf, Eonju Oh, Bo-Kyeong Jung, Chae-Ok Yun
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Zainularifeen Abduljaleel, Faisal A. Al-Allaf, Wajahatullah Khan, Mohammad Athar, Naiyer Shahzad, Mohiuddin M. Taher, Mohammed Alanazi, Mohamed Elrobh, Narasimha P. Reddy
MOLECULAR GENETICS AND GENOMICS
(2014)
Article
Biotechnology & Applied Microbiology
Ali Nowrouzi, Wing T. Cheung, Tingting Li, Xuegong Zhang, Anne Arens, Anna Paruzynski, Simon N. Waddington, Emma Osejindu, Safia Reja, Christof von Kalle, Yoahe Wang, Faisal Al-Allaf, Lisa Gregory, Matthew Themis, Maxine Holder, Niraja Dighe, Alaine Ruthe, Suzanne M. K. Buckley, Brian Bigger, Eugenio Montini, Adrian J. Thrasher, Robert Andrews, Terry P. Roberts, Robert F. Newbold, Charles Coutelle, Manfred Schmidt, Mike Themis
Article
Multidisciplinary Sciences
Zainularifeen Abduljaleel, Faisal A. Al-Allaf, Wajahatullah Khan, Mohammad Athar, Naiyer Shahzad, Mohiuddin M. Taher, Mohamed Elrobh, Mohammed S. Alanazi, Waseem El-Huneidi
Article
Hematology
Minoko Takanashi, Eileen Selogie, Jo-Anna Reems, David Stroncek, Magali J. Fontaine, John Girdlestone, Henk S. P. Garritsen, Pampee Young, David H. McKenna, Zbigniew M. Szczepiorkowski
Review
Medicine, General & Internal
Sheila A. Fisher, Antony Cutler, Carolyn Doree, Susan J. Brunskill, Simon J. Stanworth, Cristina Navarrete, John Girdlestone
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2019)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)