Article
Anesthesiology
Volodymyr Krotov, Kirill Agashkov, Marharyta Krasniakova, Boris Safronov, Pavel Belan, Nana Voitenko
Summary: This study reveals the input sources and regulation mechanisms of spinal lamina X neurons, demonstrating that primary afferent fibers are regulated by both spinal and supraspinal control through at least 5 distinct pathways.
Article
Neurosciences
Ken Muramatsu, Naoko Niimi, Masako Ikutomo, Satoshi Shimo, Toru Tamaki, Masatoshi Niwa, Kazunori Sango
Summary: Complex motor skills training has been found to improve motor disorders in diabetic patients. Electrophysiological and immunohistochemical analysis showed that this training can induce plastic changes in the rubrospinal tract, compensating for the disruption caused by diabetes in the corticospinal tract and improving motor function.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Zijue Wang, Hongmei Duan, Fei Hao, Peng Hao, Wen Zhao, Yudan Gao, Yiming Gu, Jianren Song, Xiaoguang Li, Zhaoyang Yang
Summary: An implanted NT3-chitosan scaffold can recruit neural stem cells to the lesion region and lead to the formation of functional neural circuits, promoting recovery after spinal cord injury. The scaffold facilitates the maturation of spinal neurons and the reestablishment of neural circuits, allowing for the recovery of neuromuscular function. This finding highlights the importance of the NT3-chitosan scaffold in promoting functional recovery after paraplegia.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Behavioral Sciences
Ana M. Lucas-Osma, Emma K. A. Schmidt, Romana Vavrek, David J. Bennett, Karim Fouad, Keith K. Fenrich
Summary: This study compares the effects of cervical contusion and partial transection injury models on the recovery of skilled motor tasks in injured rats. The results show that cervical contusion damages key spinal tracts important for performing skilled motor tasks and produces more extensive grey matter and ventral white matter damage. Despite initial poor performance, rehabilitative training can promote significant recovery in rats with cervical contusion injuries.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biology
Richard A. Warren, Qianyun Zhang, Judah R. Hoffman, Edward Y. Li, Y. Kate Hong, Randy M. Bruno, Nathaniel B. Sawtell
Summary: By using machine learning for high-resolution kinematic analysis, researchers uncovered the logic behind sensory-guided locomotion in mice, showing that mice choose different kinematic strategies depending on whisker-derived estimate of obstacle location and body position and velocity. While mice rely on whiskers for obstacle avoidance, lesions of primary whisker sensory cortex have minimal impact, while manipulations of motor cortex affect the execution of chosen strategy but the decision-making process remains intact. This study highlights the potential of machine learning in analyzing naturalistic behaviors and shows that subcortical brain structures are sufficient for mediating sophisticated sensorimotor decisions.
Article
Neurosciences
Hisham Sharif, Heather Alexander, Anika Azam, John H. Martin
Summary: The study found that dual epidural motor cortex intermittent theta burst stimulation (iTBS) and cathodal transcutaneous spinal direct stimulation (tsDCS) enhance the efficacy of rehabilitation in improving motor function after spinal cord injury (SCI). Stimulation+rehabilitation group showed increased corticospinal tract axon length caudal to the injury, reduced proprioceptive afferent terminal labeling in the intermediate zone, and a negative correlation between afferent fiber terminal labeling and motor recovery.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Environmental Sciences
Yosra Cherni, Alexia Tremblay, Margaux Simon, Floriane Bretheau, Andreanne K. Blanchette, Catherine Mercier
Summary: This review evaluates the effect of gait-specific training on corticospinal excitability in stroke survivors. The results suggest that gait-specific training can drive neuroplastic adaptation among stroke survivors, but further studies with better methodology are needed for conclusive evidence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Kyu Tae Choi, Sang Gyu Kwak, Min Cheol Chang
Summary: The integrity of the thalamocortical connection between the MD of thalamus and the DLPFC is crucial for motor function recovery in patients with disrupted CST integrity. This connection has no significant impact on motor outcomes in patients with preserved CST integrity.
ACTA NEUROLOGICA BELGICA
(2021)
Review
Physiology
John Kalambogias, Yutaka Yoshida
Summary: This review emphasizes the crucial interactions between corticospinal tract motor circuit and spinal interneurons, as well as the modulatory role of corticospinal tract in the spinal cord. Additionally, it explores the influence of corticospinal neurons on the dorsal column nuclei complex for processing ascending somatosensory information.
CURRENT OPINION IN PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Erin J. Prosser-Loose, Atiq Hassan, Gordon S. Mitchell, Gillian D. Muir
JOURNAL OF NEUROTRAUMA
(2015)
Article
Multidisciplinary Sciences
Atiq Hassan, Breanna M. Arnold, Sally Caine, Behzad M. Toosi, Valerie M. K. Verge, Gillian D. Muir
Article
Behavioral Sciences
Srikanth G. Kanagal, Gillian D. Muir
BEHAVIOURAL BRAIN RESEARCH
(2008)
Article
Behavioral Sciences
Sean W. Bennett, Joel L. Lanovaz, Gillian D. Muir
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Neurosciences
Srikanth G. Kanagal, Gillian D. Muir
EXPERIMENTAL NEUROLOGY
(2008)
Article
Neurosciences
Mary R. Lovett-Barr, Irawan Satriotomo, Gillian D. Muir, Julia E. R. Wilkerson, Michael S. Hoffman, Stephane Vinit, Gordon S. Mitchell
JOURNAL OF NEUROSCIENCE
(2012)
Article
Nutrition & Dietetics
Larisa K. Matwee, Mariam Alaverdashvili, Gillian D. Muir, Jonathan P. Farthing, Sarah A. Bater, Phyllis G. Paterson
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Article
Neurosciences
J. R. Nadeau, B. M. Arnold, J. M. Johnston, G. D. Muir, V. M. K. Verge
Summary: Brief electrical stimulation (ES) or acute intermittent hypoxia (AIH) treatment during surgical repair can enhance the regeneration of injured peripheral nerves by influencing the expression of regeneration-associated genes (RAG). These treatments lead to significant improvements in growth indicators and functional recovery, showing promising potential for non-invasive therapies in nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Breanna M. Arnold, Behzad M. Toosi, Sally Caine, Gordon S. Mitchell, Gillian D. Muir
Summary: This study showed that prolonged repetitive AIH combined with task-specific training improved forelimb reach-to-grasp function in rats with chronic cervical hemisection, without affecting off-target motor tasks. It further supports the idea that daily AIH can enhance limb function when combined with task-specific training.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Alicia K. Vose, Joseph F. Welch, Jayakrishnan Nair, Erica A. Dale, Emily J. Fox, Gillian D. Muir, Randy D. Trumbower, Gordon S. Mitchell
Summary: The study reviews the progress of a strategy involving therapeutic acute intermittent hypoxia (tAIH) to improve respiratory and non-respiratory motor function in people with neuromuscular disorders. Key areas of focus include greater mechanistic understanding, optimization of treatment protocols, identification of combinatorial treatments, assessment of long-term safety, and the development of a simple, safe and effective device for administering tAIH in clinical and home settings.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Srikanth G. Kanagal, Gillian D. Muir
EXPERIMENTAL NEUROLOGY
(2007)
Article
Neurosciences
Gillian D. Muir, Aubrey A. Webb, Srikanth Kanagal, Laura Taylor
EUROPEAN JOURNAL OF NEUROSCIENCE
(2007)
Review
Behavioral Sciences
AA Webb, GD Muir
BEHAVIOURAL BRAIN RESEARCH
(2005)
Article
Neurosciences
GD Muir, KSV Gowri
JOURNAL OF NEUROPHYSIOLOGY
(2005)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)