Article
Neurosciences
Camila Marques Freria, Lori Graham, Ali Azimi, Paul Lu
Summary: We propose an updated model of moderately severe bilateral cervical level 6 contusive spinal cord injury (SCI) in the rat, which is more clinically relevant than previous models and allows animals to survive the lesion. This model closely mimics the most common cervical level of SCI in humans and provides a superior tool for assessing motor recovery interventions.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Benita Jin, Monzurul Alam, Alexa Tierno, Hui Zhong, Roland R. Roy, Yury Gerasimenko, Daniel C. Lu, V. Reggie Edgerton
Summary: Serotonergic agents, specifically buspirone and fluoxetine, have shown to improve forelimb motor function recovery after spinal cord injury in adult female rats. Buspirone treatment led to rapid improvement in reaching and grasping success rates, while fluoxetine treatment resulted in a more progressive improvement in forelimb performance over time. However, both treatments did not significantly improve quadrupedal locomotion.
Article
Behavioral Sciences
Ana M. Lucas-Osma, Emma K. A. Schmidt, Romana Vavrek, David J. Bennett, Karim Fouad, Keith K. Fenrich
Summary: This study compares the effects of cervical contusion and partial transection injury models on the recovery of skilled motor tasks in injured rats. The results show that cervical contusion damages key spinal tracts important for performing skilled motor tasks and produces more extensive grey matter and ventral white matter damage. Despite initial poor performance, rehabilitative training can promote significant recovery in rats with cervical contusion injuries.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Clinical Neurology
Numaira Obaid, Kazuhito Morioka, Eleni Sinopoulou, Yvette-Nout Lomas, Ernesto Salegio, Jacqueline C. C. Bresnahan, Michael S. S. Beattie, Carolyn J. J. Sparrey
Summary: Large animal contusion models of spinal cord injury are crucial for developing and assessing treatment options for human spinal cord injury. This review examines the impact of head and neck positioning on the biomechanics and outcomes of a cervical contusion model of spinal cord injury. The results suggest that neck positioning is an important factor and standardizing it can improve inter-study consistency and comparability in cervical spinal cord injury models.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Ajay Pal, HongGeun Park, Aditya Ramamurthy, Ahmet S. Asan, Thelma Bethea, Meenu Johnkutty, Jason B. Carmel
Summary: In this study, the researchers developed a plasticity protocol in rats that aims to activate both sensory and motor connections in the spinal cord. They found that repeated application of this protocol in rats with spinal cord injury improved their forelimb dexterity and reduced hyperreflexia. This study shows the importance of targeting the sensory and motor systems in the spinal cord for promoting recovery after spinal cord injury.
Article
Pharmacology & Pharmacy
Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini Ravandi, Mahmoudreza Hadjighassem
Summary: This study found that early administration of bumetanide after spinal cord injury can promote recovery of locomotor function. The results showed that bumetanide can reduce the expression of NKCC1 gene and increase GAP protein levels, thereby having neuroprotective and regenerative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Sarah E. Mondello, Lisa Young, Viet Dang, Amanda E. Fischedick, Nicholas M. Tolley, Tian Wang, Madison A. Bravo, Dalton Lee, Belinda Tucker, Megan Knoernschild, Benjamin D. Pedigo, Philip J. Horner, Chet T. Moritz
Summary: This study aims to develop a mechanistic understanding of how to promote functional recovery following spinal cord injury. The use of optogenetic stimulation shows promising results in promoting recovery of skilled limb movements and axonal growth. This finding suggests that optogenetic stimulation could be a potential therapy for spinal cord injury.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Keith K. Fenrich, Ben W. Hallworth, Romana Vavrek, Pamela J. F. Raposo, John E. Misiaszek, David J. Bennett, Karim Fouad, Abel Torres-Espin
Summary: The study shows that more rehabilitation training and increased training intensity can improve performance in skilled forelimb motor tasks in rodents with cervical SCI, with better performance linked to differences in corticospinal tract axon collateral densities in injured spinal cords. However, the data also indicate that rehabilitation training becomes progressively less efficient as both the amount and intensity of training increases.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Critical Care Medicine
Kun-Ze Lee, Li-Min Liou, Stephane Vinit
Summary: Cervical magnetic stimulation can be used to assess post-injury excitability of phrenic motor outputs, with shorter latency and increased amplitude observed in response to acute injury. Placing the stimulation more laterally at the left spinal cord in subchronic and chronic injury stages generally leads to larger motor-evoked potentials of the diaphragm.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Pharmacology & Pharmacy
Rakib Uddin Ahmed, V. Reggie Edgerton, Shuai Li, Yong-Ping Zheng, Monzurul Alam
Summary: This study investigated the dose-response of Buspirone treatment on reaching and grasping function in cervical cord injured rats, showing that the lowest dose group had the best performance in reaching scores and grip strength.
Article
Biology
Almir Aljovic, Shuqing Zhao, Maryam Chahin, Clara de la Rosa, Valerie Van Steenbergen, Martin Kerschensteiner, Florence M. Bareyre
Summary: In this study, a new deep learning-based open-source toolbox, ALMA, was developed for automated limb motion analysis in neuroscience research. This toolbox allows consistent and comprehensive analysis of locomotor kinematics and paw placement in rodent models of neurological conditions, using basic behavioral equipment and an inexpensive camera. The ALMA toolbox has been demonstrated to track locomotor deficits after spinal cord injury, detect locomotor abnormalities after traumatic brain injury, and predict disease onset in a multiple sclerosis model.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Yapu Liu, Qi Liu, Zhou Yang, Rong Li, Zhiping Huang, Zucheng Huang, Junhao Liu, Xiuhua Wu, Junyu Lin, Xiaoliang Wu, Qingan Zhu
Summary: Trihydroxyethyl rutin exhibits robust neuroprotective effects in rats with cervical spinal cord hemi-contusion, improving limb motor function and nerve electrophysiological parameters, maintaining microvascular density, and reducing the area of injury and degree of demyelination.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Kun-Ze Lee
Summary: The study investigated the physiological and transcriptomic mechanisms of distinct diaphragm areas following mid-cervical spinal cord injury. The results showed that the injury had different impacts on the physiological responses and gene expression in different diaphragm areas. These findings have important clinical implications for future therapeutic strategies and the placement of diaphragmatic pacing electrodes.
Article
Physiology
Haiya Ge, Zhengming Wang, Zongrui Yang, Jinyu Shi, Jiehang Lu, Yuanyuan Wang, Zhengyan Li, Guoqing Du, Zhibi Shen, Hongsheng Zhan
Summary: By controlling time and force, a chronic skeletal muscle injury model was induced to better understand the pathological features of chronic skeletal muscle injuries. After 4 weeks of remodeling and repair, the acute skeletal muscle injury model induced by 10 J kinetic energy can stabilize pathological manifestations, inflammatory expression, and extracellular matrix synthesis and catabolism, making it an appropriate model for studying chronic skeletal muscle injuries caused by acute injury.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Anesthesiology
De-Yong Liang, Wen-Wu Li, Chinwe Nwaneshiudu, Karen-Amanda Irvine, J. David Clark
ANESTHESIA AND ANALGESIA
(2019)
Article
Critical Care Medicine
Allan D. Levi, Kim D. Anderson, David O. Okonkwo, Paul Park, Thomas N. Bryce, Shekar N. Kurpad, Bizhan Aarabi, Jane Hsieh, Katie Gant
JOURNAL OF NEUROTRAUMA
(2019)
Article
Anesthesiology
Wen-Wu Li, Karen-Amanda Irvine, Peyman Sahbaie, Tian-Zhi Guo, Xiao-you Shi, Vivianne L. Tawfik, Wade S. Kingery, J. David Clark
Article
Clinical Neurology
Joshua D. Burks, Katie L. Gant, James D. Guest, Aria G. Jamshidi, Efrem M. Cox, Kim D. Anderson, W. Dalton Dietrich, Mary Bartlett Bunge, Barth A. Green, Aisha Khan, Damien D. Pearse, Efrat Saraf-Lavi, Allan D. Levi
NEUROSURGICAL FOCUS
(2019)
Article
Clinical Neurology
Shinn Shafazand, Kim D. Anderson, Mark S. Nash
JOURNAL OF CLINICAL SLEEP MEDICINE
(2019)
Article
Neurosciences
Oswald Steward, Aminata P. Coulibaly, Mariajose Metcalfe, Jennifer M. Yonan, Kelly M. Yee
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Karen-Amanda Irvine, Peyman Sahbaie, Adam R. Ferguson, J. David Clark
EXPERIMENTAL NEUROLOGY
(2019)
Review
Clinical Neurology
Denise G. Tate, Tracey Wheeler, Giulia I. Lane, Martin Forchheimer, Kim D. Anderson, Fin Biering-Sorensen, Anne P. Cameron, Bruno Gallo Santacruz, Lyn B. Jakeman, Michael J. Kennelly, Steve Kirshblum, Andrei Krassioukov, Klaus Krogh, M. J. Mulcahey, Vanessa K. Noonan, Gianna M. Rodriguez, Ann M. Spungen, David Tulsky, Marcel W. Post
JOURNAL OF SPINAL CORD MEDICINE
(2020)
Article
Multidisciplinary Sciences
Peyman Sahbaie, Karen-Amanda Irvine, De-Yong Liang, Xiaoyou Shi, J. David Clark
SCIENTIFIC REPORTS
(2019)
Editorial Material
Neurosciences
Hollis Cline, Lique Coolen, Saskia de Vries, Steven Hyman, Rosalind Segal, Oswald Steward
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K. -A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, J. C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie
Summary: This study used big data integration and large-scale analytics to examine the efficacy of five different acute anti-inflammatory treatments for spinal cord injury, finding that only one treatment, intrathecal application of recombinant soluble TNF alpha receptor 1 (sTNFR1), consistently showed multidimensional benefit. Treatment with sTNFR1 at the optimal acute dose significantly affected multiple biological indices of neuroinflammation in the first 48 hours post-injury, leading to improved neurological function over 6 weeks post SCI. These results suggest a novel strategy for preclinical drug discovery and highlight the importance of TNF alpha signaling as a therapeutic target in CNS trauma.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Robin Bishop, Seok Joon Won, Karen-Amanda Irvine, Jayinee Basu, Eric S. Rome, Raymond A. Swanson
Summary: Blast exposure can lead to brain injuries through multiple mechanisms, and axonal injury is a major type of injury that is independent of head movement. Especially, axons in the cerebellar white matter are particularly vulnerable to blast exposure.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Oswald Steward, Aminata P. Coulibaly, Mariajose Metcalfe, Jamie M. Dam, Kelly M. Yee
Summary: The study shows that injections of different AAVs into the brain, spinal cord, or cerebrospinal fluid can lead to transduction of cells in the pineal gland, raising concerns about the potential adverse effects of AAV-driven expression in pinealocytes during therapeutic treatments.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Article
Clinical Neurology
Vimala N. Bharadwaj, Peyman Sahbaie, Xiaoyou Shi, Karen-Amanda Irvine, David C. Yeomans, J. David Clark
Summary: This study evaluates the effects of exercise on pain-related behaviors in a preclinical model of traumatic brain injury (TBI). The findings show that exercise reduces nociceptive sensitization, loss of diffuse noxious inhibitory control, memory deficits, and spinal nociception-related gene expression after TBI. Exercise may reduce or prevent pain after TBI.
Article
Neurosciences
Karen-Amanda Irvine, Peyman Sahbaie, Adam R. Ferguson, J. David Clark
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)