Review
Neurosciences
Mihai Ceanga, Mahmoud Dahab, Otto W. Witte, Silke Keiner
Summary: In the aftermath of a stroke, the brain undergoes various signaling cascades that reshape both the perilesional zone and more distant regions. Stroke leads to a significant increase in adult neurogenesis, offering hope for neurological recovery. However, there are significant regional differences in the effects of neurogenesis in the SVZ and SGZ post-stroke on functional recovery.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Pu-Tien Chiang, Hsin-Hsi Tsai, Ruoh-Fang Yen, Yi-Chieh Tsai, Chi-Han Wu, Ching-Hung Chiu, Li-Kai Tsai
Summary: In this study, we assessed the use of F-18-fluorothymidine (FLT) PET to detect cerebral cell proliferation and found that it is associated with stroke severity and outcomes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Yingxun Liu, Junrong Ren, Mengsi Kang, Chenyang Zhai, Qiangqiang Cheng, Jin Li, Yuzi Wu, Xiaofei Ruan, Jinlong Zhou, Juan Fan, Yingfang Tian
Summary: Research shows that PGRN treatment promotes acute functional recovery and stimulates neurogenesis in the subventricular zone after cerebral ischemia, which is beneficial for long-term recovery. The increase in neurogenesis may be associated with activation of the MAPK/ERK and PI3K/Akt pathways, suggesting a potential new strategy utilizing PGRN in ischemic stroke therapy.
Article
Pediatrics
Daniel Alonso-Alconada, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Summary: Hypoxia-ischemia can lead to a decrease in cell proliferation and neurogenesis in the neurogenic niche of the neonatal piglet, which may hinder the replacement of lost neurons and overall repair.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Jana Osacka, Alexander Kiss, Zuzana Bacova, Andrej Tillinger
Summary: Aberrant neurogenesis in the subventricular zone and hippocampus contributes to schizophrenia pathogenesis. The commonly prescribed antipsychotics haloperidol and olanzapine affect neurogenesis. This study investigates the effects of these drugs on cell proliferation and gene expression in vitro and in an animal schizophrenia model. The results suggest that chronic treatment with haloperidol and olanzapine can inhibit gene expression, but olanzapine can reverse the inhibitory effect of another drug in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Perla Leal-Galicia, Maria Elena Chavez-Hernandez, Florencia Mata, Jesus Mata-Luevanos, Luis Miguel Rodriguez-Serrano, Alejandro Tapia-de-Jesus, Mario Humberto Buenrostro-Jauregui
Summary: The generation of new neurons in the adult brain is a well-accepted phenomenon that mainly occurs in the subventricular zone and the hippocampal dentate gyrus. These new neurons are generated through an asymmetric division process and contribute to the local circuitry with their unique properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Andi Chen, Xiaohui Chen, Jianhui Deng, Jianjie Wei, Haitao Qian, Yongxin Huang, Shuyan Wu, Fei Gao, Cansheng Gong, Yanling Liao, Xiaochun Zheng
Summary: Hypoxic-ischemic brain damage (HIBD) is the main cause of neurological dysfunction in neonates. Olfactory cognitive dysfunction is important for feeding, the ability to detect hazardous situations, and social relationships. Dexmedetomidine (DEX) treatment could significantly improve olfactory cognitive dysfunction in neonatal rats with HIBD by promoting neurogenesis in the subventricular zone (SVZ) and enhancing the expression of brain-derived neurotrophic factor (BDNF) in microglia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Bin Sun, Mengran Wang, Anna Hoerder-Suabedissen, Chris Xu, Adam M. Packer, Francis G. Szele
Summary: We demonstrate, for the first time, three-photon microscopy imaging of the SVZ in live mice. This strategy could be useful for intravital visualization of cell dynamics, molecular, and pathological perturbation and regenerative events.
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Nan Yao, Yulin Li, Jinrui Han, Siting Wu, Xin Liu, Qiuyu Wang, Zhiguo Li, Fu-Dong Shi
Summary: This study reveals the detrimental role of microglia in neurogenesis and neurorepair after intraventricular hemorrhage (IVH), with CC chemokine ligand 20 (CCL20) playing a likely role in promoting pro-inflammatory responses and neural injury.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Cell Biology
Vicente Llorente, Pedro Velarde, Manuel Desco, Maria Victoria Gomez-Gaviro
Summary: This review summarizes the latest research on neural stem cells and their canonical niches, including their structure, behaviors, and role in neural diseases.
Review
Clinical Neurology
Yue Li, Weixiang Guo
Summary: Adult neurogenesis is a crucial process that generates new and functional neurons from neural stem cells throughout life. Maintaining the proper function of the neurogenic niche requires niche cells to respond to external cues and adapt their roles to influence NSC behavior. Understanding the interactive regulation of NSCs and neurogenesis by the neurogenic niche is important for maintaining the integrative process and functional integrity of the adult brain.
Article
Neurosciences
Daniel Esteve, Maria Micaela Molina-Navarro, Esther Giraldo, Noelia Martinez-Varea, Mari-Carmen Blanco-Gandia, Marta Rodriguez-Arias, Jose Manuel Garcia-Verdugo, Jose Vina, Ana Lloret
Summary: Neurogenesis and neuronal migration in the adult brain are impaired in Alzheimer's disease, leading to cell senescence and reduced odor discrimination ability. Studying the APP/PS1 Alzheimer's mouse model may provide insights for new Alzheimer's treatments based on senolytic compounds or pro-neurogenic factors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiyu Li, Chun Li, Pushpa Subedi, Xinli Tian, Xiaohong Lu, Sumitra Miriyala, Manikandan Panchatcharam, Hong Sun
Summary: Ischemic stroke is a major cause of death and disability globally, and neurogenesis plays a crucial role in post-stroke functional recovery. Alcohol consumption has a dose-dependent effect on the prognosis of ischemic stroke. The study found that light alcohol consumption can promote neurogenesis, reduce brain damage, and improve locomotor activity in mice.
Article
Neurosciences
Yali Chen, Peng Ren, Xiongjie He, Fang Yan, Rou Gu, Jie Bai, Xianwen Zhang
Summary: Olfaction is a crucial sense that relies on the olfactory bulb (OB) as the relay station. The contribution of subventricular zone (SVZ) adult neurogenesis to OB neurogenesis is still not fully understood. Recent studies have focused on understanding the molecular and signaling pathways associated with OB neurogenesis dependent on SVZ function. This understanding is important for improving olfactory dysfunction and developing new therapies based on adult neural stem cells (aNSCs).
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)