Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Bernadette C. M. van Wijk, Wolf-Julian Neumann, Daniel Kroneberg, Andreas Horn, Friederike Irmen, Tilmann H. Sander, Qiang Wang, Vladimir Litvak, Andrea A. Kuehn
Summary: This study investigated the structural connectivity profile of the subthalamic nucleus (STN) using local field potential recordings and simultaneous magnetoencephalography. The results suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, with considerable spatial overlap between functional networks.
Review
Clinical Neurology
Francesca Mameli, Eleonora Zirone, Roberta Girlando, Elena Scagliotti, Giulia Rigamonti, Edoardo Nicolo Aiello, Barbara Poletti, Roberta Ferrucci, Nicola Ticozzi, Vincenzo Silani, Marco Locatelli, Sergio Barbieri, Fabiana Ruggiero
Summary: Deep brain stimulation (DBS) is an effective treatment for motor symptoms in Parkinson's disease (PD), but patients may experience psychological distress and social maladjustments after surgery. This review examines the role of patients' expectations regarding the outcomes of DBS and highlights the need for intervention to improve pre-operative patient education and post-operative psychosocial adjustment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marisa DiMarzio, Radhika Madhavan, Ileana Hancu, Eric Fiveland, Julia Prusik, Suresh Joel, Michael Gillogly, Ilknur Telkes, Michael D. Staudt, Jennifer Durphy, Damian Shin, Julie G. Pilitsis
Summary: This study aimed to investigate the impact of altered frequencies on brain activation in PD patients. It was found that changing the frequency significantly affected the activation levels in regions such as the thalamus, globus pallidum externa, and cerebellum. Additionally, using fMRI signatures may be helpful in determining the optimal frequency for DBS programming.
Article
Clinical Neurology
Maidinamu Yakufujiang, Yoshinori Higuchi, Kyoko Aoyagi, Tatsuya Yamamoto, Toru Sakurai, Midori Abe, Yoji Okahara, Masaki Izumi, Osamu Nagano, Yoshitaka Yamanaka, Shigeki Hirano, Akihiro Shiina, Atsushi Murata, Yasuo Iwadate
Summary: This study found that preoperative evaluation using the Similarities and Object Assembly subtests in patients undergoing STN-DBS surgery may help predict cognitive declines postoperatively, especially in visuospatial functioning. A low score on the Similarities subtest may also predict future global cognitive deterioration.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang
Summary: This study demonstrates that deep brain stimulation can effectively suppress levodopa-induced dyskinesia in Parkinson's disease patients without reducing levodopa dosage. The stimulation sites with good anti-dyskinesia effect are located above the subthalamic nucleus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Johannes Kahkola, Maija Lahtinen, Tuija Keinanen, Jani Katisko
Summary: This study utilized deterministic tractography to investigate the functional subdivisions of the subthalamic nucleus (STN) and the white matter connections with the medial frontal cortex in Parkinson's disease. The results suggest that stimulating the cluster located in the preSMA region of the STN may predict better treatment outcomes, including motor improvement and reduced levodopa equivalent daily dose.
Article
Clinical Neurology
Asra Askari, Brandon J. Zhu, Xiru Lyu, Kelvin L. Chou, Parag G. Patil
Summary: The study found that STN DBS has differential effects on rigidity in upper and lower extremities in patients with Parkinson's disease. However, there was no significant difference in tremor or bradykinesia between the upper and lower extremities. Even though there were slight differences in the maximal-effect loci for stimulation between the upper and lower extremities, they were not statistically resolved.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Jiazhen Wang, Ru Pan, Ying Cui, Zhigang Wang, Qinghua Li
Summary: Compared to drug treatment, the verbal fluency of patients in the experimental group decreased significantly, especially phonemic fluency. Learning and memory abilities also showed a slight decline. Other neurocognitive functions were not significantly affected.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Keying Zhu, Sun Peng, Yulun Wu, Yuanyuan Zhao, Zhonglei Lu
Summary: Deep brain stimulation (STN-DBS) improves sleep quality, motor function, and reduces medication usage in Parkinson disease (PD) patients.
Review
Medicine, General & Internal
Jae Meen Lee, Kyoungjune Pak
Summary: The efficacy of deep brain stimulation (DBS) in patients with young-onset Parkinson disease (YOPD) and late-onset Parkinson disease (LOPD) showed similar improvements in motor symptoms. Therefore, DBS should be considered regardless of the age at Parkinson disease onset.
Article
Engineering, Biomedical
James K. Trevathan, Anders J. Asp, Evan N. Nicolai, Jonathan M. Trevathan, Nicholas A. Kremer, Takashi D. Y. Kozai, David Cheng, Mike J. Schachter, Jonathan J. Nassi, Stephani L. Otte, Jones G. Parker, J. Luis Lujan, Kip A. Ludwig
Summary: This manuscript outlines an approach combining chronic behaving single-photon microendoscope recordings in a pathological mouse model with electrical stimulation of a common deep brain stimulation (DBS) target to study neuromodulation therapy. The authors present detailed steps necessary for this approach and discuss key considerations for extending it to other DBS targets. They also make recommendations based on their experience in implementing and validating the required procedures.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)