Article
Biochemistry & Molecular Biology
Nathalie A. J. Verzele, Brendon Y. Chua, Charity W. Law, Albert Zhang, Matthew E. Ritchie, Oliver Wightman, Isaac N. Edwards, Katina D. Hulme, Conor J. Bloxham, Helle Bielefeldt-Ohmann, Matthew W. Trewella, Aung Aung Kywe Moe, Keng Yih Chew, Stuart B. Mazzone, Kirsty R. Short, Alice E. McGovern
Summary: In a mouse model, it was found that respiratory infection with Influenza A virus led to significant transcriptional changes in vagal sensory neurons, inducing a neuroinflammatory response and potentially impacting morbidity associated with influenza virus infection.
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Enrico Pracucci, Vinoshene Pillai, Didi Lamers, Riccardo Parra, Silvia Landi
Summary: Epilepsy can be both a primary pathology and a secondary effect of many neurological conditions. Neuroinflammation is believed to be a product of epilepsy, and conditions characterized by neuroinflammation are more likely to develop epilepsy. However, the bidirectional mechanism of the reciprocal interaction between epilepsy and neuroinflammation still needs further understanding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mathematics, Interdisciplinary Applications
Miaomiao Xing, Xinlin Song, Hengtong Wang, Zhuoqin Yang, Yong Chen
Summary: This work studies the response dynamics of a two-neuron network motif composed of class-1 and class-3 Morris-Lecar neurons under an external directional current. The study finds that the two neurons exhibit frequency locking and complete frequency synchronization with increases in coupling strength and input current. The class-3 neuron in the motif can produce various excitabilities with appropriate coupling strength and input current, including tonic and phasic spiking.
CHAOS SOLITONS & FRACTALS
(2022)
Article
Biochemistry & Molecular Biology
Taira Matsuo, Rie Komori, Minami Nakatani, Shiori Ochi, Aya Yokota-Nakatsuma, Junichi Matsumoto, Fuyuko Takata, Shinya Dohgu, Yasuhiro Ishihara, Kouichi Itoh
Summary: The study demonstrated that levetiracetam (LEV) suppresses the infiltration of proinflammatory cells into the brain after status epilepticus (SE), therefore preventing acute brain inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Eva Borbely, Agnes Hunyady, Krisztina Pohoczky, Maja Payrits, Balint Botz, Attila Mocsai, Alexandra Berger, Eva Szoke, Zsuzsanna Helyes
Summary: This research reveals that HK-1 plays a role in arthritic pain primarily through cellular, rather than vascular inflammatory mechanisms, independently of NK1 activation. HK-1 activates primary sensory neurons presumably via a Ca2+ channel-linked receptor. Identifying the specific target of HK-1 opens up new avenues to understand joint pain and develop novel therapeutic approaches.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Dong Cui, Ze-Hua Li, Cheng Li, Chengjie Qiu, Pingchuan Ma, Mingzheng Wu, Xue-Jun Song
Summary: The study suggests that spinal A beta 1-42 acts as an endogenous analgesic peptide by regulating cytokines and Wnt pathways. This may offer a potential target for the development of novel analgesic peptides.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Clinical Neurology
Jason P. Fernandes, William G. Branton, Eric A. Cohen, Gerrit Koopman, Ivanela Kondova, Benjamin B. Gelman, Christopher Power
Summary: Despite effective antiretroviral therapies, a significant proportion of treated HIV infection cases develop a neurodegenerative syndrome called HIV-associated neurocognitive disorder (HAND). This study investigates the mechanisms underlying neuronal damage and death in HAND and identifies a novel mechanism by which HIV triggers pyroptotic death in neurons. Targeting this mechanism could offer new diagnostic and therapeutic strategies for HAND and other neurodegenerative disorders.
Review
Neurosciences
Yizhang Chen, Lin Xiao, Jian Qiu
Summary: Neuronomodulation refers to the modulation of neural conduction and synaptic transmission through changes in membrane potential caused by chemical substances. It can occur directly through ligand-gated or voltage-gated ion channels, or indirectly through metabotropic receptor-mediated slow potentials. Understanding neuronomodulation is crucial for understanding brain function and disease.
NEUROSCIENCE BULLETIN
(2023)
Article
Food Science & Technology
Yanrong Ren, Shiwen Hu, Hongzheng Pu, Ying Zhou, Mingzhu Jiang, Yuanyuan Li, Chaofang Deng, Jie Gao, Minxuan Xu, Chenxu Ge
Summary: The study explored the regulatory potential of Jug in treating depression in vivo and in vitro, showing that Jug has neuroprotective and anti-inflammatory effects by improving AMPK activation, which may be a novel therapeutic strategy for depression treatment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Developmental Biology
Yupu Wang, Meike Lobb-Rabe, James Ashley, Purujit Chatterjee, Veera Anand, Hugo J. Bellen, Oguz Kanca, Robert A. Carrillo
Summary: This study investigates the expression patterns of Dpr and DIP genes in different types of neurons in Drosophila, revealing unique combinations of these cell-surface proteins and providing insights into neural development and synaptic connectivity.
Article
Pharmacology & Pharmacy
Ying Liu, Yiqi Wang, Xing Zhang, Yang Jiao, Lian Duan, Lingling Dai, Hong Yan
Summary: This study found that chronic exposure to ACR can lead to neuronal loss and motor dysfunction, potentially through the NLRP3 inflammasome-mediated neuroinflammation mechanism.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Oncology
Mi Shen, Chun Zhou, Yingchao Tian, Tongxin Shang, Qingyun Liang, Mengru Ming, Fei Ding, Yuhua Ji
Summary: After peripheral nerve injury, the inaccurate reinnervation of the target leads to poor functional recovery. Schwann cells (SCs) express sensory and motor phenotypes associated with selective regeneration. Semaphorin 3A (Sema3A) plays an essential role in axon growth, and SC-secreted Sema3A might play a role in selective regeneration by a preferential effect on sensory neurons (SNs).
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Clinical Neurology
Antonia S. Carroll, James Howells, Cindy S. Y. Lin, Susanna B. Park, Neil Simon, Mary M. Reilly, Steve Vucic, Matthew C. Kiernan
Summary: This study compares the excitability differences of motor and sensory axons in the main upper limb nerves and provides guidance for future research on human diseases. The results demonstrate that the excitability parameters are most comparable between the median and ulnar nerves.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tadashi Tanioku, Masayuki Nishibata, Yasuyuki Tokinaga, Kohtaro Konno, Masahiko Watanabe, Hiroaki Hemmi, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Hidemasa Furue, Tomoyuki Kawamata
Summary: This study demonstrates the essential role of Tmem45b in inflammation- and tissue injury-induced mechanical pain hypersensitivity, highlighting it as a potential therapeutic target for future treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Margot Geerts, Mike Oakes, Tim J. E. Church, Stephen G. Waxman, Sulayman D. Dib-Hajj, Catharina G. Faber, Ingemar S. J. Merkies
Article
Neurosciences
Ivo Eijkenboom, Maurice Sopacua, Auke B. C. Otten, Monique M. Gerrits, Janneke G. J. Hoeijmakers, Stephen G. Waxman, Raffaella Lombardi, Giuseppe Lauria, Ingemar S. J. Merkies, Hubert J. M. Smeets, Catharina G. Faber, Jo M. Vanoevelen
EXPERIMENTAL NEUROLOGY
(2019)
Article
Clinical Neurology
Ivo Eijkenboom, Maurice Sopacua, Janneke G. J. Hoeijmakers, Bianca T. A. de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J. M. Smeets, Stephen G. Waxman, Giuseppe Lauria, Ingemar S. J. Merkies, Catharina G. Faber, Monique M. Gerrits
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Neurosciences
Malgorzata A. Mis, yang Yang, Brian S. Tanaka, Karolina Gomis-Perez, Shujun Liu, Fadia Dib-Hajj, Talia Adi, Rolando Garcia-Milian, Betsy R. Schulman, Sulayman D. Dib-Hajj, Stephen G. Waxman
JOURNAL OF NEUROSCIENCE
(2019)
Review
Pediatrics
Luke Arthur, Kirsty Keen, Madeleine Verriotis, Judy Peters, Alison Kelly, Richard F. Howard, Sulayman D. Dib-Hajj, Stephen G. Waxman, Suellen M. Walker
JOURNAL OF PEDIATRICS
(2019)
Review
Clinical Neurology
Maurice Sopacua, Janneke G. J. Hoeijmakers, Ingemar S. J. Merkies, Giuseppe Lauria, Stephen G. Waxman, Catharina G. Faber
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2019)
Editorial Material
Neurosciences
Stephen G. Waxman, Sulayman D. Dib-Hajj
Article
Neurosciences
Mathilde R. Israel, Brian S. Tanaka, Joel Castro, Panumart Thongyoo, Samuel D. Robinson, Peng Zhao, Jennifer R. Deuis, David J. Craik, Thomas Durek, Stuart M. Brierley, Stephen G. Waxman, Sulayman D. Dib-Hajj, Irina Vetter
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Multidisciplinary Sciences
Zvonimir Vrselja, Stefano G. Daniele, John Silbereis, Francesca Talpo, Yury M. Morozov, Andre M. M. Sousa, Brian S. Tanaka, Mario Skarica, Mihovil Pletikos, Navjot Kaur, Zhen W. Zhuang, Zhao Liu, Rafeed Alkawadri, Albert J. Sinusas, Stephen R. Latham, Stephen G. Waxman, Nenad Sestan
Editorial Material
Anesthesiology
Stephen G. Waxman
Review
Anesthesiology
Stephen G. Waxman
Article
Microbiology
Joseph M. Bliss, George A. Tollefson, Abigail Cuevas, Sarah J. Longley, Matthew N. Neale, Alper Uzun, Sunil K. Shaw
Summary: Candida parapsilosis has unique biological features compared to C. albicans, with adhesion to biological surfaces being a key step for colonization. RNA-seq analysis identified differentially expressed genes related to adhesion, with up-regulated genes enriched in iron acquisition and transmembrane transport, while downregulated genes were enriched in oxidation-reduction processes. Understanding these gene expression profiles may lead to strategies for reducing colonization and disease caused by C. parapsilosis.
Article
Multidisciplinary Sciences
Sunil K. Shaw, Sarah J. Longley, Sonia S. Laforce-Nesbitt, Joseph M. Bliss
Summary: Cp is an emerging cause of bloodstream infections in certain populations and is increasingly developing resistance to antifungals. Colonization by Cp increases the risk of invasive bloodstream infections. Studying the adhesion of Cp to immobilized proteins helps to better understand its invasion mechanisms.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Erika Salvi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: This study assessed the role of fifteen ion channel genes in neuropathic pain. Variants in ion channel genes were identified in SFN patients, with TRP genes being the most frequent. Patients with these variants reported more severe pain. This study provides promising gene candidates for future research on neuropathic pain etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Sleczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam A. Ferdousi, Rayaz Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman G. Dib-Hajj, Stephen Waxman, Hubert J. M. M. Smeets, Monique G. Gerrits, Catharina Faber, Giuseppe Lauria
Summary: Rare SCG genetic variants may contribute to the development of painful neuropathy. Genetic profiling and SCG variant identification can provide better understanding of the genetic variability in patients with painful and painless neuropathy, leading to improved risk stratification and personalized pain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)