Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Emel Baloglu, Kalpana Velineni, Ezgi Ermis-Kaya, Heimo Mairbaeurl
Summary: Inflammation and hypoxia impair alveolar barrier tightness, inhibit Na- and fluid reabsorption, and cause edema. This study found that stimulated alveolar macrophages impair alveolar epithelial Na-transport by NO-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jun Li, Zhijiang Qi, Dongxiao Li, Xiao Huang, Boyang Qi, Jiali Feng, Jianyu Qu, Xiaozhi Wang
Summary: The shedding of alveolar epithelial glycocalyx aggravates the epithelial barrier and damages epithelial tight junction proteins in ARDS, with the underlying mechanism involving the effect of heparanase on ZO-1.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Sumera Qasim, Alamgeer, Muhammad Saleem, Nasser Hadal Alotaibi, Syed Nasir Abbas Bukhari, Khalid Saad Alharbi, Hafiz Muhammad Irfan, Rukhsana Anwar
Summary: The study demonstrated that prazosin exhibits significant antiarthritic effects by reducing protein denaturation, stabilizing red blood cell membrane, and alleviating paw swelling in both formaldehyde-induced arthritis and CFA-induced arthritis models. It also maintains normal hematological and biochemical profiles. Furthermore, prazosin may potentially inhibit TNF-alpha to exert its strong antiarthritic potential.
Article
Immunology
Yiping Liu, Ming Hu, Guanzhi Fan, Nanshu Xing, Rong Zhang
Summary: This study found that serum IL-6 levels were significantly elevated in patients with anti-synthase syndrome-associated ILD, and Baricitinib attenuated epithelial-mesenchymal transition in alveolar epithelial cells through the JAK/STAT signaling pathway in the presence of IL-6.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Yanxi Liu, Zhiqian Li, Shuo Wang, Changjian Zhang, Li Han, Qun Sun, Xuelin Han
Summary: The study demonstrates that swollen conidia of Aspergillus fumigatus induce the release of pro-inflammatory factors IL-8 and MCP-1 through activation of decrin-1 and CR3 receptors in lung epithelial A549 cells.
CURRENT MICROBIOLOGY
(2021)
Article
Microbiology
Eita Sasaki, Hideki Asanuma, Haruka Momose, Keiko Furuhata, Takuo Mizukami, Isao Hamaguchi
Summary: Aluminum hydroxide salts, commonly known as alum, have been included in inactivated vaccines as adjuvants to enhance vaccination effectiveness. Through the study, it was discovered that alum acts as a potent adjuvant in nasal vaccination by inducing the release of damage-associated molecules in the alveoli, stimulating immune responses. Specifically, the secretion of IL-33 from alveolar epithelial cells through necrosis plays a crucial role in triggering APC- and ILC2-mediated T cell activation, leading to an increase in Ag-specific IgA antibody production facilitated by alum.
Article
Medicine, General & Internal
Iaroslav Semin, Justus Ninnemann, Marina Bondareva, Ilia Gimaev, Andrey A. Kruglov
Summary: The microbiota in the intestine plays a crucial role in maintaining the health of the body, but imbalance can lead to inflammation. Epithelial cells act as a barrier to isolate microorganisms, and the nature and duration of stress and inflammation can influence cell responses.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marco Calafiore, Ya-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Y. Chang, Suze A. Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan Serody, Susumu Nakae, Heth Turnquist, Johan Van Es, Hans Clevers, Caroline A. Lindemans, Bruce R. Blazar, Alan M. Hanash
Summary: Intestinal stem cells produce IL-33 after radiation injury, which induces Paneth cells to produce EGF and promote regeneration of the intestinal epithelium.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Tianming Li, Yanping Liu, Xuefei Yu, Pingchuan Wang, Siyu Sun, Dongyan Liu
Summary: IL-17D is involved in the regulation of immune responses in the intestinal mucosa, potentially by modulating the expression of chemokines. Hyperoxia upregulates the expression of certain chemokines and downregulates others in intestinal epithelial cells, with IL-17D playing a role in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaopeng Wan, Jiqing Li, Yupeng Wang, Xiaofei Yu, Xijun He, Jianzhong Shi, Guohua Deng, Xianying Zeng, Guobin Tian, Yanbing Li, Yongping Jiang, Yuntao Guan, Chengjun Li, Feng Shao, Hualan Chen
Summary: This study found that the H7N9 virus can replicate efficiently in mouse lungs and activate gasdermin E (GSDME)-mediated pyroptosis, leading to a cytokine storm. Knockout of the Gsdme gene changed the death pathway of alveolar epithelial cells from pyroptosis to apoptosis, and Gsdme knockout mice survived lethal H7N9 virus infection. These findings reveal the key and unique mechanism of GSDME activation in the pulmonary cytokine storm and lethal outcome of H7N9 virus infection, providing a new avenue for the development of antivirals.
NATIONAL SCIENCE REVIEW
(2022)
Article
Pharmacology & Pharmacy
Yuling Zhang, Xiaoting Huang, Shanna Feng, Chen Chen, Dainian Guo, Ling Fang
Summary: This study explored the correlation between platinum accumulation and cancer-related fatigue (CRF), finding that the platinum concentration was positively correlated with the degree of CRF. Increased platinum accumulation may lead to CRF through mechanisms such as increasing IL-8 levels and causing inflammation or worsening anemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Vesa-Petteri Kouri, Juri Olkkonen, Katariina Nurmi, Nitai Peled, Mari Ainola, Jami Mandelin, Dan C. Nordstrom, Kari K. Eklund
Summary: IL-17A and TNF synergistically induce proinflammatory mediators in synovial fibroblasts, and ELF3 plays an important role in this process. These findings provide new insights into the pathogenesis of chronic arthritis and suggest ELF3 as a potential therapeutic target.
Review
Cell Biology
Huan Tao, Younian Xu, Shihai Zhang
Summary: Acute lung injury (ALI) usually leads to acute respiratory distress syndrome (ARDS) or even death in critically ill patients. The infiltration of immune cells in the inflamed lungs is a significant characteristic of ARDS. Macrophages, a type of immune cell, play a crucial role in the progression of ARDS through their interactions with lung alveolar epithelial cells (AECs).