Article
Biochemistry & Molecular Biology
Joseph J. Bivona, Hanna M. Crymble, Blas A. Guigni, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter, Benjamin T. Suratt
Summary: Skeletal muscle tissue may contribute to proinflammatory cytokines following acute endotoxin injury, and leukocytes can enhance this response via TNF alpha secretion.
Article
Medicine, Research & Experimental
Yaeko Hashimoto, Akifumi Eguchi, Yan Wei, Hiroyo Shinno-Hashimoto, Yuko Fujita, Tamaki Ishima, Lijia Chang, Chisato Mori, Takuji Suzuki, Kenji Hashimoto
Summary: This study investigated the impact of antibiotic-induced microbiome depletion on LPS-induced acute lung injury (ALI). The results showed that antibiotic treatment significantly attenuated LPS-induced lung injury and altered the diversity of the gut microbiota. Additionally, potential microbial markers and plasma metabolites associated with the ABX + LPS group were identified. Network analysis revealed correlations between IL-6 levels in bronchoalveolar lavage fluid (BALF) and specific gut microbes (or plasma metabolites).
Review
Biochemistry & Molecular Biology
Alyssa Elmore, Ali Almuntashiri, Xiaoyun Wang, Sultan Almuntashiri, Duo Zhang
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases. Surfactant protein-D (SP-D) has been extensively studied and found to have superior discriminatory ability for the diagnosis of ARDS. Recombinant SP-D shows potential as a drug for the treatment of ALI.
Article
Biochemistry & Molecular Biology
Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge
Summary: This study reveals that ISM1 plays an anti-inflammatory role in acute lung injury (ALI), and its deficiency leads to intensified acute lung inflammation and increased post-ALI lung fibrosis. Recombinant ISM1 effectively suppresses acute lung inflammation and ALI, and inhibits NF-κB activation in mouse alveolar macrophages.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Stefan Hall, Sufyan Faridi, Purvi Trivedi, Saki Sultana, Bithika Ray, Tanya Myers, Irene Euodia, David Vlatten, Mathieu Castonguay, Juan Zhou, Melanie Kelly, Christian Lehmann
Summary: Acute respiratory distress syndrome (ARDS) and sepsis are risk factors contributing to mortality in patients with pneumonia. Activation of cannabinoid type II receptor (CB2) has been shown to reduce cytokine release in various in vivo and in vitro studies. In this study, the specific CB2 agonist HU-308 was found to attenuate systemic and pulmonary inflammation without suppressing pulmonary immune response in a model of pneumonia-induced ALI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jianfeng Gao, Li Teng, Sijun Yang, Shuguang Huang, Linrui Li, Li Zhou, Guoquan Liu, Hongbin Tang
Summary: This study investigated the effectiveness of partial inhibition of the MAPK pathway by targeting the MNKs in the prevention and treatment of ALI. The findings demonstrated that MNK inhibition could effectively reduce LPS-induced ALI in mice, suggesting a novel and potential application for MNK-based therapy in treating this serious disease.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alessio Filippo Peritore, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Enrico Gugliandolo, Tiziana Genovese, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzeri
Summary: The study demonstrated that ultramicronized palmitoylethanolamide (um-PEA) reduced lung damage, inflammation cell infiltration, and cytokine release in LPS-induced acute lung injury (ALI) mice. um-PEA may exert its anti-inflammatory effects possibly through the p38/NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tangjia Li, Chu Zhang, Yuke Wei, Haijing Zhong, Luchen Shan, Pei Yu, Yuqiang Wang, Lipeng Xu
Summary: This study demonstrates that AL-1 effectively alleviates LPS-induced lung injury by reducing proinflammatory cytokine levels, inflammatory responses, and infiltration of inflammatory cells, thereby improving pathological changes in lung tissue.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Cai Zhang, Xinran Wang, Chunguo Wang, Cheng He, Quantao Ma, Jialin Li, Weiling Wang, Yan-Tong Xu, Ting Wang
Summary: This study identified the chemical compositions of QWZK and demonstrated its protective effects on LPS-induced ALI, potentially through inhibiting the TLR4/NF-kB signaling pathway and NLRP3 inflammasome activation. It suggested that QWZK is a potential therapeutic candidate for the treatments of ALI and pulmonary inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Rong Zhuang, Xiyu Yang, Wenchao Cai, Rongxiao Xu, Liang Lv, Yingying Sun, Yayong Guo, Jingjing Ni, Guangju Zhao, Zhongqiu Lu
Summary: The study revealed that MCTR3 can protect mice from LPS-induced ALI, alleviating lung injury and promoting lung function restoration. These protective effects are mainly achieved through down-regulation of the PINK1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Libin Yang, Wu Luo, Qiuyan Zhang, Shanshan Hong, Yi Wang, Aleksandr Samorodov, Nipon Chattipakorn, Valentin N. Pavlov, Guang Liang
Summary: Our study demonstrates that a natural product CAR attenuates LPS-induced lung injury and sepsis by inhibiting inflammation through interacting with MD2, thereby inactivating the TLR4/MD2-MyD88-MAPK/NF-kappa B signaling pathway.
Article
Immunology
Xiao-Long Zhang, Jian An, Yong-Zhi Deng, Xuan-Zheng Fang, Cai-Yun Xu, Xu-Fang Liu, Ze-Hong Bai, Gang Zhang, Ming-Yuan Cui
Summary: Severe acute lung injury (ALI) is a major cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for ALI. This study reveals a significant role for the miR-762/NFIX pathway in the pathogenesis of ALI, suggesting that targeting this pathway could be beneficial for the diagnosis, prevention, and treatment of ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wu Luo, Li-bin Yang, Chen-chen Qian, Bao Ma, Gloria M. Manjengwa, Xiao-min Miao, Jie Wang, Cheng-hong Hu, Bo Jin, Ling-xi Zhang, Chao Zheng, Guang Liang, Yi Wang
Summary: This study identified the natural compound flavokawain B (FKB) as a potential therapeutic option for acute lung injury (ALI). FKB demonstrated anti-inflammatory activity by reducing pro-inflammatory cytokine secretion in immune cells and protecting against lung injury in mice, leading to increased survival and reduced mortality in the ALI model.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Physiology
Gabriela Viegas Haute, Carolina Luft, Leonardo Pedrazza, Gessica Luana Antunes, Josiane Silveira, Bruno de Souza Basso, Vitor Giancarlo Schneider Levorse, Matheus Scherer Bastos, Denizar Melo, Ketlin Fernanda Rodrigues, Maria Claudia Garcia, Mariana Severo da Costa, Lucas Strassburger Matzenbacher, Daniela Benvenutti Kaiber, Marcio Vinicius Fagundes Donadio, Jordi Gracia-Sancho, Jarbas Rodrigues de Oliveira
Summary: Acute lung injury (ALI) is a prevalent disease characterized by excessive production of inflammatory mediators in the lungs. Inhibition of inflammatory cytokines has been proposed as an alternative treatment for ALI. This study evaluated the effects of Simvastatin (SV) on LPS-induced alveolar macrophages and ALI in mice. The results showed that SV protected alveolar macrophages from LPS activation and reduced inflammatory response in vitro and in vivo. These findings suggest that SV could be used as an anti-inflammatory agent for ALI.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mobarak Abu Mraheil, Haroldo A. Toque, Luigi La Pietra, Juerg Hamacher, Tenzing Phanthok, Alexander Verin, Joyce Gonzales, Yunchao Su, David Fulton, Douglas C. Eaton, Trinad Chakraborty, Rudolf Lucas
Summary: Pneumococci promote colonization by producing high levels of H2O2 and have unique mechanisms to protect themselves from its damage. The production of H2O2 forms an important virulence phenotype and overlaps with the activities of other virulence factors.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Anita Kovacs-Kasa, Laszlo Kovacs, Mary Cherian-Shaw, Vijay Patel, Mary L. Meadows, David J. Fulton, Yunchao Su, Alexander D. Verin
Summary: TMP269, a specific Class IIa HDACs inhibitor, attenuates LPS-induced ALI by decreasing myosin light chain phosphorylation and improving vascular barrier integrity. This suggests a specific mechanism by which Class IIa HDACs regulate endothelial permeability in response to LPS-induced injury.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lina Wang, Xiaoyu Zhang, Yapeng Cao, Qian Ma, Xiaoxiao Mao, Jiean Xu, Qiuhua Yang, Yaqi Zhou, Rudolf Lucas, David J. Fulton, Yunchao Su, Scott A. Barman, Mei Hong, Zhiping Liu, Yuqing Huo
Summary: The study demonstrates that the reduced expression of glycolytic molecules in lung macrophages due to Pfkfb3 deficiency or inhibition can effectively alleviate the development of pulmonary hypertension, with lower levels of growth factors and pro-inflammatory cytokines produced by alveolar macrophages.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Food Science & Technology
Joyce Gonzales, Trinad Chakraborty, Maritza Romero, Mobarak Abu Mraheil, Abdullah Kutlar, Betty Pace, Rudolf Lucas
Summary: Sickle cell disease is a common genetic disorder that impairs immunity and can lead to complications like acute chest syndrome. Infections with Streptococcus pneumoniae pose a particular danger to patients, as the bacterium produces toxins that can damage the lungs.
Article
Biochemistry & Molecular Biology
Yunchao Su, Weihong Han, Anita Kovacs-Kasa, Alexander D. Verin, Laszlo Kovacs
Summary: The study shows that HDAC6 expression is upregulated in patients with COPD and in a COPD animal model. Cigarette smoke extract, PDGF, and IL-6 increase protein levels and activation of HDAC6 in bronchial and pulmonary smooth muscle cells, leading to collagen synthesis and cell proliferation. Pharmacological inhibition of HDAC6 prevents airway and vascular remodeling in COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vijaya Karoor, Derek Strassheim, Timothy Sullivan, Alexander Verin, Nagavedi S. Umapathy, Edward C. Dempsey, Daniel N. Frank, Kurt R. Stenmark, Evgenia Gerasimovskaya
Summary: Butyrate shows protective effects in a rat model of hypoxic pulmonary hypertension by preventing pulmonary vascular remodeling and increased permeability, reducing right ventricular hypertrophy, and increasing histone H3 acetylation. Additionally, it modulates cytokine profiles in lung tissue and upregulates tight junctional proteins in endothelial cells, suggesting its potential as a complementary treatment for PH and other cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Rudolf Lucas, Yalda Hadizamani, Perenlei Enkhbaatar, Gabor Csanyi, Robert W. Caldwell, Harald Hundsberger, Supriya Sridhar, Alice Ann Lever, Martina Hudel, Dipankar Ash, Masuko Ushio-Fukai, Tohru Fukai, Trinad Chakraborty, Alexander Verin, Douglas C. Eaton, Maritza Romero, Juerg Hamacher
Summary: Alveolar-capillary leak is a hallmark of ARDS, which is a potentially lethal complication of severe sepsis, trauma, and pneumonia (including COVID-19). ARDS is characterized by barrier dysfunction, hyper-inflammation, and impaired alveolar fluid clearance, leading to pulmonary permeability edema and compromised gas exchange.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Physiology
Narasimham Parinandi, Evgenia Gerasimovskaya, Alexander Verin
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Robert K. Batori, Feng Chen, Zsuzsanna Bordan, Stephen Haigh, Yunchao Su, Alexander D. Verin, Scott A. Barman, David W. Stepp, Trinad Chakraborty, Rudolf Lucas, David J. R. Fulton
Summary: This study found that Cav-1 protects the endothelial barrier against PLY-induced disruption. Depletion of cholesterol in the plasma membrane increases intracellular calcium levels induced by PLY, but the presence of Cav-1 in the membrane can reduce this effect. Furthermore, Cav-1 promotes endocytosis of damaged membrane, reducing the invasion of PLY.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G. Sellers, Zach L. Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D. Verin, Lin Gan, Quansheng Du, Stephen J. Benkovic, Suowen Xu, John M. Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J. R. Fulton, Yuqing Huo
Summary: This study found that the enzyme ATIC, which mediates de novo purine synthesis, plays a critical role in the proliferation of pulmonary artery smooth muscle cells (PASMCs) and the development of pulmonary hypertension (PH). Targeting ATIC-mediated DNPS reduces the availability of purine nucleotides, leading to decreased PASMC proliferation and amelioration of PH development and progression.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hanno Huwer, Yalda Hadizamani, Ueli Moehrlen, Uz Stammberger, Florian Gebhard, Lia Bally, Albrecht Wendel, Ulrich C. Liener, Rudolf Lucas, Juerg Hamacher
Summary: The study investigates the role of post-trauma-induced oedema generation and the potential benefits of beta 2-adrenergic receptors agonists in blast-induced lung injury. The results suggest that beta 2-adrenoceptor stimulation has a beneficial impact on oedema generation, while amiloride exacerbates the condition.
Article
Multidisciplinary Sciences
Juerg Hamacher, Yalda Hadizamani, Hanno Huwer, Ueli Moehrlen, Lia Bally, Uz Stammberger, Albrecht Wendel, Rudolf Lucas
Summary: This study aimed to establish a sequence of alterations in blast-induced lung injury in rats using an advanced blast generator. The results showed that after blast lung injury, significant haemorrhage and neutrophil infiltration occurred, as well as increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory cytokines. Pulmonary oedema developed but recovered within 24 hours.
Article
Food Science & Technology
Jasmin Bazant, Benjamin Ott, Martina Hudel, Torsten Hain, Rudolf Lucas, Mobarak Abu Mraheil
Summary: H2O2 negatively affects the activity and release of PLY. Decreased H2O2 production leads to a decline in PLY release, possibly due to the upregulation of certain genes.
Article
Biochemistry & Molecular Biology
Pau Martin-Malpartida, Silvia Arrastia-Casado, Josep Farrera-Sinfreu, Rudolf Lucas, Hendrik Fischer, Bernhard Fischer, Douglas C. Eaton, Susan Tzotzos, Maria J. Macias
Summary: This article introduces the potential mechanism of solnatide as a novel therapeutic agent for treating pulmonary edema. By mimicking the action of human TNF, solnatide can activate ENaC, thereby enhancing alveolar fluid clearance. Through NMR analysis, researchers found that solnatide has a folding structure with a small hydrophobic core and two charged polarity regions. They propose a model for the interaction between solnatide and the C-terminal domain of the ENaCα subunit, which can guide future experiments and the design of new drugs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)