Article
Cardiac & Cardiovascular Systems
Alberto Canfran-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andres-Blasco, Bonne M. Thompson, Jonathan Sun, Nathan L. Price, Marta Fernandez-Fuertes, Joseph W. Fowler, Diego Gomez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J. Schneider, George Tellides, Jeffrey G. McDonald, Carlos Fernandez-Hernando, Yajaira Suarez
Summary: The accumulation of 25-hydroxycholesterol (25-HC) in human coronary atherosclerotic lesions accelerates atherosclerosis progression and promotes plaque instability through autocrine and paracrine actions. Macrophage-derived 25-HC intensifies the inflammatory response of lipid-loaded macrophages and inhibits smooth muscle cell migration within the plaque. These effects are independent of 25-HC-mediated modulation of transcriptional activity.
Article
Peripheral Vascular Disease
Nikolai V. Pakhomov, Daria S. Kostyunina, Guerrino Macori, Eugene Dillon, Tara Brady, Geetha Sundaramoorthy, Claire Connolly, Alfonso Blanco, Seamus Fanning, Lorraine Brennan, Paul McLoughlin, John A. Baugh
Summary: This study demonstrates for the first time that a high-soluble-fiber diet attenuates hypoxia-induced pulmonary vascular remodeling and the development of pulmonary hypertension in a mouse model of hypoxic pulmonary hypertension and highlights diet-derived metabolites that may have an immuno-modulatory role in the lung.
Article
Food Science & Technology
Yen-Chang Chen, Yu-Kai Cheng, Jia-Hong Chen, Cheng-Fang Tsai, Tsung-Kai Wang, Chen-Yun Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: This research investigates the effects of cardamonin on pulmonary inflammation. The results suggest that cardamonin has anti-inflammatory and anti-oxidative properties against PMA-induced pulmonary inflammation. It activates the Nrf2/HO-1 axis and reduces pro-inflammatory responses in alveolar macrophages.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eliza Mathias Melo, Vivian Louise Soares Oliveira, Daiane Boff, Izabela Galvao
Summary: Macrophages are a heterogeneous population of myeloid cells with diverse functions in the lung, where they are distributed in different compartments and can have both protective and damaging effects. Their phenotype and function are modulated by the microenvironment, allowing for responses to various stimuli such as inflammation or infection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yu-Yan Qin, Xiao-Ru Huang, Jian Zhang, Wenjing Wu, Junzhe Chen, Song Wan, Xi-Yong Yu, Hui-Yao Lan
Summary: Neuropeptide Y plays an important role in attenuating acute myocardial infarction by inhibiting cardiac inflammation and fibrosis, enhancing angiogenesis, and reducing apoptosis.
Review
Biochemistry & Molecular Biology
Marta T. Gomes, Yang Bai, Simone R. Potje, Lu Zhang, Angelia D. Lockett, Roberto F. Machado
Summary: This review discusses the role of bioenergetic and inflammatory impairments in the development of pulmonary arterial hypertension (PAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hasan H. Oz, Ee-Chun Cheng, Caterina Di Pietro, Toma Tebaldi, Giulia Biancon, Caroline Zeiss, Ping-Xia Zhang, Pamela H. Huang, Sofia S. Esquibies, Clemente J. Britto, Jonas C. Schupp, Thomas S. Murray, Stephanie Halene, Diane S. Krause, Marie E. Egan, Emanuela M. Bruscia
Summary: This study identifies CCR2+ monocytes as a previously neglected contributor to lung damage in CF, driving pathogenic TGF-β signaling and sustaining inflammation by facilitating neutrophil recruitment. Targeting CCR2 to reduce monocyte numbers in CF lungs can ameliorate neutrophil inflammation and prevent tissue damage.
Review
Health Care Sciences & Services
Zhuangzhuang Jia, Shuai Wang, Haifeng Yan, Yawen Cao, Xuan Zhang, Lin Wang, Zeyu Zhang, Shanshan Lin, Xianliang Wang, Jingyuan Mao
Summary: Pulmonary vascular remodeling, involving changes in the intima, media and adventitia, is a critical structural alteration and pathological feature in pulmonary hypertension. It includes the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), as well as interactions with pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis, and other factors are influenced by different mechanisms that contribute to disease progression. This article reviews these pathological changes and discusses the underlying mechanisms in the remodeling process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Hong Liu, Yuxiang Wang, Qingqing Zhang, Chuanchuan Liu, Yougang Ma, Pan Huang, Rili Lan, Lan Ma
Summary: This study investigated the characteristics of the inflammatory process in hypoxia-induced pulmonary hypertension. The results showed that pulmonary artery remodeling worsens progressively over time, with early-stage dominated by inflammatory cell infiltration and later-stage characterized by pulmonary vascular remodeling.
IMMUNOLOGY LETTERS
(2023)
Article
Medicine, General & Internal
YongHong He, SongPing Wang, Yuying Li, Jun Deng, Lan Huang
Summary: This study investigated the effects of atorvastatin calcium on pulmonary vascular remodeling in rats with COPD. The authors found that atorvastatin calcium can regulate the expression of HDAC2 and inhibit the production of VEGF, thereby regulating pulmonary vascular remodeling. This provides a new direction for drug treatment in COPD.
Article
Biochemistry & Molecular Biology
Li Hu, Yanfang Yu, Yueyao Shen, Huijie Huang, Donghai Lin, Kang Wang, Youjia Yu, Kai Li, Yue Cao, Qiang Wang, Xiaoxuan Sun, Zhibing Qiu, Dong Wei, Bin Shen, Jingyu Chen, David Fulton, Yong Ji, Jie Wang, Feng Chen
Summary: Pulmonary hypertension (PH) is a devastating disease characterized by irreversible pulmonary vascular remodeling (PVR) that causes right ventricular failure and death. The study found that N6-methyladenosine (m6A) modifications of RNA play an important role in phenotypic switching of pulmonary artery smooth muscle cells and PH. The study also identified Ythdf2, an m6A reader, as a critical regulator of pulmonary inflammation and redox regulation in PH.
Article
Respiratory System
Yanxia Wang, Xiaoming Li, Wen Niu, Jian Chen, Bo Zhang, Xiumin Zhang, Yingmei Wang, Shaokang Dang, Zhichao Li
Summary: The study demonstrated that under hypoxia, alveolar epithelial cells (AECs) are involved in pulmonary vascular remodeling and constriction by secreting H2O2 into the pulmonary vascular microenvironment.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jinjin Pan, Rui Wang, Yandong Pei, Dingyou Wang, Na Wu, Yuke Ji, Qing Tang, Liang Liu, Ke Cheng, Qiwang Liu, Jian Sun, Miaomiao Gong, Xu Zheng, Junxia Li, Changlin Zhang, Yuhui Yuan
Summary: This study aimed to investigate the effect and mechanism of sulforaphane (SFN) on hypoxic pulmonary hypertension (HPH). The results showed that SFN could inhibit the progression of HPH, reduce inflammation and oxidative stress, and promote apoptosis in pulmonary artery smooth muscle cells (PASMCs) under hypoxia conditions. SFN also prevented the apoptosis of pulmonary microvascular endothelial cells (ECs). These findings suggest that SFN has potential therapeutic effects on HPH by improving pulmonary vascular remodeling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vijaya Karoor, Derek Strassheim, Timothy Sullivan, Alexander Verin, Nagavedi S. Umapathy, Edward C. Dempsey, Daniel N. Frank, Kurt R. Stenmark, Evgenia Gerasimovskaya
Summary: Butyrate shows protective effects in a rat model of hypoxic pulmonary hypertension by preventing pulmonary vascular remodeling and increased permeability, reducing right ventricular hypertrophy, and increasing histone H3 acetylation. Additionally, it modulates cytokine profiles in lung tissue and upregulates tight junctional proteins in endothelial cells, suggesting its potential as a complementary treatment for PH and other cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Eun-Jung Park, Mi-Jin Yang, Min-Sung Kang, Young-Min Jo, Cheolho Yoon, Hyun-bin Kim, Dong-Wan Kim, Gwang-Hee Lee, Ik-Hwan Kwon, Hee-Jin Park, Jin-Bae Kim
Summary: This study investigated the pulmonary toxicity of dust collected from an air purifier in a busy subway station in Seoul. The dust contained elements related to subway facilities and equipment, and exposure to this dust led to inflammatory responses and dysfunction of alveolar macrophages. The study concluded that the health risks associated with subway dust should consider the concentrations of certain elements.