Article
Immunology
Hong Xie, Lingqin Wu, Xingzhi Chen, Shifang Gao, Huihui Li, Yuan Yuan, Jinbao Liang, Xiaoli Wang, Shuying Wang, Changyan Xu, Liang Chu, Bin Zhan, Rui Zhou, Xiaodi Yang
Summary: Sj-Cys is a potent immunomodulatory protein that exerts anti-inflammatory effects by activating M2 macrophage polarization. The findings suggest that Sj-Cys itself or Sj-Cys-induced M2 macrophages could be used as therapeutic agents in the treatment of sepsis or other inflammatory diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mehrdad Hefazi, Sara Bolivar-Wagers, Bruce R. Blazar
Summary: This review provides the latest preclinical and clinical data on Treg cell therapy in the context of GVHD, highlighting the importance of T cell therapy in preventing and treating GVHD, and discussing future research directions and challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Pradeep Shrestha, Ali Turan, Lalit Batra, Ayse Ece Gulen, Zhengda Sun, Helen Tan, Nadir Askenasy, Haval Shirwan, Esma S. Yolcu
Summary: Displaying FasL fusion protein on the surface of donor cells is an effective approach for eliminating alloreactive T-effector cells and preventing acute graft-versus-host disease (aGVHD) associated with hematopoietic stem cell transplantation.
Article
Medicine, Research & Experimental
Shizuka Otsuka, Nicolas Melis, Matthias M. Gaida, Debjani Dutta, Roberto Weigert, Jonathan D. Ashwell
Summary: Inhibitors of calcineurin phosphatase activity are commonly used to treat transplant rejection and graft-versus-host disease by inhibiting NFAT-dependent gene expression, but they may also suppress TCR-proximal signaling by preventing Lck(S59) dephosphorylation. Studies have shown that calcineurin inhibitors are ineffective in treating disease when T cells express Lck(S59A), suggesting that targeting TCR-associated calcineurin directly could provide more effective therapies with less toxicity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Neurosciences
Huan Wang, Zhao Wang, Qianqian Wu, Yujia Yuan, Wen Cao, Xiangjian Zhang
Summary: Regulatory T cells (Tregs) play a crucial role in the inflammatory response and neuroplasticity process of ischemic stroke through various mechanisms. However, it remains unclear whether Tregs have a beneficial or deleterious effect in ischemic stroke and their specific roles in different stages are not well understood.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell & Tissue Engineering
Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng, Yi Zhang
Summary: High expression of miR-223 in MSCs-Exo was found, and it could inhibit the adhesion and migration of T cells by targeting ICAM-1. Infusion of miR-223 Agomir alleviated clinical symptoms of aGvHD, reduced donor T cell infiltration, and lowered levels of inflammatory cytokines IFN-gamma, TNF-alpha, and IL-17.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Gaurav Tripathi, Rutvij A. Khanolkar, Rehan M. Faridi, Amit Kalra, Poonam Dharmani-Khan, Meer-Taher Shabani-Rad, Noureddine Berka, Andrew Daly, Jan Storek, Faisal M. Khan
Summary: This study performed molecular and functional characterization of candidate cytokine genes in allogeneic hematopoietic cell transplantation (HCT) and found that recipients carrying the -1082GG IL10 gene promoter variant had a lower incidence of GVHD. This is the first study to report genome-to-cellular evidence for a non-HLA donor immunogenetic variant that appears to be protective against GVHD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Chan Woo Cho, Gyu-Seong Choi, Do Hyeon Lee, Hyoung Joo Kim, Sung Su Yun, Dong-Shik Lee, Jinsoo Rhu, Jong Man Kim, Jae-Won Joh, Kyeong Sik Kim
Summary: This study compares the surgical outcomes of pure laparoscopic donor right posterior sectionectomy (PLDRPS) and pure laparoscopic donor right hemihepatectomy (PLDRH). The results suggest that PLDRPS is technically feasible and safe in live liver donors under experienced surgeons. Although there are some differences in recipient outcomes, further research is needed to evaluate the usefulness of PLDRPS.
LIVER TRANSPLANTATION
(2023)
Article
Immunology
Saurabh Kumar Gupta, Dievya Gohil, Deepshikha Dutta, Girish Ch Panigrahi, Puja Gupta, Kajal Dalvi, Twinkle Khanka, Subhash Yadav, Rajiv Kumar Kaushal, Akanksha Chichra, Sachin Punatar, Anant Gokarn, Sumeet Mirgh, Nishant Jindal, Lingaraj Nayak, Prasanth R. Tembhare, Syed Khizer Hasan, Santosh Kumar Sandur, Lal Hingorani, Navin Khattry, Vikram Gota
Summary: Researchers have found that Withaferin-A (WA), a phytomolecule obtained from Withania somnifera, has significant efficacy in preventing and treating acute graft versus host disease (aGvHD), which accounts for a significant proportion of non-relapse mortality and morbidity in patients undergoing allogeneic hematopoietic stem cell transplantation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Physiology
Zhengcan Zhou, Ting Shang, Xiurong Li, Hongyan Zhu, Yu-Bo Qi, Xin Zhao, Xi Chen, Zhe-Xin Shi, Guixiang Pan, Yue-Fei Wang, Guanwei Fan, Xiumei Gao, Yan Zhu, Yuxin Feng
Summary: Combining XBJ with a reduced dose of CsA showed superior efficacy in protecting gut microbiota, attenuating aGVHD progression, and improving survival rates in a murine model. This regimen also reduced levels of proinflammatory cytokines and reversed dysbiosis at various levels in the gut microbiota of aGVHD mice. The combination treatment appeared to enhance intestinal tissue integrity and reduce intestinal permeability in aGVHD mice, potentially offering a novel strategy to manage aGVHD and improve quality of life for allo-HSCT recipients.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Motoko Koyama, Daniel S. Hippe, Sujatha Srinivasan, Sean C. Proll, Oriana Miltiadous, Naisi Li, Ping Zhang, Kathleen S. Ensbey, Noah G. Hoffman, Christine R. Schmidt, Albert C. Yeh, Simone A. Minnie, Susan M. Strenk, Tina L. Fiedler, Namita Hattangady, Jacob Kowalsky, Willian M. Grady, Mariapia A. Degli-Esposti, Antiopi Varelias, Andrew D. Clouston, Marcel R. M. van den Brink, Neelendu Dey, Timothy W. Randolph, Kate A. Markey, David N. Fredricks, Geoffrey R. Hill
Summary: Acute graft-versus-host disease (aGVHD) is a major limitation of allogeneic stem cell transplantation (SCT), and severe intestinal manifestation is the leading cause of early mortality. Intestinal microbiota control MHC class II (MHC-II) expression by ileal intestinal epithelial cells (IECs), promoting GVHD. This study showed that genetically identical mice from different vendors had different intestinal microbiota and MHC-II expression levels, resulting in varying severity of GVHD.
Article
Immunology
Alexander Hackel, Sebastian Vollmer, Kirsten Bruderek, Stephan Lang, Sven Brandau
Summary: This study evaluated the immunoregulatory properties of MSCs and their EVs, finding that primed MSCs and MSC-EVs had enhanced immunomodulatory effects, including increased induction of regulatory T cells and reduction of graft-versus-host disease. These effects were mediated through the PD-1 ligands.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Hua Jiang, Denggang Fu, Alan Bidgoli, Sophie Paczesny
Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) is crucial for treating hematological malignancies, but acute and chronic graft-versus-host disease (aGVHD and cGVHD) are major complications. Understanding the roles of T cell subsets in GVHD pathogenesis is essential for identifying new therapeutic targets and improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Chunyue Hao, Wei Wang, Bin Zhan, Zixia Wang, Jingjing Huang, Ximeng Sun, Xinping Zhu
Summary: The study demonstrates that the Trichinella-derived protein rTsPmy can ameliorate disease progression and reduce inflammatory responses in experimental colitis, by specifically promoting the expansion and differentiation of regulatory T cells in the inflamed colon. These findings provide insights into the immunological mechanisms involved in the therapeutic effect of helminth-derived proteins in inflammatory bowel diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)