Article
Endocrinology & Metabolism
Sigridur Bjornsdottir, Bart Clarke, Outi Makitie, Anna Sandstrom, Eleonor Tiblad, Tim Spelman, Olle Kampe
Summary: The study found that pregnant women with chronic hypoPT are more likely to have accompanying diabetes and chronic kidney disease compared to the control group, and are at increased risk of induction of labor and slightly lower infant birth weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Jessica L. Gleason, Jagteshwar Grewal, Zhen Chen, Alison N. Cernich, Katherine L. Grantz
Summary: Women with disabilities have a higher risk of adverse neonatal outcomes compared to those without disabilities, and this risk is partially mediated by pre-term birth and caesarean delivery.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Urology & Nephrology
Zheng Li, Shi Chen, Ying Tan, Jicheng Lv, Minghui Zhao, Qian Chen, Yingdong He
Summary: This study analyzed the association between proteinuria levels and adverse pregnancy outcomes among CKD patients treated with or without steroids/immunosuppressive therapy in early pregnancy. The study found that higher levels of proteinuria were associated with adverse pregnancy outcomes, and the impact differed based on whether patients received treatment.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Lanbo Yang, Alexander M. Friedman, Nicole M. Krenitsky, Timothy Wen, Mary E. D'Alton, Jason D. Wright, Whitney Booker, Yongmei Huang
Summary: This study aimed to determine whether longitudinal health data of patients with chronic hypertension would contribute to organ injury or death. The analysis of 64,799 deliveries to 61,854 women found that the utilization of healthcare services before pregnancy was associated with adverse maternal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Gillian Lever, Hlupekile Chipeta, Tracey Glanville, Christian Selinger
Summary: Patients with inflammatory bowel disease (IBD) have a higher rate of caesarean section (CS) and stillbirth compared to non-IBD patients. However, preterm delivery, low birthweight, and admission to NICU are not more common in IBD patients. Active disease during pregnancy does not increase the risks of adverse outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Elaine Ku, Charles E. E. McCulloch, Lesley A. A. Inker, Hocine Tighiouart, Franz Schaefer, Elke Wuehl, Piero Ruggenenti, Giuseppe Remuzzi, Barbara A. A. Grimes, Mark J. J. Sarnak
Summary: This pooled analysis of seven trials shows that intensive blood pressure control can delay the onset of kidney replacement therapy in patients with CKD stages 4-5, but does not necessarily have an effect in CKD stage 3 patients. Therefore, future trials focusing on blood pressure targets in populations with advanced kidney disease are needed.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Environmental Sciences
Andrew D. Williams, Jenna Kanner, Katherine L. Grantz, Marion Ouidir, Shanshan Sheehy, Seth Sherman, Candace Robledo, Pauline Mendola
Summary: Pregnant women with type 1 diabetes may be at greater risk for adverse outcomes when exposed to air pollution than women without autoimmune disease, suggesting a vulnerability to pollution-associated risks during pregnancy.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Joan T. Price, Yuri Sebastiao, Bellington Vwalika, Stephen R. Cole, Felistas M. Mbewe, Winifreda M. Phiri, Bethany L. Freeman, Margaret P. Kasaro, Marc Peterson, Dwight J. Rouse, Elizabeth M. Stringer, Jeffrey S. A. Stringer
Summary: Comparing the risks of preterm birth and stillbirth between IPOP and ZAPPS studies showed a significantly lower risk in IPOP, even after adjusting for baseline characteristics. The possible benefits of additional monetary reimbursement, more frequent visits, and group-based care in IPOP warrant further investigation to understand the reasons for the lower risk observed.
Article
Medicine, General & Internal
Jessica L. Gleason, Jagteshwar Grewal, Zhen Chen, Alison N. Cernich, Katherine L. Grantz
Summary: Women with disabilities during pregnancy are at higher risk of adverse outcomes, including a broad range of severe maternal morbidities and maternal mortality.
Article
Multidisciplinary Sciences
Yiping Huang, Junbi Xu, Bin Peng, Weiying Zhang
Summary: This study examined risk factors for adverse pregnancy outcomes among Chinese females and provided recommendations for prevention and preservation of women's well-being. Pregnancy frequency, education level, gestational diabetes, and age were found to be significant risk factors.
Article
Medicine, General & Internal
Ying Yang, Tonglei Guo, Jinrong Fu, Jian Kuang, Yuanyuan Wang, Ya Zhang, Hongguang Zhang, Yuan He, Zuoqi Peng, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Xu Ma, Haixia Guan
Summary: This study investigated the associations between preconception thyrotropin levels and pregnancy outcomes, finding that both low and high maternal thyrotropin levels were associated with significantly increased risk of adverse pregnancy outcomes. The optimal preconception thyrotropin levels may be between 0.37 mIU/L and 2.50 mIU/L to prevent adverse pregnancy outcomes.
Review
Oncology
Shinje Moon, Ka Hee Yi, Young Joo Park
Summary: This meta-analysis found that thyroid cancer treatment (including RAIT) does not increase the risk of adverse pregnancy outcomes for patients, and the results regarding miscarriage, preterm labor, and congenital anomalies are similar to those in the general population.
Article
Dermatology
Laura Fitzpatrick, Jennifer Hsiao, Rachel Tannenbaum, Andrew Strunk, Amit Garg
Summary: Hidradenitis suppurativa (HS) appears to be an independent risk factor for adverse pregnancy and maternal outcomes, with influencing factors that may be improved through early identification and management.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Endocrinology & Metabolism
Yutong Han, Xiaotong Gao, Xichang Wang, Chenyu Zhang, Boshen Gong, Bingcong Peng, Jiashu Li, Aihua Liu, Zhongyan Shan
Summary: In this systematic review and meta-analysis, the relationship between isolated hypothyroxinemia in pregnancy and adverse pregnancy and neonatal outcomes was examined. The findings suggest that isolated hypothyroxinemia is associated with an increased risk of preterm birth, premature rupture of membranes, gestational diabetes, macrosomia, and fetal distress. However, it remains uncertain whether levothyroxine treatment can mitigate these adverse outcomes.
Article
Peripheral Vascular Disease
Sukainah Al Khalaf, Lucy C. C. Chappell, Ali S. S. Khashan, Fergus P. P. McCarthy, Eilis J. O'Reilly
Summary: There is a strong association between chronic hypertension and the risk of cardiovascular disease (CVD) in mothers, especially those with adverse pregnancy outcomes (APOs). This risk can lead to premature CVD, thus intervention programs targeting these high-risk groups might reduce their risk of subsequent CVD.
Article
Obstetrics & Gynecology
Laura Lucaccioni, Alessandra Boncompagni, Marisa Pugliese, Giovanna Talucci, Elisa Della Casa, Natascia Bertoncelli, Alessandra Coscia, Luca Bedetti, Alberto Berardi, Lorenzo Iughetti, Fabrizio Ferrari
Summary: Despite significant catch-up growth at 3 months, some late FGR infants still had auxological parameters below the 3rd percentile, and a lower percentage of late FGR infants showed fidgety movements compared to AGA controls. The cranial circumference at birth was a predictive factor for fidgety movements. At 2 years of age, significant differences in neurodevelopmental outcomes were observed between late FGR and AGA infants.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biology
Valeria Bellisario, Enrico Cocchi, Roberta Tassinari, Giulia Squillacioti, Tiziana Musso, Stefano Sottemano, Michael Zorzi, Paola Dalmasso, Alessandra Coscia, Claudio Medana, Roberto Bono
Summary: The study aimed to evaluate the impact of bisphenol (BP) exposure during pregnancy and neonatal life. Results showed no significant correlations between maternal and neonatal BP levels, but positive correlations were found between pacifier use and BP S concentrations in newborns. Additionally, a significant correlation was found between oral glucose administration and free BPA levels. The study emphasized the role of lifestyle, hospital procedures, and neonatal devices in BP exposure and called for further research on the effects of various BP forms on human health and development.
Review
Biology
Alessandra Coscia, Flaminia Bardanzellu, Elisa Caboni, Vassilios Fanos, Diego Giampietro Peroni
Summary: The human microbiota plays a crucial role in promoting and modulating overall health, with factors from pre-conception to perinatal period impacting an individual's life course significantly.
Article
Obstetrics & Gynecology
Laura Lucaccioni, Natascia Bertoncelli, Martina Comini, Laura Martignoni, Alessandra Coscia, Licia Lugli, Elena Righi, Lorenzo Iughetti, Alberto Berardi, Fabrizio Ferrari
Summary: The study observed three main epochs in the development of movements towards midline in full term healthy infants: occasional movements in the first 4 weeks post-term, decreased movements in the following 4 weeks, and increased movements after 8 weeks. These movements changed from simple contact to manipulation, with a temporal overlap with fidgety movements.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Immunology
Ganna Galitska, Alessandra Coscia, Diego Forni, Lars Steinbrueck, Simone De Meo, Matteo Biolatti, Marco De Andrea, Rachele Cagliani, Agata Leone, Enrico Bertino, Thomas Schulz, Angela Santoni, Santo Landolfo, Manuela Sironi, Cristina Cerboni, Valentina Dell'Oste
Summary: The study reveals that HCMV clinical strains exhibit varying levels of genetic characteristics that affect their ability to modulate NK cell responses. Aggressive HCMV strains differentially regulate the expression of ligands for NK cell-activating receptors, resulting in increased IFN-gamma production.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Chiara Peila, Enrico Bertino, Francesco Cresi, Alessandra Coscia
Summary: Current studies on the impact of preeclampsia on breast milk composition are limited, with existing results suggesting that preeclampsia may alter the composition of breast milk.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Francesco Cresi, Federica Chiale, Elena Maggiora, Silvia Maria Borgione, Mattia Ferroglio, Federica Runfola, Giulia Maiocco, Chiara Peila, Enrico Bertino, Alessandra Coscia
Summary: This study aims to compare the short-term effects of synchronized and non-synchronized nasal intermittent positive pressure ventilation on cardiorespiratory events in preterm infants, in order to identify the best ventilation modality. The study will use a crossover design and incorporate multidimensional monitoring of cardiorespiratory data in RDS patients.
Review
Nutrition & Dietetics
Federica Chiale, Elena Maggiora, Arianna Aceti, Nadia Liotto, Alessandra Coscia, Chiara Peila, Maria Elisabetta Baldassarre, Enrico Bertino, Francesco Cresi
Summary: This systematic review analyzed literature on the introduction of allergenic foods and gluten among preterm infants, revealing that current guidelines are not directly applicable to preterm infants and further research is needed for evidence-based weaning guidelines. Suggestions included introducing allergenic foods and gluten when complementary feeding starts after 4 months of corrected age in preterm infants, and avoiding large amounts of gluten despite limited evidence supporting this.
Article
Immunology
Michele Pinon, Laura Giugliano, Emanuele Nicastro, Omar Kakaa, Alessandra Coscia, Caterina Carbonara, Lorenzo D'Antiga, Pier Luigi Calvo
Summary: A retrospective analysis in Italy found that some newborns received HBV vaccination within 12 hours of birth, but two cases of vertical transmission still occurred despite timely immunoprophylaxis. It is recommended to give immunoprophylaxis to babies born to HBsAg positive mothers within 12 hours to prevent perinatal HBV infection, and further implementation of policies aimed at eliminating viral hepatitis is needed to achieve the WHO 2030 goal.
Article
Food Science & Technology
Costanza Pira, Gianfranco Trapani, Maurizio Fadda, Concetta Finocchiaro, Enrico Bertino, Alessandra Coscia, Catalina Ciocan, Magdalena Cuciureanu, Simona-Codruta Heghes, Maria Vranceanu, Doina Miere, Lorena Filip
Summary: The study found that Romanian children born in Italy or migrated to Italy have better adherence to the Mediterranean diet compared to those who stayed in Romania, but they are more exposed to a westernized diet and engage in less physical activity.
Article
Chemistry, Applied
Marzia Giribaldi, Stefano Nebbia, Valerie Briard-Bion, Julien Jardin, Chiara Peila, Alessandra Coscia, Didier Dupont, Laura Cavallarin, Amelie Deglaire
Summary: The study found that High Temperature-Short Time pasteurization and Holder pasteurization have different effects on peptide release in human milk during simulated preterm infant gastrointestinal digestion. The peptidomic profile of human milk differed according to the pasteurization type, with HTST pasteurization showing a greater similarity to raw milk.
Article
Obstetrics & Gynecology
Chiara Peila, Mariangela Longini, Anna Laura Toni, Stefano Sottemano, Enrico Bertino, Giuseppe Buonocore, Alessandra Coscia
Summary: This study investigated the effects of storing Human Milk at 4 degrees C for up to 96 hours on oxidative stress markers Isoprostanes. The results showed that refrigeration under controlled conditions did not significantly affect the bioactivity and nutritional quality of Human Milk related to these biomarkers.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Francesca Monari, Giuseppe Chiossi, Giancarlo Gargano, Michela Ballarini, Dante Baronciani, Alessandra Coscia, Fabio Facchinetti
Summary: This study aimed to investigate the adverse outcomes in late preterm (LP) babies and their association with gestational age at delivery, delivery indication, and prenatal risk factors. The results showed that LP babies delivered at 34 and 35 weeks had a higher risk of adverse outcomes compared to those delivered at 36 weeks, and indicated deliveries were also associated with worse outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Pediatrics
Chiara Azzari, Eugenio Baraldi, Paolo Bonanni, Elena Bozzola, Alessandra Coscia, Marcello Lanari, Paolo Manzoni, Teresa Mazzone, Fabrizio Sandri, Giovanni Checcucci Lisi, Salvatore Parisi, Giorgio Piacentini, Fabio Mosca
Summary: Respiratory syncytial virus (RSV) is a major global cause of respiratory infections in infants, leading to a significant number of hospitalizations and deaths each year. More efforts are needed to develop new drugs and prevention strategies. In Italy, RSV is active between November and April, and prevention strategies must protect all neonates and infants under 1 year of age. Improvement in infection surveillance and reporting is crucial, along with the development of access pathways for new agents to reduce the burden of infections and hospitalizations.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Gregorio Serra, Luigi Memo, Alessandra Coscia, Mario Giuffre, Ambra Iuculano, Mariano Lanna, Diletta Valentini, Anna Contardi, Sauro Filippeschi, Tiziana Frusca, Fabio Mosca, Luca A. Ramenghi, Corrado Romano, Annalisa Scopinaro, Alberto Villani, Giuseppe Zampino, Giovanni Corsello
Summary: Genetic diseases have a significant impact on patients and their families, and effective communication during diagnosis is crucial. A consensus document with practical recommendations was developed by multiple scientific societies and parents' associations to improve doctor-patient/family interactions and enhance health outcomes for children with genetic diseases.
ITALIAN JOURNAL OF PEDIATRICS
(2021)