Article
Multidisciplinary Sciences
Byung Chul Kang, Junyeong Yi, Song Hee Kim, Jhang Ho Pak, Jong Woo Chung
Summary: The study investigated the protective effect of dexamethasone on TNF-alpha-induced ototoxicity in mouse auditory hair cells and cochlear explants. Results showed that dexamethasone restored cell viability, decreased ROS accumulation, and attenuated apoptotic signaling activation induced by TNF-alpha.
Article
Pharmacology & Pharmacy
Zehra Kanli, Hulya Cabadak, Banu Aydin
Summary: The study aimed to investigate the effects of pilocarpine on the expression of M-3 muscarinic acetylcholine receptor, AChE activity, IL-8 release, and proliferation in K562 cells. The results showed that pilocarpine inhibited proliferation and reduced M-3 muscarinic acetylcholine receptor protein expression in chronic myeloid cells. Pilocarpine also increased caspase expression and promoted apoptosis. These findings suggest that pilocarpine has therapeutic potential in chronic myeloid leukemia.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Victor Pallares, Yaiza Nunez, Laura Sanchez-Garcia, Aida Falgas, Naroa Serna, Ugutz Unzueta, Alberto Gallardo, Lorena Alba-Castellon, Patricia Alamo, Jorge Sierra, Antonio Villaverde, Esther Vazquez, Isolda Casanova, Ramon Mangues
Summary: This study successfully induced apoptosis in CXCR4+ leukemic cells using a self-assembling protein nanoparticle, and in a mouse model, blocked the dissemination of AML cells without inducing toxicity in healthy tissues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Regis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Benedicte Brounais-Le Royer, Franck Verrecchia, Francoise Redini, Romain Guiho
Summary: Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors in children. Triggering the TRAIL pro-apoptotic pathway shows promise in treating these tumors, but resistance mechanisms have limited its effectiveness. This study used human cell lines and xenograft models to investigate the differences in signaling pathways between TRAIL-sensitive and TRAIL-resistant cells, and proposed two strategies to overcome resistance.
Article
Biochemistry & Molecular Biology
Giulia Lombardi, Roberta Valeria Latorre, Alessandro Mosca, Diego Calvanese, Luisa Tomasello, Christian Boni, Manuela Ferracin, Massimo Negrini, Nader Al Dewik, Mohamed Yassin, Mohamed A. Ismail, Bruno Carpentieri, Claudio Sorio, Paola Lecca
Summary: This study analyzed the modulation of the K562 transcriptome in the context of Chronic Myeloid Leukemia (CML) using the tumor suppressor gene PTPRG and the tyrosine kinase inhibitor Imatinib. The analysis identified genes whose expression levels were altered by PTPRG and Imatinib, providing insights into the transcriptomic landscape of CML. Two different methods were used in the analysis, with one focusing on gene set enrichment analysis and the identification of transcription factors, and the other focusing on selecting transcription factors from differentially expressed genes. The study revealed the potential upregulation of RARG and CD36 genes by PTPRG, suggesting a role in cell differentiation. The findings provide new insights into the molecular mechanisms of tumor suppression in the context of CML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jichun Sun, Hongbo Xu, Zhao Lei, Zhiqiang Li, Hongwei Zhu, Zhen Deng, Xiao Yu, Xiaoxin Jin, Zhi Yang
Summary: The tumor-suppressive lncRNA CASC2 is downregulated in hepatocellular carcinoma (HCC) and its low expression is associated with shorter overall survival. CASC2 overexpression inhibits HCC cell proliferation and induces cell apoptosis. CASC2 regulates TRAIL-sensitive HCC cells through the miR-24/caspase-8 and miR-221/caspase-3 axes and caspase cascades, while in TRAIL-resistant HCC cells, it regulates cell growth through the miR-18a/RIPK1 axis and the NF-kappa B signaling.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Atsushi Watanabe, Kunio Miyake, Koshi Akahane, Kumiko Goi, Keiko Kagami, Hideo Yagita, Takeshi Inukai
Summary: Immunotherapies specific for BCP-ALL, such as anti-CD19 CAR T-cells and blinatumomab, have significantly improved outcomes in refractory cases. The methylation status of DR4 and DR5 genes is associated with gene expression levels, cell-surface expression, and TRAIL-sensitivities, suggesting potential clinical relevance in predicting immunotherapy efficacy. Evaluating methylation status of DR4 and DR5 genes may be informative in certain cases with unfavorable karyotypes.
Article
Cell Biology
Adrien Grenier, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, Clement Larrue, Ambrine Sahal, Rudy Birsen, Victoria Ghesquier, Justine Decroocq, Fetta Mazed, Mireille Lambert, Mamy Andrianteranagna, Benoit Viollet, Patrick Auberger, Andrew A. Lane, Pierre Sujobert, Didier Bouscary, Jean-Emmanuel Sarry, Jerome Tamburini
Summary: AMPK activation in AML cells triggers the unfolded protein response, leading to repression of oxidative phosphorylation, TCA cycle, and pyrimidine biosynthesis, as well as enhanced mitochondrial apoptotic signaling. Combination therapy with the AMPK activator GSK621 and the Bcl-2 inhibitor venetoclax shows synergistic effects, suggesting therapeutic potential in AML.
Article
Genetics & Heredity
Ezeldine K. Abdalhabib, Abdulrahman Algarni, Muhammad Saboor, Fehaid Alanazi, Ibrahim K. Ibrahim, Ayman H. Alfeel, Abdullah M. Alanazi, Abdulmajeed M. Alanazi, Abdulaziz M. Alruwaili, Muath H. Alanazi, Nahla A. Alshaikh
Summary: This study found that the rs1800629 polymorphism of the TNF-alpha gene is associated with a higher risk of adult B-ALL, with no significant correlation with age at diagnosis and gender.
Article
Oncology
Khalid Rashid, Christian Roeder, Freya Goumas, Jan-Hendrik Egberts, Holger Kalthoff
Summary: In this study, the inhibition of CD95 signaling altered the chemotherapeutic effects of gemcitabine by suppressing the pro-inflammatory responses from CD95L-positive tumor cells as well as from the TNF-a and TRAIL signaling in a bi-lateral crosstalk manner.
Article
Biochemistry & Molecular Biology
Jing-Ting Chiou, Yi-Jun Shi, Yuan-Chin Lee, Liang-Jun Wang, Ying-Jung Chen, Long-Sen Chang
Summary: SEM-LA activates TNF-α-mediated apoptosis in U937 cells through the NOX4/p38 MAPK/PP2A axis and promotes this process via Ca2+-NOX4-ROS axis-mediated p38 MAPK activation. Restoration of TTP expression alleviates the effects of TNF-α upregulation and cell death induced by SEM-LA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Ahmed K. K. Hamdy, Takashi Sakamoto, Tsugumasa Toma, Masaharu Sakamoto, Mohammed A. S. Abourehab, Masami Otsuka, Mikako Fujita, Hiroshi Tateishi, Mohamed O. O. Radwan
Summary: Isatin is a unique natural compound with strong chemotherapeutic potential, showing significant antiproliferative activities against different cancer genotypes. Compounds 5b and 5g demonstrate remarkable apoptosis and moderate cell cycle arrest at the G1 phase of HL-60 cells, with high selectivity against PBMC from healthy donors.
Article
Oncology
Shuchong Mei, Yuan Zhang, Li Yu, Guoan Chen, Fuming Zi
Summary: The study found that there were significant differences in FAP alpha expression between AML patients and healthy donors in BM samples, and BMMSCs can protect AML cells from apoptosis through activating the beta-catenin signaling pathway. FAP alpha plays an important role in the AML BM microenvironment and its increased expression may be a poor prognostic factor for AML patients.
Article
Biochemistry & Molecular Biology
Barbara Pesce, Carolina H. Ribeiro, Milton Larrondo, Veronica Ramos, Lilian Soto, Diego Catalan, Juan Carlos Aguillon
Summary: Tumor necrosis factor (TNF)-alpha regulates cytokine production by CD4+ T helper cells, and targeting TNFR2 may be an alternative strategy to normalize key cytokine levels that contribute to the pathogenesis of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Giordana Feriotto, Federico Tagliati, Arianna Brunello, Simone Beninati, Claudio Tabolacci, Carlo Mischiati
Summary: This study found that caffeic acid (CA) has antiproliferative and pro-apoptotic effects on chronic myeloid leukemia (CML) cells. The activity of TG2 enzyme was found to be related to the anticancer effects of CA, by increasing reactive oxygen species (ROS) and inhibiting caspase activation and apoptosis. Knocking down TGM2 transcripts confirmed the importance of TG2 activation in CML cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Andrew Jay Portuguese, Aya Albittar, Ted H. Gooley, Hans Joachim Deeg
Summary: This study found that patients with a prior solid tumor can be successfully transplanted, despite a higher incidence of acute graft-versus-host disease. However, overall survival and relapse rates did not significantly differ. These findings are encouraging for patients who have survived a prior cancer and are considering transplantation.
Letter
Hematology
Eduardo Rodriguez-Arboli, Megan Othus, Corentin Orvain, Lucas C. Zarling, Brenda M. Sandmaier, Filippo Milano, Gary Schoch, Chris Davis, H. Joachim Deeg, Frederick R. Appelbaum, Rainer Storb, Roland B. Walter
Article
Astronomy & Astrophysics
Emil Knudstrup, Simon H. Albrecht, Davide Gandolfi, Marcus L. Marcussen, Elisa Goffo, Luisa M. Serrano, Fei Dai, Seth Redfield, Teruyuki Hirano, Szilard Csizmadia, William D. Cochran, Hans J. Deeg, Malcolm Fridlund, Kristine W. F. Lam, John H. Livingston, Rafael Luque, Norio Narita, Enric Palle, Carina M. Persson, Vincent Van Eylen
Summary: TOI-640 b is a large exoplanet with characteristics similar to Jupiter, orbiting a slightly evolved F-type star. Through spectroscopic in-transit observations, the researchers measured the Rossiter-McLaughlin effect and determined the obliquity of both the planet and the star. The planet's inclination suggests a unique orbital configuration, joining a group of planets orbiting over stellar poles. The origin of this configuration remains unknown.
ASTRONOMY & ASTROPHYSICS
(2023)
Article
Biophysics
Roland B. Walter, Brenda M. Sandmaier, Megan Othus, Corentin Orvain, Eduardo Rodriguez-Arboli, Masumi U. Oshima, Gary Schoch, Chris Davis, H. Joachim Deeg, Rainer Storb
Summary: Reduced intensity conditioning (RIC) and nonmyeloablative (NMA) conditioning regimens are viable options for allogeneic hematopoietic cell transplantation (HCT) in AML patients. However, the relative efficacies and toxicities of these regimens are not well-defined. This study compared outcomes between RIC and NMA HCT patients and found no significant differences in relapse risk, relapse-free survival, overall survival, and non-relapse mortality. These findings suggest that the choice between RIC and NMA conditioning may not significantly impact outcomes in AML patients undergoing allografting.
BONE MARROW TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Jeannine S. McCune, Sandi L. Navarro, K. Scott Baker, Linda J. Risler, Brian R. Phillips, Timothy W. Randolph, Laura Shireman, H. Gary Schoch, H. Joachim Deeg, Yuzheng Zhang, Alex Men, Loes Maton, Alwin D. R. Huitema
Summary: A linear regression model of 13 endogenous metabolomic compounds (EMCs) can be used to predict an individual's busulfan clearance (BuCL) before administration. This pharmacometabolomics method is more effective than using a busulfan test dose or pharmacogenomics to guide dosing.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Astronomy & Astrophysics
E. Knudstrup, D. Gandolfi, G. Nowak, C. M. Persson, E. Furlan, J. Livingston, E. Matthews, M. S. Lundkvist, M. L. Winther, J. L. Rorsted, S. H. Albrecht, E. Goffo, I Carleo, H. J. Deeg, K. A. Collins, N. Narita, H. Isaacson, S. Redfield, F. Dai, T. Hirano, J. M. Akana Murphy, C. Beard, L. A. Buchhave, S. Cary, A. Chontos, I Crossfield, W. D. Cochran, D. Conti, P. A. Dalba, M. Esposito, S. Fajardo-Acosta, S. Giacalone, S. K. Grunblatt, P. Guerra, A. P. Hatzes, R. Holcomb, F. G. Horta, A. W. Howard, D. Huber, J. M. Jenkins, P. Kabath, S. Kane, J. Korth, K. W. F. Lam, K. Lester, R. Matson, K. K. McLeod, J. Orell-Miquel, F. Murgas, E. Palle, A. S. Polanski, G. Ricker, P. Robertson, R. Rubenzahl, J. E. Schlieder, S. Seager, A. M. S. Smith, P. Tenenbaum, E. Turtelboom, R. Vanderspek, L. Weiss, J. Winn
Summary: We have discovered and confirmed the planetary system TOI-1288, which consists of a late G dwarf and two planets: TOI-1288 b and TOI-1288 c. Through a combination of TESS space-borne and ground-based transit photometry, as well as high-precision Doppler measurements, we have determined the masses and radii of the planets in the system. TOI-1288 b is a hot transiting super-Neptune, located in the Neptunian desert, with a period of 2.699835(-0.000003)(+0.000004) days, a radius of 5.24 +/- 0.09 R-circle plus, and a mass of 42 +/- 3 M-circle plus. TOI-1288 c, on the other hand, has not been detected in the TESS data.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Review
Hematology
Nicola Polverelli, Juan Carlos Hernandez-Boluda, Tomasz Czerw, Tiziano Barbui, Mariella D'Adda, Hans Joachim Deeg, Markus Ditschkowski, Claire Harrison, Nicolaus Martin Kroger, Ruben Mesa, Francesco Passamonti, Francesca Palandri, Naveen Pemmaraju, Uday Popat, Damiano Rondelli, Alessandro Maria Vannucchi, Srdan Verstovsek, Marie Robin, Antonio Colecchia, Luigi Grazioli, Enrico Damiani, Domenico Russo, Jessica Brady, David Patch, Slawomir Blamek, Gandhi Laurent Damaj, Patrick Hayden, Donal P. McLornan, Ibrahim Yakoub-Agha
Summary: Splenomegaly is a common complication in myelofibrosis patients and can negatively impact outcomes of allogeneic hematopoietic cell transplantation (HCT). This Position Paper provides a shared position statement on the management of splenomegaly before HCT. The assessment, prevalence, and clinical significance of splenomegaly are discussed, along with the need for therapeutic intervention. Specific scenarios, such as splanchnic vein thrombosis and COVID-19, are also addressed.
LANCET HAEMATOLOGY
(2023)
Article
Oncology
Corentin Orvain, Eduardo Rodriguez-Arboli, Megan Othus, Brenda M. Sandmaier, H. Joachim Deeg, Frederick R. Appelbaum, Roland B. Walter
Summary: This study retrospectively analyzed 739 patients with de novo AML, 125 with antecedent hematologic disorder (AHD)/AML, and 115 with therapy-related AML who received allografts while in first or second remission. The results showed that relative to patients with de novo AML, relapse rates were similar for patients with AHD and therapy-related AML after multivariable adjustment, as were relapse-free survival and overall survival. Non-relapse mortality was higher for AHD AML. These findings suggest that the clinical history by itself has limited prognostic value for AML patients undergoing allografting.
Article
Astronomy & Astrophysics
H. J. Deeg, I. Y. Georgieva, G. Nowak, C. M. Persson, B. L. Cale, F. Murgas, E. Palle, D. Godoy-Rivera, F. Dai, D. R. Ciardi, J. M. Akana Murphy, P. G. Beck, C. J. Burke, J. Cabrera, I. Carleo, W. D. Cochran, K. A. Collins, Sz. Csizmadia, M. El Mufti, M. Fridlund, A. Fukui, D. Gandolfi, R. A. Garcia, E. W. Guenther, P. Guerra, S. Grziwa, H. Isaacson, K. Isogai, J. M. Jenkins, P. Kabath, J. Korth, K. W. F. Lam, D. W. Latham, R. Luque, M. B. Lund, J. H. Livingston, S. Mathis, S. Mathur, N. Narita, J. Orell-Miquel, H. L. M. Osborne, H. Parviainen, P. P. Plavchan, S. Redfield, D. R. Rodriguez, R. P. Schwarz, S. Seager, A. M. S. Smith, V. Van Eylen, J. Van Zandt, J. N. Winn, C. Ziegler
Summary: TOI-1416 is a late G- or early K-type dwarf star with a small transiting planet, TOI-1416 b, which has a mass of approximately 3.48 M Earth and a radius of approximately 1.62 R Earth. The presence of another planet, TOI-1416 c, is suspected but cannot be verified. The discovery of TOI-1416 b provides valuable insights into the composition and nature of short-period super-Earth-like planets, and it challenges the notion of a special group for planets with periods less than one day.
ASTRONOMY & ASTROPHYSICS
(2023)
Article
Astronomy & Astrophysics
J. Korth, D. Gandolfi, J. Subjak, S. Howard, S. Ataiee, K. A. Collins, S. N. Quinn, A. J. Mustill, T. Guillot, N. Lodieu, A. M. S. Smith, M. Esposito, F. Rodler, A. Muresan, L. Abe, S. H. Albrecht, A. Alqasim, K. Barkaoui, P. G. Beck, C. J. Burke, R. P. Butler, D. M. Conti, K. I. Collins, J. D. Crane, F. Dai, H. J. Deeg, P. Evans, S. Grziwa, A. P. Hatzes, T. Hirano, K. Horne, C. X. Huang, J. M. Jenkins, P. Kabath, J. F. Kielkopf, E. Knudstrup, D. W. Latham, J. Livingston, R. Luque, S. Mathur, F. Murgas, H. L. M. Osborne, E. Palle, C. M. Persson, J. E. Rodriguez, M. Rose, P. Rowden, R. P. Schwarz, S. Seager, L. M. Serrano, L. Sha, S. A. Shectman, A. Shporer, G. Srdoc, C. Stockdale, T. -G. Tan, J. K. Teske, V. Van Eylen, A. Vanderburg, R. Vanderspek, S. X. Wang, J. N. Winn
Summary: The TOI-1130 planetary system contains a gas giant planet, TOI-1130 c, and an inner Neptune-sized planet, TOI-1130 b, both of which have small eccentric orbits in a 2:1 resonant configuration. The masses and radii of these planets have been determined through photodynamical modeling and spectroscopic analysis. Additionally, a linear RV trend suggests the possible presence of an outer massive companion.
ASTRONOMY & ASTROPHYSICS
(2023)
Letter
Oncology
Tao Zhang, Paul Auer, Jing Dong, Corey Cutler, Amy E. Dezern, Shahinaz M. Gadalla, H. Joachim Deeg, Aziz Nazha, Karen-Sue Carlson, Stephen Spellman, Yung-Tsi Bolon, Wael Saber
Summary: Through whole-genome sequencing, we identified 12 novel regions and 3 molecular signatures that are significantly associated with overall survival in myelodysplastic syndromes (MDS). We also discovered two novel gene mutations, CHD1 and DDX11, which have a negative impact on survival in AML/MDS and lymphoid cancer data. Furthermore, we identified additional molecular signatures related to MDS through both unsupervised and supervised clustering. By combining genomic candidates, subgroups, and clinical variables, our prognostic model achieved superior performance compared to models using only clinical variables.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Letter
Oncology
Jing Dong, Christopher Staffi Buradagunta, Tao Zhang, Stephen Spellman, Yung-Tsi Bolon, Amy E. DeZern, Shahinaz M. Gadalla, H. Joachim Deeg, Aziz Nazha, Corey Cutler, Chao Cheng, Raul Urrutia, Paul Auer, Wael Saber
Summary: This study performed whole-genome sequencing on patients with myelodysplastic neoplasia who underwent allogenic hematopoietic cell transplantation. The results showed that an increased number of mitochondrial DNA mutations was associated with poorer transplantation outcomes. Mutations in specific mitochondrial genes were independent predictors of overall survival, relapse, relapse-free survival, and transplant-related mortality after allo-HCT. Integrating mitochondrial DNA mutations into models based on clinical factors significantly improved prognostic stratification efforts.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Meeting Abstract
Oncology
M. Savona, J. Mccloskey, E. Griffiths, K. Yee, A. Zeidan, A. Al-Kali, H. J. Deeg, P. Patel, M. Sabloff, M. -M. Keating, N. Zhu, N. Gabrail, S. Fazal, J. Maly, O. Odenike, H. Kantarjian, A. Dezern, C. O'Connell, G. Roboz, L. Busque, R. Buckstein, H. Amin, J. Randhawa, B. Leber, K. -H. Dao, Y. Sano, B. Mirakhur, H. Keer, G. Garcia-Manero
Article
Astronomy & Astrophysics
Elisa Goffo, Davide Gandolfi, Jo Ann Egger, Alexander J. Mustill, Simon H. Albrecht, Teruyuki Hirano, Oleg Kochukhov, Nicola Astudillo-Defru, Oscar Barragan, Luisa M. Serrano, Artie P. Hatzes, Yann Alibert, Eike Guenther, Fei Dai, Kristine W. F. Lam, Szilard Csizmadia, Alexis M. S. Smith, Luca Fossati, Rafael Luque, Florian Rodler, Mark L. Winther, Jakob L. Rorsted, Javier Alarcon, Xavier Bonfils, William D. Cochran, Hans J. Deeg, Jon M. Jenkins, Judith Korth, John H. Livingston, Annabella Meech, Felipe Murgas, Jaume Orell-Miquel, Hannah L. M. Osborne, Enric Palle, Carina M. Persson, Seth Redfield, George R. Ricker, Sara Seager, Roland Vanderspek, Vincent Van Eylen, Joshua N. Winn
Summary: Researchers have discovered that GJ 367 is a bright star hosting a transiting ultra-short period subEarth and two non-transiting low-mass companions. The planetary mass and radius of GJ 367 b were found to be higher than Earth's, resulting in a high bulk density. The internal composition of GJ 367 b suggests the presence of an iron core.
ASTROPHYSICAL JOURNAL LETTERS
(2023)
Editorial Material
Hematology
H. Joachim Deeg
Summary: In this study, DeZern et al demonstrate successful transplantation outcomes using HLA-haploidentical family members in patients with aplastic anemia who had not received immunosuppressive therapy. The conditioning regimen consisting of cyclophosphamide, fludarabine, rabbit antithymocyte globulin, and total body irradiation facilitated engraftment, and the addition of posttransplant cyclophosphamide effectively reduced the incidence of graft-versus-host disease to less than 10%.