期刊
EXPERIMENTAL GERONTOLOGY
卷 57, 期 -, 页码 6-12出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2014.04.013
关键词
Leukocyte telomere length; Elderly men; All-cause mortality; Cancer mortality; Cardiovascular mortality
资金
- Swedish Research Council [523-2007-7111]
- Swedish Foundation for Strategic Research
- ALF/LUA research grant in Gothenburg [ALFGBG-146841]
- Lundberg Foundation
- Torsten and Ragnar Soderberg's Foundation
- Novo Nordisk Foundation
- Magnus Bergvall Foundation
- Ake Wiberg Foundation
- Tore Nilson Foundation
- Swedish Society for Medical Research
Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81 years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0 years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR) = 1.05, 95% confidence interval (CI) 0.85-1.28 and HR = 0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not associate with cancer (197 events) or cardiovascular disease (CVD, 206 events) mortality (tertile 1 vs. tertile 3; HR = 0.94, 95% CI 0.67-1.34 and HR = 0.94, 95% CI 0.68-1.30, respectively). The lack of association between LTL and mortality remained also after adjustment for multiple covariates. Our results demonstrate that LTL is not associated with all-cause mortality or mortality due to cancer or CVD in elderly men. Further studies are needed to determine whether LTL can predict the risk of mortality in elderly women. (C) 2014 Elsevier Inc. All rights reserved.
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