期刊
EXPERIMENTAL GERONTOLOGY
卷 48, 期 6, 页码 557-564出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2013.03.002
关键词
Renin-angiotensin system; Alzheimer's disease; Aminopeptidase A; Aminopeptidase N; Aminopeptidase B; Insulin-regulated aminopeptidase; Aspartyl aminopeptidase; Gender differences; Apolipoprotein E; ROC curve analysis
资金
- Consejeria de Salud [PI-0473-2009]
- Consejeria de Innovacion, Ciencia y Empresa [P07-CVI-02758]
Alterations in blood pressure and components of the renin-angiotensin system (RAS) contribute to the development and progression of Alzheimer's disease (AD), resulting in changes that can lead or contribute to cognitive decline. Aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase N (APN) and aminopeptidase B (APB) catabolise circulating angiotensins, whereas insulin-regulated aminopeptidase (IRAP) has been described as the AT(4) receptor. We have found in AD patients a significant decrease of APA activity in men but not in women, and of APN, APB and IRAP in both genders, when compared with control subjects. No changes were found in ASAP activity. Also, APN, APB and IRAP but not APA correlated with the Mini-Mental test, but no relationship with APOE genotype was found. We conclude that several components of the RAS are modified in AD patients, with gender differences. Furthermore, ROC analysis indicates that APN, APB and IRAP activities could be useful non-invasive biomarkers of AD from the earliest stages. (C) 2013 Elsevier Inc. All rights reserved.
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