期刊
EXPERIMENTAL GERONTOLOGY
卷 48, 期 10, 页码 1043-1048出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2013.01.009
关键词
Dietary restriction; Stress resistance; Ischemia reperfusion injury; Chemotherapy; Inflammation
资金
- NIH (National Institute on Aging) [AG036712]
- NIH (National Institute of Diabetes and Digestive and Kidney Diseases) [DK090629]
- Ellison Medical Foundation
- Glenn Foundation for Medical Research
Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition, imparts many benefits in model organisms. Extended longevity is the most popularized benefit but the least clinically relevant due to the requirement for long-term food restriction. DR also promotes stress resistance and metabolic fitness. Emerging data in experimental models and in humans indicate that these benefits occur rapidly upon initiation of DR, suggesting potential clinical relevance. Here we review data on the ability of short-term DR to induce beneficial effects on clinically relevant endpoints including surgical stress, inflammation, chemotherapy and insulin resistance. The encouraging results obtained in these preclinical and clinical studies, and the general lack of mechanistic understanding, both strongly suggest the need for further research in this emerging area. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据