Review
Pharmacology & Pharmacy
Debora Nunes, Joana A. Loureiro, Maria Carmo Pereira
Summary: Alzheimer's disease is the most common form of dementia, requiring the development of more effective treatment strategies. Approved drugs for treatment have limited effectiveness and unwanted side effects. Utilizing drug delivery systems can enhance drug efficacy and reduce unwanted side effects.
Article
Neurosciences
Jiri Kassa, Jana Zdarova Karasova
Summary: The combination of memantine and donepezil significantly increased post-exposure effectiveness, mitigating the toxicity of soman and boosting post-exposure treatment.
NEUROTOXICITY RESEARCH
(2021)
Review
Neurosciences
Maja Przybylowska, Krystyna Dzierzbicka, Szymon Kowalski, Klaudia Chmielewska, Iwona Inkielewicz-Stepniak
Summary: This review examines the development of tacrine analogues and other drug hybrids in the past three years for the treatment of Alzheimer's disease, highlighting their potential multifunctional therapeutic effects and related mechanisms.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Servan Veysanoglu, Busra Ertas, Ece Guler, Fadime Topal, Gul Sinemcan Ozcan, Gokhan Duruksu, Burak Ece, Cansun Sahin Cam, Oguzhan Aydemir, Muhammet Emin Cam
Summary: In this study, polyvinyl alcohol/polyvinylpyrrolidone nanofibers loaded with rivastigmine, memantine, and Gingko biloba extract were developed and investigated for their anti-Alzheimer's effects. The nanofibers showed good compatibility and rapid disintegration, making them suitable for sublingual application. They were found to be safe and promising candidates, significantly improving learning and memory impairment in an Alzheimer's disease model and reducing the levels of key proteins associated with the disease.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Marco Zuin, Antonio Cherubini, Stefano Volpato, Luigi Ferrucci, Giovanni Zuliani
Summary: This study evaluated the effect of acetylcholinesterase inhibitors (AChEIs) on cognitive decline and overall survival in older patients with late onset Alzheimer's disease, vascular dementia, or Lewy body disease. The results showed that AChEIs treatment was associated with slower cognitive decline and reduced mortality.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Samuel A. Florentino, Mohammad H. Bawany, Heather M. Ma
Summary: Acetylcholinesterase inhibitors (AChEIs) are used to aid neuro-recovery in traumatic brain injury (TBI) patients, with limited evidence suggesting moderate benefits and minimal side effects that cease rapidly upon discontinuation. Ongoing research, including a large randomized controlled trial, is needed to determine the true efficacy of AChEIs in TBI recovery.
Article
Plant Sciences
Jiajia Zhao, Kun Li, Yingying Wang, Dan Li, Qianwen Wang, Shengsheng Xie, Jianxin Wang, Zhong Zuo
Summary: The study found that co-treatment of EGb 761 and donepezil significantly improved cognitive function, increased brain levels of superoxide dismutase, and decreased brain levels of acetylcholinesterase and malondialdehyde in scopolamine-induced cognitive impairment rats. Despite these beneficial pharmacodynamic outcomes, the co-treatment did not alter the plasma pharmacokinetics and brain uptake of donepezil or bilobalide.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agricultural Engineering
Junru Yang, Zhi Feng, Wei Liu, Yuanqing Wang, Guibin Wang, Wanwen Yu, Guo Yang, Tingting Yang, Yiqiang Wang, Meng Li
Summary: Ginkgolic acid is a phenolic acid specifically distributed in Ginkgo biloba, with potential applications in improving ginkgolic acid accumulation in G. biloba seeds. The study found a close relationship between the variation of endogenous hormone levels and ginkgolic acid content during the development of G. biloba episperms. Exogenous hormone treatment significantly increased episperm yield and ginkgolic acid content in developing G. biloba fruits, providing a cost-effective way to enhance ginkgolic acid accumulation.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Clinical Neurology
Hong Xu, Sara Garcia-Ptacek, Linus Jonsson, Anders Wimo, Peter Nordstrom, Maria Eriksdotter
Summary: The study showed that ChEIs are associated with a slower cognitive decline in Alzheimer's disease patients as well as a decreased risk of severe dementia or death. Galantamine was particularly effective in reducing mortality and the risk of severe dementia, while all ChEIs had a modest but persistent effect on cognitive benefits over time.
Article
Horticulture
Teodora Tomova, Iva Slavova, Desislav Tomov, Gergana Kirova, Mariana D. Argirova
Summary: Ginkgo biloba has been cultivated in Bulgaria since the late 19th century, with individual specimens found in almost every park. Research has shown that locally grown ginkgo seeds can be utilized as a source of beneficial compounds, with chemical composition similar to seeds from other geographical areas.
Review
Geriatrics & Gerontology
Dawei Li, Jinlong Ma, Baojian Wei, Shuang Gao, Yanmei Lang, Xueying Wan
Summary: This meta-analysis compared the efficacy and safety of ginkgo biloba preparations combined with donepezil hydrochloride vs. donepezil for the treatment of Alzheimer's disease. The results showed that ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes. However, more relevant high-quality RCTs are needed in the future to validate these results.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Sanika Rege, Ryan M. Carnahan, Michael L. Johnson, Hua Chen, Holly M. Holmes, Rajender R. Aparasu
Summary: This study found a 27% increased risk of antipsychotic initiation among users of rivastigmine compared with donepezil users. There was no significant difference in antipsychotic initiation between galantamine and donepezil users. Despite the study's limitations, the results suggest that donepezil or galantamine may be more suitable treatments for older patients with dementia to reduce antipsychotic use.
Article
Chemistry, Medicinal
Jia Ke, Meng-Ting Li, Ya-Jing Huo, Yan-Qiong Cheng, Shu-Fen Guo, Yang Wu, Lei Zhang, Jianpeng Ma, Ai-Jun Liu, Yan Han
Summary: Our study showed that the combination of GBE50 and aspirin could enhance the antiplatelet effects by synergistic and additive effects, with stronger inhibition of platelet aggregation. GBE50 interfered with platelet aggregation through cAMP pathway, AA metabolism and calcium signaling pathway, while aspirin regulated platelet aggregation through AA metabolism and platelet activation. Demonstrating the potential application of GBE50 as a supplementary therapy for thrombosis-related diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Agricultural Engineering
Isaac Duah Boateng, Xiao-Ming Yang
Summary: This review provides a comprehensive overview of the uses, global market revenue, and processing techniques of Ginkgo biloba seeds, emphasizing the impact of processing methods on toxicity and bioactive components.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Hongwei Yang, Jianghua Du
Summary: This study investigates the crystallization kinetics of GF/PLA composites by melt blending GFs and PLA. The results show that the presence of GFs significantly promotes PLA crystallization, accelerates the crystallization rate, and shortens the crystallization time. Additionally, the calculation of crystallization activation energy indicates that GFs enhance the crystallization capacity and decrease the effective potential barrier of the composite.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)