Article
Cell Biology
Dalia Ali, Florence Figeac, Atenisa Caci, Nicholas Ditzel, Clarissa Schmal, Greet Kerckhofs, Jesper Havelund, Nils Faergeman, Alexander Rauch, Michaela Tencerova, Moustapha Kassem
Summary: This study investigated the combined effects of obesity and estrogen deficiency on the skeleton. By feeding ovariectomized mice with a high-fat diet, it was found that obesity and estrogen deficiency can impair bone formation and decrease bone mass, leading to increased bone fragility.
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng Lu, Yan-Jun Zhao, Jian-Ming Ni, Yu Jiang, Fang-Ming Chen, Zhong-Juan Wang, Zhui-Yang Zhang
Summary: This study assessed the predictive value of the combination of bone marrow PDFF and liver R2* for osteopenia and osteoporosis, as well as the additional role of liver R2*. The results demonstrate the potential of liver R2* as a biomarker for osteopenia and osteoporosis in healthy women.
EUROPEAN RADIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jessica L. Pierce, Anuj K. Sharma, Rachel L. Roberts, Kanglun Yu, Debra L. Irsik, Vivek Choudhary, Jennifer S. Dorn, Husam Bensreti, Reginald D. Benson, Helen Kaiser, Andrew Khayrullin, Colleen Davis, Chase J. Wehrle, Maribeth H. Johnson, Wendy B. Bollag, Mark W. Hamrick, Xingming Shi, Carlos M. Isales, Meghan E. McGee-Lawrence
Summary: Deficiency in glucocorticoid receptor (GR) in aging-associated osteoporosis leads to low bone mass and bone marrow adipose tissue accumulation, as well as alterations in muscle mass, metabolic rate, and blood pressure. The study suggests a role for GR in facilitating healthy bone maintenance with aging in females and highlights the importance of bone as an endocrine organ.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenghua Liu, Dageng Huang, Yonghong Jiang, Xiaowen Ma, Yuting Zhang, Rong Chang
Summary: This study investigated the correlation between R2* and vertebral fat fraction (FF) and bone mineral density (BMD), and explored its role in the quantitative assessment of osteoporosis (OP). The results showed that R2* was significantly correlated with FF and BMD. In addition, the area under the curve (AUC) for FF in diagnosing OP was higher than that for R2*. Therefore, R2* can be used as a complement to FF and BMD for the quantitative assessment of OP.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Zhao, Dong Han, Si-Rui He, Long-Yan Wu, Wu-Yang Liu, Zhao-Ming Zhong
Summary: Bone marrow endothelial cells (BMECs) are crucial for maintaining bone homeostasis. The decline in BMECs is associated with abnormal bone development and loss. The mechanism of age-related oxidative stress enhancement in BMEC dysfunction remains unclear. This study investigated the injury caused by oxidative stress enhancement in BMECs and evaluated the potential therapeutic effect of N-Acetyl-L-cysteine (NAC) in senile osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
F. T. Gassert, A. Kufner, F. G. Gassert, Y. Leonhardt, S. Kronthaler, B. J. Schwaiger, C. Boehm, M. R. Makowski, J. S. Kirschke, T. Baum, D. C. Karampinos, A. S. Gersing
Summary: The bone marrow proton density fat fraction (PDFF) assessed with MRI can differentiate between osteoporotic/osteopenic patients with and without vertebral fractures.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Andrey V. Malkovskiy, Lauren D. Van Wassenhove, Yury Goltsev, Kwame Osei-Sarfo, Che-Hong Chen, Bradley Efron, Lorraine J. Gudas, Daria Mochly-Rosen, Jayakumar Rajadas
Summary: The ALDH2 inactivating mutation is the most common mutation leading to bone morphological abnormalities. It is associated with exacerbating osteoporosis and changes in bone biomaterial due to elevated ethanol consumption. The study found a significant decrease in mineral content and an increase in fat content in bone samples with ALDH2*2 mutation.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Plant Sciences
Xiaoyan Qin, Qiu Wei, Ran An, Yun Yang, Mingqi Cai, Xiaoling Han, Haoping Mao, Xiumei Gao
Summary: This study investigates the anti-osteoporotic effects of an ethanol extract of FLL in ovariectomized mice and explores the underlying mechanism. The results show that FLL prevents bone loss and improves bone microstructure by modulating bone and fat balance, suggesting its potential as a therapeutic agent for postmenopausal osteoporosis.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Florian Tilman Gassert, Leander Glanz, Christof Boehm, Jonathan Stelter, Felix Gerhard Gassert, Yannik Leonhardt, Georg C. Feuerriegel, Markus Graf, Markus Wurm, Thomas Baum, Rickmer F. Braren, Benedikt J. Schwaiger, Marcus R. Makowski, Dimitrios Karampinos, Alexandra S. Gersing
Summary: This study longitudinally assessed changes in proton-density fat fraction (PDFF), T2* and cross-sectional area (CSA) of the paraspinal musculature (PSM) over 6 months in patients with and without osteoporosis. The results showed that the PSM CSA decreased significantly longitudinally in patients with osteoporosis/osteopenia, compared to those without. Higher vertebral and PSM PDFF at baseline were associated with stronger changes in vertebral bone marrow T2*.
Review
Endocrinology & Metabolism
Dalia Ali, Michaela Tencerova, Florence Figeac, Moustapha Kassem, Abbas Jafari
Summary: Osteoporosis is a skeletal disease characterized by decreased bone mass and micro-architectural deterioration, increasing the risk of fractures. Obesity and Type 2 Diabetes (T2D) can contribute to bone fragility in the elderly population by causing metabolic disturbances. These metabolic complications are associated with impaired bone homeostasis and higher fracture risk, with the expansion of Bone Marrow Adipose Tissue (BMAT) being a key mechanism underlying osteoporosis and bone fragility in obesity and T2D. This review provides an overview of the mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the connection between obesity, T2D, BMA, and bone fragility in aging osteoporotic individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell & Tissue Engineering
Chao Ma, Juan Gao, Jun Liang, Weixiang Dai, Zhenfei Wang, Mengjiao Xia, Tao Chen, Sen Huang, Jian Na, Long Xu, Shiming Feng, Kerong Dai, Guangwang Liu
Summary: Senile osteoporosis is a common and severe disease affecting the elderly, characterized by increased risk of fractures due to bone fragility. Research focused on investigating the mechanisms underlying defective bone formation in age-related bone loss, particularly the role of histone acetylation. Inhibition of HDAC6 was found to improve osteogenic potential in aged mice, providing insights for potential therapies to treat senile osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Luis Gracia-Marco, Sheila Gonzalez-Salvatierra, Antonia Garcia-Martin, Esther Ubago-Guisado, Beatriz Garcia-Fontana, Jose Juan Gil-Cosano, Manuel Munoz-Torres
Summary: This study analyzed differences in 3D DXA parameters at the hip site among patients with acromegaly or AGHD and healthy controls. The study found cortical bone impairment in AGHD patients and highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and controls. 3D-DXA provided useful information about bone involvement in GH-related disorders, with AGHD patients showing distinct involvement of the cortical structure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Wenting Xu, Cheng Ni, Yuxuan Wang, Guoqing Zheng, Jinshan Zhang, Youjia Xu
Summary: The study revealed a decline in serum Gal-1 levels in mice and men with age-related trabecular bone loss, indicating its potential as a biomarker for BMSC senescence, early osteoporosis diagnosis, and trabecular bone loss monitoring. Gal-1 was positively correlated with bone mineral density and showed differential secretion by BMSC, HSC, and MP in aged mice.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Jennifer C. Coulombe, Blayne A. Sarazin, Zachary Mullen, Alicia M. Ortega, Eric W. Livingston, Ted A. Bateman, Louis S. Stodieck, Maureen E. Lynch, Virginia L. Ferguson
Summary: Research shows that microgravity has a greater impact on bone changes in older mice, especially in terms of trabecular bone, while there was no significant change in trabecular thickness in young mice.
Review
Medicine, Research & Experimental
Li Tian, Lingyun Lu, Yang Meng
Summary: This review describes the relationship between bone marrow adipose tissue and aging osteoporosis, focusing on the fate of bone marrow mesenchymal stem cell osteogenic-adipose differentiation with aging and the mechanisms responsible for these changes. Age-related bone mass loss is accompanied by increased bone marrow adiposity due to imbalanced differentiation of bone marrow mesenchymal stem cells, resulting in adipogenesis. Transcription factors and classical regulating pathways are involved in this process during aging. Therefore, finding molecular mechanisms controlling adipogenesis in bone marrow mesenchymal stem cells during aging is important for preventing and treating age-related bone loss.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jesse Zanker, Marc Sim, Kate Anderson, Saliu Balogun, Sharon L. Brennan-Olsen, Elsa Dent, Gustavo Duque, Christian M. Girgis, Mathis Grossmann, Alan Hayes, Tim Henwood, Vasant Hirani, Charles Inderjeeth, Sandra Iuliano, Justin Keogh, Josh Lewis, Gordon S. Lynch, Julie A. Pasco, Steven Phu, Esmee M. Reijnierse, Nicholas Russell, Lara Vlietstra, Renuka Visvanathan, Troy Walker, Debra L. Waters, Solomon Yu, Andrea B. Maier, Robin M. Daly, David Scott
Summary: Sarcopenia is an age-related skeletal muscle condition characterized by low muscle mass, strength, and physical performance. There is currently no international consensus on the definition of sarcopenia. The Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR) developed consensus guidelines for sarcopenia prevention, assessment, management, and research through a four-phase Delphi process, involving topic experts, consumers, and evidence. These guidelines are intended for use by health professionals and researchers in Australia and New Zealand.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Endocrinology & Metabolism
Kerensa M. Beekman, Gustavo Duque, Alessandro Corsi, Michaela Tencerova, Peter H. Bisschop, Julien Paccou
Summary: This review focuses on the impact of bone marrow adipose tissue (BMAT) on bone health, summarizing the variations of BMAT in relation to age, sex, and skeletal sites, and providing updates on noninvasive imaging techniques for quantifying human BMAT. The review also discusses the role of BMAT in patients with osteoporosis and interventions affecting BMAT.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Endocrinology & Metabolism
Sara Vogrin, Ebrahim Bani Hassan, Fernan Munandar Putra, Julie A. Pasco, Mark A. Kotowicz, Gustavo Duque
Summary: Sarcopenia and osteoporosis, characterized by muscle and bone tissue loss, are prevalent in older people and have adverse outcomes. Using mid-thigh dual-energy X-ray absorptiometry (DXA), this study found that unconventional regions of interest (ROIs) in the thigh could effectively identify osteoporosis, low lean mass, and muscle performance-related factors. However, further validation is needed for the prediction of fractures.
Editorial Material
Geriatrics & Gerontology
Gustavo Duque
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Review
Endocrinology & Metabolism
Jared Buratto, Ben Kirk, Steven Phu, Sara Vogrin, Gustavo Duque
Summary: This study investigated the effects of testosterone therapy on musculoskeletal health and clinical outcomes in men. The study found that testosterone therapy can increase hip bone density and total lean mass in men within 6 months, but its effects on lumbar spine bone density and handgrip strength are unclear. More research is needed to further understand the safety and efficacy of testosterone on musculoskeletal health and clinical outcomes.
ENDOCRINE PRACTICE
(2023)
Review
Geriatrics & Gerontology
Lara Vlietstra, Ben Kirk, Gustavo Duque, Clifford Qualls, Bruno Vellas, Sandrine Andrieu, John E. Morley, Debra L. Waters
Summary: This study aimed to classify transitions in osteosarcopenia using minimal clinically important differences (MCIDs) and analyze the effects of demographic variables on these transitions. The use of MCIDs reflected the fluctuation and dynamic nature of health in older adults. Future research should focus on modifiable markers transitions to design intervention trials.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Ben Kirk, Stephanie L. Harrison, Jesse Zanker, Andrew J. Burghardt, Eric Orwoll, Gustavo Duque, Peggy M. Cawthon
Summary: This study aimed to investigate the interaction between bone and muscle in predicting fractures in older men. Cox proportional hazards models were used with prospective data from the Osteoporotic Fractures in Men study. The results showed an interaction between D3Cr muscle mass and distal tibia total volumetric BMD (Tt.BMD) in the occurrence of fractures in older men. Importance rating: 7/10.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Neurosciences
Xuzhu Lin, Cassandra Smith, Alba Moreno-Asso, Navabeh Zarekookandeh, Tara C. Brennan-Speranza, Gustavo Duque, Alan Hayes, Itamar Levinger
Summary: This study investigates the protective effects of the combination of undercarboxylated osteocalcin (ucOC) and ibandronate (IBN) against immobilization-induced muscle wasting and insulin resistance. The results show that the combined treatment significantly increases muscle weight and improves glucose tolerance compared to individual treatments.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Endocrinology & Metabolism
Reshma Aziz Merchant, Yiong Huak Chan, Gustavo Duque
Summary: This study aimed to investigate the association between GDF-15 and diabetes mellitus (DM) with and without poor physical function, and to develop a prediction model for poor physical function in prefrail older adults. The results showed that participants in the highest tertile of GDF-15 had a higher prevalence of DM and poorer physical performance. After adjusting for various factors, the odds of having DM and poor physical function were significantly higher in the highest tertile of GDF-15.
JOURNAL OF DIABETES RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Natasha K. Brusco, Keith D. Hill, Terry Haines, Jeremy Dunn, Maya G. Panisset, Briony Dow, Frances Batchelor, Stuart J. H. Biddle, Gustavo Duque, Pazit Levinger
Summary: The ENJOY program, which utilizes specialized outdoor equipment and a physical activity program, is cost-effective in reducing healthcare costs and improving the quality of life for older adults.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Review
Medicine, General & Internal
Rebekah Jane Moles, Lin Perry, Justine M. Naylor, Jacqueline Center, Peter Ebeling, Gustavo Duque, Gabor Major, Christopher White, Christopher Yates, Matthew Jennings, Mark Kotowicz, Thach Tran, Dana Bliuc, Lei Si, Kathryn Gibson, Benjamin Joseph Basger, Patrick Bolton, Stephen Barnett, Geraldine Hassett, Ayano Kelly, Barbara Bazarnik, Wafaa Ezz, Kate Luckie, Stephen Ross Carter
Summary: This paper describes a protocol for a randomized controlled trial to determine the efficacy of a home medication review (HMR) service for patients who have sustained minimal trauma fractures (MTFs). The trial will evaluate the impact of the HMR service on patients' intake of sedative/anticholinergic drugs, adherence to antiosteoporosis medications, and other secondary outcomes.
Meeting Abstract
Endocrinology & Metabolism
Mahdi Imani, Thang Ngoc Quoc Dao, Peggy Cawthon, Erik Meijering, Gustavo Duque
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Ben Kirk, Stephanie L. Harrison, Jesse Zanker, Gustavo Duque, Peggy M. Cawthon
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Ben Kirk, Simon Zhang, Sara Vogrin, Christel Harijanto, Myrla Sales, Gustavo Duque
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Ben Kirk, Jatupol Kositsawat, Sara Vogrin, Gustavo Duque
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
