Article
Microbiology
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajana, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Summary: Gram-positive bacterial infections can cause organ failure and death in sepsis. Bacillus anthracis PGN, a component shed during bacterial replication, can promote sepsis-like pathology. This study found that purified Bacillus anthracis PGN can activate human dendritic cells (DCs), promote the production of proinflammatory cytokines, and induce the differentiation of T(H)17 cells.
Review
Immunology
Ning Huang, Hao Dong, Yuqi Luo, Bin Shao
Summary: Periodontitis is a chronic disease driven by pathogens and inflammation, modulated by the immune system, particularly Th17 cells. Th17 cells play a key role in driving periodontal inflammation and their cytokines are major players in the pathogenesis of periodontitis. Understanding regulators of Th17 cells is crucial for potential clinical interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.
Article
Rheumatology
Tingting Ding, Baochen Li, Rui Su, Ronghui Su, Yanyan Wang, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: AS-CVD group had significantly elevated Th17/Treg cell ratio (0.30 vs 0.19, P = 0.014) and absolute number of Th17 cells (7.27 cells/μL vs 4.34 cells/μL, P < 0.001). Multivariate logistic regression revealed that elevated Th17 cells (OR = 1.20, P = 0.016) were associated with CVD complications in AS. ROC curve analysis showed that Th17 cells contribute to distinguishing AS patients with CVD.
Review
Medical Laboratory Technology
Raghumoy Ghosh, Prasenjit Mitra, P. V. S. N. Kiran Kumar, Taru Goyal, Praveen Sharma
Summary: Depression is a common neuropsychiatric disorder and neuroinflammation may play a significant role in its pathophysiology. Th17 cells are believed to play an important role in depression, but the exact mechanism by which they influence neuroinflammation in depression is not yet fully understood.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jing Chen, Siyu Yang, Wanyu Li, Wei Yu, Zhaowei Fan, Mengyao Wang, Zhenyue Feng, Chunyu Tong, Baifen Song, Jinzhu Ma, Yudong Cui
Summary: The study revealed that infection with Streptococcus agalactiae can induce the differentiation of CD4+ T cells into Th17 cells, which highly express IL-17A and play an important role in defending against the bacteria.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Oncology
Qinqin Liu, Mingqiang Hua, Chen Zhang, Ruiqing Wang, Jinting Liu, Xinyu Yang, Fengjiao Han, Ming Hou, Daoxin Ma
Summary: The bone marrow microenvironment in AML patients exhibits immunosuppressive features, and NLRP3-activated BMDCs are found to promote the differentiation of Th1 cells while inhibiting leukemia cell proliferation. This study sheds light on potential immunotherapeutic strategies for AML patients.
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Julia N. Khantakova, Anastasia Mutovina, Kseniya A. Ayriyants, Natalia P. Bondar
Summary: Depression is a severe mental disorder that is influenced by steroid resistance and Th17 lymphocytes, but the exact mechanisms are not fully understood.
Article
Pharmacology & Pharmacy
Jiang-Min Liu, Quan-Xin Jin, Manabu Fujimoto, Fang-Fang Li, Lin-Bo Jin, Ran Yu, Guang-Hai Yan, Lian-Hua Zhu, Fan-Ping Meng, Qing-Gao Zhang, Gui-Hua Jin
Summary: DHA inhibits the progression of psoriasis by regulating the expression of Th17 cells and related cytokines, improving skin symptoms and immune cell infiltration, restoring cellular composition in the spleen, and ultimately suppressing the development of psoriasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yongsheng Luo, Jingjing Guo, Pingbao Zhang, Yin Celeste Cheuk, Yamei Jiang, Jiyan Wang, Shihao Xu, Ruiming Rong
Summary: The increase in Th17-mediated pro-inflammatory response and decrease in Treg-mediated anti-inflammatory effect aggravate renal tubular epithelial cell injury. MSC can control the imbalance between Th17 and Treg by inhibiting mTOR signaling, promoting Treg generation while restraining Th17 differentiation. This suggests that MSC-mediated Th17-to-Treg polarization could serve as a new immunotherapy approach for kidney injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ying Wang, Ningning Xue, Ziyuan Wang, Xin Zeng, Ning Ji, Qianming Chen
Summary: With improving quality of life, the pressure on oral health is increasing. Common oral mucosal diseases, such as oral lichen planus and gingivitis, are related to the destruction of the oral immune barrier. T-helper 17 (Th17) cells and their cytokines play vital roles in maintaining oral immune homeostasis. An excessive Th17/IL-17 response can lead to autoimmune damage, highlighting the importance of understanding the role of Th17 cells in oral mucosa and their potential as therapeutic targets for oral mucosal diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li, Zhiwen Zhang
Summary: The study found that high expression of miR-206 in patients with OA was positively correlated with peripheral Th17/Treg imbalance. MiR-206 disrupted the Th17/Treg balance by targeting SOCS3 and Foxp3. In vivo experiments showed that antagomiR against miR-206 restored the Th17/Treg balance during the development of OA.
MOLECULAR MEDICINE
(2021)
