Review
Biochemistry & Molecular Biology
Francesca Reggiani, Giulia Gobbi, Alessia Ciarrocchi, Valentina Sancisi
Summary: YAP and TAZ are paralog transcriptional regulators that play roles in cell growth and differentiation by integrating mechanical, metabolic, and signaling inputs. They have both common and distinctive structural features and regulatory mechanisms, interacting with different transcriptional partners and controlling nonidentical transcriptional programs. Despite being considered functionally redundant in most literature, they have distinct or even contrasting roles in different contexts, implying significant implications for mechanistic and translational studies.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Review
Cell Biology
Mylene Zarka, Eric Hay, Martine Cohen-Solal
Summary: YAP and TAZ are key regulators in organ growth and bone biology, responding to mechanical and cytoskeletal cues to control cell fate. They play significant roles in bone and cartilage homeostasis and their precise functions have been investigated in mouse and cellular models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Regina Komsa-Penkova, Adelina Yordanova, Pencho Tonchev, Stanimir Kyurkchiev, Svetla Todinova, Velichka Strijkova, Mario Iliev, Borislav Dimitrov, George Altankov
Summary: This study reveals that the structural changes of collagen caused by oxidization significantly affect the behavior of adipose tissue-derived mesenchymal stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Haofeng Wu, Yachong Liu, Zhibin Liao, Jie Mo, Qiaofeng Zhang, Bixiang Zhang, Lei Zhang
Summary: This article reviews the role of YAP1 in liver cancer stem cells and its correlation with tumor initiation and progression.
BIOMARKER RESEARCH
(2022)
Review
Immunology
Hui Liu, Mingyue Sun, Nan Wu, Bin Liu, Qingxin Liu, Xueli Fan
Summary: Vascular remodeling is a fundamental pathological process characterized by abnormal changes in the morphology, structure, and function of vascular cells. Various growth factors and pathways, including TGF-beta, VEGF, and Hippo-YAP/TAZ signaling pathway, play important roles in vascular remodeling. Inflammatory reactions contribute to changes in vascular structure and microenvironment, leading to vascular remodeling.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Chunle Zhao, Jun Gong, Yu Bai, Taoyuan Yin, Min Zhou, Shutao Pan, Yuhui Liu, Yang Gao, Zhenxiong Zhang, Yongkang Shi, Feng Zhu, Hang Zhang, Min Wang, Renyi Qin
Summary: With a 5-year survival rate of approximately 10%, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in humans. A study found that the transcriptional coactivator TAZ could be a potential therapeutic target in PDAC. Through unbiased deubiquitinase (DUB) library screening, researchers identified USP14 as a key regulator of TAZ stabilization, and the USP14-TAZ loop was found to promote cancer progression and liver metastasis in PDAC models. Inhibition of USP14 with the small molecule inhibitor IU1 showed promising anti-cancer effects in PDAC models.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Xiaolei Zhao, Li Tang, Tram P. Le, Bao H. Nguyen, Wen Chen, Mingjie Zheng, Hiroyuki Yamaguchi, Brian Dawson, Shuangjie You, Idaliz M. Martinez-Traverso, Shannon Erhardt, Jianxin Wang, Min Li, James F. Martin, Brendan H. Lee, Yoshihiro Komatsu, Jun Wang
Summary: Yap and Taz play redundant roles in determining the specification and differentiation of neural crest cells into osteoblasts or chondrocytes. They interact with the Wnt-beta-catenin pathway to promote osteogenesis and prevent chondrogenesis.
Article
Multidisciplinary Sciences
Kepeng Che, Ajaybabu Pobbati, Caleb N. Seavey, Yuriy Fedorov, Anton A. Komar, Ashley Burtscher, Shuang Ma, Brian P. Rubin
Summary: In this study, the researchers identified a pharmacologically active small molecule called aurintricarboxylic acid (ATA) that can disrupt the formation of the TAZ-TEAD complex. They found that ATA inhibits TC/TEAD transcriptional activity and prevents anchorage-independent growth associated with dysregulated TAZ/TEAD activity.
Article
Chemistry, Medicinal
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Jakub Gunera, Anita Seshire, Lisa Koetzner, Sarah Schlesiger, Djordje Musil, Heike Schilke, Benjamin Doerfel, Patrizia Diehl, Pia Boepple, Ana R. Lemos, Pedro M. F. Sousa, Filipe Freire, Tiago M. Bandeiras, Emma Carswell, Nicholas Pearson, Sameer Sirohi, Mollie Hooker, Elisabeth Trivier, Rebecca Broome, Alexander Balsiger, Abigail Crowden, Christian Dillon, Dirk Wienke
Summary: The dysregulated Hippo pathway and hyperactivity of the YAP/TAZ-TEAD transcriptional complexes are associated with diseases like cancer. This study describes the discovery and optimization of a P-site binding fragment to target the TEAD transcription factors. The optimized in vivo tool, MSC-4106, exhibited desirable potency, mouse pharmacokinetic properties, and in vivo efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ana Sousa-Ortega, Javier Vazquez-Marin, Estefania Sanabria-Reinoso, Jorge Corbacho, Rocio Polvillo, Alejandro Campoy-Lopez, Lorena Buono, Felix Loosli, Maria Almuedo-Castillo, Juan R. Martinez-Morales
Summary: YAP signaling is involved in regulating cell migration during embryonic axis assembly by sustaining intracellular tension. Knockout of yap and yap1b in medaka disrupts axis assembly and reduces cell displacement and migratory persistence. Yap targets genes involved in cytoskeletal organization and cell-ECM adhesion to promote cortical actin and focal adhesions recruitment in migratory cells.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Iwao Shimomura, Naoaki Watanabe, Tomofumi Yamamoto, Minami Kumazaki, Yuji Tada, Koichiro Tatsumi, Takahiro Ochiya, Yusuke Yamamoto
Summary: The study found that verteporfin can effectively inhibit the viability of KRAS-mutant lung cancer cells and suppress KRAS-driven lung tumors. The mechanism of verteporfin action is partially independent of YAP1 inhibition and leads to apoptotic cell death in KRAS-mutant lung cancer cells by inducing endoplasmic reticulum stress pathway.
Review
Biochemistry & Molecular Biology
Boon Chin Heng, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Yan Wei, Martin Fussenegger, Xuliang Deng
Summary: YAP and TAZ are crucial proteins involved in maintaining tissue/organ size and have diverse roles in various biological processes, including cell proliferation, tissue regeneration, cell fate determination, tumorigenesis, and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Zheng-wei Shi, Yuan Tuo, Chao-shuai Feng, Lei Zhu, Zong-rang Song, Tuan-jiang Liu, Ding-jun Hao
Summary: Intervertebral disc degeneration (IVDD) is a common cartilage-degenerative disease and a major cause of low back pain (LBP). The Hippo-YAP/TAZ signaling pathway, as an evolutionarily and functionally conserved pathway, plays a crucial role in IVDD progression. This review discusses the regulation of Hippo-YAP/TAZ signaling, its role in cartilage homeostasis and IVDD, and the potential of using Hippo-YAP/TAZ signaling for IVDD treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Yibo Guo, Juan Luo, Hailin Zou, Chenxin Liu, Liang Deng, Peng Li
Summary: This article provides an overview of the core components and upstream regulators of Hippo-YAP/TAZ signaling in mammals, and systematically summarizes the identified transcription factors or partners responsible for the downstream transcriptional output of YAP/TAZ in various cancers.
Review
Oncology
Caleb N. Seavey, Ajaybabu V. Pobbati, Brian P. Rubin
Summary: Epithelioid hemangioendothelioma (EHE) is a rare vascular cancer with a unique WWTR1(TAZ)-CAMTA1 gene fusion. Studying this disease can provide insights into how dysregulation of TAZ promotes tumorigenesis and these findings can be applied to other YAP/TAZ-dependent cancers.
Article
Ophthalmology
Joshua T. Morgan, Heung Sun Kwon, Joshua A. Wood, Dori L. Borjesson, Stanislav I. Tomarev, Christopher J. Murphy, Paul Russell
EXPERIMENTAL EYE RESEARCH
(2015)
Article
Ophthalmology
Joshua T. Morgan, Vijay Krishna Raghunathan, Yow-Ren Chang, Christopher J. Murphy, Paul Russell
EXPERIMENTAL EYE RESEARCH
(2015)
Article
Oncology
Joshua T. Morgan, Vijay Krishna Raghunathan, Yow-Ren Chang, Christopher J. Murphy, Paul Russell
Article
Materials Science, Biomaterials
Vijay Krishna Raghunathan, Joshua T. Morgan, Yow-Ren Chang, Darren Weber, Brett Phinney, Christopher J. Murphy, Paul Russell
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2015)
Article
Materials Science, Biomaterials
Vijay Krishna Raghunathan, Joshua T. Morgan, Yow-Ren Chang, Darren Weber, Brett Phinney, Christopher J. Murphy, Paul Russell
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2015)
Article
Multidisciplinary Sciences
VijayKrishna Raghunathan, J. Seth Eaton, Brian J. Christian, Joshua T. Morgan, James N. Ver Hoeve, Chen-Yuan Charlie Yang, Haiyan Gong, Carol A. Rasmussen, Paul E. Miller, Paul Russell, T. Michael Nork, Christopher J. Murphy
SCIENTIFIC REPORTS
(2017)
Article
Cell & Tissue Engineering
Joshua T. Morgan, Wade G. Stewart, Robert A. McKee, Jason P. Gleghorn
CELLULAR AND MOLECULAR BIOENGINEERING
(2018)
Article
Ophthalmology
Sara M. Thomasy, Vijay Krishna Raghunathan, Hidetaka Miyagi, Alexander T. Evashenk, Jasmyne C. Sermeno, Geneva K. Tripp, Joshua T. Morgan, Christopher J. Murphy
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Ophthalmology
Joshua T. Morgan, Joshua A. Wood, Naomi J. Walker, Vijay Krishna Raghunathan, Dori L. Borjesson, Christopher J. Murphy, Paul Russell
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2014)
Article
Chemistry, Physical
Christopher C. Zirnmer, Ying X. Liu, Joshua T. Morgan, Guohua Yang, Kang-Hsin Wang, Ian M. Kennedy, Abdul I. Barakat, Gang-yu Liu
JOURNAL OF PHYSICAL CHEMISTRY B
(2014)
Article
Engineering, Biomedical
Yow-Ren Chang, Vijay Krishna Raghunathan, Shaun P. Garland, Joshua T. Morgan, Paul Russell, Christopher J. Murphy
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2014)
Article
Engineering, Biomedical
Joshua T. Morgan, Jasmine Shirazi, Erica M. Comber, Christian Eschenburg, Jason P. Gleghorn
Article
Endocrinology & Metabolism
Joshua T. Morgan, Alan K. Robbins, Abigail B. Mateson, Kazuki Sawamoto, Shunji Tomatsu, Dione R. Gray, Jason P. Gleghorn, Julia Spencer Barthold
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
Jasmine Shirazi, Joshua T. Morgan, Erica M. Comber, Jason P. Gleghorn
Article
Ophthalmology
Vijay Krishna Raghunathan, Joshua T. Morgan, Shin Ae Park, Darren Weber, Brett S. Phinney, Christopher J. Murphy, Paul Russell
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)