Article
Immunology
Elisabet Van Loon, Baptiste Lamarthee, Thomas Barba, Sandra Claes, Maarten Coemans, Henriette de Loor, Marie-Paule Emonds, Priyanka Koshy, Dirk Kuypers, Paul Proost, Aleksandar Senev, Ben Sprangers, Claire Tinel, Olivier Thaunat, Amaryllis H. Van Craenenbroeck, Dominique Schols, Maarten Naesens
Summary: Through multiplex assay, we found that kidney transplant patients with donor-specific anti-human leukocyte antigen antibodies and histological rejection have increased levels of pro-inflammatory cytokines in blood. Even in patients without histological rejection, elevated pro-inflammatory cytokine levels can be observed. These findings challenge the concept of histology as the gold standard for identifying ongoing allo-immune activation after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
James E. Crowe
Summary: Antibodies have been widely used for preventing and treating viral infections since the nineteenth century, and the development of potent human monoclonal antibodies has paved the way for unprecedented activities. Modifications that extend antibody half-life and the clinical development of broad and potent antibodies have the potential to make antibodies the principal tool in managing future viral epidemics. Furthermore, these antibodies are crucial for research and developing effective vaccines.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Review
Immunology
Henning Jacobsen, Sabra L. Klein
Summary: The ongoing COVID-19 pandemic has highlighted the sex-specific differences in immunity and outcomes following SARS-CoV-2 infection, with evidence suggesting a male bias in disease severity mediated by differential immune responses. While males are more susceptible to most viral infections, females possess immunological features that make them vulnerable to distinct immune-related disease outcomes. Sex chromosome complement, related genes, and sex steroids all play crucial roles in mediating these sex differences in immunity to viral infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jorge Andrade-Sierra, Alfonso M. Cueto-Manzano, Enrique Rojas-Campos, Ernesto Cardona-Munoz, Jose Cerrillos-Gutierrez, Eduardo Gonzalez-Espinoza, Luis A. Evangelista-Carrillo, Miguel Medina-Perez, Basilio Jalomo-Martinez, Juan Nieves Hernandez, Leonardo Pazarin-Villasenor, Claudia A. Mendoza-Cerpa, Benjamin Gomez-Navarro, Alejandra G. Miranda-Diaz
Summary: The study compares the incidence of DSA in renal transplantation with and without steroids in immunosuppression, finding that early steroid withdrawal may favor the positivity of DSA. T-cell mediated rejection is associated with the development of DSA, particularly DSA class II. Strict monitoring of DSA is necessary in the early stages of transplantation to clarify the relationship between T-cell mediated rejection and DSA.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Hematology
Xiaoli Zheng, Hongmin Yan, Dongmei Han, Li Ding, Ling Zhu, Jing Liu, Mei Xue, Sheng Li, Hengxiang Wang
Summary: The combination of rituximab, high-dose IVIG, and PE proved to be effective in desensitizing haploidentical allograft recipients with high levels of DSA, leading to successful hematopoietic recovery and overall good survival outcomes.
ANNALS OF HEMATOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Giuseppe Pantaleo, Bruno Correia, Craig Fenwick, Victor S. Joo, Laurent Perez
Summary: Monoclonal antibodies are attractive as potential therapeutics and prophylactics for viral infections due to their high specificity and ability to enhance immune responses. Advances in antibody engineering and structural biology have led to the development of monoclonal antibodies targeting various viruses, and have implications for vaccine design.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Article
Immunology
Julien Subburayalu, Sebastian Dolff, Shilei Xu, Ming Sun, Monika Lindemann, Andreas Heinold, Falko M. Heinemann, Jan Willem Cohen Tervaert, Ute Eisenberger, Johannes Korth, Alexandra Brinkhoff, Andreas Kribben, Oliver Witzke, Benjamin Wilde
Summary: TFH cells and TFR cells play important roles in the formation of dnDSA after renal transplant. Activation of TFH cells is associated with the development of dnDSA, while TFR cells have an inhibitory effect on TFH cells.
CLINICAL IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Adrienne Seitz, Katherine Mounsey, Pamela Hughes, Katherine Cullen, Matthew Welberry Smith, Sunil Daga, Clive Carter, Brendan Clark, Richard Baker
Summary: This study aimed to evaluate the clinical outcomes of renal transplants with pre-existing isolated HLA-DP-DSAs. The results showed that the presence of HLA-DP-DSAs was a major factor associated with antibody-mediated rejection, and patients with HLA-DP-DSAs showed more severe pathological changes on biopsy.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Medicine, General & Internal
Jin Zheng, Hui Guo, Hui-Lin Gong, Ping Lan, Chen-Guang Ding, Yang Li, Xiao-Ming Ding, Wu-Jun Xue
Summary: PTC C4d+ is mainly observed in cases of AMR. DSAs, glomerulitis, and HLA B eplet MM are independent risk factors for PTC C4d+. The combination of DSAs, glomerulitis, and HLA B eplet MM improves the predictability of PTC C4d+.
CHINESE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Michael Y. T. Chow, Harry W. Pan, Han Cong Seow, Jenny K. W. Lam
Summary: Monoclonal antibodies are an exciting therapeutic option for respiratory viral infections. However, their delivery to the airways is challenging due to the limitations of conventional parenteral administration. Inhaled therapy and advancements in antibody engineering offer potential solutions to enhance the efficacy and safety of neutralizing antibodies against respiratory viral infections.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Rebecca Abraham, Madeleine S. Durkee, Junting Ai, Margaret Veselits, Gabriel Casella, Yuta Asano, Anthony Chang, Kichul Ko, Charles Oshinsky, Emily Peninger, Maryellen L. Giger, Marcus R. Clark
Summary: This study reveals that different inflammatory states are associated with the severity and progression of lupus nephritis. Higher densities of B cells are associated with immune protection, while higher densities of CD8+, d cells, and other CD4-CD8- T cells are associated with renal failure and disease progression.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Microbiology
Eric Lewitus, Samantha M. Townsley, Yifan Li, Gina C. Donofrio, Bethany L. Dearlove, Hongjun Bai, Eric Sanders-Buell, Anne Marie O'Sullivan, Meera Bose, Hannah Kibuuka, Lucas Maganga, Sorachai Nitayaphan, Fredrick K. Sawe, Leigh Anne Eller, Nelson L. Michael, Victoria R. Polonis, Julie A. Ake, Sandhya Vasan, Merlin L. Robb, Sodsai Tovanabutra, Shelly J. Krebs, Morgane Rolland
Summary: This study investigates the relationship between diversity in the HIV-1 envelope gene and the development of neutralization breadth. The results suggest that the presence of slightly different HIV-1 variants in the early stages of infection may promote the induction of broadly neutralizing antibodies. Vaccination with a mixture of minimally distant antigens could be a potential strategy for eliciting broadly neutralizing antibodies.
Article
Multidisciplinary Sciences
Tiago Fazolo, Karina Lima, Julia C. Fontoura, Priscila Oliveira de Souza, Gabriel Hilario, Renata Zorzetto, Luiz Rodrigues Junior, Veridiane Maria Pscheidt, Jayme de Castilhos Ferreira Neto, Alisson F. Haubert, Izza Gambin, Aline C. Oliveira, Raissa S. Mello, Matheus de Bastos Balbe E Gutierres, Rodrigo Benedetti Gassen, Lais Durco Coimbra, Alexandre Borin, Rafael Elias Marques, Ivaine Tais Sauthier Sartor, Gabriela Oliveira Zavaglia, Ingrid Rodrigues Fernandes, Helder Nakaya, Fernanda Hammes Varela, Marcia Polese-Bonatto, Thiago J. Borges, Sidia Maria Callegari-Jacques, Marcela Santos Correa da Costa, Jaqueline de Araujo Schwartz, Marcelo Comerlato Scotta, Renato T. Stein, Cristina Bonorino
Summary: The study reveals that children with COVID-19 exhibit stronger cellular immunity but higher viral load compared to adults, suggesting a differential response mechanism between children and adults in the disease manifestation.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
T. Tramper, D. L. Roelen, S. H. Brand-Schaaf, J. A. Kal-van Gestel, M. M. L. Kho, M. E. J. Reinders, J. I. Roodnat, J. van de Wetering, M. G. H. Betjes, A. E. de Weerd
Summary: In this retrospective analysis, the impact of donor-specific antibodies (DSA) in HLA-incompatible living donor kidney transplant recipients was studied. The results showed that recipients with DSA had inferior graft survival compared to those without DSA, and this effect was independent of the flowcytometric crossmatch, MFI value, HLA class, and origin of DSA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xinyu Xiang, Yu Tao, Jonathan DiRusso, Fei-Man Hsu, Jinchun Zhang, Ziwei Xue, Julien Pontis, Didier Trono, Wanlu Liu, Amander T. Clark
Summary: This study unveils the crucial role of Hominidae-specific transposable element LTR5Hs in the specification of primordial germ cells (PGCs) in humans. LTR5Hs becomes transcriptionally active during PGC specification and facilitates germ cell development.
NATURE COMMUNICATIONS
(2022)
Article
Surgery
Michael Mengel, Alexandre Loupy, Mark Haas, Candice Roufosse, Maarten Naesens, Enver Akalin, Marian C. Clahsen-van Groningen, Jessy Dagobert, Anthony J. Demetris, Jean-Paul Duong van Huyen, Juliette Gueguen, Fadi Issa, Blaise Robin, Ivy Rosales, Jan H. Von Der Thusen, Alberto Sanchez-Fueyo, Rex N. Smith, Kathryn Wood, Benjamin Adam, Robert B. Colvin
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Alexandre Loupy, Mark Haas, Candice Roufosse, Maarten Naesens, Benjamin Adam, Marjan Afrouzian, Enver Akalin, Nada Alachkar, Serena Bagnasco, Jan U. Becker, Lynn D. Cornell, Marian C. Clahsen-van Groningen, Anthony J. Demetris, Duska Dragun, Jean-Paul Duong van Huyen, Alton B. Farris, Agnes B. Fogo, Ian W. Gibson, Denis Glotz, Juliette Gueguen, Zeljko Kikic, Nicolas Kozakowski, Edward Kraus, Carmen Lefaucheur, Helen Liapis, Roslyn B. Mannon, Robert A. Montgomery, Brian J. Nankivell, Volker Nickeleit, Peter Nickerson, Marion Rabant, Lorraine Racusen, Parmjeet Randhawa, Blaise Robin, Ivy A. Rosales, Ruth Sapir-Pichhadze, Carrie A. Schinstock, Daniel Seron, Harsharan K. Singh, Rex N. Smith, Mark D. Stegall, Adriana Zeevi, Kim Solez, Robert B. Colvin, Michael Mengel
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Letter
Hematology
Brian Hanley, Candice A. Roufosse, Michael Osborn, Kikkeri N. Naresh
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Editorial Material
Urology & Nephrology
T. Alp Ikizler
KIDNEY INTERNATIONAL
(2020)
Article
Urology & Nephrology
Aikaterini Nikolopoulou, Catarina Teixeira, H. Terry Cook, Candice Roufosse, Thomas H. D. Cairns, Jeremy B. Levy, Charles D. Pusey, Megan E. Griffith
Summary: This study described a cohort of patients with MN associated with viral infections, including rare cases of HIV-MN with PLA2R and THSD7A positivity. Further investigation is needed to explore the mechanism of coincidental or viral-related MN.
CLINICAL KIDNEY JOURNAL
(2021)
Letter
Urology & Nephrology
Maria Prendecki, Candice Clarke, Tom Cairns, Terry Cook, Candice Roufosse, David Thomas, Michelle Willicombe, Charles D. Pusey, Stephen P. McAdoo
KIDNEY INTERNATIONAL
(2020)
Editorial Material
Surgery
Maarten Naesens, Mark Haas, Alexandre Loupy, Candice Roufosse, Michael Mengel
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cell Biology
Andreas Kousios, Stephen Mcadoo, Sarah Blakey, Linda Moran, Maria Atta, Frederick W. K. Tam, H. Terence Cook, Aristeidis Chaidos, Candice Roufosse
Article
Urology & Nephrology
Benjamin A. Adam, Naoka Murakami, Graeme Reid, Katie Du, Ruqaya Jasim, Christie L. Boils, Lihong Bu, Peter D. Hill, Allan G. Murray, Karine Renaudin, Candice Roufosse, Astrid Weins, Kevin Wen, Leonardo V. Riella, Michael Mengel
Summary: This study found significant molecular overlap between immune checkpoint inhibitor-associated acute interstitial nephritis and T cell-mediated rejection. A novel biomarker, IFI27, was identified and validated to differentiate between these entities. Biopsy-based measurement of IFI27 gene expression represents a potential tool for distinguishing immune checkpoint inhibitor-associated rejection from acute interstitial nephritis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Oncology
Maria Prendecki, Kavita Gulati, Tabitha Turner-Stokes, Gurjeet Bhangal, Derick Chiappo, Kevin Woollard, H. Terence Cook, Frederick W. K. Tam, Candice Roufosse, Charles D. Pusey, Stephen P. McAdoo
Summary: Experimental autoimmune vasculitis (EAV) induced by myeloperoxidase (MPO) immunization in susceptible rat strains can be augmented by sub-nephritogenic dose of nephrotoxic serum (NTS) containing heterologous antibodies, leading to increased severity of glomerulonephritis with important features of human disease. The pauci-immune glomerulonephritis is strictly dependent on autoimmunity to MPO, showcasing potential for studying glomerular leukocyte behavior and novel therapeutics in antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV).
JOURNAL OF PATHOLOGY
(2021)
Article
Rheumatology
Kavita Gulati, Candice Roufosse, Stephen P. McAdoo
Article
Pathology
Edwin Garcia, Jonathan Lightley, Sunil Kumar, Ranjen Kalita, Frederik Gorlitz, Yuriy Alexandrov, Terry Cook, Christopher Dunsby, Mark A. A. Neil, Candice A. Roufosse, Paul M. W. French
Summary: The combination of electron microscopy (EM) and immunofluorescence (IF) imaging is crucial for diagnosing human glomerular diseases, but EM is limited to specialized institutions and not widely available. Recent advancements in fluorescence microscopy now allow for cost-effective adaptation of conventional widefield microscopes to provide super-resolved image information in biological specimens. By applying single-molecule localization microscopy to clinical histological sections stained with standard IF techniques, it is possible to enhance imaging resolution and aid in the diagnosis of kidney diseases where EM is not available.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2021)
Article
Oncology
Sandra Gray-Rodriguez, Melanie P. Jensen, Maria Otero-Jimenez, Brian Hanley, Olivia C. Swann, Patrick A. Ward, Francisco J. Salguero, Nadira Querido, Ildiko Farkas, Elisavet Velentza-Almpani, Justin Weir, Wendy S. Barclay, Miles W. Carroll, Zane Jaunmuktane, Sebastian Brandner, Ute Pohl, Kieren Allinson, Maria Thom, Claire Troakes, Safa Al-Sarraj, Magdalena Sastre, Djordje Gveric, Steve Gentleman, Candice Roufosse, Michael Osborn, Javier Alegre-Abarrategui
Summary: This study comprehensively validates and analyzes the organ tropism of SARS-CoV-2 at the histological level. The findings demonstrate the widespread involvement of the respiratory, digestive, haematopoietic, genitourinary, and nervous systems. The results provide important insights into the transmission and pathogenic mechanisms of the virus.
JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Shenzhen Tempest-Roe, Maria Prendecki, Stephen P. McAdoo, Candice Clarke, Anisha Tanna, Tabitha Turner-Stokes, Esteban S. Masuda, Michelle Willicombe, H. Terence Cook, Candice Roufosse, David Taube, Charles D. Pusey, Frederick W. K. Tam
Summary: The study found that treatment with the selective SYK inhibitor fostamatinib in sensitized rats effectively blocked the production of circulating DSA without affecting overall immunoglobulin levels, and this inhibition was sustained up to 5 weeks post-completion of the treatment regimen. The treatment did not impact the levels of mature B cell subsets or plasma cells, indicating a potential alternative therapeutic option for patients at risk of sensitization while awaiting renal transplant.
SCIENTIFIC REPORTS
(2022)
Article
Transplantation
Frederic Toulza, Kathy Dominy, Michelle Willicombe, Jack Beadle, Eva Santos, H. Terence Cook, Richard M. Szydlo, Adam McLean, Candice Roufosse
Summary: This study investigates the application of 'increased expression of thoroughly validated gene transcripts/classifiers strongly associated with AMR' as diagnostic criteria.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)