Review
Biochemistry & Molecular Biology
Hyung-Keun Lee, Sang-Mok Lee, Dong-Ihll Lee
Summary: The cornea, a transparent and avascular tissue, plays a crucial role in light refraction and acts as a physical barrier against the external environment. Corneal avascularity is a unique histological feature that is essential for maintaining corneal immune privilege. While corneal lymphangiogenesis is recognized as a common pathological feature in various eye diseases, it has not been studied as extensively as hemangiogenesis. Researchers are focusing on understanding the pathogenesis of ocular lymphangiogenesis, particularly in conditions like corneal allograft rejection and dry eye disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joon Keit Loi, Yannick O. Alexandre, Kirthana Senthil, Dominik Schienstock, Sarah Sandford, Sapna Devi, Susan N. Christo, Laura K. Mackay, Holly R. Chinnery, Peregrine B. Osborne, Laura E. Downie, Erica K. Sloan, Scott N. Mueller
Summary: This study used intravital microscopy to investigate T cell responses in the cornea and identified the presence of tissue-resident memory T (T-RM) cells, which can provide local protective immunity.
Review
Pathology
Michael J. Zilliox, Charles S. Bouchard
Summary: The ocular surface microbiome is a new and emerging field of study that focuses on the microorganisms found on the surface of the eye and their role in maintaining homeostasis and causing diseases. It is not yet clear whether these microorganisms inhabit the ocular surface and if there is a core microbiome present in healthy eyes. The presence of novel organisms and their redistribution may play a role in disease pathogenesis, response to therapies, and the healing process. However, there are technical challenges in studying the ocular surface microbiome, and standardization is needed to advance the field.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biochemical Research Methods
Pei-Shan Wu, Hsin-Yu Liu, Tzu-Hsuan Wong, Jui-Ti Lin, Fung-Rong Hu, Miao-Hsia Lin
Summary: This study used proteomic analysis to investigate the molecular changes in corneal stroma during storage. The findings suggest that longer preservation time leads to downregulation of proteins involved in ocular surface immunomodulation and upregulation of proteins associated with extracellular matrix reorganization and fibrosis. This may result in stromal fibrosis, compromising tissue clarity and vision.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Hui Shi, Jianhong Zhou, Yuan Wang, Yutuo Zhu, Deqing Lin, Lei Lei, Serhii Vakal, Jiaqing Wang, Xingyi Li
Summary: This study presents a minimally invasive delivery system for treating fungal keratitis using a dissolving microneedle patch based on Poly(D,L-lactide) and hyaluronic acid. The microneedle patch shows excellent properties and can penetrate the cornea with no ocular irritation. In a rabbit model, the microneedle patch medication exhibits superior therapeutic effects compared to eye drops and is comparable to intrastromal injection, offering a cost-effective treatment solution.
Article
Ophthalmology
Robert C. Augusteyn, Ashik Mohamed
Summary: This study examined the effects of age, gender, and population origin on human globe and corneal dimensions and explored the relationships between these dimensions. The findings showed an asymptotic increase in globe and corneal dimensions with age until late teens, with significant correlations between population and dimensions in individuals over the age of 20. Male globes and corneas were larger than female ones, and dimensions in Hyderabad were significantly larger than in Miami.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Emergency Medicine
Timothy Kolosionek, Danielle A. Sultan, Katherine Tsay, Kristine L. Schultz, Richard S. MacKenzie, Nicole C. Elliott
Summary: Globe rupture is a visually striking and sight-threatening injury that requires timely ophthalmologic surgical intervention for optimal outcomes. While most cases are due to ocular trauma, this case highlights a rare instance of spontaneous globe rupture in a patient with a history of extensive ocular surgeries.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Manuel Chacon, Manuel Sanchez, Natalia Vazquez, Mairobi Persinal-Medina, Sergio Alonso-Alonso, Begona Baamonde, Jose F. Alfonso, Luis Fernandez-Vega-Cueto, Jesus Merayo-Lloves, Alvaro Meena
Summary: Impedance analysis can be used to evaluate cell maturation and detect slight cell damages in RhCE models, providing a faster and simpler method for assessing ocular irritancy with comparable accuracy to current methodologies.
BIOELECTROCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Seongchan Kim, Yoon Young Choi, Taewan Kim, Yong Min Kim, Dong Hae Ho, Young Jin Choi, Dong Gue Roe, Ju-Hee Lee, Joongpill Park, Ji-Woong Choi, Jeong Won Kim, Jin-Hong Park, Sae Byeok Jo, Hong Chul Moon, Sohee Jeong, Jeong Ho Cho
Summary: In this paper, a biomimetic ocular prosthesis system based on quantum dots embedded photonic synapses is proposed. By mimicking human light modulation response and emulating pupil and corneal reflections, the system can perceive objects and regulate the intensity of external stimuli.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analia Trevani, Jeremias G. Galletti
Summary: Proper sight depends on a smooth and transparent cornea, and corneal nerves play a crucial role in maintaining corneal integrity and immunoregulation. This study found that the type of immune response can influence the development of corneal neuropathy, with Th1-skewed immune response leading to corneal nerve damage. However, Th2-skewed immune response also resulted in mild corneal neuropathy, potentially due to adjuvant-induced neurotoxicity. These findings have implications for therapeutic interventions in ocular surface disorders.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Oncology
Yue Xu, Ying-Ming Wang, Zheng-Tai Sun, Xiao-Long Yang, Xin-Yu Zhuang, Ya-Ru Ren, Ying-Jie Chen, Feng Chen, Xiao Ma, Xiao-Wen Tang, Xiao-Feng Zhang
Summary: This study retrospectively reported seven cases of corneal perforation after allogeneic hematopoietic stem cell transplantation. The results showed that corneal perforation patients often have involvement of other GVHD organs. Early diagnosis and long-term follow-up are crucial for visual recovery in these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Muhammed Batur, Muhammet Derda Ozer, Rifki Ucler, Erbil Seven, Serek Tekin, Fikret Unal
Summary: This study compared ocular findings of acromegaly patients with healthy individuals and found a possible correlation between serum IGF-1 and GH levels with ocular parameters. Increased lens length was observed in acromegaly patients, and pituitary tumor size was associated with thinning of the retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Ophthalmology
Theodore Bowe, Anthony Serina, Mikhayla Armstrong, Jennifer E. Welcher, Olumuyiwa Adebona, Charlotte Gore, Steven J. Staffa, David Zurakowski, Ankoor S. Shah
Summary: The study evaluated the timing of ocular hypertension after pediatric closed-globe injury and traumatic hyphema, finding that OHT occurred at different periods and identifying several risk factors.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Pharmacology & Pharmacy
Liping Li, Fan Jia, Youxiang Wang, Jiamin Liu, Yi Tian, Xinghuai Sun, Yuan Lei, Jian Ji
Summary: This review focuses on recent advancements in using nanomaterials for efficient drug transport across the cornea, categorizing and analyzing their mechanisms, and examining potential principles to improve drug penetration through the cornea and other natural barriers in the eye. The aim is to inspire the development of more effective drug delivery systems for better treatment of ocular diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Maddalena De Bernardo, Livio Vitiello, Mario Gagliardi, Luigi Capasso, Nicola Rosa, Carolina Ciacci
Summary: This observational case-control study evaluated the anterior ocular segment parameters of patients with celiac disease using a Scheimpflug imaging system and found no significant differences compared to a healthy controls group. However, routine ophthalmological examinations are recommended for celiac patients due to potential ocular manifestations of the disease.
SCIENTIFIC REPORTS
(2022)
Letter
Ophthalmology
Bhupesh Bagga, Savitri Sharma, Ruchi Pratap Singh Gour, Joveeta Joseph, Ashik Mohamed, Varsha Rathi, Prashant Garg
Article
Ophthalmology
Swathi Kaliki, Richa Dharap Wagh, Vijitha S. Vempuluru, Anasua Ganguly Kapoor, Saumya Jakati, Dilip K. Mishra, Ashik Mohamed
Summary: Orbital tumour extension of ocular surface squamous neoplasia (OSSN) is rare and is associated with risk factors such as outdoor occupation, HIV infection, prolonged duration of symptoms, and tumour bilaterality.
Article
Ophthalmology
Bhupesh Bagga, Pratima Vishwakarma, Savitri Sharma, Joveeta Jospeh, Sanchita Mitra, Ashik Mohamed
Summary: This study assessed the sensitivity and concordance of potassium hydroxide and calcofluor white (KOH+CFW) mount in the diagnosis of Pythium keratitis. The results showed that KOH+CFW has good sensitivity and specificity in diagnosing Pythium keratitis, and there is good concordance among the three microbiologists.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Shravya Sri Durgam, Sowjanya Bagari, Sushma Nandyala, Ashik Mohamed, Nagaraju Konda, Sunita Chaurasia, Pravin K. Vaddavalli, Jean-Marie Parel
Summary: This study evaluated the visual photosensitivity threshold and objective photosensitivity luminance in healthy eyes, providing normative data for understanding diseases causing photophobia.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2022)
Article
Ophthalmology
Mayank Rai, Ashik Mohamed, Sunita Chaurasia, Sirisha Senthil
Summary: This study assessed the efficacy of Ahmed glaucoma valve (AGV) in controlling intraocular pressure (IOP) in eyes with Descemet's stripping endothelial keratoplasty (DSEK) and glaucoma, and identified risk factors for failure. The results showed that AGV was effective in IOP control but had a high risk of long-term graft failure in eyes requiring tube intervention.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Philippa Lloyd, Mark Westcott, Swathi Kaliki, Xunda Ji, Yihua Zou, Riffat Rashid, Sadia Sultana, Sadik Taju Sherief, Nathalie Cassoux, Rosdali Yesenia Diaz Coronado, Juan Luis Garcia Leon, Arturo Manuel Zapata Lopez, Vladimir G. Polyakov, Tatiana L. Ushakova, Soma Rani Roy, Alia Ahmad, Lamis Al Harby, Jesse L. Berry, Jonathan Kim, Ashley Polski, Nicholas J. Astbury, Covadonga Bascaran, Sharon Blum, Richard Bowman, Matthew J. Burton, Allen Foster, Nir Gomel, Naama Keren-Froim, Shiran Madgar, Andrew W. Stacey, Ashik Mohamed, Marcia Zondervan, Mandeep S. Sagoo, Ido Didi Fabian, M. Ashwin Reddy
Summary: This cohort study found no association between advanced maternal age, birth order, or GDP per capita and the development of a de novo pathogenic variant in RB1.
Article
Ophthalmology
Ashi Morawala, Ashik Mohamed, Ajay Krishnamurthy, Sai Divya Jajapuram, Swathi Kaliki
Summary: This study assessed the prognostic value of the T category of the 8th edition AJCC classification in periocular sebaceous gland carcinoma (SGC). The results showed that T4 tumors had higher rates of lymph node metastasis, systemic metastasis, and death compared to T1, T2, and T3 tumors. However, there was no significant association between T category and tumor recurrence.
Article
Ophthalmology
Jaishree Gandhi, Satyashree Gagan, Ashik Mohamed, Taraprasad Das, Vivek Pravin Dave, Joveeta Joseph
Summary: The study suggests that vitreous Galactomannan (GM) and 1,3 beta-D-Glucan (BDG) levels can be used for the diagnosis of fungal endophthalmitis, including culture-negative cases.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Anahita Kate, Bhupesh Bagga, Lakshmi Prasanna Ponnapati, Shalini Singh, Sahil Shah, Ashik Mohamed, Joveeta Joseph
Summary: The purpose of this study was to compare the clinico-microbiological features and outcomes of Serratia keratitis and Pseudomonas aeruginosa keratitis. The results showed that Serratia keratitis usually occurs in eyes with a compromised surface and has good resolution with medical therapy. There were no significant differences in outcomes between Serratia and Pseudomonas aeruginosa keratitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Biochemical Research Methods
Duardo Martinez-Enriquez, Andrea Curatolo, Alberto de Castro, Judith S. Birkenfeld, Ana M. Gonzalez, Ashik Mohamed, Marco Ruggeri, Fabrice Manns, Zvietcovich Fernando, Susana Marcos
Summary: In this study, we successfully estimated the full shape of the in vivo crystalline lens using the eigenlenses method, which only utilizes information visible through the pupil. Compared to previous methods, eigenlenses showed improved repeatability, robustness, and computational resource utilization in estimating crystalline lens shape. Eigenlenses can efficiently describe the full shape changes of the crystalline lens with accommodation and refractive error.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Goura Chattannavar, Ashik Mohamed, Vishwesh Malgi, Ramesh Kekunnaya
Summary: This study compared the visual, refractive, and surgical outcomes of intraocular lens (IOL) implantation and aphakia in children with microspherophakia. The results showed that in-the-bag IOL implantation can be considered as a treatment option, especially in developing nations with limited resources for regular follow-up.
BMJ OPEN OPHTHALMOLOGY
(2023)
Article
Biochemical Research Methods
Eduardo Martinez-Enriquez, Bianca Maceo Heilman, Alberto de Castro, Ashik Mohamed, Marco Ruggeri, Fermamdp Zvietcovich, Fabrice Manns, Susana Marcos
Summary: Quantifying the geometry of human crystalline lens as a function of age and accommodation is crucial for better treatments of cataract and presbyopia. This study validates the use of eigenlenses to estimate the full shape of dis-accommodated lenses in vivo. The results demonstrate that eigenlenses can accurately estimate the shape of dis-accommodated lenses.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Vijitha S. Vempuluru, Neha Ghose, Monalisha Pattnaik, Ashik Mohamed, Swathi Kaliki
Summary: This study compared the risk factors, clinical features, and management outcomes of ocular surface squamous neoplasia (OSSN) with 360 degrees of limbal involvement (360-OSSN) and segmental limbal involvement (SL-OSSN). The results showed that 360-OSSN patients more often had longer duration of symptoms, prior misdiagnosis, and prior intervention. They also had a higher incidence of scleral fixity, corneal/scleral melt, intraocular and orbital tumor extension, and advanced T stage at presentation compared to SL-OSSN patients. Furthermore, lymph node and distant metastasis were more common in the 360-OSSN group during the follow-up period. Aggressive management is required for this advanced form of the disease.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sirisha Senthil, Mayank Rai, Ashik Mohamed, Bhupesh Bagga, Muralidhar Ramappa
Summary: This study evaluated the efficacy and safety of Ahmed glaucoma valve implantation in pediatric patients with keratoplasty and glaucoma. The results showed significant reduction in intraocular pressure postoperatively, satisfactory AGV survival and corneal graft survival outcomes.
OPHTHALMOLOGY GLAUCOMA
(2022)
Article
Ophthalmology
Vijitha S. Vempuluru, Harini Indusekhar, Ashik Mohamed, Swathi Kaliki
Summary: This study aimed to describe the risk factors, clinical features, management, and outcomes in patients with metastatic conjunctival squamous cell carcinoma (mcSCC). The findings showed that smoking, thicker tumors, orbital tumor extension, and poor tumor differentiation were significant risk factors for mcSCC. In addition, mcSCC was associated with high mortality.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
