期刊
EXPERIMENTAL EYE RESEARCH
卷 92, 期 6, 页码 521-527出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2011.03.015
关键词
ischemia; post-conditioning; rat; retina
资金
- National Institutes of Health (Rockville, MD) [EY10343, EY10343-16S1, AG029795-02, UL1RR024999]
- Illinois Society for the Prevention of Blindness (Chicago, IL)
- France and Chicago Collaborating in the Sciences (The Chicago-France Center, Chicago, IL)
- Dean's Research Advisory Committee of the Division of Biological Sciences of the University of Chicago
- American Academy of Neurology, St Paul, MN
In previous studies, it was shown that post-conditioning, a transient period of brief ischemia following prolonged severe ischemia in the retina, could provide significant improvement in post-ischemic recovery, attenuation of cell loss, and decreased apoptosis. These studies showed that post-conditioning effectively prevented damage after retinal ischemia when it was instituted early (within 1 h) in the post-ischemic period. While post-ischemic conditioning holds high promise of clinical translation, patients often present late after the onset of retinal ischemia and therefore immediate application of this anti-ischemic maneuver is generally not feasible. In this study, we examined the hypothesis that application of a post-conditioning stimulus at 24 h or greater following the end of prolonged ischemia would decrease the extent of ischemic injury. Ischemia was induced in rat retina in vivo. Recovery after ischemia followed by 5 min of post-conditioning brief ischemia 24 or 48 h after prolonged ischemia was assessed functionally (electroretinography) and histologically at 7 days after ischemia and post-conditioning or sham post-conditioning. We found that the brief ischemic stimulus applied 24, but not 48 h after prolonged ischemia significantly improved functional recovery and decreased histological damage induced by prolonged ischemia. We conclude that within a defined time window, delayed post-ischemic conditioning ameliorated post-ischemic injury in rats. Compared to earlier studies, the present work demonstrates for the first time the novel ability of a significantly delayed ischemic stimulus to provide robust neuroprotection in the retina following ischemia. (C) 2011 Elsevier Ltd. All rights reserved.
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