Article
Neurosciences
Yeboah Kofi Gyening, Keren Boris, Mignot Cyril, Richard S. S. Brush, Marie-Cecile Nassogne, Martin-Paul Agbaga
Summary: This article reports a case of SCA34 patient who exhibited early childhood onset and rapidly progressive cerebellar degeneration and retinal dysfunction. Through genetic sequencing, a novel ELOVL4 variant, c.503 T > C (p. L168S), was identified in the patient, and experimental results showed that this variant led to a defect in the synthesis of very long chain fatty acids. The study suggests that imbalance of saturated fatty acids and polyunsaturated fatty acids may be an important factor in the pathogenesis of SCA34.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Gyening Kofi Yeboah, Ekaterina S. Lobanova, Richard S. Brush, Martin-Paul Agbaga
Summary: Lipids, specifically VLC-PUFA and VLC-SFA synthesized by the enzyme ELOVL4, play critical roles in maintaining cellular function in tissues such as the retina and brain. ELOVL4 and its products are essential for life, with mutations affecting fatty acid biosynthesis leading to various tissue-specific human disorders. This review highlights the importance of ELOVL4 and its products in cellular function and the need for further research in understanding their roles.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Dongmei Zhang, Qijun Li, Chenghu Yan, Wei Cong
Summary: The study demonstrates the feasibility of using ATR-FTIR spectroscopy as a rapid screening method for evaluating biomass and lipid content, especially the specific fatty acid profile of microalgae. By analyzing characteristic bands and establishing PLSR models, accurate prediction of the main fatty acid contents in microalgae can be achieved.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Review
Biochemistry & Molecular Biology
Zahra Asefy, Asghar Tanomand, Sirus Hoseinnejhad, Zaker Ceferov, Ebrahim Abbasi Oshaghi, Mohsen Rashidi
Summary: Many clinical studies have shown the beneficial effects of -3 and -6 fatty acids on various diseases, including cardiovascular disorders, asthma, rheumatoid arthritis, osteoporosis, and most cancers. Polyunsaturated fatty acids (PUFAs) have been shown to have a toxic effect on cancer cells, although the exact mechanism is still unknown.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Nutrition & Dietetics
Eveline Gart, Kanita Salic, Martine C. Morrison, Martien Caspers, Wim van Duyvenvoorde, Marieke Heijnk, Martin Giera, Ivana Bobeldijk-Pastorova, Jaap Keijer, Andreas B. Storsve, Petter-Arnt Hals, Robert Kleemann
Summary: Long-term treatment with krill oil leads to increased concentrations of anti-inflammatory compounds in white adipose tissue and liver, resulting in beneficial effects on metabolism and inflammation at the tissue level.
Review
Biochemistry & Molecular Biology
Mayra Montecillo-Aguado, Belen Tirado-Rodriguez, Sara Huerta-Yepez
Summary: Cancer is a global public health issue with a poor prognosis despite advancements in detection and treatment. The role of omega-6 polyunsaturated fatty acids (PUFAs) in apoptosis in cancer is controversial, with some studies supporting their activation and others suggesting inhibition. This review presents diverse molecular mechanisms evidence in both in vitro and in vivo models to clarify the controversial involvement of omega-3 and omega-6 PUFAs in apoptosis mechanisms in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Uzoamaka Nwagbo, Paul S. Bernstein
Summary: Lipids play various roles in the neural system, including synaptic stabilization, DNA regulation, and neuroprotection. They also regulate inflammation, maintain cellular membrane structure, and balance ions and signaling molecules. Imbalance of lipid subgroups is involved in the progress of retinal diseases, and diet can influence their onset, progression, and severity. Very-long-chain polyunsaturated fatty acids (VLC-PUFAs) are found exclusively in mammalian retinas and are depleted in retinas of patients with certain diseases. The implications of reduced VLC-PUFA levels are still not well understood, but dietary supplementation and transgene studies have shown positive outcomes in retinal health and potential therapies against retinal disease.
Article
Environmental Sciences
Xingzhong Wang, Jie Li, Xiang Tan, Weibo Wang, Ying Zheng
Summary: This research aims to investigate the effects of abiotic variables on the fatty acid composition of macroinvertebrate scrapers. The study found that the variation in fatty acids was mainly related to PUFA, SAFA, (1)3 PUFA, and u)6 PUFA. Multiple factor analysis showed a strong correlation between the fatty acid profiles and the physical variables of the scrapers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Agata Grzybkowska, Katarzyna Anczykowska, Jedrzej Antosiewicz, Szczepan Olszewski, Magdalena Dzitkowska-Zabielska, Maja Tomczyk
Summary: The aim of this study was to identify suitable reference genes for physical exercise and omega-3 fatty acids supplementation intervention. The qRT-PCR method was used to test the mRNA levels of six potential reference genes in the leukocytes of 18 eligible participants. Multiple algorithms were used to analyze the results and found GAPDH, TUBB, and HPRT to be the most stably expressed genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Ramesh Kumar Saini, Awraris Derbie Assefa, Young-Soo Keum
Summary: This study aimed to analyze the fatty acid composition of spices and herbs and found significant variations among different types; seed spices are rich in oleic and linoleic acids while herbs contain palmitic, stearic, oleic, linoleic, and alpha-linolenic acids; based on fat quality indices, cumin, coriander, fennel, and dill seeds are considered to have the healthiest fatty acid profiles.
Article
Biotechnology & Applied Microbiology
Marco Sebastiano Nicolo, Concetta Gugliandolo, Maria Giovanna Rizzo, Vincenzo Zammuto, Nicola Cicero, Giacomo Dugo, Salvatore Pietro Paolo Guglielmino
Summary: The study aimed to analyze biomass production and fatty acid profiles in Coccomyxa AP01 under different nutritional conditions. Results showed that nutrient deprivation induced significant changes in fatty acid profiles, with phosphate deprivation leading to high biomass yield and production of valuable saturated and polyunsaturated fatty acids. Coccomyxa AP01 is considered a promising source of various fatty acids for commercial purposes, including biodiesel production, pharmaceutical and cosmetic applications, and aquaculture fish feeds.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Mingliang Zhang, Huaidong Zhang, Qin Li, Yangle Gao, Lijun Guo, Liu He, Shanshan Zang, Xing Guo, Jianzhong Huang, Li Li
Summary: This study presents the crystal structure of a trans-acting enoyl reductase from Shewanella piezotolerans, providing insights into the biosynthetic mechanisms of microbial long-chain polyunsaturated fatty acids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Ramesh Kumar Saini, Abdur Rauf, Anees Ahmed Khalil, Eun-Young Ko, Young-Soo Keum, Sirajudheen Anwar, Abdulwahab Alamri, Kannan R. R. Rengasamy
Summary: The study characterized sterols and fatty acid compositions of fifteen types of edible mushrooms marketed in Korea, finding significant variations in sterol contents. Ergosterol was the most abundant sterol, while linoleic acid was the most common fatty acid. The fat quality indices indicated that mushroom fats are beneficial for health.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Review
Cardiac & Cardiovascular Systems
Camila Tureck, Bernardo Paz Barboza, Liliana Paula Bricarello, Anabelle Retondario, Mariane de Almeida Alves, Amanda de Moura Souza, Ricardo Fernandes, Francisco de Assis Guedes de Vasconcelos
Summary: This study conducted a systematic review of the scientific evidence on the oral intake of omega-3 and omega-6 fatty acids and metabolic syndrome in adolescents. The results suggest that oral intake of omega-3 fatty acids may have a decreasing effect on blood pressure, glycemia, and triglycerides, and an increasing effect on HDL cholesterol. However, there is controversy in the scientific evidence due to the heterogeneity between studies and the divergence of results for the same metabolic syndrome component.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Correction
Cell Biology
Jie Zhu, Chang Ming, Xin Fu, Yaou Duan, Duc Anh Hoang, Jeffrey Rutgard, Runze Zhang, Wenqiu Wang, Rui Hou, Daniel Zhang, Edward Zhang, Charlotte Zhang, Xiaoke Hao, Wenjun Xiong, Kang Zhang
Article
Biochemistry & Molecular Biology
Huiying Liang, Brian Y. Tsui, Hao Ni, Carolina C. S. Valentim, Sally L. Baxter, Guangjian Liu, Wenjia Cai, Daniel S. Kermany, Xin Sun, Jiancong Chen, Liya He, Jie Zhu, Pin Tian, Hua Shao, Lianghong Zheng, Rui Hou, Sierra Hewett, Gen Li, Ping Liang, Xuan Zang, Zhiqi Zhang, Liyan Pan, Huimin Cai, Rujuan Ling, Shuhua Li, Yongwang Cui, Shusheng Tang, Hong Ye, Xiaoyan Huang, Waner He, Wenqing Liang, Qing Zhang, Jianmin Jiang, Wei Yu, Jianqun Gao, Wanxing Ou, Yingmin Deng, Qiaozhen Hou, Bei Wang, Cuichan Yao, Yan Liang, Shu Zhang, Yaou Duan, Runze Zhang, Sarah Gibson, Charlotte L. Zhang, Oulan Li, Edward D. Zhang, Gabriel Karin, Nathan Nguyen, Xiaokang Wu, Cindy Wen, Jie Xu, Wenqin Xu, Bochu Wang, Winston Wang, Jing Li, Bianca Pizzato, Caroline Bao, Daoman Xiang, Wanting He, Suiqin He, Yugui Zhou, Weldon Haw, Michael Goldbaum, Adriana Tremoulet, Chun-Nan Hsu, Hannah Carter, Long Zhu, Kang Zhang, Huimin Xia
Article
Multidisciplinary Sciences
Zhangming Yan, Norman Huang, Weixin Wu, Weizhong Chen, Yiqun Jiang, Jingyao Chen, Xuerui Huang, Xingzhao Wen, Jie Xu, Qiushi Jin, Kang Zhang, Zhen Chen, Shu Chien, Sheng Zhong
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cell Biology
Daniel Chen, Daniel L. Chao, Lorena Rocha, Matthew Kolar, Viet Anh Nguyen Huu, Michal Krawczyk, Manish Dasyani, Tina Wang, Maryam Jafari, Mary Jabari, Kevin D. Ross, Alan Saghatelian, Bruce A. Hamilton, Kang Zhang, Dorota Skowronska-Krawczyk
Article
Cell Biology
Huiyan Luo, Qi Zhao, Wei Wei, Lianghong Zheng, Shaohua Yi, Gen Li, Wenqiu Wang, Hui Sheng, Hengying Pu, Haiyu Mo, Zhixiang Zuo, Zexian Liu, Chaofeng Li, Chuanbo Xie, Zhaolei Zeng, Weimin Li, Xiaoke Hao, Yuying Liu, Sumei Cao, Wanli Liu, Sarah Gibson, Kang Zhang, Guoliang Xu, Rui-hua Xu
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Kang Zhang, Xiaohong Liu, Jun Shen, Zhihuan Li, Ye Sang, Xingwang Wu, Yunfei Zha, Wenhua Liang, Chengdi Wang, Ke Wang, Linsen Ye, Ming Gao, Zhongguo Zhou, Liang Li, Jin Wang, Zehong Yang, Huimin Cai, Jie Xu, Lei Yang, Wenjia Cai, Wenqin Xu, Shaoxu Wu, Wei Zhang, Shanping Jiang, Lianghong Zheng, Xuan Zhang, Li Wang, Liu Lu, Jiaming Li, Haiping Yin, Winston Wang, Oulan Li, Charlotte Zhang, Liang Liang, Tao Wu, Ruiyun Deng, Kang Wei, Yong Zhou, Ting Chen, Johnson Yiu-Nam Lau, Manson Fok, Jianxing He, Tianxin Lin, Weimin Li, Guangyu Wang
Article
Biochemistry & Molecular Biology
Yi Xu, Xufang Li, Bing Zhu, Huiying Liang, Chunxiao Fang, Yu Gong, Qiaozhi Guo, Xin Sun, Danyang Zhao, Jun Shen, Huayan Zhang, Hongsheng Liu, Huimin Xia, Jinling Tang, Kang Zhang, Sitang Gong
Article
Multidisciplinary Sciences
Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng, Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang, Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu, Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang, Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang, Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin, Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue, Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang, Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li, Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau, Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang, Guangwen Lu, Xiawei Wei
Article
Biochemistry & Molecular Biology
Xin Xu, Jian Sun, Sheng Nie, Huiyuan Li, Yaozhong Kong, Min Liang, Jinlin Hou, Xianzhong Huang, Dongfeng Li, Tean Ma, Jiaqing Peng, Shikui Gao, Yong Shao, Hong Zhu, Johnson Yiu-Nam Lau, Guangyu Wang, Chunbao Xie, Li Jiang, Ailong Huang, Zhenglin Yang, Kang Zhang, Fan Fan Hou
Article
Pediatrics
Xiaolei Wang, Shi-Ming Li, Luoru Liu, Siyuan Li, Lei Li, Mengtian Kang, Shifei Wei, Ningli Wang
Summary: This study used spectral-domain optical coherence tomography to investigate the distribution of macular ganglion cell complex (GCC) thickness in 7-year-old children in China and its associations with ocular and systemic parameters. The results showed negative associations between GCC thickness and axial length, cup-to-disc area ratio, horizontal and vertical C-D ratios, and positive correlations with spherical equivalent, RNFL thickness, height, fovea parameters, and optic nerve head volume. GCC thickness was not significantly associated with intraocular pressure, age, sex, or weight.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Xian Xia, Xingwei Chen, Gang Wu, Fang Li, Yiyang Wang, Yang Chen, Mingxu Chen, Xinyu Wang, Weiyang Chen, Bo Xian, Weizhong Chen, Yaqiang Cao, Chi Xu, Wenxuan Gong, Guoyu Chen, Donghong Cai, Wenxin Wei, Yizhen Yan, Kangping Liu, Nan Qiao, Xiaohui Zhao, Jin Jia, Wei Wang, Brian K. Kennedy, Kang Zhang, Carlo Cannistraci, Yong Zhou, Jing-Dong J. Han
Article
Biochemistry & Molecular Biology
Hua Jiang, Zhiying Ou, Yingyi He, Meixing Yu, Shaoqing Wu, Gen Li, Jie Zhu, Ru Zhang, Jiayi Wang, Lianghong Zheng, Xiaohong Zhang, Wenge Hao, Liya He, Xiaoqiong Gu, Qingli Quan, Edward Zhang, Huiyan Luo, Wei Wei, Zhihuan Li, Guangxi Zang, Charlotte Zhang, Tina Poon, Daniel Zhang, Ian Ziyar, Run-Ze Zhang, Oulan Li, Linhai Cheng, Taylor Shimizu, Xinping Cui, Jian-kang Zhu, Xin Sun, Kang Zhang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Review
Biotechnology & Applied Microbiology
Christopher G. Bell, Robert Lowe, Peter D. Adams, Andrea A. Baccarelli, Stephan Beck, Jordana T. Bell, Brock C. Christensen, Vadim N. Gladyshev, Bastiaan T. Heijmans, Steve Horvath, Trey Ideker, Jean-Pierre J. Issa, Karl T. Kelsey, Riccardo E. Marioni, Wolf Reik, Caroline L. Relton, Leonard C. Schalkwyk, Andrew E. Teschendorff, Wolfgang Wagner, Kang Zhang, Vardhman K. Rakyan
Review
Medicine, Research & Experimental
Jie Xu, Kanmin Xue, Kang Zhang
Article
Ophthalmology
Andrea R. Waksmunski, Michelle Grunin, Tyler G. Kinzy, Robert P. Igo, Jonathan L. Haines, Jessica N. Cooke Bailey, Lars G. Fritsche, Wilmar Igl, Felix Grassmann, Sebanti Sengupta, Jennifer L. Bragg-Gresham, Kathryn P. Burdon, Scott J. Hebbring, Cindy Wen, Mathias Gorski, Ivana K. Kim, David Cho, Donald Zack, Eric Souied, Hendrik P. N. Scholl, Elisa Bala, Kristine E. Lee, David J. Hunter, Rebecca J. Sardell, Paul Mitchell, Joanna E. Merriam, Valentina Cipriani, Joshua D. Hoffman, Tina Schick, Yara T. E. Lechanteur, Robyn H. Guymer, Matthew P. Johnson, Yingda Jiang, Chloe M. Stanton, Gabrielle H. S. Buitendijk, Xiaowei Zhan, Alan M. Kwong, Alexis Boleda, Matthew Brooks, Linn Gieser, Rinki Ratnapriya, Kari E. Branham, Johanna R. Foerster, John R. Heckenlively, Mohammad Othman, Brendan J. Vote, Helena Hai Liang, Emmanuelle Souzeau, Ian L. McAllister, Timothy Isaacs, Janette Hall, Stewart Lake, David A. Mackey, Ian J. Constable, Jamie E. Craig, Terrie E. Kitchner, Zhenglin Yang, Zhiguang Su, Hongrong Luo, Daniel Chen, Hong Ouyang, Ken Flagg, Danni Lin, Guanping Mao, Henry Ferreyra, Klaus Stark, Claudia N. von Strachwitz, Armin Wolf, Caroline Brandl, Guenther Rudolph, Matthias Olden, Margaux A. Morrison, Denise J. Morgan, Matthew Schu, Jeeyun Ahn, Giuliana Silvestri, Evangelia E. Tsironi, Kyu Hyung Park, Lindsay A. Farrer, Anton Orlin, Alexander Brucker, Mingyao Li, Christine A. Curcio, Saddek Mohand-Said, Jose-Alain Sahel, Isabelle Audo, Mustapha Benchaboune, Angela J. Cree, Christina A. Rennie, Srinivas Goverdhan, Shira Hagbi-Levi, Peter Campochiaro, Nicholas Katsanis, Frank G. Holz, Frederic Blond, Helene Blanche, Jean-Francois Deleuze, Barbara Truitt, Neal S. Peachey, Stacy M. Meuer, Chelsea E. Myers, Emily L. Moore, Ronald Klein, Michael A. Hauser, Eric A. Postel, Monique D. Courtenay, Stephen G. Schwartz, Jaclyn L. Kovach, William K. Scott, Gerald Liew, Ava G. Tan, Bamini Gopinath, John C. Merriam, R. Theodore Smith, Jane C. Khan, Humma Shahid, Anthony T. Moore, J. Allie McGrath, Renee Laux, Milam A. Brantley, Anita Agarwal, Lebriz Ersoy, Albert Caramoy, Thomas Langmann, Nicole T. M. Saksens, Eiko K. de Jong, Carel B. Hoyng, Melinda S. Cain, Andrea J. Richardson, Tammy M. Martin, John Blangero, Daniel E. Weeks, Bal Dhillon, Cornelia M. van Duijn, Kimberly F. Doheny, Jane Romm, Caroline C. W. Klaver, Caroline Hayward, Michael B. Gorin, Michael L. Klein, Paul N. Baird, Anneke den Hollander, Sascha Fauser, John R. W. Yates, Rando Allikmets, Jie Jin Wang, Debra A. Schaumberg, Barbara E. K. Klein, Stephanie A. Hagstrom, Itay Chowers, Andrew J. Lotery, Thierry Leveillard, Kang Zhang, Murray H. Brilliant, Alex W. Hewitt, Anand Swaroop, Emily Y. Chew, Margaret A. Pericak-Vance, Margaret DeAngelis, Dwight Stambolian, Sudha K. Iyengar, Bernhard H. F. Weber, Goncalo R. Abecasis, Iris M. Heid
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
