期刊
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
卷 9, 期 4, 页码 307-312出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2015.01.009
关键词
Arrhythmia; case-control study; nutrition; renin-angiotensin-aldosterone system
资金
- Turkish Society of Cardiology [X306]
Vitamin D deficiency is associated with various cardiovascular disorders including hypertension, coronary artery disease, and heart failure. The renin-angiotensin-aldosterone system (RAS) axis is activated in vitamin D deficiency. The RAS axis also plays a role in the pathophysiology of atrial fibrillation (AF). We aimed to investigate whether vitamin D deficiency is a risk factor for the development of new-onset AF in hypertension. A total of 227 hypertensive patients were enrolled, of whom 137 had new-onset AF; 90 patients without AF were included in the control group. The age of the patient, left atrial diameter, and vitamin D deficiency increased the probability of new-onset AF independent from confounding factors (odds ratio [On 1.04; 95% confidence interval [CI] 1.01-1.08; P = .03 for age; OR, 1.88; 95% CI, 1.15-3.45; P = .03 for left atrial diameter; OR, 1.68; 95% CI, 1.18-2.64; P = .03 for vitamin D deficiency). Vitamin D deficiency is associated with new-onset AF in hypertension. (C) 2015 American Society of Hypertension. All rights reserved.
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