Article
Urology & Nephrology
Jinyu Li, Luiz Henrique Geraldo, Alexandre Dubrac, Georgia Zarkada, Anne Eichmann
Summary: The study uncovers a novel role of Slit2-Robo signaling in glomerular vascularization, where Slit2 specifically affects glomerular endothelium in the developing kidney vasculature. Deletion of Slit2 impacts nephrogenesis and inhibits vascularization of developing glomeruli, indicating potential for enhancing glomerular angiogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Developmental Biology
Francoise Helmbacher
Summary: The study reveals the crucial role of the FAT1 cadherin in regulating astrocyte migration, proliferation, and maturation, which in turn impacts retinal vascular development and maintenance.
Article
Peripheral Vascular Disease
Xixiang Tang, Joshua J. Wang, Jinli Wang, Hanna E. Abboud, Yanming Chen, Sarah X. Zhang
Summary: Nox4, a major isoform of NADPH oxidases, plays a crucial role in retinal vascular development and pathological angiogenesis by regulating VEGF/VEGFR2 and angiopoietin-2/integrin alpha V/ERK pathways. Targeting endothelial Nox4 in ischemic/hypoxic retinal diseases should be approached with caution.
Article
Ophthalmology
Xinwen Yao, Mengyuan Ke, Yijie Ho, Emily Lin, Damon W. K. Wong, Bingyao Tan, Leopold Schmetterer, Jacqueline Chua
Summary: This study compared the retinal vessel diameter measurements obtained from Swept-Source Optical Coherence Tomography Angiography (OCTA) and Adaptive Optics Ophthalmoscope (AOO), with results showing that the vessel diameter measured from OCTA scans was generally wider than that from AOO scans. Different OCTA scan protocols may also affect vessel diameter measurements.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Thales Antonio Cabral de Guimaraes, Malena Daich Varela, Michalis Georgiou, Michel Michaelides
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world, with promising treatment prospects for wet AMD but challenges remain for dry AMD. Various therapeutic approaches are being investigated, including drugs with antioxidative properties, complement cascade inhibitors, gene therapy, etc., with promising results from early clinical trials.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Bilal Haj Najeeb, Gabor G. Deak, Ursula Margarethe Schmidt-Erfurth, Bianca S. Gerendas
Summary: The study on macular neovascularisation type III (MNV3) arising from cilioretinal arteries (CRAs) found that this condition can be solitary or accompanied by other macular neovascular lesions, often associated with extensive exudative maculopathy and intraretinal haemorrhage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biology
Jonathan P. Alberding, Timothy W. Secomb
Summary: A theoretical model is used to describe the development of retinal circulation in the human eye, showing the formation of two vascular plexuses. The model suggests that random sprouting angiogenesis, controlled by vascular responses, leads to the generation of a specialized three-dimensional vascular structure.
BULLETIN OF MATHEMATICAL BIOLOGY
(2023)
Article
Cell Biology
M. Constanza Gonzalez-Ramirez, Francisca Rojo-Cortes, Noemi Candia, Jorge Garay-Montecinos, Pablo Guzman-Palma, Jorge M. M. Campusano, Carlos Oliva
Summary: In this study, the role of the Slit-Robo3 signaling pathway in the morphogenesis of the Drosophila optic lobe was investigated. It was found that Slit and Robo3 are expressed in the same neuronal population and they regulate the compartmentalization of the optic lobe through an autocrine/paracrine mechanism. Furthermore, interactions with genes involved in endocytosis and actin dynamics were detected, indicating the involvement of the endocytic pathway and small GTPases in this process. This study reveals the important role of the Slit-Robo3 pathway in CNS development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ruowen Gong, Ruyi Han, Xiaonan Zhuang, Wenyi Tang, Gezhi Xu, Lei Zhang, Jihong Wu, Jun Ma
Summary: miR-375 alleviates cell proliferation and angiogenesis in retinal microvascular endothelial cells, potentially providing new therapeutic targets for retinal diseases.
Review
Pharmacology & Pharmacy
Rafael Andre da Silva, Vinicius Moraes de Paiva Roda, Luiz Philipe de Souza Ferreira, Sonia M. Oliani, Ana Paula Girol, Cristiane D. Gil
Summary: Annexins, Ca2+/phospholipid-binding proteins, play important roles in various eye diseases, but their exact functions and expressed cell types in the eye are not well understood. AnxAs serve as important targets in ocular tissue homeostasis, particularly in infectious, autoimmune, degenerative, fibrotic, and angiogenic conditions.
DRUG DISCOVERY TODAY
(2022)
Article
Ophthalmology
William Hellstrom, Tobias Martinsson, Eva Morsing, Lotta Granse, David Ley, Ann Hellstrom
Summary: This study revealed that a lower fraction of HbF during the neonatal period in preterm infants is associated with later retinopathy of prematurity, while a higher fraction of HbF is linked to a reduced prevalence of ROP. The predictive ability of HbF fraction in the first week of life for ROP development was relatively high.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Thales Antonio Cabral de Guimaraes, Michalis Georgiou, James W. B. Bainbridge, Michel Michaelides
Summary: Age-related macular degeneration is a leading cause of irreversible blindness, and antivascular endothelial growth factor therapy has improved the management of neovascular AMD. Gene therapy approaches show promise in addressing challenges, but there are still controversies and safety concerns.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Kimberley Delaunay, Alexandre Sellam, Virginie Dinet, Alexandre Moulin, Min Zhao, Emmanuelle Gelize, Jeremie Canonica, Marie-Christine Naud, Patricia Crisanti-Lassiaz, Francine Behar-Cohen
Summary: MTRN, enriched in the macula of both human and non-human primate retina, exhibits potential anti-angiogenic effects by regulating multiple pathways to inhibit laser-induced CNV, making it a promising therapeutic candidate for wet AMD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Developmental Biology
Chenqi Tao, Neoklis Makrides, Jen-Zen Chuang, Yihua Wu, Steven E. Brooks, Jeffrey D. Esko, Ching-Hwa Sung, Xin Zhang
Summary: The study demonstrates the essential role of glycosaminoglycans in retinal angiogenesis, blood vessel pruning, and establishment of the basement membrane. The absence of heparan sulfate affects VEGF signaling, disrupts retinal inner limiting membrane assembly, and increases retinal permeability.
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)