Article
Psychiatry
Jingqi He, Yisen Wei, Jinguang Li, Ying Tang, Junyu Liu, Zhangyin He, Risheng Zhou, Xingtao He, Honghong Ren, Yanhui Liao, Lin Gu, Ning Yuan, Xiaogang Chen, Jinsong Tang
Summary: This study compared serum IL-6 levels between TRS and PRS patients and explored potential sex differences in the association between TRS and IL-6 levels. The results showed that TRS patients had higher serum IL-6 levels, especially in females. The findings suggest that the inflammatory response system may play a role in the pathogenesis of TRS in a sex-dependent manner.
Article
Multidisciplinary Sciences
Yang Cao, Laurent Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan, Timothy M. Moore, Manuel Rosa-Garrido, Todd H. Kimball, Zhiqiang Zhou, Sarada Charugundla, Christoph D. Rau, Marcus M. Seldin, Jessica Wang, Yibin Wang, Thomas M. Vondriska, Karen Reue, Aldons J. Lusis
Summary: This study reveals that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, and identifies Acsl6 as a mitochondrial sex-biased regulator of diastolic function. By conducting genetic studies in mice and analyzing human cohorts, the authors find that heart mitochondrial DNA levels and function are reduced in females compared to males, and the expression of genes encoding mitochondrial proteins is higher in males. The study also shows that mitochondrial gene expression is highly correlated with diastolic function, an important trait in HFpEF.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Kai Wang, Lu Xu, Lili Liu, Siyan Zhan, Shengfeng Wang, Yongfeng Song
Summary: This study aimed to investigate the association between insulin resistance and cognitive decline, and explore the impact of sex and age on this association. The study found that an increased TyG index was related to an increased risk of cognitive decline in men.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Qiyang Xie, Maobin Kuang, Song Lu, Xin Huang, Chao Wang, Shuhua Zhang, Guotai Sheng, Yang Zou
Summary: This study investigated the association and sex differences between metabolic score for insulin resistance (MetS-IR) and prediabetes risk in a Chinese population. The results showed an independent and positive correlation between MetS-IR and the risk of prediabetes, with a stronger association in women than in men.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu Yu, Jing Wang, Ligang Ding, Hao Huang, Sijing Cheng, Yu Deng, Min Gu, Chi Cai, Xiaohui Ning, Xuhua Chen, Hongxia Niu, Wei Hua
Summary: This prospective cohort study analyzed data from 7,851 US adults and found a U-shaped association between the triglyceride glucose (TyG) index and all-cause and cardiovascular mortality in the general population. Sex differences were observed in the association once it exceeded a certain threshold.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Public, Environmental & Occupational Health
Kathryn L. Gwizdala, Lydia A. Bazzano, Robert L. Newton Jr, Owen T. Carmichael
Summary: Glycemic markers throughout life are associated with worse midlife cognition, especially in women, African Americans, and White Americans. This association may reflect broader health disparities.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Jinxia Wu, Zhenchang Li, Hongwei Zhu, Yajie Chang, Quanquan Li, Jing Chen, Guiping Shen, Jianghua Feng
Summary: The aim of this study was to identify the differential metabolic characteristics of children with overweight and obesity and understand their potential mechanism in different age stratifications. Four and sixteen potential biomarkers related to overweight and two and twenty potential biomarkers related to obesity were identified from younger and older children, respectively. Fluctuations in phenylalanine, tyrosine, glutamine, leucine, histidine, and ascorbate co-occurred in children with obesity at two age stratifications. The disturbances in biosynthesis and metabolism of amino acids, lipid metabolism, and galactose metabolism disturbance were mainly involved in children with overweight and obesity. These findings will promote the mechanistic understanding of childhood overweight and obesity.
Article
Pediatrics
Nuria Romero-Parra, Adrian Solera-Alfonso, Daniel Bores-Garcia, Jose M. Delfa-de-la-Morena
Summary: This study found that females in Spain have lower levels of MVPA and intrinsic and integrated motivation across all educational levels, particularly among primary school students compared to secondary school students. This suggests that inner motivation plays a more determinant role in increasing engagement in MVPA activities, emphasizing the need to reinforce it before the transition to secondary school and to focus on females' preferences.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Xiaohui Li, Jia Liu, Biao Zhou, Yinhui Li, Zhengyu Wu, Hua Meng, Guang Wang
Summary: Adipose tissue insulin resistance (adipose-IR) in males is higher than in females with similar BMI levels. Adipose-IR increases progressively from overweight to class III obesity in both genders, but is significantly higher in males than females in the class III obesity group. Testosterone levels are negatively correlated with adipose-IR in males, while positively correlated in females. Low testosterone levels may contribute to more severe adipose-IR in obese males.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Che-Wei Liao, Chih-Fu Wei, Mei-Huei Chen, Wu-Shiun Hsieh, Ching-Chun Lin, Pau-Chung Chen
Summary: Maternal shift work during pregnancy is associated with childhood overweight and insulin resistance.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Ronan Bergin, David Kinlen, Nidhi Kedia-Mehta, Eadaoin Hayes, Fearon C. Cassidy, Declan Cody, Donal O'Shea, Andrew E. Hogan
Summary: This study investigated the impact of MAIT cells on insulin resistance in children with obesity and the role of IL-17 in insulin signaling. The results showed that children with obesity had increased frequencies of MAIT cells, which produced elevated levels of TNF-alpha and IL-17 when activated. IL-17 production was associated with insulin resistance. Furthermore, it was found that recombinant IL-17 blocked insulin-mediated glucose uptake by inhibiting phosphorylated Akt and extracellular signal-regulated kinase.
Article
Nutrition & Dietetics
Susan Thurstans, Charles Opondo, Andrew Seal, Jonathan C. Wells, Tanya Khara, Carmel Dolan, Andre Briend, Mark Myatt, Michel Garenne, Andrew Mertens, Rebecca Sear, Marko Kerac
Summary: A recent review explored the potential early life mechanisms underlying the sex differences in child undernutrition, suggesting that a complex interaction of social, environmental, and genetic factors likely contribute to these differences.
Article
Obstetrics & Gynecology
Riddhi Thaker, Hina Oza, Vinita Verma, Mansi Gor, Sunil Kumar
Summary: This study explored the role of cytokines IL-6 and IL-10 in cases of spontaneous abortion, finding a positive correlation between IL-6 and the number of SAb cases, and a negative correlation with IL-10. The results suggest a beneficial role for IL-10 and detrimental role for IL-6 on pregnancy outcomes. Additional data is needed to confirm these findings.
REPRODUCTIVE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Ying Wei, Jia Liu, Guang Wang, Ying Wang
Summary: This study found sex differences in the association between adipose insulin resistance (Adipo-IR) and non-alcoholic fatty liver disease (NAFLD), with a stronger correlation in hyperlipidemic women. The association was also stronger in women over 50 years old. Targeting Adipo-IR for treatment may be valuable in alleviating NAFLD, especially in hyperlipidemic women after menopause.
BIOLOGY OF SEX DIFFERENCES
(2023)
Review
Endocrinology & Metabolism
Mona Mohamed Ibrahim Abdalla
Summary: The increasing global burden of type 2 diabetes highlights the need for more reliable and quicker strategies to improve early identification of insulin resistance in high-risk groups. Salivary biomarkers offer a promising alternative to serum collection, with adipocytokines like leptin being potential biomarkers for insulin resistance. Studies on salivary resistin as a biomarker for IR show conflicting findings on its potential role in linking obesity and IR.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Elvira Silajdzija, Sofie Bliddal, Line Borgwardt, Maria Rossing, Anne Jarlov, Claus Henrik Nielsen, Ulla Feldt-Rasmussen
Summary: This article reports a case of autoimmune polyglandular syndrome type II (APS II) in a patient who was initially diagnosed with hypothyroidism and presented with fatigue and rapid weight loss. Through examinations and genetic sequencing, the final diagnoses included Hashimoto's thyroiditis, Addison's disease, vitiligo, and pernicious anemia. The findings suggest that awareness of potential polyautoimmunity in patients with thyroid disease can improve diagnosis and even be life-saving.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Immunology
Blaine G. Fritz, Julius B. Kirkegaard, Claus Henrik Nielsen, Klaus Kirketerp-Maller, Matthew Malone, Thomas Bjarnsholt
Summary: This study analyzed the transcriptome of lower extremity ulcers to identify host gene expression patterns associated with bacterial infections. The results showed that these transcriptome patterns were often inconsistent with clinical infection severity classifications. A set of 20 genes, including immune-associated genes, accurately identified samples with signs of infection. This suggests that transcriptomic fingerprinting could be a useful objective method for classifying infection severity and studying host-pathogen interactions.
Article
Dentistry, Oral Surgery & Medicine
Christian Damgaard, Laura Massarenti, Anne Katrine Danielsen, Jonas H. Graversen, Palle Holmstrup, Claus H. Nielsen, Yaseelan Palarasah
Summary: Complement activation is increased in patients with periodontitis, but there is no difference between PD-B and PD-C. PD-B is associated with systemic complement activation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dermatology
Christian Enevold, Nikolai Loft, Anne Bregnhoj, Claus Zachariae, Lars Iversen, Lone Skov, Claus Henrik Nielsen
Summary: This case series study suggests an association between drug monitoring and clinical treatment response. Monitoring patient levels of circulating brodalumab may aid clinical decision-making and help prevent ineffective therapy.
Article
Immunology
Dina Leth Moller, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengelov, Anders Elm Pedersen, Lars Peter Ryder, Klaus Muller
Summary: This study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christina Aniol-Nielsen, Christian Enevold, Henrik Toft-Hansen, Claus Henrik Nielsen
Summary: Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, and anti-insulin antibodies (IAs) may be associated with insulin treatment in patients with diabetes. This study found that two SNPs in the human insulin gene and two SNPs in the insulin receptor gene were associated with type 1 diabetes and glycaemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christian Enevold, Dres Damgaard, Peter Riis Hansen, Morten Frisch, Niels Odum, Soren Jacobsen, Claus Henrik Nielsen
Summary: Epidemiological studies have shown an association between periodontitis and rheumatoid arthritis (RA). This study investigated whether this association is influenced by genetic polymorphisms. The study found that carrying specific alleles of certain genes increased the risk of RA in individuals with periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Sarah Weischendorff, Silvia De Pietri, Mathias Rathe, Thomas Leth Frandsen, Henrik Hasle, Claus H. Nielsen, Claus Moser, Klaus Mueller
Summary: This study investigated whether measurements of neutrophil chemotaxis could be used as risk markers for bloodstream infections (BSI) in children with acute lymphoblastic leukemia (ALL). The results showed that patients who developed BSI during induction treatment had increased levels of chemokines CXCL1 and CXCL8, suggesting that these markers may help identify patients at increased risk of BSI during chemotherapy-induced neutropenia.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clara Sophie Bramsen Andersen, Amanda Kvist-Hansen, Mie Siewertsen, Christian Enevold, Peter Riis Hansen, Diljit Kaur-Knudsen, Claus Zachariae, Claus Henrik Nielsen, Nikolai Loft, Lone Skov
Summary: This study examined the usefulness of various inflammation biomarkers in personalizing biologic treatment for psoriasis patients. It was found that the neutrophil-to-lymphocyte ratio (NLR) and interleukin-6 (IL-6) levels could serve as predictive biomarkers for treatment response to TNF-alpha inhibitor therapy. The study also measured other biomarkers such as TNF-alpha, IL-1 beta, IFN-alpha, IL-17A, IL-6, soluble IL-6 receptor (sIL-6R), and soluble IL-6 signal transducer (sIL-6ST) in different patient groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Maria Teresa Martin Monreal, Bjarke E. Hansen, Pernille F. Iversen, Christian Enevold, Niels Odum, Finn Sellebjerg, Peter Hojrup, Marina Rode von Essen, Claus H. Nielsen
Summary: The research suggests that citrullination, a post-translational modification, may play a role in the development of multiple sclerosis (MS). The autoimmune response to myelin basic protein (MBP) is enhanced when it is hypercitrullinated in MS patients. In addition, citMBP binds more effectively to HLA-DR15, which is associated with MS, compared to native MBP. These findings point to the importance of citrullination in breaching tolerance to MBP and maintaining the autoimmune response in MS patients.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Oncology
Peter Schmidt-Andersen, Anna Stage, Anna Pouplier, Louise H. Bastholm, Klaus G. Mueller, Anders Larsen, Kirsten K. Ness, Hanne B. Larsen, Jan Christensen, Martin K. Fridh
Summary: The evidence suggests that children with cancer experience impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the limited number of studies and the clinical heterogeneity of the available evidence reduces its certainty.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Hematology
Marte B. Kammersgaard, Katrine Kielsen, Claus H. Nielsen, Marianne Ifversen, Anne-Helene Bohr, Klaus Muller Ller
Summary: Neutrophil engraftment is crucial for successful hematopoietic stem cell transplantation (HSCT), but it may also lead to transplant-related complications. This study investigated the relationship between the neutrophil activation marker MRP-8/14, neutrophil recovery, and toxicities after pediatric HSCT. The results showed significant associations between MRP-8/14 levels and neutrophil engraftment, bacterial bloodstream infections, engraftment syndrome, and acute graft-versus-host disease.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Letter
Biophysics
Sidsel Mathiesen, Christian Fuglesang S. Jensen, Anna Byrjalsen, Lise Aksglaede, Niels Jorgensen, Dana Ohl, Jens Sonksen, Klaus Muller
BONE MARROW TRANSPLANTATION
(2023)
Meeting Abstract
Endocrinology & Metabolism
Freja Barrett Mork, Jens Otto Broby Madsen, Kasper Ascanius Pilgaard, Andreas Kryger Jensen, Heidi Klakk, Jakob Tarp, Anna Bugge, Malene Heidemann, Gerrit Van Hall, Flemming Pociot, Niels Wedderkopp, Jesper Johannesen
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Nutrition & Dietetics
Xuan Ren, Sofus Christian Larsen, Lotte Lauritzen, Jeanett Friis Rohde, Lars Bo Andersen, Anna Bugge, Britt Wang Jensen, Ina Olmer Specht, Berit Lilienthal Heitmann
Summary: This study found no significant associations between fat intake and weight or body fat development in school-aged children, suggesting that fat composition in the diet may not play a major role in obesity development.
