Article
Plant Sciences
Joao Francisco Camara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, Joao Antonio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Juliao Zocolo, Icaro Gusmao Pinto Vieira, Nagila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to characterize the chemical profile of Agaricus blazei Murill extract and evaluate its gastroprotective effect. The results showed that the extract had antioxidant activity and could protect the gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Maria Leonia da Costa Gonzaga, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Renata Ferreira de Carvalho Leita, Maria Elenir Nobre Pinho Ribeiro
Summary: This study investigated the potential of polysaccharides from Agaricus blazei Murill mushroom (PAbs) as wound dressings. The results showed that PAbs had no significant impact on the viability of human neutrophils in a concentration range of 1-100 μg mL-1. Moreover, PAbs improved the mechanical properties, thickness, and water vapor permeation of the films, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Matheus da Silva Campelo, Cecilia Brilhante Araga, Izabell Maria Martins Teixeira, Erlania Alves de Siqueira, Carlos Jose Alves da Silva-Filho, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Cristiani Lopes Capistrano Goncalves de Oliveira, Celli Rodrigues Muniz, Francisco Geraldo Barbosa, Jair Mafezoli, Tiago Lima Sampaio, Maria Elenir Nobre Pinho Ribeiro
Summary: Pentacyclic triterpene-loaded emulsions were stabilized using polysaccharides from Agaricus blazei Murill mushroom (PAb). Compatibility tests showed no physicochemical incompatibilities between the drug and excipient. The addition of PAb at 0.75% resulted in stable emulsions with small droplet size, moderate polydispersity, and high zeta-potential. Encapsulation of the drug in PAb-stabilized emulsions improved its cytocompatibility against PC12 and murine astrocyte cells, reducing cytotoxicity and maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Wenshuai Wang, Min Liu, Mengyu Zhang, Wenxue Sun, Jianjun Zhang, Le Jia
Summary: The study evaluated the protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung in MODS mice induced by zymosan. Results showed that ABMP improved the survival rate, alleviated abnormal physiological behavior, and reduced tissue oxidative stress in MODS mice. Additionally, ABMP inhibited the activation of NF-kappa B signaling pathway and decreased the expressions of inflammatory cytokines.
Review
Food Science & Technology
Kaiyuan Huang, Hesham R. El-Seedi, Baojun Xu
Summary: This study comprehensively summarizes the chemical composition of Agaricus blazei Murrill (AbM) and thoroughly characterizes its health promotion effects such as antitumor and antidiabetic impacts. AbM is composed of abundant bioactive substances including polysaccharides, lipids, proteins, and vitamins. Research has shown that AbM polysaccharides have immunoregulation, anti-inflammatory, hepato-protective, and antitumor functions. Furthermore, AbM extracts are believed to have potential in treating diabetes and bacterial infections, as well as exhibiting anticarcinogenic and antimutagenic functions. However, some of the mechanisms behind these health promotion effects remain unclear, and there is a need for further clinical trials.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yanping Zhao, Nana Tian, Hongjun Wang, Hong Yan
Summary: Sulfated modifications of Agaricus blazei Murill (AbM) polysaccharides have shown strong anti-HIV properties, making them promising candidates for biomedical applications in HIV/AIDS treatment.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Physical
Thiago Magalhaes Farias Menezes, Matheus da Silva Campelo, Ana Beatriz Nogueira Lima, Joao Francisco Camara Neto, Matheus Morais Saraiva, Joao Antonio Costa de Sousa, Maria Leonia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria Elenir Nobre Pinho Ribeiro, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares
Summary: This study evaluated the effects of polysaccharides from Lentinus edodes Berk and Agaricus blazei Murill mushrooms on the gelation process of the Pluronic (R) F127 copolymer. The results showed that these polysaccharides have good rheological properties and potential for pharmaceutical formulation development.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Engineering, Biomedical
Matheus da Silva Campelo, Lucas Barroso Mota, Joao Francisco Camara Neto, Maria Lucianny Lima Barbosa, Maria Leonia da Costa Gonzaga, Luzia Kalyne Almeida Moreira Leal, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to develop and evaluate the wound healing activity of films based on sodium alginate, polyvinyl alcohol, and Agaricus blazei extract. The films showed promising water vapor barrier properties and enhanced antioxidant and tissue repairing capabilities for wound healing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Food Science & Technology
Yukun Zhang, Feng Lu, Hang Zhang, Yuwei Ye, Penghu Liu, Dongmei Lin, Hong Zhou, Min Li, Baoxue Yang
Summary: This study investigated the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) and selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on ulcerative colitis (UC) using a mouse model. The results showed that both ABP and ABP-Se alleviated UC symptoms and improved colonic barrier functions, while reducing inflammation and oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Zhong-Hao Ji, Song He, Wen-Yin Xie, Pei-Sen Zhao, Wen-Zhi Ren, Wei Gao, Bao Yuan
Summary: The study found that Agaricus blazei Murrill polysaccharide (ABP) has protective effects against DSS-induced acute colitis. ABP significantly reduces colitis symptoms, inflammatory responses, and oxidative stress, while maintaining intestinal barrier integrity and improving gut microbiota disruption and metabolic abnormalities.
Article
Medicine, Research & Experimental
Kaveri M. Adki, Yogesh A. Kulkarni
Summary: The study demonstrated that Paeonol can effectively lower blood glucose levels in diabetic rats and alleviate mechanical and thermal hypersensitivity caused by neuropathy. Additionally, Paeonol also improved nerve conduction velocity, reduced oxidative stress, and prevented neuronal damage in the sciatic nerve.
Article
Spectroscopy
Fatma Kucuk Baloglu, Damla Guldag Tas, Okkes Yilmaz, Feride Severcan
Summary: Type I diabetes is a complex disease that affects carbohydrate, protein, and fat metabolisms due to high blood sugar levels, resulting in oxidative stress. Vitamin C acts as a powerful antioxidant and can protect biomolecules in testicular tissue from oxidative damage. This study aimed to investigate the changes in biomolecular composition and structure in rat testes due to STZ-induced type I diabetes and found that diabetes leads to lipid peroxidation and protein degradation. However, the administration of Vit C can effectively recover from these diabetes-induced structural damages.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Xianrong Zhou, Guan-sheng Shang, Qian Tan, Qin He, Xiaoyu Tan, Kun-Young Park, Xin Zhao
Summary: L. fermentum TKSN041 shows potential preventive and therapeutic effects on type 2 diabetes in rats, reducing water intake, controlling blood glucose levels, decreasing harmful substances, and protecting organ functions.
Article
Pharmacology & Pharmacy
Muhammad Aslam, Hammad Ahmed, Tayyaba Mumtaz, Gahzal Hakani
Summary: The study evaluated the antiparkinsonian activity of Agaricus blazei Murill using different animal models, demonstrating its significant potential in reducing oxidative stress and improving the behavior and motor functions in rats affected by Parkinson's disease.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Qingxia Feng, Yingna Li, Xuechun Lu, Ying Yu, Guangxin Yuan, Jingbo Sun, Chenxi Tian, Lian Hu, Guangyu Xu, Liping An, Peige Du
Summary: The experiment optimized the extraction technology of ABp and found that ABp has anti-aging effects in an aging mouse model, possibly by regulating the Keap1/Nrf2/P53 signaling pathway and related factors.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Francisco Carlos da Silva, Alessandra Hubner de Souza, Bruna Kempfer Bassoli, Gleiciane Alves Prates, Cintia Daudt, Dionatas Ulises de Oliveira Meneguetti, Aurea Pandolfo Correa, Iasmine Berbigier de Oliveira, Sandro de Vargas Schons, Maria Fernanda Pessano Fialho, Dione Silva Correa, Jaqueline Nascimento Picada, Alexandre de Barros Falcao Ferraz
Summary: The Myrciaria dubia fruit has high levels of vitamin C and phenolic compounds, making it promising for natural treatment of pain disorders. The phytochemical profile of M. dubia juice revealed major compounds like ascorbic acid, rutin, and ellagic acid. Studies showed that M. dubia juice exhibited antinociceptive and antiedematogenic potential without affecting animal locomotion.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Environmental Sciences
Mariana Terezinha Selbach, Amanda Souza Scotti, Cleverson Costa Feistel, Caroline C. Nicolau, Daiana Dalberto, Natalia Garcia dos Santos, Guilherme Borsoi, Alexandre Barros Falcao Ferraz, Ivana Grivicich, Guilherme Mauricio Soares de Souza, Paola Chytry, Johnny Ferraz Dias, Dione Silva Correa, Juliana da Silva
Summary: Sida planicaulis is a weed with neurotoxic effects that adversely impact livestock breeding, causing cell death and DNA damage. The ethanolic extracts of this plant showed cytotoxicity and genotoxicity in vitro, indicating a potential risk to human health and agricultural industry.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2021)
Article
Developmental Biology
Ana Claudia Reis Schneider, Ana Carolina de Moura, Fabiano Barbosa Carvalho, Thiago Alves, Fabio Meurer, Marilene Porawski, Themis Reverbel da Silveira
Summary: Fructose exposure led to hepatic steatosis in zebrafish, but melatonin significantly reduced the liver damage. Intestinal leptin expression increased in animals exposed to fructose compared to those administered with melatonin.
Article
Pathology
Carlos Gustavo Sakuno Rosa, Josieli Raskopf Colares, Sandielly Rebeca Benitez da Fonseca, Gabriela dos Santos Martins, Fabiano Moraes Miguel, Alexandre Simoes Dias, Claudio Augusto Marroni, Jaqueline Nascimento Picada, Mauricio Lehmann, Norma Anair Possa Marroni
Summary: The study evaluated the effects of MLT and exercise on the quadriceps muscle in rats with biliary cirrhosis, suggesting that these treatments may contribute to reducing muscle changes in cirrhotic patients.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rodrigo Bitencourt Da Rosa, Guilherme Borsoi, Lucas Umpierre Conter, Cleverson Feistel, Anderson Leonardo Gottems, Flavio Henrique Reginatto, Ivana Grivicich, Alexandre De Barros Falcao Ferraz
Summary: Plants of the Calea genus contain lipophilic compounds with cytotoxic effects against cancer cells. This study investigated the chemical profiles and cytotoxic activities of different fractions from Calea phylolepis leaves, showing that the hexane and ethyl acetate fractions exhibited higher cytotoxic effects, with 6-epi-beta-verbesinol coumarate identified as a major bioactive compound. This compound demonstrated activity against breast cancer cells similar to etoposide, while showing low cytotoxicity to normal fibroblast cells.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Joao Neto, Jeferson Jantsch, Simone de Oliveira, Matheus Filipe Braga, Luis Felipe dos Santos Castro, Bruna Ferrary Diniz, Jose Claudio Fonseca Moreira, Marcia Giovenardi, Marilene Porawski, Renata Padilha Guedes
Summary: Obesity leads to higher mortality in COVID-19 patients and generates neuroinflammation, but DHA/EPA supplementation may reduce these harmful effects. In an animal experiment, DHA/EPA was found to decrease inflammation in the liver and brain caused by obesity, as well as alleviate anxiety-like behavior.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Engineering, Biomedical
Diogo Scalon, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Ariane Taina da Silva, Josieli Raskopf Colares, Norma Anair Possa Marroni
Summary: Photobiomodulation (PBM) may be an effective intervention to alleviate sarcopenia in cirrhotic patients. The study evaluated the beneficial effects of PBM on the structural and functional properties of skeletal muscle in cirrhotic rats, showing improvements in locomotion, muscle fiber morphology, oxidative stress, and inflammation without causing DNA damage.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Chemistry, Applied
Henrique Bridi, Ana Paula Pustay, Sergio Augusto de Loreto Bordignon, Simone Ulrich Picoli, Gilsane Lino von Poser, Alexandre de Barros Falcao Ferraz
Summary: In this study, hexanic extracts from various species of Hypericum were tested for their antimicrobial activity against different bacteria, including resistant strains. The results showed that these extracts exhibited better inhibitory effects on certain pathogenic strains, such as MRSA and S. aureus MLSb.
NATURAL PRODUCT RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Josieli R. Colares, Renata M. Hartmann, Elizangela G. Schemitt, Sandielly R. B. Fonseca, Marilda S. Brasil, Jaqueline N. Picada, Alexandre S. Dias, Aline F. Bueno, Claudio A. Marroni, Norma P. Marroni
Summary: The study evaluated the effects of MLT on oxidative stress, inflammatory process, and DNA damage in an experimental model of secondary biliary cirrhosis. Administration of MLT significantly reduced inflammatory markers, oxidative stress levels, and DNA damage in the treated groups.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Joao C. Fernandes, Elizangela G. Schemitt, Juliana Da Silva, Norma P. Marroni, Ana Lima, Ricardo B. Ferreira
Summary: Our study found that the combination of trans-resveratrol and epsilon-viniferin can reduce oxidative damage, have a hepatoprotective effect, and regulate antioxidant pathways while inhibiting inflammatory development.
Article
Food Science & Technology
Katry Dall Acua, Sueli Fiorini Sommer, Marc Francois Richter, Fernanda Leal Leaes, Voltaire Sant'Anna
Summary: The aim of this study was to evaluate consumers' perception and sensory analysis of pinhcio and pinhdo-based products. The findings revealed that consumers had high expectations for pinhao-based products, but incorporating more than 50% of pinhao flour in the formulation could negatively impact the acceptance of the product.
JOURNAL OF CULINARY SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Grace dos Santos Feijo, Jeferson Jantsch, Lidia Luz Correia, Sarah Eller, Orlando Vieira Furtado-Filho, Marcia Giovenardi, Marilene Porawski, Elizandra Braganhol, Renata Padilha Guedes
Summary: Zinc supplementation improves long-term recognition memory and reduces neuroinflammatory response in obese rats, while BCAA supplementation does not have the same effect. Obesity leads to increased neuroinflammation, particularly in the cerebral cortex and hippocampus, which can be alleviated by zinc supplementation.
METABOLIC BRAIN DISEASE
(2022)
Article
Nutrition & Dietetics
Samia Squizani, Jeferson Jantsch, Fernanda da Silva Rodrigues, Matheus Filipe Braga, Sarah Eller, Tiago Franco de Oliveira, Alexandre Kleber Silveira, Jose Claudio Fonseca Moreira, Marcia Giovenardi, Marilene Porawski, Renata Padilha Guedes
Summary: This study aimed to evaluate the effects of zinc supplementation on the intestinal microbiota, fatty acid profile, and neurofunctional parameters in obese rats. The findings showed that zinc supplementation did not protect obese animals from intestinal dysbiosis, but an increase in acetate levels was observed, suggesting a partial beneficial effect of zinc.
Article
Neurosciences
Lucia Paola Facciola Gonzalez, Fernanda da Silva Rodrigues, Jeferson Jantsch, Gabriel de Farias Fraga, Samia Squizani, Luis Felipe dos Santos Castro, Lidia Luz Correia, Joao Pereira Neto, Marcia Giovenardi, Marilene Porawski, Renata Padilha Guedes
Summary: The study aimed to evaluate the effects of n3 on behavior and neuroinflammation in obese animals. The results showed that n3 improved lipid profile and insulin sensitivity, but had no effect on anxiety-like behaviors. The hippocampus exhibited disrupted blood-brain barrier and reduced expression of glial fibrillary acidic protein (GFAP) and toll-like receptor 4 (TLR-4) in treated obese animals, but n3 could not reverse the increase in TLR-4 expression in the cerebral cortex.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Simone Oliveira, Grace dos Santos Feijo, Joao Neto, Jeferson Jantsch, Matheus Filipe Braga, Luis Felipe dos Santos Castro, Marcia Giovenardi, Marilene Porawski, Renata Padilha Guedes
Summary: This study found that zinc partially reversed obesity-related metabolic dysfunction, reduced neuroinflammation, and improved memory deficits caused by the CAF diet.
