Review
Endocrinology & Metabolism
Joon Ho Moon, Hak Chul Jang
Summary: Gestational diabetes mellitus (GDM) is a common complication during pregnancy, associated with adverse pregnancy outcomes and long-term complications. There are two diagnostic approaches with controversial clinical benefits.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Endocrinology & Metabolism
Lowri A. Allen, Peter N. Taylor, Kathleen M. Gillespie, Richard A. Oram, Colin M. Dayan
Summary: This review examines the difference in the transmission rate of type 1 diabetes from affected fathers compared to affected mothers. It explores possible mechanisms for this difference and highlights the importance of understanding it in order to identify individuals at high risk and develop interventions to reduce their risk of disease.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Physiology
Vanessa Caruline Araujo-Silva, Alice Santos-Silva, Andressa Silva Lourenco, Cristielly Maria Barros-Barbosa, Rafaianne Queiroz Moraes-Souza, Thaigra Sousa Soares, Barshana Karki, Veronyca Goncalves Paula, Yuri Karen Sinzato, Debora Cristina Damasceno, Gustavo Tadeu Volpato
Summary: Exposure to maternal diabetes and high-fat/high-sugar diet during pregnancy leads to adverse effects on both maternal and fetal health, including increased blood sugar, embryonic loss rate, obesity index, caloric intake, and reduced gravid uterus weight. These effects may be related to inflammatory processes and intrauterine growth restriction.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Jun S. Lai, Shirong Cai, Bee Lan Lee, Keith M. Godfrey, Peter D. Gluckman, Lynette P. Shek, Fabian Yap, Kok Hian Tan, Yap Seng Chong, Choon Nam Ong, Michael J. Meaney, Anne Rifkin-Graboi, Birit F. P. Broekman, Mary F. F. Chong
Summary: Current study found that higher maternal plasma carotenoids concentrations, especially beta-cryptoxanthin, were positively associated with early offspring cognitive and motor development at 2 years old, but not at 4.5 years old. Further investigations are needed to explore if the prenatal influences sustain beyond early childhood.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Malene Dybdahl, Christine Dalgard, Dorte Glintborg, Marianne Skovsager Andersen, Henrik Thybo Christesen
Summary: This study aimed to investigate the association between maternal testosterone concentrations in the third trimester and offspring handgrip strength (HGS) at the age of 5. The results showed that higher concentrations of free testosterone in the third trimester were associated with lower HGS in 5-year-old children, suggesting a negative effect of maternal testosterone on offspring muscle strength.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Hajir Al-Jorani, Richard Christian Jensen, Mikaela T. E. Jonasson, Anna Birukov, Anne Vibeke Schmedes, Henrik Thybo Christesen, Anja F. Dreyer, Tina K. Jensen, Dorte Glintborg, Boye L. Jensen, Marianne S. Andersen
Summary: This study investigated the association between maternal cortisol levels in the third trimester of pregnancy and offspring blood pressure (OBP). The results showed negative associations between maternal cortisol levels and OBP, specifically in boys. This suggests that maternal cortisol is not a risk factor for higher blood pressure in offspring up to the age of 5.
Article
Multidisciplinary Sciences
Valentina Chiavaroli, Sarah A. Hopkins, Janene B. Biggs, Raquel O. Rodrigues, Sumudu N. Seneviratne, James C. Baldi, Lesley M. E. McCowan, Wayne S. Cutfield, Paul L. Hofman, Jose G. B. Derraik
Summary: The study found that increased maternal BMI during mid-pregnancy was associated with higher weight in offspring at 1 year, and with increased weight, BMI, and body fat percentage in children at 7 years. Excessive gestational weight gain was linked to higher abdominal adiposity and less favorable lipid profiles in offspring. Both maternal BMI and excessive GWG independently contributed to increased adiposity in children at age 7.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Tsuyoshi Murata, Hyo Kyozuka, Toma Fukuda, Karin Imaizumi, Hirotaka Isogami, Shun Yasuda, Akiko Yamaguchi, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori
Summary: This study investigated the association between maternal magnesium intake and childhood wheezing incidence in 3-year-old offspring. Higher maternal magnesium intake was found to decrease the incidence of childhood wheezing. Further research is needed to explore the relationship between other prenatal factors and childhood wheezing incidence.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Randi K. Johnson, Roy Tamura, Nicole Frank, Ulla Uusitalo, Jimin Yang, Sari Niinisto, Carin Andren Aronsson, Anette-G. Ziegler, William Hagopian, Marian Rewers, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris
Summary: The study found that maternal food consumption during late pregnancy was not significantly associated with offspring risk for IA or type 1 diabetes.
Article
Endocrinology & Metabolism
Louise Curtin, Marie C. Conway, Mark T. Kilbane, Malachi J. McKenna, Fionnuala M. McAuliffe
Summary: Maternal nutrition during pregnancy does not affect offspring bone mineral density at 5 years. Offspring bone mineral density is correlated with offspring body mass index, and is higher in boys than girls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jelena Meinila, Miira M. Klemetti, Emilia Huvinen, Elina Engberg, Sture Andersson, Beata Stach-Lempinen, Saila Koivusalo
Summary: The study found that maternal macronutrient intake during pregnancy is associated with offspring adiposity at 5 years old, and gestational diabetes may modify the relationship between prenatal n-3 PUFA intake and offspring anthropometrics.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Obstetrics & Gynecology
Alexander Lichtwald, Catherine Weiss, Anja Lange, Till Ittermann, Heike Allenberg, Hans J. Grabe, Matthias Heckmann
Summary: Maternal pre-pregnancy overweight and obesity are negatively associated with school performance and leisure time behavior in offspring, while underweight does not show a significant correlation.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
C. B. Holzman, P. Senagore, J. Xu, G. L. Dunietz, K. L. Strutz, Y. Tian, B. L. Bullen, M. Eagle, J. M. Catov
Summary: PE-related placental/extraplacental membrane findings can help identify women with moderately elevated blood pressure during pregnancy who are at increased risk for developing hypertension later in life. Placental findings are associated with the mother's risk of later-life hypertension.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Endocrinology & Metabolism
Qinwen Du, Yishai Sompolinsky, Asnat Walfisch, Huiping Zhong, Yan Liu, Weiwei Feng
Summary: The study identified a gender-specific association between maternal GDM and the risk of overweight in female offspring at the age of 1 year.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Marta Marlena Zietek, Silvestre Sampino
Summary: Embryos conceived by old females develop normally when transferred to young recipients. However, offspring conceived by old females exhibit altered behaviors even when fostered by young females. Maternal age-related embryonic and uterine factors contribute to pregnancy complications and offspring behavior.
BIOLOGY OF REPRODUCTION
(2023)
Review
Medicine, Research & Experimental
Richard E. Lloyd, Manasi Tamhankar, Ake Lernmark
Summary: Type 1 diabetes is a chronic autoimmune disease characterized by insulin deficiency and hyperglycemia. Virus infections, particularly enteroviruses, are believed to play a potential role in triggering the disease. This review examines the association between enteroviruses and autoimmune development in Type 1 diabetes, as well as the molecular mechanisms involved.
ANNUAL REVIEW OF MEDICINE
(2022)
Correction
Biochemistry & Molecular Biology
Lauric A. Ferrat, Kendra Vehik, Seth A. Sharp, Ake Lernmark, Marian J. Rewers, Jin-Xiong She, Anette-G. Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey P. Krischer, Michael N. Weedon, Richard A. Oram, William A. Hagopian
Article
Endocrinology & Metabolism
Kendra Vehik, David Boulware, Michael Killian, Marian Rewers, Richard McIndoe, Jorma Toppari, Ake Lernmark, Beena Akolkar, Anette-G. Ziegler, Henry Rodriguez, Desmond A. Schatz, Jeffrey P. Krischer, William Hagopian
Summary: This study suggests that an increase of >= 10% in HbA(1c) from baseline is as informative as OGTT 2-hPG in predicting the risk of stage 3 in children with diabetes-associated autoantibodies.
Article
Endocrinology & Metabolism
Jeffrey P. Krischer, Xiang Liu, Ake Lernmark, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar
Summary: The objective of this study was to distinguish predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. The results showed that different predictors were associated with the different types of first appearing autoantibodies. Factors such as male sex, Finnish residence, having a sibling with type 1 diabetes, specific genes, were associated with seroconversion. The predictors of progression to diabetes differed from the predictors of progression to multiple autoantibodies.
Article
Endocrinology & Metabolism
Falastin Salami, Roy Tamura, Lu You, Ake Lernmark, Helena Elding Larsson, Markus Lundgren, Jeffrey Krischer, Anette-Gabriele Ziegler, Jorma Toppari, Riitta Veijola, Marian Rewers, Michael J. Haller, William Hagopian, Beena Akolkar, Carina Torn
Summary: The study found that increased levels of HbA1c were associated with a higher risk of type 1 diabetes, while a decrease in HbA1c levels predicted the development of IA-2A autoantibody. The trajectory of HbA1c can predict the appearance of autoantibodies and the onset of type 1 diabetes.
PEDIATRIC DIABETES
(2022)
Article
Pediatrics
Mohamed Ghalwash, Vibha Anand, Olivia Lou, Frank Martin, Marian Rewers, Anette-G Ziegler, Jorma Toppari, William A. Hagopian, Riitta Veijola
Summary: Screening for islet autoantibodies in adolescents aged 10-18 can effectively predict the development of type 1 diabetes, allowing for education and prevention measures.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Endocrinology & Metabolism
Xiang Liu, Suzanne Bennett Johnson, Kristian F. Lynch, Kerry Cordan, Russell Pate, Martha D. Butterworth, Ake Lernmark, William A. Hagopian, Marian J. Rewers, Richard A. McIndoe, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Jimin Yang, TEDDY Study Grp
Summary: This study found that increasing the daily duration of moderate to vigorous physical activity can reduce the risk of developing type 1 diabetes in children aged 5-15 who have multiple islet autoantibodies.
Article
Endocrinology & Metabolism
Steffen U. Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup-Poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi M. Virtanen, Jill M. Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin-Xiong She, Beena Akolkar, Stephen Rich, Carin Andren Aronsson, Ake Lernmark, Anette-Gabriele Ziegler, Jorma Toppari, Jeffrey Krischer, Hemang M. Parikh, Christina Ellervik, Jannet Svensson
Summary: It is found that iron intake and genetically determined iron overload may interact in predisposing to the development of childhood islet autoimmunity and type 1 diabetes. A U-shaped association between iron intake and risk of GAD antibody as the first autoantibody in children was found. High iron intake was associated with an increased risk of IA with insulin as the first autoantibody in children with 2 or more iron risk alleles.
Review
Medicine, General & Internal
Ake Lernmark, Beena Akolkar, William Hagopian, Jeffrey Krischer, Richard McIndoe, Marian Rewers, Jorma Toppari, Kendra Vehik, Anette-G. Ziegler, TEDDY Study Grp
Summary: The etiology of type 1 diabetes involves pancreatic islet beta-cell autoimmune pathogenesis that leads to the clinical onset of the disease. By testing autoantibodies against insulin, glutamic acid decarboxylase, islet antigen-2, and ZnT8 transporter, children can be monitored from birth until the appearance of the first islet autoantibody. The incidence rate of the first-appearing autoantibody follows two different patterns, and an innate immune reaction may precede the adaptive response.
JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Medical Laboratory Technology
David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Ake Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
Summary: This article summarizes the scientific evidence and recommendations for laboratory tests used in the diagnosis and management of patients with diabetes mellitus. The quality of the evidence supporting these tests varies, so an expert committee evaluated and compiled evidence-based recommendations. The guidelines were reviewed and revised based on feedback from reviewers and the public. They were then reviewed and approved by multiple professional organizations.
CLINICAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Ake Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
Summary: This passage discusses the use of laboratory tests in the diagnosis and management of diabetes mellitus, and provides evidence-based recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes.
CLINICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Ake Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
Summary: This article provides evidence-based recommendations for laboratory analysis in patients with diabetes, including diagnostic methods, monitoring of glycemic control, and measurement of other related markers. The recommendations are based on published data or expert consensus.
Article
Endocrinology & Metabolism
Ulla Uusitalo, Lazarus K. Mramba, Carin Andren Aronsson, Kendra Vehik, Jimin Yang, Sandra Hummel, Ake Lernmark, Marian Rewers, William Hagopian, Richard Mcindoe, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Suvi M. Virtanen, Jill M. Norris, TEDDY Study Grp
Summary: This study aimed to investigate the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to the risk of islet autoimmunity (IA). The results showed that early introduction of solid foods (<6 months) was associated with increased IA risk in children with the HLA DR3/4 genotype and no probiotic exposure during the first year of life. Introducing rice at 4-5.9 months, compared to other time periods in the US, was also associated with an increased risk of IA.
Letter
Medicine, General & Internal
Jeffrey P. Krischer, Ake Lernmark, William A. Hagopian, Marian J. Rewers, Richard McIndoe, Jorma Toppari, Anette-Gabriele Ziegler, Beena Akolkar
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cell Biology
Ernesto S. Nakayasu, Lisa M. Bramer, Charles Ansong, Athena A. Schepmoes, Thomas L. Fillmore, Marina A. Gritsenko, Therese R. Clauss, Yuqian Gao, Paul D. Piehowski, Bryan A. Stanfill, Dave W. Engel, Daniel J. Orton, Ronald J. Moore, Wei-Jun Qian, Salvatore Sechi, Brigitte I. Frohnert, Jorma Toppari, Anette-G. Ziegler, Ake Lernmark, William Hagopian, Beena Akolkar, Richard D. Smith, Marian J. Rewers, Bobbie-Jo M. Webb-Robertson, Thomas O. Metz, Teddy Study Grp
Summary: Type 1 diabetes (T1D) is caused by autoimmune destruction of b cells. The insufficient availability of biomarkers hinders understanding of the disease. This study identifies and validates biomarkers predictive of T1D development through plasma proteomics, highlighting the pathways affected during T1D progression.
CELL REPORTS MEDICINE
(2023)
