Role of integrin signalling through integrin-linked kinase in skin physiology and pathology

Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis

(2013) Michal Tomcik et al.   ANNALS OF THE RHEUMATIC DISEASES

ILK: a pseudokinase with a unique function in the integrin–actin linkage

(2013) Sushmita Ghatak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

(2013) Korana Radovanac et al.   EMBO JOURNAL

Canonical Wnt signalling as a key regulator of fibrogenesis - implications for targeted therapies?

(2013) Clara Dees et al.   EXPERIMENTAL DERMATOLOGY

Disorders of the cutaneous basement membrane zone—The paradigm of epidermolysis bullosa

(2013) Leena Bruckner-Tuderman et al.   MATRIX BIOLOGY

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Local injection of latency-associated peptide, a linker propeptide specific for active form of transforming growth factor-beta1, inhibits dermal sclerosis in bleomycin-induced murine scleroderma

(2011) Taeko Nakamura-Wakatsuki et al.   EXPERIMENTAL DERMATOLOGY

Biochemical, Proteomic, Structural, and Thermodynamic Characterizations of Integrin-linked Kinase (ILK)

(2011) Koichi Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Scleroderma: from pathophysiology to novel therapeutic approaches

(2010) Nicolas Hunzelmann et al.   EXPERIMENTAL DERMATOLOGY

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGF 1 levels and RhoA activity

(2010) K. Blumbach et al.   JOURNAL OF CELL SCIENCE

Integrin-Linked Kinase Is Required for TGF-β1 Induction of Dermal Myofibroblast Differentiation

(2010) Linda Vi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

(2009) Sara A Wickström et al.   EMBO JOURNAL

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

(2009) Koichi Fukuda et al.   MOLECULAR CELL

Integrin-linked kinase is an adaptor with essential functions during mouse development

(2009) Anika Lange et al.   NATURE

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

β1 Integrin-Mediated Adhesion Signalling Is Essential for Epidermal Progenitor Cell Expansion

(2009) Aleksandra Piwko-Czuchra et al.   PLoS One

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Critical regulation of TGF  signaling by Hsp90

(2008) K. H. Wrighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional role of β1 integrin-mediated signalling in the human hair follicle

(2007) J.E. Kloepper et al.   EXPERIMENTAL CELL RESEARCH