Article
Biochemistry & Molecular Biology
Janin Henkel, Julia Klauder, Meike Statz, Anne-Sophie Wohlenberg, Sonja Kuipers, Madita Vahrenbrink, Gerhard Paul Pueschel
Summary: The study found that a mix of palmitate, insulin, and PGE(2) in dysfunctional adipose tissue can induce the production of the pro-inflammatory cytokine IL-8. Insulin and PGE(2) amplify the effect of palmitate on IL-8 induction, exacerbating inflammation and insulin resistance.
Article
Oncology
Lee Peng Karen-Ng, Usama Sharif Ahmad, Luis Gomes, Keith David Hunter, Hong Wan, Eleni Hagi-Pavli, Eric Kenneth Parkinson
Summary: Early treatment of oral cancer is crucial for better cure rates and reduced disability. Oral cancer is difficult to detect early as it develops unseen. Two types of epithelial cells in oral tissue may contribute to the progression to malignancy. Regulators of prostaglandin secretion in premalignant oral cells have been identified as potential targets for future therapies.
Article
Biochemistry & Molecular Biology
Piotr Wojcik, Michal Biernacki, Natalia Domian, Neven Zarkovic, Elzbieta Skrzydlewska
Summary: This study evaluated the impact of Celecoxib on apoptosis in keratinocytes, and the results suggested that COX-2 inhibition can attenuate UVB-induced apoptosis, with AEA playing a significant role as an anti-apoptotic agent in this process.
Article
Agriculture, Multidisciplinary
Kai-yuan Ji, Ru-jun Wen, Zheng-zhou Wang, Qian-qian Tian, Wei Zhang, Yun-hai Zhang
Summary: In mammals, miRNAs regulate the expression of target genes and play crucial roles in various biological processes. The expression levels of miR-370-5p differ significantly in sheep with different hair colors, but its function is not clear. This study investigated the roles of miR-370-5p in sheep melanocytes and found that its overexpression significantly inhibited cell proliferation (P<0.01), tyrosinase activity (P=0.001), and melanin production (P<0.001).
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Jeong Hyeon Lee, Myoung Eun Choi, Hongchan An, Ju Won Moon, Hye Jin Yeo, Youngsup Song, Sung Eun Chang
Summary: BCI-215 effectively inhibits melanogenesis by suppressing the expression of microphthalmia-associated transcription factor (MITF) and its downstream enzymes. This study provides a new therapeutic strategy for treating pigmentation disorders using DUSP-related signaling modulators.
Article
Biochemistry & Molecular Biology
Hitesh Soni, Ravi Kumar, Praghalathan Kanthakumar, Adebowale Adebiyi
Summary: IL-1 beta induces Ca2+ entry via TRPA1 channels, leading to MAPK-dependent mesangial cell proliferation without stimulating fibronectin production.
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Kenta Murata, Manami Oyama, Misaki Ogata, Nina Fujita, Ryuji Takahashi
Summary: This study demonstrated that Jumihaidokuto (JHT) can effectively prevent UVB-induced skin damage by inhibiting the production of proinflammatory mediators.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Biochemistry & Molecular Biology
Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Hidekazu Suzuki, Takamitsu Konishi, Asato Maekawa, Kazuma Murata, Kengo Yamamoto
Summary: The molecular mechanism of discogenic low back pain involves nonphysiological nerve invasion into a degenerated intervertebral disc induced by nerve growth factor. Selective cyclooxygenase-2 inhibitors are used to treat low back pain by suppressing the inflammatory mediator prostaglandin E-2. However, it was found that prostaglandins PGE(2) and PGE(1) can suppress the expression of nerve growth factor induced by IL-1 beta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Integrative & Complementary Medicine
Ji-Ae Hong, Donghyuk Bae, Kyo-Nyeo Oh, Dool-Ri Oh, Yujin Kim, Yonguk Kim, So Jeong Im, Eun-Jin Choi, Seul-Gi Lee, Moonjong Kim, Changsik Jeong, Chul Yung Choi
Summary: The water extract of Quercus acuta Thunb. (QAF) contains gallotannic acid and ellagic acid, which can reduce oxidative stress and collagen degradation in UVB-irradiated human keratinocytes. QAF inhibits MMP-1 expression and prevents skin photoaging by inactivating the ERK/AP-1 signaling pathway. Overall, QAF shows potential as a natural biomaterial for inhibiting UVB-induced skin aging.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biotechnology & Applied Microbiology
Mingming Ma, Qiao Luo, Lijing Fan, Weilong Li, Qiang Li, Yu Meng, Chen Yun, Hongwei Wu, Yongping Lu, Shuang Cui, Fanna Liu, Bo Hu, Baozhang Guan, Huanhuan Liu, Shengling Huang, Wenxue Liang, Stanislao Morgera, Bernhard Kraemer, Shaodong Luan, Lianghong Yin, Berthold Hocher
Summary: This study found that urinary exosomes from premature infants can reduce serum creatinine levels, prevent renal tubular cell apoptosis, and decrease mouse mortality.
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)