Article
Dermatology
Keiko Nakahashi, Kaito Nihira, Miyoko Suzuki, Toshihiko Ishii, Kazuhiro Masuda, Kiyotoshi Mori
Summary: In this study, a new mouse model of CTCL was developed to evaluate the efficacy of PUVA therapy, and the combination treatment of PUVA and mogamulizumab showed greater antitumor activity than either monotherapy.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Hematology
Sara Beygi, George E. Duran, Sebastian Fernandez-Pol, Alain H. Rook, Youn H. Kim, Michael S. Khodadoust
Summary: Resistance to mogamulizumab in mycosis fungoides and Sezary syndrome is often associated with loss of CCR4 expression and emergence of CCR4 genomic alterations. This finding has significant implications for the management and monitoring of patients receiving mogamulizumab and the development of future CCR4-directed therapies.
Review
Biochemistry & Molecular Biology
Shuichi Nakai, Eiji Kiyohara, Rei Watanabe
Summary: CTCL is a heterogeneous group of non-Hodgkin lymphoma, mainly including MF and SS, with malignant cells possibly originating from different T cell phenotypes. The pathogenesis and therapeutic strategies for CTCL remain unclear due to the similar characteristics between malignant cells and anti-tumor T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A. Teichmann, Fan Bai, Yang Wang
Summary: Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphoma characterized by clonal malignant T cells. This study analyzed CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Zhen Han, Renee J. Estephan, Xiwei Wu, Chingyu Su, Yate-Ching Yuan, Hanjun Qin, Sung Hee Kil, Corey Morales, Daniel Schmolze, James F. Sanchez, Lei Tian, Jianhua Yu, Marcin Kortylewski, Steven T. Rosen, Christiane Querfeld
Summary: Cutaneous T cell lymphoma (CTCL) is a malignant tumor characterized by chronic inflammation. This study found that miR-155-5p, miR-130b-3p, and miR-21-3p positively correlated with immune checkpoint gene expression in CTCL and were enriched in the IL-6/Jak/signal transducer and activator of transcription signaling pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Cell Biology
Amy Xiao, Oleg E. Akilov
Summary: The loss of CD47 on aging cells signals macrophages to eliminate the target. CD47 acts as a "do-not-eat-me" sign that prevents macrophagal phagocytosis by interacting with its ligand SIRP alpha. Malignant lymphocytes highly express CD47, making them ideal candidates for targeted anti-CD47 therapies. There are various types of anti-CD47-SIRP alpha therapeutic molecules, including monoclonal antibodies, bioengineered proteins, miRNAs, and bispecific antibodies. Blocking the CD47-SIRP alpha axis in combination with targeting secondary tumor microenvironment (TME) may enhance the effectiveness of current immunotherapeutic approaches.
Article
Biochemistry & Molecular Biology
Minami Sakamoto, Tomomitsu Miyagaki, Hiroaki Kamijo, Tomonori Oka, Hikari Boki, Naomi Takahashi-Shishido, Hiraku Suga, Makoto Sugaya, Shinichi Sato
Summary: CD147 and CypA are overexpressed in tumor cells of mycosis fungoides and Sezary syndrome patients, and CypA is also expressed by epidermal keratinocytes in lesional skin. Serum CypA levels are elevated and correlated with disease severity markers. Anti-CD147 and/or anti-CypA antibodies can suppress the proliferation of CTCL cell lines by downregulating signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Sara Peru, Martina Prochazkova-Carlotti, Floriane Cherrier, Joanne Velazquez, Elodie Richard, Yamina Idrissi, David Cappellen, Lamia Azzi-Martin, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio, Sandrine Poglio
Summary: Cutaneous T-cell lymphoma (CTCL) is characterized by abnormal infiltration of T lymphocytes in the skin. In this study, the researchers found that the expression of cutaneous lymphocyte antigen (CLA) in CTCL cells is crucial for their migration and survival. The use of a CLA antibody significantly reduced the migration and survival of CTCL cells both in vitro and in vivo. These findings suggest that inhibiting CLA could be a potential therapeutic strategy for CTCL patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Genetics & Heredity
Vladimir Vasku, Jan Machal, Filip Zlamal, Anna Vasku
Summary: This study evaluated the survival of CTCL patients and analyzed 19 gene variants. The results showed that the TT genotype at position 2677 of the MDR1 gene is associated with longer survival in CTCL patients.
Review
Cell Biology
Melika Motamedi, Maggie Z. X. Xiao, Aishwarya Iyer, Robert Gniadecki
Summary: Mycosis fungoides (MF) has varying prognoses at different stages, with late stages associated with an increased risk of mortality. This study identified transcriptomic changes involved in MF pathogenesis and progression, highlighting 15 genes that play a role in MF progression.
Article
Oncology
Yixin Luo, Maarten H. Vermeer, Frank R. de Gruijl, Willem H. Zoutman, Marjolein Sluijter, Thorbald van Hall, Cornelis P. Tensen
Summary: This study investigates the mechanisms of MF by creating mouse models. The results show that knockout of the Socs1 gene can lead to skin lesions and activation of CD4 T cells. However, single copy loss of Socs1 is insufficient to induce a phenotype resembling early stage MF in the presence of sustained inflammation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Daniel Falkenhain-Lopez, Mario Puerta-Pena, Jon Fulgencio-Barbarin, Alba Sanchez-Velazquez, Cristina Vico-Alonso, Concepcion Postigo-Llorente, Pablo L. Ortiz-Romero
Summary: This study reported 36 patients who received PEG-DOXO for MF or SS, showing the best overall responses for skin, lower response rates for nodal involvement, and moderate responses for blood disease. The treatment was well tolerated without severe adverse events, and no cardiotoxicity was observed on cardiac function monitoring.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Dermatology
Kazuyasu Fujii
Summary: Mycosis fungoides (MF) and Sezary syndrome (SS) are representative cutaneous lymphomas, with a shift from Th1 to Th2 environment as the disease progresses. Staphylococcus aureus is highly sensitive in advanced stages, and susceptibility to infection is related to the main symptoms of MF.
JOURNAL OF DERMATOLOGY
(2022)
Article
Cell Biology
Philipp Licht, Volker Mailaender
Summary: Cutaneous T-Cell Lymphomas (CTCL) exhibit clinical variability and transcriptional heterogeneity, with different T-cell subtypes suggested as sources of the disease. The microbiome may play a role in disease progression and transcriptional heterogeneity, and microbial approaches have the potential to aid in diagnosis and treatment of CTCL.
Article
Hematology
Fengjie Liu, Yumei Gao, Bufang Xu, Shan Xiong, Shengguo Yi, Jingru Sun, Zhuojing Chen, Xiangjun Liu, Yingyi Li, Yuchieh Lin, Yujie Wen, Yao Qin, Shuxia Yang, Hang Li, Trilokraj Tejasvi, Lam Tsoi, Ping Tu, Xianwen Ren, Yang Wang
Summary: This study identified unique transcriptional programs and enriched expression of genes at the chr7q locus in tumors undergoing large-cell transformation (LCT) in late-stage mycosis fungoides (MF). Aberrant expression of the imprinted gene Paternally Expressed Gene 10 (PEG10) in LCT was shown to drive cell size increase, promote proliferation, and confer treatment resistance through a PEG10/KLF2/NF-kappa B axis. Pharmacological targeting of PEG10 reversed the proliferation and treatment resistance phenotypes in LCT, suggesting PEG10 inhibition as a promising therapeutic approach.
Article
Dermatology
Maria Gluud, Simon Fredholm, Edda Blumel, Andreas Willerslev-Olsen, Terkild Brink Buus, Claudia Nastasi, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Anders Woetmann, Lars Iversen, Thomas Litman, Carsten Geisler, Niels Odum, Lise M. Lindahl
Summary: This study provides evidence that miR-93 targets the cell cycle regulator p21 and promotes growth of malignant T cells in MF. Inhibition of miR-93 can increase p21 expression and inhibit malignant proliferation. Treatment with SAHA reduces miR-93 expression and enhances p21 expression in malignant T cells, partly through an inhibition of miR-93.
Article
Allergy
Anders B. Funch, Veronika Mraz, Anne-Sofie O. Gadsboll, Mia H. Jee, Julie F. Weber, Niels Odum, Anders Woetmann, Jeanne D. Johansen, Carsten Geisler, Charlotte M. Bonefeld
Summary: This study demonstrates that epidermal CD8(+) T-RM cells play a crucial role in causing ACD flare-ups through rapid recruitment of neutrophils to the epidermis.
Article
Immunology
Daniel Villalba Lopez, Fatima A. H. Al-Jaberi, Anders Woetmann, Niels Odum, Charlotte Menne Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: The active form of vitamin D-3, 1,25(OH)(2)D-3, has a significant impact on T cell effector function. However, vitamin D binding protein (DBP) can hinder its effectiveness. Recent research shows that in highly inflammatory conditions, M1 macrophages can produce sufficient levels of 1,25(OH)(2)D-3 to suppress T cell-mediated inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Daniel V. Lopez, Fatima A. H. Al-Jaberi, Nkerorema D. Damas, Brian T. Weinert, Urska Pus, Sara Torres-Rusillo, Anders Woetmann, Niels Odum, Charlotte M. Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Th22 cells are a CD4(+) T cell subset that produces interleukin (IL)-22 and primarily acts on epithelial cells, affecting keratinocyte proliferation, differentiation, and maturation. The regulation of IL-22 production in human T cells involves the transcription factors AhR and ROR gamma t, as well as the active form of vitamin D-3. The inhibition of IL-22 production by 1,25(OH)(2)D-3 through VDR and VDRE has been identified as a key mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Martin Kongsbak-Wismann, Fatima A. H. Al-Jaberi, Jonas Damgard Schmidt, Mustafa Ghanizada, Cecilie Bo Hansen, Daniel Villalba Lopez, Anders Woetmann, Niels odum, Charlotte Menne Bonefeld, Anette Stryhn, Peter Garred, Soren Buus, Carsten Geisler
Summary: The COVID-19 pandemic has had a significant impact worldwide, leading to increased interest in measures to combat the virus, including the role of vitamin D. Recent studies suggest an inverse relationship between plasma vitamin D levels and susceptibility to SARS-CoV-2. However, a study of a family with a mutated vitamin D receptor has questioned the central role of vitamin D in generating an adaptive immune response against SARS-CoV-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Allergy
Misbah Noshela Ghazanfar, Ewa Anna Bartko, Nicolai Skovbjerg Arildsen, Lars K. Poulsen, Bettina Margrethe Jensen, Christian Enevold, Jesper Gronlund Holm, Anders Woetmann, Niels odum, Simon Francis Thomsen
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Hematology
Maria Gluud, Emil M. H. Pallesen, Terkild B. Buus, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Maria R. Kamstrup, Michael Bzorek, Maria Danielsen, Rikke Bech, Madalena N. Monteiro, Edda Blumel, Andreas Willerslev-Olsen, Anders Lykkebo-Valloe, Chella Krishna Vadivel, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Carsten Geisler, Juergen C. Becker, Sergei B. Koralov, Lars Iversen, Thomas Litman, Anders Woetmann, Niels Odum
Summary: Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms and increase the risk of bacterial infection. The study found that malignant T cells secrete cytokines that downregulate the expression of filaggrin and filaggrin-2, leading to compromised skin barrier. Treatment with JAK inhibitors can reverse this effect and increase filaggrin expression in patients with advanced CTCL.
Article
Oncology
Cheng Chi, Lisa Harth, Marina Ramirez Galera, Marina Passos Torrealba, Chella Krishna Vadivel, Carsten Geisler, Charlotte Menne Bonefeld, Pia Rude Nielsen, Michael Bzorek, Juergen C. Becker, Lise Mette Rahbek Gjerdrum, Niels Odum, Anders Woetmann
Summary: In this study, researchers found that FASN is highly expressed in CTCL cells, and inhibition of FASN affects cell viability and proliferation. The upregulation of FASN induced by FASN inhibitors can be partially reversed by SREBP. Therefore, the combination of FASN and SREBP inhibitors may have promising therapeutic effects in CTCL.
Article
Cell Biology
Anna K. O. Rode, Terkild Brink Buus, Veronika Mraz, Fatima Abdul Hassan Al-Jaberi, Daniel Villalba Lopez, Shayne L. Ford, Stephanie Hennen, Ina Primon Eliasen, Ib Vestergaard Klewe, Leila Gharehdaghi, Adrian Dragan, Mette M. Rosenkilde, Anders Woetmann, Lone Skov, Niels Odum, Charlotte M. Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Studies show that activated human T cells express functional GLP-1R, with a pronounced expression in induced Treg cells. Through single-cell sequencing, the presence of GLP-1R in iTreg cells was confirmed.
Article
Allergy
Anders Boutrup Funch, Julie Friis Weber, Rebecca Kitt Davidson Lohmann, Veronika Mraz, Kelvin Yeung, Mia Hamilton Jee, Niels Odum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menne Bonefeld
Summary: This study reveals that clinically relevant contact allergens can generate pathogenic, epidermal CD8(+) T-RM cells that recruit neutrophils following re-exposure to the allergen, but this response is normally suppressed by the induction of anti-inflammatory CD4(+) T cells.
CONTACT DERMATITIS
(2023)
Article
Biochemistry & Molecular Biology
Kelly Cristina Gomes Manfrere, Marina Passos Torrealba, Frederico Moraes Ferreira, Emanuella Sarmento Alho de Sousa, Denis Miyashiro, Franciane Mouradian Emidio Teixeira, Ricardo Wesley Alberca Custodio, Helder I. Nakaya, Yasmin Alefe Leuzzi Ramos, Mirian Nacagami Sotto, Anders Woetmann, Niels odum, Alberto Jose da Silva Duarte, Jose Antonio Sanches, Maria Notomi Sato
Summary: This study investigated the expression levels of inflammatory markers IL-1B and IL-18 in the skin, serum, blood cells, and lymph nodes of patients with Sezary syndrome, as potential markers of inflammasome activation. The findings showed compartmentalized expressions of IL-1B and IL-18, with increased expression of IL-1B in the epidermis and increased expression of IL-18 in the dermis. In advanced stages of the disease, enhanced expression of IL-18 and downregulation of IL-1B were observed in the lymph nodes. This study provided the first evidence of the imbalance of IL-1B and IL-18 in patients with Sezary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Veronika Mraz, Anders B. Funch, Mia H. Jee, Anne-Sofie O. Gadsboll, Julie F. Weber, Kelvin Yeung, Rebecca K. D. Lohmann, Alana Hawkes, Niels Odum, Anders Woetmann, Dianne Mckay, Deborah Witherden, Carsten Geisler, Charlotte M. Bonefeld
Summary: CD8(+) TRM cells play a key role in allergic contact dermatitis (ACD), and CD100 is an essential protein for the activation of CD8(+) TRM cells and the flare-up response of ACD.
CONTACT DERMATITIS
(2023)
Article
Allergy
Veronika Mraz, Rebecca K. D. Lohmann, Mandy Menzel, Alana Hawkes, Helen Vaher, Anders B. Funch, Mia H. Jee, Anne-Sofie o. Gadsboll, Julie F. Weber, Kelvin Yeung, Niels Odum, Anders Woetmann, Dianne Mckay, Deborah Witherden, Carsten Geisler, Charlotte M. Bonefeld
Summary: This study reveals the central role of JAML in CHS and suggests a potential new target for the treatment of ACD in humans.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Pia Rude Nielsen, Jens Ole Eriksen, Mia Dahl Sorensen, Ulrike Wehkamp, Lise M. Lindahl, Michael Bzorek, Lars Iversen, Anders Woetman, Niels Odum, Thomas Litman, Lise Mette Rahbek Gjerdrum
Summary: Mycosis fungoides is the most common cutaneous T-cell lymphoma, and it has been found that B-cells play an important role in the disease and show upregulation during disease progression. These findings could potentially lead to new treatment strategies for mycosis fungoides.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)