期刊
EXPERIMENTAL DERMATOLOGY
卷 19, 期 2, 页码 151-153出版社
WILEY
DOI: 10.1111/j.1600-0625.2009.01028.x
关键词
actinic keratosis; carcinoma; epidermal growth factor receptor; fluorescence; in situ hybridization; squamous cell
类别
资金
- Fondo de Investigacion Sanitaria (FIS) [PI04/1728]
- Spanish Ministry of Health
- AECC 2007
- Catalunya contra el Cancer, Barcelona, Spain
- Instituto de Salud Carlos III FEDER
- Ministerio de Sanidad y Consumo (Spain)
- Red Tematica de Investigacion Cooperativa en Cancer (RTICC) [RD07/0020/2004]
Epidermal growth factor receptor (EGFR) gene amplification and protein overexpression are common in several cancers. EGFR status has seldom been studied in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein overexpression in 25 AKs and 35 invasive SCCs by means of fluorescence in situ hybridization (FISH) and immunohistochemistry. EGFR numerical aberrations were detected in 52% of AKs and 77.1% of SCCs (P = 0.042). EGFR amplification was identified in 12% of AKs and 20% of SCCs. No differences regarding EGFR numerical aberrations were observed when AKs with high-grade dysplasia were compared with SCCs. A good correlation was observed between EGFR numerical aberrations and EGFR overexpression. Our results suggest that EGFR numerical aberrations occur in the early stages of epithelial carcinogenesis in skin, not playing a role in the progression from low-grade SCCs into more aggressive phenotypes.
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