期刊
EXPERIMENTAL DERMATOLOGY
卷 19, 期 12, 页码 1105-1107出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0625.2010.01134.x
关键词
IL-1; keratinocytes; psoriasis; T helper cells
类别
资金
- DFG [GRK 1441, SFB 566, A6]
- Royal Society [2008/R4]
Keratinocytes and activated T cells interact in skin inflammation by virtue of chemokines and cytokines. T cell-derived IL-17 has been described to play an important role in the course of psoriatic inflammation. In this study, we addressed how keratinocytes influence the secretion of IL-17 in autologous T cell subsets. We found that a co-culture of autologous keratinocytes and T cell-receptor-stimulated T cells markedly enhanced the production of IL-17. Besides the importance of direct cell contact, this effect was mainly mediated by IL-1 and could be blocked by the IL-1 antagonist anakinra. An additional increase in IL-17 production by IL-23 was only seen in the presence of IL-1, which thus plays a permissive role for the action of IL-23. Importantly, co-culture of keratinocytes with CCR6+ CD4+ T cells that are enriched for Th17 cells resulted in significantly higher IL-17 production compared to co-culture with CD4+ T cells.
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