Article
Biochemistry & Molecular Biology
Laurence Bouillet, Alban Deroux, Meryem Benmarce, Chloe Guerin, Laura Bouvet, Olivia Garnier, Donald K. Martin, Isabelle Vilgrain
Summary: Long COVID-19 syndrome is characterized by acute damage to microcapillaries, microthrombi, and endothelialitis after SARS-CoV-2 infection. It has been discovered that VE-cadherin, a component of endothelial cell junctions, is a target for ACE2 cleavage. This cleavage leads to the production of soluble fragments of VE-cadherin, which serve as potential biomarkers for vascular disease in Long COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Yan Zhang, Ke Xu, Dengke Zhi, Mengyuan Qian, Kaizheng Liu, Qizhi Shuai, Zheng Qin, Jinghui Xie, Kai Wang, Jun Yang
Summary: In this study, a novel bioactive surface integrating human VE-cadherin-Fc and VEGF-Fc fusion proteins was developed for the modification of electrospun fibrous grafts, which promoted the regeneration of functional endothelium and improved the patency of artificial vascular grafts. The VE-cadherin/VEGF surface upregulated the expression of endogenous VE-cadherin and activated the signaling pathways related to endothelial function. Additionally, it enhanced cellularization and capillary formation, leading to accelerated regeneration of functional endothelium and smooth muscle.
ADVANCED FIBER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xi Tan, Bjorn Petri, Rebekah DeVinney, Craig N. Jenne, George Chaconas
Summary: Lyme disease, caused by Borrelia burgdorferi, is the most common tick-transmitted disease in the northern hemisphere. The mechanism by which these spirochetes breach the blood vessel wall to reach distant tissues is not well understood. Research has revealed that host neutrophils play a role in promoting bacterial escape into surrounding tissue by producing specific cytokines.
MOLECULAR MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tanja Gerlza, Margareta Nagele, Zala Mihalic, Christina Trojacher, Andreas Kungl
Summary: The study found that removing heparan sulfate from the surface of neutrophils and monocytes significantly reduced leukocyte migration, while monocyte chemotaxis induced by CCL2 also depended on chondroitin sulfate. These results suggest that glycosaminoglycans on immune cell surfaces act synergistically with GPC receptors during leukocyte migration, and are influenced by glycosaminoglycans on the inflamed tissue.
Article
Cell Biology
Sofia K. H. Morsing, Timo Rademakers, Sanne L. N. Brouns, Anne-Marieke D. van Stalborch, Marjo M. P. C. Donners, Jaap D. van Buul
Summary: The study reveals that endothelial ADAM10 plays a role in facilitating neutrophil transendothelial migration by cleaving ICAM-1, supporting the efficient release of neutrophils from the endothelium. Silencing or inhibiting endothelial ADAM10 leads to a significantly longer diapedesis step for neutrophils due to impaired dissociation from ICAM-1. Increased ICAM-1 levels on transmigrating neutrophils and potential membrane transfer from endothelium to neutrophils are also observed.
Review
Biochemistry & Molecular Biology
Olivia Garnier, Isabelle Vilgrain
Summary: The endothelial cells in established blood vessels are quiescent but play a crucial role in controlling the permeability of the blood vessel interior. Adherens junctions, which are intercellular contacts, are important for the organization and maintenance of the endothelial cell monolayer. The dysfunction of adherens junctions and the role of sphingosine-1-phosphate signaling in vascular disease are still open questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Arturo Flores-Pliego, Jael Miranda, Sara Vega-Torreblanca, Yolotzin Valdespino-Vazquez, Cecilia Helguera-Repetto, Aurora Espejel-Nunez, Hector Borboa-Olivares, Salvador Espino y Sosa, Paloma Mateu-Rogell, Moises Leon-Juarez, Victor Ramirez-Santes, Arturo Cardona-Perez, Isabel Villegas-Mota, Johnatan Torres-Torres, Angeles Juarez-Reyes, Thelma Rizo-Pica, Rosa O. Gonzalez, Lorenza Gonzalez-Mariscal, Guadalupe Estrada-Gutierrez
Summary: Research has shown that COVID-19 can lead to leaky endothelium and thrombosis in placental vessels, with severity of the disease playing a role in the manifestation of these conditions.
Article
Immunology
Zuzana Parackova, Irena Zentsova, Marketa Bloomfield, Adam Klocperk, Rudolf Horvath, Hana Malcova, Dita Cebecauerova, Anna Sediva
Summary: This study analyzed gene expression of PBMCs in children with JIA and found that LDNs existed in patients' PBMCs with altered gene expression and release of products. LDNs were described as primed, degranulated, immature cells with impaired suppressive activities, correlated with serum calprotectin levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Karen V. Lithgow, Emily Tsao, Ethan Schovanek, Alloysius Gomez, Leigh Anne Swayne, Caroline E. Cameron
Summary: Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses endothelial barriers using a cholesterol-dependent endocytosis mechanism without disrupting barrier permeability. The bacteria disrupt the main endothelial junctional protein structure and may also utilize a paracellular route for traversal.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Hematology
Shigeo Godo, Akira Suda, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa
Summary: Accumulating evidence over the past few decades has shown that structural and functional abnormalities of coronary microvasculature are highly prevalent and associated with adverse clinical outcomes in patients with various cardiovascular diseases. CMD has been recognized as an important clinical entity, with potential mechanisms including enhanced coronary vasoconstrictive reactivity at the microvascular level.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Janine J. G. Arts, Eike K. Mahlandt, Lilian Schimmel, Max L. B. Gronloh, Sanne van der Niet, Bart J. A. M. Klein, Mar Fernandez-Borja, Daphne van Geemen, Stephan Huveneers, Jos van Rijssel, Joachim Goedhart, Jaap D. van Buul
Summary: In an inflammatory response, leukocytes need to cross the endothelial monolayer to enter tissue and clear pathogens. Focal adhesions mark the migration path of neutrophils, which recognize and navigate around them to continue their movement. The manipulation of focal adhesion quantity affects the basolateral crawling of neutrophils, demonstrating their importance in leukocyte migration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Sergiy Yakovlev, Leonid Medved
Summary: This study reveals the dual function of the β N-domains of fibrin, with their C-terminal regions promoting leukocyte transmigration and their N-terminal regions inhibiting this process. The (β40-66)2 fragment bound to VLDLR, promoting endothelial permeability and leukocyte transmigration, while the (β15-44)2 fragment did not interact with this receptor and had no effect on leukocyte transmigration.
THROMBOSIS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Daniel Delgado-Bellido, F. J. Oliver, Maria Victoria Vargas Padilla, Laura Lobo-Selma, Antonio Chacon-Barrado, Juan Diaz-Martin, Enrique de alava
Summary: Tumor growth can be facilitated by the expansion of blood vessels or the development of vasculogenic mimicry (VM), a novel pathway involving aggressive tumor cells expressing endothelial cell markers. VM is associated with high tumor grade, cancer cell invasion, metastasis, and reduced survival. This review summarizes studies on angiogenesis and aberrant angiogenesis by tumor cells, discusses the intracellular signaling mechanisms involved in VM formation, and explores the implications for tumor angiogenesis and targeted therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Derek C. Sung, Xiaowen Chen, Mei Chen, Jisheng Yang, Susan Schultz, Apoorva Babu, Yitian Xu, Siqi Gao, T. C. Stevenson Keller, Patricia Mericko-Ishizuka, Michelle Lee, Ying Yang, Joshua P. Scallan, Mark L. Kahn
Summary: This study shows that VE-cadherin plays a crucial role in trophoblast migration and endovascular invasion during placental development in mice. Deficiency of VE-cadherin results in failure of spiral artery remodeling, decreased maternal blood flow into the placenta, and fetal growth restriction. These findings highlight a non-endothelial function of VE-cadherin in trophoblasts and suggest that endothelial proteins may have unique roles in these cells.
Editorial Material
Cell Biology
Natalia Reglero-Real, Lorena Perez-Gutierrez, Sussan Nourshargh
Summary: Inflammatory reactions are characterized by the infiltration of neutrophils into tissues, which is regulated by endothelial cell autophagy. Specifically, autophagy machinery controls the architecture of endothelial cell contacts and the reorganization and degradation of adhesion molecules, serving as a physiological brake on leukocyte trafficking.
Review
Biochemistry & Molecular Biology
Francesca De Santis, Giovanni Fuca, Dirk Schadendorf, Alberto Mantovani, Luca Magnani, Michael Lisanti, Stephen Pettitt, Matteo Bellone, Giannino Del Sal, Saverio Minucci, Alexander Eggermont, Paolo Bruzzi, Silvio Bicciato, Pierfranco Conte, Roberta Noberini, John Hiscott, Filippo De Braud, Michele Del Vecchio, Massimo Di Nicola
Summary: Experts at the Tenth Edition of the Annual Congress on Anticancer Innovative Therapy shared the latest knowledge and novel therapeutic approaches in fields such as immuno-oncology, epigenetics, cancer metabolism, cancer stem cells, tumor cell signaling, and the immune system. The conference also discussed possible mechanisms of resistance to these innovative therapies, particularly with respect to immune checkpoint blockers (ICB), providing a broad overview of future challenges and hopes for improving cancer treatment in the medium-short term.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Multidisciplinary Sciences
Audrey Baeyens, Sabrina Bracero, Venkata S. Chaluvadi, Alireza Khodadadi-Jamayran, Michael Cammer, Susan R. Schwab
Summary: S1P regulates immune cell residence time in lymph nodes, affecting T cell differentiation and disease severity by modulating S1P receptor signaling.
Article
Multidisciplinary Sciences
Cristian Scatena, Giovanni Fanelli, Giuseppe Nicolo Fanelli, Michele Menicagli, Paolo Aretini, Valerio Ortenzi, Sara Piera Civitelli, Lorenzo Innocenti, Federica Sotgia, Michael P. Lisanti, Antonio Giuseppe Naccarato
Summary: Recent evidence indicates that loss of caveolin expression in the stromal compartment of human invasive breast carcinoma may be predictive of disease recurrence, metastasis, and poor prognosis. Additionally, a study on sCav-1 expression in breast cancer and axillary lymph nodes suggests that the loss of Cav-1 in lymph nodes may contribute to metastatic spread in breast cancer.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Marco Fiorillo, Cristian Scatena, Antonio Giuseppe Naccarato, Federica Sotgia, Michael P. Lisanti
Summary: This study identifies high ATP production by the mitochondrial ATP-synthase as a new therapeutic target for anticancer therapy, particularly for inhibiting tumor progression. ATP-high cancer cells exhibit aggressive phenotypes with increased proliferation, stemness, anchorage-independence, cell migration, invasion, and multi-drug resistance, along with high antioxidant capacity. ATP depletion through targeting ATP5F1C may serve as a promising strategy for preventing metastasis and avoiding treatment failure, making ATP5F1C a potential biomarker and molecular target for future drug development to prevent metastatic disease progression.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Camillo Sargiacomo, Sophie Stonehouse, Zahra Moftakhar, Federica Sotgia, Michael P. Lisanti
Summary: MTDR can be used to target and eradicate cancer stem cells by selectively interfering with mitochondrial metabolism in breast cancer cells. It significantly inhibits tumor growth and metastasis with little to no toxicity observed in a preclinical animal model.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Filippo Di Pisa, Elisa Pesenti, Maria Bono, Andrea N. Mazzarello, Cinzia Bernardi, Michael P. Lisanti, Giovanni Renzone, Andrea Scaloni, Ermanno Ciccone, Franco Fais, Silvia Bruno, Paolo Scartezzini, Fabio Ghiotto
Summary: This study sheds light on the potential role of SH3BGRL3 in regulating myosin-cytoskeleton interaction and cell migration. It was found that SH3BGRL3 specifically interacts with Myo1c in a Ca2+-dependent manner, suggesting a potential regulatory mechanism for cytoskeleton dynamics involving SH3BGRL3 and Myo1c.
BMC MOLECULAR AND CELL BIOLOGY
(2021)
Article
Cell Biology
Chen-Yuan Tseng, Michael Burel, Michael Cammer, Sneh Harsh, Maria Sol Flaherty, Stefan Baumgartner, Erika A. Bach
Summary: This study reveals that germline stem cells lacking the transcription factor Chinmo have a competitive advantage and can replace the entire germline stem cell pool over time. The study also suggests that the influence of germline stem cell competition may extend beyond individual stem cell niche dynamics to population-level allelic drift and evolution.
DEVELOPMENTAL CELL
(2022)
Review
Oncology
Marco Fiorillo, Bela Ozsvari, Federica Sotgia, Michael P. Lisanti
Summary: The study suggests that high mitochondrial ATP production is a new therapeutic target for cancer treatment, isolating metabolically fit cancer cells with enhanced stem-like properties and invasive abilities. By regulating mitochondrial ATP-synthase, prevention of metastasis in cancer cells is possible.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Madeleine M. LaRue, Seth Parker, Joseph Puccini, Michael Cammer, Alec C. Kimmelman, Dafna Bar-Sagi
Summary: Tumor-associated macrophages play a role in remodeling the extracellular matrix, which affects the growth and development of tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Matteo Brindisi, Luca Frattaruolo, Marco Fiorillo, Vincenza Dolce, Federica Sotgia, Michael P. Lisanti, Anna Rita Cappello
Summary: This study found that elevated cholesterol levels increase the aggressiveness of breast cancer cells and promote the release of pro-inflammatory factors. Furthermore, there is a close symbiotic relationship between breast cancer cells and the microenvironment. These findings highlight the potential of targeting the cholesterol-ERR alpha synergy for breast cancer treatment.
Article
Multidisciplinary Sciences
Yu Matsuzawa-Ishimoto, Xiaomin Yao, Akiko Koide, Beatrix M. Ueberheide, Jordan E. Axelrad, Bernardo S. Reis, Roham Parsa, Jessica A. Neil, Joseph C. Devlin, Eugene Rudensky, M. Zahidunnabi Dewan, Michael Cammer, Richard S. Blumberg, Yi Ding, Kelly Ruggles, Daniel Mucida, Shohei Koide, Ken Cadwell
Summary: Loss of Paneth cells is associated with Crohn's disease. γδ IELs promote the viability of Paneth cells by secreting API5.
Article
Biochemistry & Molecular Biology
Ting-An Yie, Cynthia A. Loomis, Johannes Nowatzky, Alireza Khodadadi-Jamayran, Ziyan Lin, Michael Cammer, Clea Barnett, Valeria Mezzano, Mark Alu, Jackson A. Novick, John S. Munger, Matthias C. Kugler
Summary: Normal lung development relies on the coordinated action of HH and PDGF signaling pathways, which are crucial for mesenchymal differentiation and proliferation. Recent studies have shown that HH is necessary for alveolar myofibroblast differentiation. In this study, we investigated the relationship between HH and PDGF signaling during postnatal lung development in mice. Our findings suggest that HH and PDGF signaling pathways intersect to support myofibroblast function during secondary alveolar septum formation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Qi Sun, Wendy Lee, Hai Hu, Tatsuya Ogawa, Sophie De Leon, Ioanna Katehis, Chae Ho Lim, Makoto Takeo, Michael Cammer, M. Mark Taketo, Denise L. Gay, Sarah E. Millar, Mayumi Ito
Summary: For unknown reasons, the melanocyte stem cell (McSC) system fails earlier than other adult stem cell populations, leading to hair greying in most humans and mice. Contrary to current beliefs, McSCs are not reserved in an undifferentiated state in the hair follicle niche, but rather transition between transit-amplifying and stem cell states. This finding suggests that dedifferentiation is integral to homeostatic stem cell maintenance and may provide new insights for preventing hair greying.
Article
Oncology
Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z. Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Summary: BH3 mimetics are effective in inducing cell death in various blood malignancies, including acute myeloid leukemia (AML). Loss of mitophagy modulators, such as MFN2, sensitizes AML cells to different BH3 mimetics. Targeting MFN2 can enhance the efficacy of BH3 mimetics and increase apoptosis in AML.
Article
Nanoscience & Nanotechnology
Qinqin Sun, Jia Yao, Zhijun Zhang, Juan Li, Xue Zhang, Hui Wang, Xufang Du, Min Li, Ying Zhao
Summary: In recent years, cardiac vascular disease caused by acute myocardial infarction and heart failure has led to death worldwide. To address the complications associated with existing treatments, researchers have developed a new hydrogel material for the repair of acute myocardial infarction. Experimental results show that the hydrogel can effectively restore the infarcted heart.
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)