期刊
EXPERIMENTAL CELL RESEARCH
卷 329, 期 1, 页码 94-100出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.08.032
关键词
DNA repair; DSB repair; NER; Transcription factors; NR4A; PARP
资金
- Medical Research Council, UK
- European Union FP7 grants NeuroStemCell and mdDANEURODEV
- Vetenskapsradet [K2012-99X-22328-01-3]
- Swedish Foundation
- MRC [MC_UP_A600_1109] Funding Source: UKRI
- Medical Research Council [MC_UP_A600_1109] Funding Source: researchfish
Cellular systems for DNA repair ensure prompt removal of DNA lesions that threaten the genomic stability of the cell. Transcription factors (TFs) have long been known to facilitate DNA repair via transcriptional regulation of specific target genes encoding key DNA repair proteins. However, recent findings identified TFs as DNA repair components acting directly at the DNA lesions in a transcription-independent fashion. Together this recent progress is consistent with the hypothesis that TFs have acquired the ability to localize DNA lesions and function by facilitating chromatin remodeling at sites of damaged DNA. Here we review these recent findings and discuss how TFs may function in DNA repair. (C) 2014 The Authors. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据