期刊
EXPERIMENTAL CELL RESEARCH
卷 319, 期 11, 页码 1596-1603出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.03.022
关键词
Cancer-associated fibroblasts; Inflammation; Cancer; Microenvironment
资金
- European Union Seventh Framework Programme (FP7) [276890]
- Israel Cancer Association [20110078]
- Israel Cancer Research Fund (Research Career Development Award)
Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment functional activation status, and retention of immune cells in the tumor microenvironment. (c) 2013 Elsevier Inc. All rights reserved.
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