Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
Review
Biochemistry & Molecular Biology
Nathalie Tisch, Carmen Ruiz de Almodovar
Summary: The formation of new blood vessels involves proliferation of endothelial cells and vessel sprout elongation, along with vessel remodeling and regression to adapt vessel density. Recent studies focus on how vessel regression and cell death contribute to this process, challenging the simplistic view of cell death machinery as only promoting cellular demise. This review highlights the role of cell death signaling pathways, particularly apoptosis and necroptosis, in blood vessel formation during development and pathology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Elmira Roshani Asl, Mohammad Amini, Souzan Najafi, Behzad Mansoori, Ahad Mokhtarzadeh, Ali Mohammadi, Parisa Lotfinejad, Mehdi Bagheri, Solmaz Shirjang, Ziba Lotfi, Yousef Rasmi, Behzad Baradaran
Summary: The highly conserved MAPK signal transduction pathway plays a crucial role in cancer progression, while miRNAs act as critical regulators in cancer initiation and progression. The interaction between miRNAs and the MAPK signaling pathway is pivotal in the development of human cancers.
Article
Geriatrics & Gerontology
Zhen Yang, Han Li, Dan Yan, Pengcheng Luo, Yuqi Guan, Mandi Luo, Hao Nie, Yi Huang, Le Zhang, Lei Ruan, Jinhua Yan, Cuntai Zhang
Summary: This study found that Netrin-1 levels were significantly decreased in the plasma of elderly individuals, and delivering Netrin-1 to aged mice improved vascular conditions and inhibited cell senescence in endothelial cells. These findings suggest that modulating Netrin-1 signaling can improve vascular health, and Netrin-1 may have therapeutic potential for age-related ischemic diseases.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Oncology
Claudia Palazzo, Alessio D'Alessio, Luca Tamagnone
Summary: Extracellular vesicles (EVs) play an important role in the communication mechanisms between cancer and endothelial cells, and may have potential implications in the treatment of vascular pathologies. EVs are able to transport a variety of cell constituents and regulate the functions of endothelial cells. Cancer cell-derived EVs have been found to have a controlling effect on endothelial cell functions and are involved in tumor angiogenesis and cancer progression.
Review
Pharmacology & Pharmacy
Shadab Md, Nabil A. Alhakamy, Shahid Karim, Gamal A. Gabr, Mohammad Kashif Iqubal, Samar S. A. Murshid
Summary: Lung cancer is a common and complex disease that presents a significant challenge for treatment. Researchers are exploring various signaling pathways and developing new drugs to target it. MiRNA has emerged as a promising target for lung cancer therapy, but faces challenges such as low stability. Nanocarrier-based drug delivery systems show promise for overcoming limitations and enhancing therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Yuechao Dong, Guixing Ma, Xiaoting Hou, Yingying Han, Zhen Ding, Wanze Tang, Litong Chen, Yangshan Chen, Bo Zhou, Feng Rao, Kaosheng Lv, Changzheng Du, Huiling Cao
Summary: Kindlin-2 plays critical roles in the development and homeostasis of multiple key organs, and our study reveals its importance in NOTCH-mediated physiological angiogenesis. We demonstrate that KINDLIN-2 enhances various functions of endothelial cells induced by VEGF-A and is crucial for maintaining the integrity of NOTCH1. The deficiency of KINDLIN-2 leads to impaired angiogenesis and avascular retinas, which can be rescued by the inhibitor DAPT, and we also find that KINDLIN-2 is involved in hyperactive angiogenesis stimulated by high glucose and could be a potential therapeutic target for diabetic retinopathy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Maryam Dokhanchi, Katayoon Pakravan, Sara Zareian, Bashdar Mahmud Hussen, Mahsa Farid, Ehsan Razmara, Majid Mossahebi-Mohammadi, William C. Cho, Sadegh Babashah
Summary: In this study, a signature of four circulating serum-derived miRNAs (miR-19a-3p, miR-203-3p, miR-221-3p, and let-7f-5p) was identified as a novel diagnostic biomarker for CRC, with their expressions positively correlated with lymph node metastasis. MiR-221-3p transferred by CRC-EVs promoted endothelial cell angiogenesis by targeting SOCS3 and regulating the STAT3/VEGFR-2 signaling pathway. The findings highlight the potential clinical significance of miR-221-3p in CRC and its role in promoting tumor angiogenesis.
Article
Biology
Hilda Espinoza, Xavier F. Figueroa
Summary: Endothelial cell migration, a crucial process in angiogenesis, is driven by coordinated generation of Ca2+ signals in caveolar microdomains. Connexins (Cx) play a central role in endothelial cell function through direct cell-to-cell communication and the release of autocrine/paracrine signals. We propose that endothelial cell migration relies on Cx43 hemichannel opening. Our findings reveal a novel mechanism of Ca2+ signaling and suggest that Cx43 hemichannels are key players in endothelial cell migration, providing potential therapeutic targets for deregulated angiogenesis in pathological conditions like cancer.
Article
Genetics & Heredity
Shu Yan, Ji Hu, Jia Li, Pengchao Wang, Yilong Wang, Zhaohui Wang
Summary: PRMT4 is upregulated in ischemic muscles and promotes angiogenesis. It regulates VEGF expression by interacting with YB1. Knockdown of YB1 attenuates PRMT4-mediated angiogenic effects in vitro.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Jaeseob Lee, Young-June Jin, Moon-Sung Lee, Young-Myeong Kim, Hansoo Lee
Summary: MIC-1 is a potent activator of endothelial cells, promoting both normal and injury-related angiogenesis. Through MEK/ERK and PI3K/Akt-dependent pathways, MIC-1 induces proangiogenic effects in ECs. The receptor GFRAL is essential for MIC-1 signaling events in ECs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zi Guo, Zhaohui Mo
Summary: During vertebrate development, the cardiovascular system becomes functional earlier than other organs. Endothelial cells play a crucial role in vasculogenesis and angiogenesis, with cellular biology and epigenetics being important factors in these processes. There is growing interest in the role of proteins and signaling molecules in controlling embryonic vascular development, and the transplantation of iPSC-ECs shows promise in treating cardiovascular diseases. However, challenges in maintaining cell viability and function limit the clinical application of iPSC-ECs in regenerative medicine.
Review
Pathology
Bashdar Mahmud Hussen, Abbas Salihi, Sara Tharwat Abdullah, Mohammed Fatih Rasul, Hazha Jamal Hidayat, Mohammadreza Hajiesmaeili, Soudeh Ghafouri-Fard
Summary: This article investigates the mechanisms of miRNA regulation in tumor angiogenesis and highlights the applications of anti-angiogenic therapy and miRNA delivery methods in inhibiting angiogenesis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, General & Internal
Nadia Meyer, Lars Brodowski, Katja Richter, Constantin S. von Kaisenberg, Bianca Schroeder-Heurich, Frauke von Versen-Hoeynck
Summary: Pravastatin enhances the functional capacities of ECFCs and promotes angiogenic signaling and protein expression, improving endothelial health. These effects may offer a promising option for ameliorating endothelial dysfunction and understanding the pleiotropic function of statins.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Review
Cardiac & Cardiovascular Systems
Sanjay Sinha, Massimo Mattia Santoro
CARDIOVASCULAR RESEARCH
(2018)
Review
Cell Biology
Massimo Mattia Santoro
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2018)
Review
Pharmacology & Pharmacy
Roxana E. Oberkersch, Massimo M. Santoro
VASCULAR PHARMACOLOGY
(2019)
Article
Cell Biology
Massimo M. Santoro, Monica Beltrame, Daniela Panakova, Arndt F. Siekmann, Natascia Tiso, Marina Venero Galanternik, Hyun Min Jung, Brant M. Weinstein
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Editorial Material
Cell Biology
Massimo M. Santoro
Review
Biochemistry & Molecular Biology
Liaisan R. Arslanbaeva, Massimo M. Santoro
Article
Cell Biology
Nicola Facchinello, Claudio Laquatra, Lisa Locatello, Giorgia Beffagna, Raquel Branas Casas, Chiara Fornetto, Alberto Dinarello, Laura Martorano, Andrea Vettori, Giovanni Risato, Rudy Celeghin, Giacomo Meneghetti, Massimo Mattia Santoro, Agnes Delahodde, Francesco Vanzi, Andrea Rasola, Luisa Dalla Valle, Maria Berica Rasotto, Tiziana Lodi, Enrico Baruffini, Francesco Argenton, Natascia Tiso
Summary: The study successfully generated zebrafish Polg models to faithfully mimic multiple defects detected in POLG disorders, providing a valuable platform for therapeutic research on the disease.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Matteo Astone, Massimo M. Santoro
Summary: The circadian clock plays a crucial role in cancer, and targeting it can effectively inhibit tumor growth. Future research should focus on further understanding the complex interplay between the circadian clock and cancer to provide more breakthroughs for targeted therapies.
DRUG DISCOVERY TODAY
(2021)
Review
Developmental Biology
Michael Donadon, Massimo M. Santoro
Summary: The article primarily describes the developmental origin of smooth muscle cells in different organs, as well as their specification and differentiation in the cardiovascular, respiratory, and intestinal systems. It discusses the important roles of smooth muscle in organ development and how they instruct the development of other organs through signaling and mechanical feedback mechanisms. By understanding smooth muscle cell development, the aim is to advance therapeutic approaches related to tissue regeneration and other smooth muscle-related diseases.
Article
Cell Biology
Chiara Camillo, Nicola Facchinello, Giulia Villari, Giulia Mana, Noemi Gioelli, Chiara Sandri, Matteo Astone, Dora Tortarolo, Fabiana Clapero, Dafne Gays, Roxana E. Oberkersch, Marco Arese, Luca Tamagnone, Donatella Valdembri, Massimo M. Santoro, Guido Serini
Summary: Dynamic modulation of endothelial cell adhesion and barrier function by the adhesion G protein-coupled receptor Latrophilin 2 (LPHN2) and its ligand FLRT2 plays a crucial role in blood vessel development and functioning.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liaisan Arslanbaeva, Giovanni Tosi, Marco Ravazzolo, Manuela Simonato, Francesco A. Tucci, Salvatore Pece, Paola Cogo, Massimo M. Santoro
Summary: This study demonstrates that the expression of UBIAD1 is associated with poor overall survival in human melanoma patients, and UBIAD1 and CoQ10 levels are upregulated in melanoma cells. The study also shows that UBIAD1 and plasma membrane CoQ10 sustain melanoma cell survival and proliferation by preventing lipid peroxidation and cell death.
Review
Oncology
Jacopo Lidonnici, Massimo M. Santoro, Roxana E. Oberkersch
Summary: Angiogenesis plays an important role in tumor growth and metastasis, and understanding the metabolic characteristics and interactions of tumor endothelial cells (TECs) with tumor cells is crucial. The metabolic differences between normal and tumor vasculature provide a basis for developing targeted therapies with higher specificity and fewer side effects, improving patient outcomes.
Article
Cardiac & Cardiovascular Systems
Matteo Astone, Roxana E. Oberkersch, Giovanni Tosi, Alberto Biscontin, Massimo M. Santoro
Summary: This study demonstrates that endothelial cells possess an endogenous circadian clock, and core clock genes exhibit robust circadian oscillations. Impairing the function of the circadian clock transcriptional activator BMAL1 leads to angiogenesis defects in both developmental and pathological contexts. BMAL1 regulates endothelial cell cycle progression by binding to the promoters of CCNA1 and CDK1 genes.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemical Research Methods
Cristina Arce Recatala, Mattia Albiero, Massimo Mattia Santoro
Summary: This article presents a protocol for evaluating post-natal angiogenesis in a mouse hind limb ischemia model, which is a useful tool for assessing metabolic and cellular responses. The protocol involves inducing a severe restriction of blood supply to mimic the real-life scenario observed in clinical settings, followed by laser Doppler imaging to compare the post-ischemic responses of different mouse strains in triggering compensatory arteriogenesis.
Article
Endocrinology & Metabolism
Nicola Facchinello, Matteo Astone, Matteo Audano, Roxana E. Oberkersch, Marianna Spizzotin, Enrica Calura, Madalena Marques, Mihaela Crisan, Nico Mitro, Massimo M. Santoro
Summary: Endothelial cell metabolism regulates blood vessel maturation by controlling vascular matrix composition and the recruitment of vascular mural cells.
