Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate

The decision between death and survival is a difficult phase of a cell life. It may depend on the intensity of a stress stimulus, on the presence of invasive pathogens, or on specific signals from neighbouring cells. Death-related molecules are being shown to possess different, and sometimes opposite roles, which they play also according to a number of environmental clues. In this review, we will analyse some of these molecules and their roles, with particular regard to mitochondria-related factors, such as BCL2 family members, the apoptosome components, the autophagy/death cross-talkers and molecules regulating mitochondrial structure and functions. Turning the double-edged swords of death molecules into plougshares may turn out to be strategically crucial in molecular oncology. (C) 2012 Elsevier Inc. All rights reserved.