Article
Physiology
Caroline Barbe, Audrey Loumaye, Pascale Lause, Olli Ritvos, Jean-Paul Thissen
Summary: Myostatin, a negative regulator of muscle development, inhibits muscle growth and requires activation of specific signaling pathways. Pak1 has been identified as a potential mediator of Myostatin action on skeletal muscle mass, playing a permissive role in the skeletal muscle mass increase caused by Myostatin inhibition.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Wouter Eilers, Mark Cleasby, Keith Foster
Summary: The study found that a modest reduction in myostatin transcript levels induced by antisense phosphorodiamidate morpholino oligomers (PMO) is sufficient to increase muscle mass, but a greater degree of inhibition may be required to improve muscle glucose uptake.
SCIENTIFIC REPORTS
(2021)
Review
Genetics & Heredity
Marek Kruszewski, Maksim Olegovich Aksenov
Summary: This study conducted a systematic review and meta-analysis and found an association between MSTN gene polymorphism (K153R) and the strength phenotype of athletes. Athletes in the strength-oriented group had a higher frequency of the R minor variant compared to the control group.
Article
Biotechnology & Applied Microbiology
Aline Goncalves Lio Copola, Iria Gabriela Dias dos Santos, Luiz Lehmann Coutinho, Luiz Eduardo Vieira Del-Bem, Paulo Henrique de Almeida Campos-Junior, Izabela Mamede Costa Andrade da Conceicao, Julia Meireles Nogueira, Alinne do Carmo Costa, Gerluza Aparecida Borges Silva, Erika Cristina Jorge
Summary: This study reports the global transcription expression profile of RGMa-treated C2C12 myoblasts during differentiation, revealing the modulation of transcript expression, involvement in RNA splicing and degradation, induction of nuclei accretion and muscle hypertrophy mechanisms, and promotion of skeletal muscle structural protein expression.
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Mohammad Hassan Baig, So-Young Park, Jeong Ho Lim, Syed Sayeed Ahmad, Shahid Ali, Khurshid Ahmad, Inho Choi
Summary: This study reports the potential of novel peptides MIF1 and MIF2 derived from MSTN in enhancing myogenesis and reducing adipogenesis. Modified MIF1 and MIF2 showed better cell proliferation and differentiation compared to non-modified peptides. Pretreatment of mice with (Ac)-MIF1 or (Ac)-MIF2-(NH2) promoted muscle regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Takayuki Ozawa, Masato Morikawa, Yasuyuki Morishita, Kazuki Ogikubo, Fumiko Itoh, Daizo Koinuma, Per-Ake Nygren, Kohei Miyazono
Summary: Targeting the signaling pathway of GDF8 is considered a promising strategy to increase muscle mass, with FSTL3 being an endogenous antagonist that can neutralize activin, GDF8, and GDF11. The use of monovalent FSTL3-Fc has shown to effectively promote muscle growth, overcoming challenges faced by current anti-GDF8 therapies.
Article
Multidisciplinary Sciences
Yumin Wang, Satoshi Ikeda, Katsunori Ikoma
Summary: This study investigated the effects of passive repetitive stretching on muscle mass, myofiber cross-sectional area, protein synthesis pathways, and myogenic regulatory factors in senescence-accelerated mice. The findings suggest that passive stretching can lead to muscle hypertrophy and counteract muscle atrophy mainly by provoking protein turnover. These results are valuable for clinical muscle strengthening and sarcopenia prevention.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Ryan Paul, Kim Whiteman, Shelley J. Falconer, Jenny M. Oldham, Ferenc Jeanplong, Kenneth G. Matthews, Heather K. Smith, Mark Thomas, Trevor Watson, Christopher D. McMahon
Summary: The study found that IGF1 plays an important role in regulating muscle growth during the rapid growth phase, and when myostatin is absent and IGF1 is in excess, there is a significant increase in body and muscle mass. However, sexual dimorphism still exists, with a more pronounced IGF1-induced activation of AKT in male mice.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Dong-Hwan Kim, Young Min Choi, Joonbum Lee, Sangsu Shin, Sanggu Kim, Yeunsu Suh, Kichoon Lee
Summary: This study analyzed the expression of Mstn isoforms and muscle development in broiler and layer chicken breeds. It found that broilers had higher expression ratios of Mstn-B to -A in their muscles, leading to greater muscle growth. The study suggests that the expression of Mstn isoforms could be used as a genetic marker for selecting chickens with higher muscle growth.
Article
Biochemistry & Molecular Biology
Chih-Hsuan Chou, Elisabeth R. Barton
Summary: Glucose is a vital energy source for active skeletal muscles, and AMPK plays a crucial role in glucose uptake during muscle contraction. The study aimed to investigate the impact of increased muscle IGF-I on AMPK α phosphorylation and activity. The results demonstrated that high muscle IGF-I enhances glucose uptake under resting conditions but does not inhibit AMPK activity during muscle contraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Christopher G. Vann, Robert W. Morton, Christopher B. Mobley, Ivan J. Vechetti, Brian K. Ferguson, Cody T. Haun, Shelby C. Osburn, Casey L. Sexton, Carlton D. Fox, Matthew A. Romero, Paul A. Roberson, Sara Y. Oikawa, Chris McGlory, Kaelin C. Young, John J. McCarthy, Stuart M. Phillips, Michael D. Roberts
Summary: This study examined the association between genotype and resistance training-induced changes in lean soft tissue mass and muscle fiber cross-sectional area, identifying potential links between GLI3 gene variant and hypertrophic responses. Future studies are needed to confirm this association.
Article
Cell Biology
Hiroki Ishihara, Yoshinori Otani, Kazuki Tanaka, Hisao Miyajima, Huy Xuan Ngo, Masashi Fujitani
Summary: This study demonstrates the critical role of the insulin-like growth factor-1 receptor (IGF1R) signaling pathway in the regeneration of neuromuscular junction (NMJ) and muscle recovery after botulinum toxin-A (BTX) injection. Inhibition of IGF1R affects the recovery from BTX-induced neurogenic paralysis and alters the synaptic components at the NMJ. Furthermore, IGF1R inhibition regulates the wet weight and frequency distribution of muscle fibers and increases the number of Pax7+-satellite cells in the muscle. These findings suggest that targeting the IGF1R pathway could be beneficial in prolonging the effects of BTX treatment and reducing the number of injections.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Ming-Ming Chen, Yi-Ping Zhao, Yue Zhao, Shou-Long Deng, Kun Yu
Summary: Myostatin, a member of the TGF-β superfamily, negatively regulates skeletal muscle growth and development through autocrine or paracrine signaling, with mutations leading to increased muscle mass. It regulates myogenic differentiation, protein synthesis, and oxidative stress in skeletal muscle.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bing Fu, Jinzeng Yang, Yan Yang, Jun Xia, Yinglin He, Qing Wang, Huihong Zhao, Huirong Yang
Summary: This study investigated the role of myostatin in E. coioides and demonstrated the positive effects of autologous nucleic acid vaccine on muscle growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Boin Lee, Dong-Hwan Kim, Joonbum Lee, Michael D. Cressman, Young Min Choi, Kichoon Lee
Summary: This study compared the histological characteristics of muscle fibers and bundles in meat-type (broiler) and egg-type (layer) chickens. The results showed that broilers had a greater number and size of muscle fibers and bundles compared to layers. The increased muscle mass in broilers was attributed to both hyperplasia and hypertrophy of muscle fibers and bundles.
FRONTIERS IN PHYSIOLOGY
(2023)