Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Multidisciplinary Sciences
Stephen Arnovitz, Priya Mathur, Melissa Tracy, Azam Mohsin, Soumi Mondal, Jasmin Quandt, Kyle M. Hernandez, Khashayarsha Khazaie, Marei Dose, Akinola Olumide Emmanuel, Fotini Gounari
Summary: This study reveals that aberrant activation of beta-catenin in thymocytes contributes to leukemias by promoting translocations and transformation. Lymphomas resembling T-ALL are sensitive to PARP inhibitors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li, Xinzhi Peng
Summary: The study revealed the transcriptional regulation of LINC01278 by beta-catenin/LEF-1 transcription factor and its negative feedback regulation on beta-catenin signal in papillary thyroid carcinoma (PTC) cells. This negative regulation inhibits downstream target gene expression activated by the Wnt/beta-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Developmental Biology
Antonio Herrera, Anghara Menendez, Andrea Ochoa, Lidia Bardia, Julien Colombelli, Sebastian Pons
Summary: In the developing spinal cord, neurogenesis stimulates Tcf-dependent transcription through the nuclear accumulation of beta-catenin, independently of Wnt signaling. This process regulates genes involved in contralateral axon growth, including axon guidance and adhesion. These findings demonstrate the importance of Wnt-independent Tcf/beta-catenin regulation in controlling commissural axon growth in the chick spinal cord.
Article
Endocrinology & Metabolism
Yasaman Badakhshi, Weijuan Shao, Dinghui Liu, Lili Tian, Juan Pang, Jianqiu Gu, Jim Hu, Tianru Jin
Summary: This study reveals that hepatic FGF21 is downregulated in male LTCFDN mice compared to females, implicating the involvement of estrogen-beta-cat/TCF signaling pathway. In mouse primary hepatocytes, FGF21 transcription is positively regulated by the Wnt pathway effector beta-cat/TCF. Ovariectomized female mice show reduced hepatic FGF21 production, correlated with decreased hepatic TCF expression and beta-catenin phosphorylation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Cell Biology
Johnny Bou-Rouphael, Beatrice C. Durand
Summary: Since its discovery in the late 90s, Wnt canonical signaling has been shown to play a crucial role in various neural developmental processes, with recent focus on the TCF/LEF-mediated switch from transcriptional activation to repression. Barhl2 is highlighted for its important functions in vertebrate brain development, while TCF/LEF activities in organizer formation and caudal forebrain growth are also discussed. The dysregulation of the Wnt/beta-catenin pathway could lead to tumorigenesis in both embryonic and neural stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Tijana Sopin, Frantisek Liska, Tomas Kucera, Dusan Cmarko, Tomas Vacik
Summary: In this study, we discovered a novel mechanism by which KDM2A promotes the proteasomal degradation of TCF/LEF proteins, thus affecting canonical Wnt signaling. This regulation depends on the CXXC domain of KDM2A and the C-terminal region of TCF7L2.
Article
Cell Biology
Chengbo Ji, Mili Zhang, Junjie Hu, Can Cao, Qisheng Gu, Youdong Liu, Xu Li, Duogang Xu, Le Ying, Yuqin Yang, Hugh Gao, Jikun Li, Liang Yu
Summary: The activity of integrin-linked kinase (ILK) plays a crucial role in gastric cancer by promoting cellular senescence. ILK depletion leads to senescence and inhibits clathrin-mediated endocytosis. Small molecule inhibitors of ILK activity can be used as therapeutic options to induce cellular senescence in gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen, Chung-Liang Ho
Summary: In this study, a combined bioinformatics and experimental approach was used to identify potential target genes of the Wnt/beta-catenin signaling pathway. It was found that RMI2 is a new target gene of this pathway and that it promotes epithelial-mesenchymal transition markers, hepatocellular carcinoma cell invasion, and metastasis. These findings suggest that RMI2 could be a potential target for preventing or mitigating the progression of hepatocellular carcinoma.
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim
Summary: This study found that DKK1 is overexpressed in patients with hepatocellular carcinoma (HCC), and inhibiting DKK1 can enhance the anti-tumor efficacy of sorafenib in HCC. By regulating the activity of GSK3 beta and inhibiting the PI3K/Akt and Wnt/β-catenin pathways, a new therapeutic strategy for HCC has been identified.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Pathirennehelage Chandrasekera, Mark Perfetto, Congyu Lu, Minghui Zhuo, Harinath Bahudhanapati, Jiejing Li, Wei-Chih Chen, Pallavi Kulkarni, Laura Christian, Jun Liu, Yvette Y. Yien, Chundong Yu, Shuo Wei
Summary: This study demonstrates that ADAM9 in mammals can cleave ephrin-B1 and ephrin-B2, promoting neural crest induction. The study also found that ADAM9 expression is elevated in colorectal cancer (CRC) tissues and knocking down ADAM9 inhibits the migration and invasion of CRC cells, mediated by reducing Akt kinase activity. Additionally, the study reveals differential effects of ADAM9 knockdown on Wnt signaling and mTOR signaling in different CRC cell lines.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Guoying Zhang, Cheng Xue, Yiming Zeng
Summary: The study showed that beta-elemene suppresses the hyperactive ILK/Akt pathway in airway granulation fibroblasts by modulating the MIR143HG/miR-1275/ILK axis, leading to inhibition of cell proliferation and alleviation of airway stenosis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Food Science & Technology
Jing Li, Xiaoling Lyu, Pan Wang, Bao Ting Zhu
Summary: This study found that bilberry anthocyanins have a modulating effect on the pathogenesis of Alzheimer's disease. They reduce amyloid plaque load and beta-amyloid 1-42 levels, improve mitochondrial morphology, and decrease NO and ROS levels. In HT22 cells, bilberry anthocyanins also protect against A beta 42-induced cytotoxicity by reducing ROS levels and restoring mitochondrial homeostasis, partly through the upregulation of Mfn2. These findings suggest that bilberry anthocyanins can protect against the development of Alzheimer's disease by restoring mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pathology
Po-Han Chen, Veerle Bossuyt, Emily Reisenbichler
Summary: The study evaluates the nuclear expression of LEF-1 and beta-catenin in fibroepithelial lesions of the breast, finding significantly increased expression in malignant/borderline Phyllodes. This suggests an important role of the Wnt/beta-catenin signaling pathway in the biological progression of Phyllodes tumors.