Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Review
Oncology
Manuel Scimeca, Donata Trivigno, Rita Bonfiglio, Sara Ciuffa, Nicoletta Urbano, Orazio Schillaci, Elena Bonanno
Summary: This review highlights the latest aspects of breast cancer metastasis into the bone, including biomarkers, biological processes related to the origin of metastatic cells, the role of Breast Osteoblast-Like Cells, and the prognostic value of breast microcalcifications for bone metastatic disease. Additionally, the use of molecular imaging investigations for identifying early neoplastic lesions with high propensity to form bone metastasis in vivo is proposed.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Biochemistry & Molecular Biology
Stefano Zapperi, Caterina A. M. La Porta
Summary: Finding prognostic and predictive markers for TNBC is highly desirable, and the recently developed transcriptomic test ARIADNE shows promising capabilities in this regard.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Summary: The study demonstrates that breast cancer brain metastasis cells undergo epithelial-to-mesenchymal transition (EMT) when infiltrating the brain parenchyma, and removing these infiltrated tumor cells can improve surgical efficacy, providing new avenues for patient treatment.
Article
Multidisciplinary Sciences
Shunhao Wang, Jingchao Li, Mei Chen, Liting Ren, Wenya Feng, Lining Xu, Xiaolan Chen, Tian Xia, Nanfeng Zheng, Sijin Liu
Summary: Palladium nanoplates inhibit lung metastasis by suppressing EMT signaling in breast cancer cells and interacting with TGF-beta proteins, leading to reduced downstream signaling activation. NIR irradiation enhances the inhibitory effects of PdPL on both primary tumors and metastasis.
NATIONAL SCIENCE REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo A. Acuna, Manuel Varas-Godoy, Diego Herrera-Sepulveda, Mauricio A. Retamal
Summary: Connexins are a family of proteins that play a crucial role in cellular communication, but certain types may have pro-tumorigenic effects. Research has shown that Cx46 can modulate the characteristics of cancer stem cells and epithelial-to-mesenchymal transition in breast cancer cells, potentially influencing future cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Atiye Seda Yar Saglam, Handan Kayhan, Ebru Alp, Hacer Ilke Onen
Summary: Sequential administration of RSV and FL118 suppressed TNBC cell viability, reduced migratory and invasive capabilities, reversed EMT process, increased apoptotic cells, and affected cell cycle distribution.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ran Sun, Jin He, Qin Xiang, Yixiao Feng, Yijia Gong, Yijiao Ning, Chaoqun Deng, Kexin Sun, Mingjun Zhang, Zhaobo Cheng, Xin Le, Qi Xiong, Fengsheng Dai, Yongzhong Wu, Tingxiu Xiang
Summary: Breast cancer metastasis can occur even with a small primary tumor. Neurotrophin 4 (NTF4) has been found to play a dual role in breast cancer by promoting proliferation and metastasis. High levels of NTF4, especially in early stages, are associated with poor clinical outcomes, emphasizing the importance of metastasis in breast cancer mortality. Mechanistically, NTF4 activates specific pathways to promote epithelial-mesenchymal transition and cell motility, while inhibiting cell proliferation and promoting apoptosis. These findings suggest that NTF4 could be a prognostic marker and potential therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michal Rakowski, Szymon Porebski, Agnieszka Grzelak
Summary: The study demonstrates that silver nanoparticles can modulate the metastasis of breast cancer cells through induction of epithelial-to-mesenchymal transition (EMT) pathway, as well as alter the metabolism of cancer cells by increasing reactive oxygen species, triggering pathways related to metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hossein Javdani, Homa Mollaei, Farzaneh Karimi, Shiva Mahmoudi, Ali Farahi, Mohamad Javad Mirzaei-Parsa, Arman Shahabi
Summary: This article discusses the significant role of epithelial to mesenchymal transition (EMT) in breast cancer, as well as the functional changes of transcription factors, signaling pathways, and microRNAs that promote EMT. While there is ongoing debate about the relevance of EMT to breast cancer in vivo, the importance of EMT in cancer progression and metastasis warrants continued research and development of treatment approaches targeting EMT.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Integrative & Complementary Medicine
Rui-yuan Jiang, Zi-ru Fang, Huan-ping Zhang, Jun-yao Xu, Jia-yu Zhu, Ke-yu Chen, Wei Wang, Xiao Jiang, Xiao-jia Wang
Summary: Tumor cells possess specific characteristics, such as high metabolic activity, mitochondrial dysfunction, and resistance to cell death, which differentiate them from normal cells. Modifying these characteristics could serve as a potential approach for tumor treatment. Ginsenoside, through altering the functional hallmarks of tumor cells, shows promise as a therapeutic agent for breast cancer.
Article
Genetics & Heredity
Narges Maleki, Negar Yavari, Maryam Ebrahimi, Ahmad Faisal Faiz, Roya Khosh Ravesh, Aysan Sharbati, Mohammad Panji, Keivan Lorian, Abdollah Gravand, Mojtaba Abbasi, Omid Abazari, Mehdi Shafiee Mehr, Yasin Eskandari
Summary: Silibinin exhibits strong inhibitory effects on ovarian cancer by suppressing cell viability, migration, and invasion, and promoting apoptosis. It also reverses epithelial-mesenchymal transition mechanism and ameliorates tumor growth.
Article
Pharmacology & Pharmacy
Yiran Lu, Yu Ding, Jiahui Wei, Song He, Xinmiao Liu, Huihao Pan, Bao Yuan, Qing Liu, Jiabao Zhang
Summary: Breast cancer is a common malignant tumor with EMT being a crucial process that allows tumor cells to acquire invasive and metastatic properties. Therapies targeting EMT have become increasingly important in cancer treatment, and studies have shown that Traditional Chinese Medicine compounds can inhibit breast cancer cell growth and development by inhibiting EMT.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)