期刊
EXPERIMENTAL CELL RESEARCH
卷 316, 期 9, 页码 1513-1522出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.03.002
关键词
Fas receptor; Raft nanodomains; Cell death signalling; Actin cytoskeleton
资金
- Centre National de la Recherche Scientifique (CNRS)
- Ligue Nationale Contre le Cancer (LNCC)
- INCA (Institut National du Cancer)
- ANR (Agence Nationale de la Recherche)
- Marie Curie EST fellowship
- Association pour la Recherche sur le Cancer (ARC)
Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of Fas signalling induced by Fas ligand binding. Particularly, Fas localisation in the raft nanodomains, ezrin-mediated interaction with the actin cytoskeleton and subsequent internalization are critical steps in Fas-mediated cell death. We identified a lysine-rich region (LRR) in the cytoplasmic, membrane-proximal region of Fas as a key determinant modulating these initial events. Through a genetic approach, we demonstrate that Fas LRR represents another signal additional to palmitoylation targeting Fas to the raft nanodomains, and modulates Fas interaction with the cytoskeleton. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据