期刊
EXPERIMENTAL CELL RESEARCH
卷 316, 期 16, 页码 2560-2564出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.04.022
关键词
Neurodegenerative disease; Non-neuronal cells; Disease modeling; Disease material; Disease therapy
资金
- Ministry of Health and Labour
- JSPS [21591079]
- Takeda Science Foundation
- Kanae Foundation for the Promotion of medical science
- NOVARTIS Foundation for Gerontological Research
- CREST
- JST
Neurodegenerative disease-specific induced pluripotent stem cell (iPSC) research contributes to the following 3 areas; Disease modeling, Disease material and Disease therapy. Disease modeling, by recapitulating the disease phenotype in vitro, will reveal the pathomechanisms. Neurodegenerative disease-specific iPSC-derived non-neuronal cells harboring disease-causative protein(s), which play critical roles in neurodegeneration including motor neuron degeneration in amyotrophic lateral sclerosis, could be Disease material, the target cell(s) for drug screening. These differentiated cells also could be used for Disease therapy, an autologous cellular replacement/neuroprotection strategy, for patients with neurodegenerative disease. Further progress in these areas of research can be made for currently incurable neurodegenerative diseases. (C) 2010 Elsevier Inc. All rights reserved.
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