Review
Cell Biology
Karol Borensztejn, Pawel Tyrna, Agata M. Gawel, Ireneusz Dziuba, Cezary Wojcik, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Cell-in-cell (CIC) phenomenon, known for over 100 years, is experiencing a renaissance due to modern visualization techniques and its potential prognostic and diagnostic value for cancer patients. However, there are many unresolved questions and challenges in studying CIC, which involve complex cell interactions and molecular mechanisms.
Article
Multidisciplinary Sciences
Hao Chen, Huaxiao Yang, Chen Zhang, Si Chen, Xin Zhao, Mark Zhu, Zhiming Wang, Yuebing Wang, Hung-Ta Wo, Kai Li, Zhen Cheng
Summary: The development of a molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window has enabled real-time monitoring of in vivo cell behaviors in healthy and diseased animal models. The tracker has shown complete cell labeling, low cytotoxicity, and long-term tracking ability for biodistribution of transplanted stem cells. This technique allows for discrimination of response of stem cells in different diseased environments and ultrafast real-time tracking of cellular migration with high spatial resolution.
Article
Immunology
Katharina M. Glaser, Teresa K. Tarrant, Tim Laemmermann
Summary: G-protein coupled receptor kinases (GRKs) participate in the regulation of chemokine receptors, but they also have other functions beyond GPCR desensitization in primary immune cells. The interplay between different GRK family members and their effects on different immune cell types and GPCRs are complex and unpredictable. This study demonstrates the importance of studying GRK functions in primary immune cells to understand their specific roles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yuli Lin, Qian Cai, Yu Chen, Tiancong Shi, Weiren Liu, Li Mao, Bo Deng, Zhen Ying, Yuan Gao, Haoyang Luo, Xuguang Yang, Xiaowu Huang, Yinghong Shi, Rui He
Summary: This study demonstrates that cancer-associated fibroblasts (CAFs) promote cancer stemness by regulating myeloid-derived suppressor cells (MDSCs) in intrahepatic cholangiocarcinoma (ICC). The 5-LO/LTB4-BLT2 axis may serve as promising therapeutic targets for overcoming ICC chemoresistance by targeting cancer stemness.
Article
Cell Biology
Ruizhi Wang, Hao Zhong, Chenxi Wang, Xiaohui Huang, Anpei Huang, Nannan Du, Dong Wang, Qiang Sun, Meifang He
Summary: The study investigates the effects of CICs formation on tumor progression and found that tumor cells can acquire genetic information and malignant phenotypes from parental cells undergoing CICs formation. The derivatives from CICs displayed increased abilities in proliferation and invasiveness, indicating epithelial-mesenchymal transition. Whole exome sequencing analysis identified potential genes involved in CIC-mediated genetic transfer. These results suggest that CICs formation may promote genetic transfer and gain of malignancy during tumor progression.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Daniele Campisi, Laurence Desrues, Kleouforo-Paul Dembele, Alexandre Mutel, Renaud Parment, Pierrick Gandolfo, Helene Castel, Fabrice Morin
Summary: ATG9A protein plays a critical role in chemotactic migration by promoting the formation of lamellipodia and the adhesion of cells to the extracellular matrix.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Immunology
Ofer Regev, Marina Kizner, Francesco Roncato, Maya Dadiani, Massimo Saini, Francesc Castro-Giner, Olga Yajuk, Stav Kozlovski, Nehora Levi, Yoseph Addadi, Ofra Golani, Shifra Ben-Dor, Zvi Granot, Nicola Aceto, Ronen Alon
Summary: ICAM-1 expressed by breast cancer cells is involved in innate immunity and can inhibit intravascular breast cancer metastasis to lungs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Nicola Hellen, Gregory I. Mashanov, Ianina L. Conte, Sophie le Trionnaire, Victor Babich, Laura Knipe, Alamin Mohammed, Kazim Ogmen, Silvia Martin-Almedina, Katalin Torok, Matthew J. Hannah, Justin E. Molloy, Tom Carter
Summary: This study investigates the response of P-selectin to vascular damage. By tracking individual P-selectin molecules, it is found that they initially show fast diffusion but later become increasingly restricted in movement, with around 50% of the molecules becoming completely immobile. Manipulation of the molecule's structure or disruption of the adapter complex can alter its mobility. P-selectin spreads rapidly from sites of exocytosis and then becomes less mobile, which is better suited for its anchoring function.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jia He, Wenting Huang, Jingru Wang, Guiqiang Li, Qi Xin, Zepeng Lin, Xiaodong Chen, Xusheng Wang
Summary: The study reveals the phenotypic and functional heterogeneity of CD34+ cells in normal, anagen, and diabetic wounds. CD34+ fibroblasts C2 showed the highest proportion in anagen wounds and were associated with inflammation and extracellular matrix. Increased CD34+ endothelial cells, fibroblasts C4, and neutrophils were found in diabetic wounds, while decreased fibroblasts C1 were observed. This study provides important insights into the specific roles of CD34+ cells in anagen and diabetic wounds, sheds light on the possible mechanisms of wound healing, and identifies potential therapeutic approaches.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Daniela Giordano, Runa Kuley, Kevin E. Draves, Keith B. Elkon, Natalia V. Giltiay, Edward A. Clark
Summary: The BAFF-producing cells, including neutrophils, monocytes, dendritic cells, T cells, and B cells, were found to be expanded in lupus models. BAFF expression in monocytes and dendritic cells was crucial for maintaining systemic BAFF levels and mature B cell pools.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kenichiro Ishii, Yasuhisa Nakagawa, Chise Matsuda, Daisuke Katoh, Masako Ichishi, Taku Shirai, Yoshifumi Hirokawa, Masaya Fujiwara, Yoshiki Sugimura, Masatoshi Watanabe
Summary: The study found that contact between PCa cells and patient-derived fibroblasts from different sources can induce morphological changes in PCa cells growing on a viscous substrate in vitro.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Immunology
Kristoffer H. Johansen, Dominic P. Golec, Julie H. Thomsen, Pamela L. Schwartzberg, Klaus Okkenhaug
Summary: PI3K signaling is crucial for T cell activation, differentiation, and trafficking, with PI3K delta being the dominant isoform in T cells. It regulates T cell functions by controlling adhesion receptors and their interaction with antigen-presenting cells. Understanding the role of PI3K delta in T cell migration and localization is important for potential impacts of PI3K delta inhibitors on T cell redistribution and function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xun Wu, Haixiao Liu, Qing Hu, Jin Wang, Shenghao Zhang, Wenxing Cui, Yingwu Shi, Hao Bai, Jinpeng Zhou, Liying Han, Leiyang Li, Yang Wu, Jianing Luo, Tinghao Wang, Chengxuan Guo, Qiang Wang, Shunnan Ge, Yan Qu
Summary: The pivotal role of extracellular vesicles (EVs) in the pathogenesis of central nervous system (CNS) disorders, including acute brain injury, is highlighted in this study. The study discovers a correlation between EVs-packaged miR-143-3p and perihematomal edema and neurological outcomes in intracerebral hemorrhage (ICH) patients. It also reveals that EVs-miR-143-3p is secreted by astrocytes upon ICH and can shuttle into brain microvascular endothelial cells (BMECs), leading to the upregulation of cell adhesion molecules (CAMs) and increased neutrophil migration. The study demonstrates the therapeutic potential of engineered EVs as a nucleotide drug delivery system for CNS disorders.
Article
Biochemical Research Methods
Toru Nakamura, Michio Iwata, Momoko Hamano, Ryohei Eguchi, Jun-ichi Takeshita, Yoshihiro Yamanishi
Summary: In this article, the authors present a new computational method called COMPRENDRE for predicting compound combinations that can regulate direct reprogramming pathways. The method successfully identifies new candidate combinations and reproduces experimentally verified compounds, making it a valuable tool for regenerative medicine.
Article
Biochemistry & Molecular Biology
Yihe Ma, Yumiao Lin, Wenting Huang, Xusheng Wang
Summary: The study explores the conversion of fibroblasts into dermal-papilla-cell-like cells using small molecules, with different fibroblasts requiring different compounds or combinations for conversion, and TTNPB alone efficiently converting adult mouse fibroblasts into DPC-LCs with stronger hair-inducing capacity. Transcriptome analysis reveals increased expression of genes associated with hair-inducing capacity in DPC-LCs, suggesting the potential of this pharmacological approach for hair follicle regeneration and hair loss therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
