Article
Biochemistry & Molecular Biology
Erik Wahlen, Frida Olsson, Doroteya Raykova, Ola Soderberg, Johan Heldin, Johan Lennartsson
Summary: This study investigates the internalization process of EGFR and PDGFR-β using immunofluorescent microscopy. The results show that these two receptors utilize separate internalization routes, but merge in a common endosomal compartment after 45 minutes of stimulation. The association between EGFR and caveolin-1 is stronger compared to PDGFR-β, and disruption of lipid rafts affects the signaling of EGFR and PDGFR-β differently.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Joo-Hui Han, Hyun-Soo Park, Do-Hyung Lee, Jun-Hwan Jo, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study suggests that PDGF-BB-induced VSMC autophagy is mainly regulated by Erk1/2, independent of the mTOR pathway. Targeting autophagy modulation may be a potential therapeutic strategy for addressing abnormal VSMC proliferation and migration.
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Cell Biology
Akira Takaguri, Rena Ishizaka, Shota Maki, Kumi Satoh
Summary: This study reveals the important role of TRIB2 in VSMC proliferation, which is upregulated following vascular injury and PDGF-BB stimulation. The expression of TRIB2 is mediated by ROS/ERK/EGR-1 pathways and plays a critical role in VSMC proliferation via modulation of ERK activity.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Cell & Tissue Engineering
Fiona R. Passanha, Madeleine L. Divinagracia, Vanessa L. S. LaPointe
Summary: Cadherin-11 regulates the activity of RTKs in hMSCs, affecting the activation of the MAPK pathway and cell proliferation.
Article
Cell Biology
Jung-Chien Cheng, Xiaoyu Han, Qingxue Meng, Yanjie Guo, Boqun Liu, Tinglin Song, Yuanyuan Jia, Lanlan Fang, Ying-Pu Sun
Summary: This study reveals that HB-EGF can enhance the luteal function in humans by inducing StAR expression and progesterone production through the activation of the ERK1/2 signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Jing Wang, Yuan-wei Zhang, Nian-jie Zhang, Shuo Yin, Du-ji Ruan, Nian He, Xu Chen, Xue-feng Yang
Summary: The study revealed that NP could induce CRC cell growth by influencing the expression of multiple genes such as CCDC80, and CCDC80 and ERK1/2 inhibitors may be suitable therapeutic targets in NP-related CRC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Yuhan Li, Xiurui Lv, Huan Chen, Zhengke Zhi, Zhonghong Wei, Binyu Wang, LingLing Zhou, Hongxing Li, Weibing Tang
Summary: Hirschsprung's disease (HSCR) is characterized by a lack of ganglion cells in the digestive tract, and its development may be influenced by the interaction of multiple genes and microenvironmental factors. Research suggests that substances in the intestinal microenvironment play a crucial role in the disease progression. Recent studies have shown that endogenous peptides derived from AHNAK protein may be involved in the pathogenesis of HSCR.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Oncology
Jianyou Gu, Wenjie Huang, Junfeng Zhang, Xianxing Wang, Tian Tao, Ludi Yang, Yao Zheng, Songsong Liu, Jiali Yang, Liwei Zhu, Huaizhi Wang, Yingfang Fan
Summary: TMPRSS4 is upregulated in pancreatic cancer and associated with poor prognosis, serving as an independent risk factor in PDAC. It promotes cellular proliferation and inhibits apoptosis, possibly through activating the ERK1/2 signaling pathway. This study suggests TMPRSS4 as a potential prognostic biomarker and therapeutic target for pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Lasse K. Markussen, Elizabeth A. Rondini, Olivia Sveidahl Johansen, Jesper G. S. Madsen, Elahu G. Sustarsic, Ann-Britt Marcher, Jacob B. Hansen, Zachary Gerhart-Hines, James G. Granneman, Susanne Mandrup
Summary: This study uncovers the transcriptional network controlled by lipolysis in brown adipocytes and shows that lipolysis is required for the activation of the thermogenic gene program by beta-adrenergic signals. PPARs are identified as key mediators of lipolysis-induced activation of lipid metabolism and thermogenic genes. Additionally, lipolysis also activates the unfolded protein response and regulates the core circadian transcriptional machinery independently of PPARs.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Mengqi Liu, Yi Qin, Qiangsheng Hu, Wensheng Liu, Shunrong Ji, Wenyan Xu, Guixiong Fan, Zeng Ye, Zheng Zhang, Xiaowu Xu, Xianjun Yu, Qifeng Zhuo
Summary: In this study, it was found that SETD8 interacted with STAT3 on the DUSP10 promoter region to epigenetically silence DUSP10 expression, leading to enhanced ERK1/2 activation and unfavorable prognosis in pancreatic adenocarcinoma (PDAC). This study highlights the role of epigenetic mechanisms in modulating ERK1/2 activation and cell proliferation in PDAC.
Article
Multidisciplinary Sciences
Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Mueller, Anke Toenjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Bluher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer
Summary: This study reveals that inosine, a metabolite released during apoptosis, enhances the thermogenic program in healthy adipocytes and regulates energy expenditure. The equilibrative nucleoside transporter 1 (ENT1) controls inosine levels in brown adipose tissue, affecting thermogenic capacity. In humans, a loss of function mutation in ENT1 is associated with lower body mass index and reduced odds of obesity.
Article
Oncology
Mateusz Kozlowski, Dominika Borzyszkowska, Justyna Mirko, Agnieszka Turon-Skrzypinska, Katarzyna Piotrowska, Aleksandra Toloczko-Grabarek, Sebastian Kwiatkowski, Maciej Tarnowski, Iwona Rotter, Aneta Cymbaluk-Ploska
Summary: This study suggests that PDGF-AB, PDGF-BB, TGF-alpha, EGF, and ANG-2 may serve as potential diagnostic markers for endometrial cancer due to their significantly higher serum levels in endometrial cancer patients compared to those with non-cancerous endometrial lesions.
Article
Cell Biology
Hong-Beom Park, Sohyun Hwang, Kwang-Hyun Baek
Summary: This study analyzed the potential substrate proteins of USP7 using bioinformatics tools and confirmed Raf-1 as one of its substrates. By removing ubiquitin from Raf-1, USP7 inhibits the activation of the ERK1/2 signaling pathway, resulting in the suppression of lung adenocarcinoma cell proliferation.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Katrin Fischer, Henry H. Ruiz, Kevin Jhun, Brian Finan, Douglas J. Oberlin, Verena van der Heide, Anastasia V. Kalinovich, Natasa Petrovic, Yochai Wolf, Christoffer Clemmensen, Andrew C. Shin, Senad Divanovic, Frank Brombacher, Elke Glasmacher, Susanne Keipert, Martin Jastroch, Joachim Nagler, Karl-Werner Schramm, Dasa Medrikova, Gustav Collden, Stephen C. Woods, Stephan Herzig, Dirk Homann, Steffen Jung, Jan Nedergaard, Barbara Cannon, Matthias H. Tschoep, Timo D. Mueller, Christoph Buettner
Editorial Material
Endocrinology & Metabolism
Alexander W. Fischer, Barbara Cannon, Jan Nedergaard
MOLECULAR METABOLISM
(2017)
Article
Endocrinology & Metabolism
Jessica M. Olsen, Robert I. Csikasz, Nodi Dehvari, Li Lu, Anna Sandstrom, Anette I. Oberg, Jan Nedergaard, Sharon Stone-Elander, Tore Bengtsson
MOLECULAR METABOLISM
(2017)
Article
Endocrinology & Metabolism
Alexander W. Fischer, Barbara Cannon, Jan Nedergaard
MOLECULAR METABOLISM
(2018)
Article
Endocrinology & Metabolism
Jasper M. A. de Jong, Barbara Cannon, Jan Nedergaard
Review
Endocrinology & Metabolism
Alexander W. Fischer, Barbara Cannon, Jan Nedergaard
Article
Biochemistry & Molecular Biology
Marie S. Isidor, Sally Winther, Lasse K. Markussen, Astrid L. Basse, Bjorn Quistorff, Jan Nedergaard, Brice Emanuelli, Jacob B. Hansen
Article
Physiology
Barbara Cannon, Jasper M. A. de Jong, Alexander W. Fischer, Jan Nedergaard, Natasa Petrovic
EXPERIMENTAL PHYSIOLOGY
(2020)
Review
Biology
Jan Nedergaard, Gabriella von Essen, Barbara Cannon
Summary: This article discusses whether a decrease in UCP1 activity could cause obesity in humans. Studies in mice suggest that the absence of UCP1 leads to obesity. It is still unknown if similar mechanisms exist in humans.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Gabriella von Essen, Erik Lindsund, Elaina M. Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
Summary: This study examines the possibility of countering obesity by activating brown or beige adipose tissue and UCP1. The findings show that although UCP1 protein may increase, it is not necessarily utilized for diet-induced thermogenesis. Constant activation of UCP1 is required to effectively ameliorate obesity development.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Alexander W. Fischer, Irina G. Shabalina, Charlotte L. Mattsson, Gustavo Abreu-Vieira, Barbara Cannon, Jan Nedergaard, Natasa Petrovic
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Endocrinology & Metabolism
Gabriella von Essen, Erik Lindsund, Barbara Cannon, Jan Nedergaard
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Endocrinology & Metabolism
Jasper M. A. de Jong, Rene T. F. Wouters, Nathalie Boulet, Barbara Cannon, Jan Nedergaard, Natasa Petrovic
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Biochemistry & Molecular Biology
Anastasia V. Kalinovich, Jasper M. A. de Jong, Barbara Cannon, Jan Nedergaard
Article
Cell Biology
Irina G. Shabalina, Mikhail Yu. Vyssokikh, Natalia Gibanova, Robert I. Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, Lora E. Bakeeva, Valeria B. Vays, Antonina V. Pustovidko, Maxim V. Skulachev, Barbara Cannon, Vladimir P. Skulachev, Jan Nedergaard